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What is Revia?
Revia is supplied as a pale yellow film-coated tablets for oral use , which on one side is labeled "R11", and the other side with "50 ." Each film-coated tablet contains 50 mg of active substance naltrexone hydrochloride.
Revia ® film-coated tablets also contain inactive ingredients: lactose monohydrate, microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate, coating (pale yellow opadry). Revia ® is available in packs of 1, 2 or 4 cards in 7 tabletki.Naltrexone hydrochloride is an opioid antagonist , which means that it blocks the effects of opioid agents ( e.g., dihydrocodeine, morphine and heroin) , as well as substances having a similar effect , naturally occurring in the brain. It is believed that the use of alcohol increases the level of these substances in the body, a sense of satisfaction . Revia blocks the effects of opioids and thus reduces dependence and craving for alcohol. Revia ® does not cause zavisimost.Aktivnoto substance Revia ®, naltrexone hydrochloride, are rapidly absorbed from the gastro -intestinal tract after oral administration. After metabolism is obtained metabolite 6 - beta- naltrexone . When dosed once daily , naltrexone hydrochloride is excreted in about 4 hours, and 6 - beta- naltrexone for about 13 hours. The drug is excreted primarily through the kidneys.
In which cases Revia?
Revia ® not be used alone for treatment of opioid or alcohol dependence, and apply integrated with other forms of treatment ( psychotherapy, behavioral therapy , psycho -social measures) . Naltrexone hydrochloride reduces craving for opioids and intake of alcohol , thus reducing the risk of relapse.
What you should know before starting treatment with Revia?
You should not take Revia :
• If you are allergic to the active ingredient in Revia or any of the excipients .
• If you are currently taking opioid substances (in this case can occur abstinence syndrome ) or are in a state of abstinence ( may worsen ) .
• If you are taking medicines containing opioids , eg some antitussive , antidiarrheal and sedation .
Warning : Revia ® does not block the effects of pain medication that does not contain opioids (eg, ibuprofen, paracetamol or aspirin) .
• If you are currently in a state of opioid withdrawal syndrome
• If the test for the presence of opioids in the urine is positive.
• If you experience symptoms of opioid withdrawal after injection of naloxone.
• If you suffer from acute hepatitis or liver failure.
• If you experience any of the above conditions or are not sure assessment, consult your doctor.
There are no adequate test data and results from the use of this medicine by children under 18 years.
Pregnancy and lactation
In animal studies have teratogenic effects of naltrexone. However, the drug should be administered to pregnant or lactating women in urgent indications and after weighing the potential benefits and possible risks to mother and child.
What should you tell your doctor before taking Revia ?
• If you have liver or kidney disease.
• If you are pregnant , planning a pregnancy or breastfeeding.
• Are taking medications containing opioids (see above) or other drugs , such as . thioridazine .
• You need to tell your doctor about any other medicines you are taking , including those bought without a prescription .
If you feel tired or dizzy after taking medication do not drive or operate machinery until you discuss this problem with your doctor.
How to take pills Revia ?
At least 7-10 days before starting treatment with Revia you should stop taking any opioid substances. Your doctor should do a test ( urine ) which will confirm whether treatment with Revia ® can begin. On the first day, said patient is administered 25 mg naltrexone hydrochloride, and then monitored for one hour to determine whether they will experience symptoms of withdrawal . If you do not show symptoms, the patient is given the remaining 25 doza.Obichaynata mg daily dose is 1 tablet (50 mg naltrexone hydrochloride). This dose can block the effect of 25 mg of intravenous pure heroin for 24 h.Dozoviyat mode can be changed and your doctor may prescribe a different dosage, thereby improving the comprehensive treatment and reduce the symptoms of addiction. For example , the appointment of 2 tablets (= 100 mg naltrexone hydrochloride) on Monday and Wednesday and 3 tablets ( = 150 mg naltrexone hydrochloride) in petak.Revia be taken as prescribed by a physician for 3 or more mesetsa.Ako take more prescribed dose , contact your doctor immediately . Treatment of overdose simptomatichno.Ako miss a dose , do not worry . Take your next dose as scheduled , without trying to make up for the missed dose by doubling .
