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Active ingredient: Each tablet contains 5 mg of selegiline hydrochloride.
Excipients: milk sugar, microcrystalline cellulose, corn starch, povidone K-25 and stearic acid.
Treatment of Parkinson's Disease and Symptomatic Parkinsonism: Yamax is intended for the treatment of Parkinson's disease and symptomatic parkinsonism, alone or in combination with levodopa (another medicine for the treatment of Parkinson's disease), with or without a peripheral enzyme inhibitor. The early stages of Parkinson's disease, Yamax, may be used to delay the onset of levodopa administration (with or without an enzyme inhibitor). Only Yamax treatment in the early or moderate stage of the disease results in good results.
Administration of Yamax alleviates but does not prevent the development of symptoms and does not improve mobility without the addition of levodopa (with or without peripheral enzyme inhibitors). In late stages of Parkinson's disease, taking Yamax may increase the therapeutic effect of levodopa.
• Hypersensitivity to selegiline or other ingredients of the medicine
• Extrapyramidal disorders Psychotic disorders and depression.
The combination of Yamax with levodopa may have sympathomimetic effects (ie, it may affect the sympathetic nervous system), therefore Yamax treatment is contraindicated in high blood pressure, thyrotoxicosis (increased thyroid function), pheochromocytoma Benign adrenal tumor), glaucoma, prostate adenoma, tachycardia (accelerated pulse), arrhythmias and acute forms of angina pectoris (coronary heart disease). Yamax should not be given concomitantly with serotonin reuptake inhibitors (antidepressants such as fluoxetine, sertraline, paroxetine), tricyclic antidepressants, sympathomimetics and pethidine (meperidine). MAO inhibitors (moxamine oxidase inhibitors). Serotonin agonists.
Precautions and precautions for use
The action of Yamax can. To be associated with the following side effects: involuntary movements, coordination disturbance, psychotic episodes, behavioral and / or sleep disturbances, gastrointestinal disorders and orthostatic hypotension (decrease in blood pressure and dizziness). 10 mg daily, due to an increased risk of hypertonic reactions as a result of levodopa treatment, also avoid excessive consumption of tyramine-rich food (cheese, red wine, chicken liver, herring, yeast products).
Caution should be exercised in patients with Parkinson's disease who suffer from ulcer disease as there may be an exacerbation of the disease.
It is recommended to take precautions when administering general anesthesia to patients who are taking MAO inhibitors (see "Drug Interactions")
Gastrointestinal disorders may occur in patients who are intolerant to milk sugar because of the lactose content of the tablets.
1. Drug Interactions
Sympathicomimetics: (the action of these drugs resembles the functioning of the syphilis nervous system) Because of the risk of hypertension during treatment with Yamax, sympathomimetics are not administered. MAO inhibitors (medicines that inhibit the activity of monoamine oxidase (enzyme) in brain tissue and thus affect mood): concomitant administration of Yamax and MAO inhibitors may cause lowering of blood pressure. Lethidine (a strong opioid analgesic): Concomitant administration of Yamax and aerodynamic agents is contraindicated due to the possible occurrence of delirium, stupor, and stiffness in the muscles.
Selective serotonin reuptake inhibitors (such as fluoxetine sertraline): Yamax is not given concurrently with fluoxetine due to the risk of manic symptoms, chills, sweating, and hypertension. Selective serotonin reuptake inhibitors. May be applied at the earliest. Two. Weeks after. Discontinuation, Yamax. The use of such products should be discontinued for at least two weeks prior to initiating treatment with Yamax. "Tricyclic antidepressants (such as amipramine, amitriptyline, etc.): Serious central nervous system complaints such as dizziness, tremor, seizures , Sometimes at the same time - with hypertension or hypotension (increase or decrease in blood pressure), sweating. Therefore, concomitant treatment with tricyclic antidepressants and Yamax is contraindicated.
Oral contraceptives: Concomitant use of Yamax and oral contraceptives leads to an increased concentration of Yamax in the body. This may lead to a risk of hypertonic reactions. Therefore, concomitant use of Yamax and oral contraceptives should be avoided.
Dosage and route of administration:
Daily dose: A single 5 mg dose taken once a day in the morning or 10 mg divided into two 5 mg doses - during breakfast and lunch. Yamax is taken alone or in combination with medicines containing levodopa or in combination with levodopa and medicines that are peripheral enzyme inhibitors.
Adverse drug reactions
Treatment with Yamax alone is usually well tolerated.
The following undesirable effects may occur: hallucinations, delirium, anxiety, agitation, confusion, sleep disorders, involuntary movements, mood swings, abdominal pain, fatigue, vertigo, bradycardia (dyspnoea).
From the gastrointestinal tract side, as a result of Yamax administration, nausea, vomiting, anorexia (withdrawal from food intake), or exacerbation of ulcer disease may occur.
Other side effects observed include orthostatic hypotension (severe blood pressure), skin reactions, dry mouth, unpleasant taste, headache, dizziness, sweating, hypertension (increase in blood pressure), palpitations, transient elevations of liver enzymes Of the treatment), urinary retention
Adverse reactions may be aggravated by the combination of Yamax with other medicines, especially combination with a levodopa / enzyme inhibitor. In most cases, decreasing doses of levodopa, the enzyme inhibitor and Yamax reduce the side effects.
Overdose with Yamax has no specific clinical picture: Since MAO-B selective inhibition is only achieved at doses recommended for the treatment of Parkinson's disease (5 to 10 mg / day), overdose resembles that obtained with non-selective monoamine oxidase inhibitors Of the nervous and cardiovascular system). There is no specific antidote and treatment is symptomatic.
Pregnancy and breastfeeding
The influence of Yamax on the development of the fetus during pregnancy is unknown. It is not clear whether Yamax crosses the placental barrier and reaches the fetus. No fetal-damaging effects have been observed. It is not known whether Yamax is excreted by breast milk. For these reasons, the use of Yamax during pregnancy and lactation should be avoided.
Effects on ability to drive and use machines:
No studies have been conducted to evaluate the effect of Yamax on the ability to drive and use machines. Yamax recipients should be warned of the possibility of nervous system reactions such as fatigue, dizziness, dizziness, confusion and visual disturbances that may disrupt the ability to drive and use machines.
To be used before the expiry date stated on the packaging. Store in a place protected from light and moisture, unobstructed for children, at temperatures below 30 ° C.
One pack contains 30 tablets of 5 mg.
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