What can happen if prnemete alcohol during treatment with Revia ?
Concomitant intake of Revia ® alcohol does not cause typical , unpleasant sensations ( disulfiramov type reaction). However, if you continue to drink alcohol during treatment , the levels of alcohol in your blood will rise, leading to physical and mental narusheniya.Na patients taking Revia, should not apply medicines containing opioids (some antitussive , antidiarrheal and analgesic agents) , as Revia may reduce their efekti.Ako in an emergency use of opioid analgesics, it is necessary to apply a higher dose in order to provide adequate analgesia. In these cases , because of the risk of respiratory depression, or manifestation of other side effects, it is necessary to monitor the patsienta.Ako taking low dose of heroin or other opioids , naltrexone hydrochloride will prevent opioid effects.
What are the possible side effects ?
Most patients tolerate the drug. As with other drugs , however , sometimes causes so-called Revia ® . side effects in some patients , which may occur as symptoms of abstinence syndrome to morphine .
During treatment with Revia marked the following adverse reactions :
Digestive system :
Abdominal pain , cramping in the stomach and intestines , nausea, vomiting , diarrhea, constipation ( constipation ), loss of appetite.
Headache , sleep disturbances , insomnia , mood changes ( irritability , discomfort ), feeling of fear, passivity , feelings of confusion , hallucinations, nervousness , dizziness , visual disturbances .
Skin rash , itching, acne.
Increased sweating and tearing, leg pain , joint and muscle pain, ear pain , thirst, weight loss, delayed ejaculation , abnormal potentnostta.Nablyudavan a single case of idiopathic thrombocytopenic purpura, which disappeared with corticosteroid terapiya.Pri study patients with drug or alcohol dependence, it was observed increase of liver transaminases during treatment . In an earlier study of obese patients who received 300 mg naltrexone per day ( 6 times daily intake) for a long period of time , the level of liver transaminases were elevated in some patients . The increase in liver transaminases is reversible upon discontinuation of treatment , and can be attributed to the high doses naltrexone.V starting and during the treatment, at the discretion of the physician , may be required to carry out blood tests for opioid . This is because Revia is metabolized in the liver, and the tests are an indicator of liver function.If feel stomach pain which lasts a few days , have loose stools , dark color of urine or yellowing of the eyes should immediately stop taking the medicine and tell your lekar.Patsientite treated Revia ® need to carry a card containing information about their full name , the medicine you take and the period of treatment. They should always carry a map , so that if necessary , in an emergency, to ensure the appropriate lechenie.Revia ® can block the effects of drugs containing opioids (some antitussive , antidiarrheal and sedation ) . Do not try to overcome the blockade , taking higher doses of these drugs because it can be life-threatening effects. If you become ill and need treatment , tell your doctor and / or pharmacist that you are taking Revia ®. They will recommend the right medicine .
What you should remember about Revia!
Check the expiry date of the drug. Do not use after the expiry date stated on the packaging. Do not store above 25 ° S. Tell your doctor that you are taking naltrexone hydrochloride.Testat in urine naltrexone hydrochloride should not be done when the patient exhibits clinical symptoms of withdrawal or if there are traces of opioids in the urine. The test was repeated at appropriate time intervals ( daily) , until it is verified that there is no presence of opioids in the urine. It is recommended to make regular laboratory tests for controlling the presence of opioids and other substances of zavisimost.Predi beginning, and during the treatment with Revia ® is recommended control of liver function ( transaminase ) . Remember that this medicine is for you must not be taken by anyone without medical predpisanie.Priemayte medicine as prescribed by your doctor . Keep out of the reach of children mesta.Kogato stop taking the medicine , return unused tablets to your doctor or pharmacist.
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