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WHAT AKRUKS PLUS AND WHAT IT IS USED
Your medicine is called AKRUKS PLUS. Used to treat high blood pressure (hypertension) in adults. It contains two active ingredients: candesartan cilexetil and hydrochlorothiazide. They work together to lower your blood pressure.
Candesartan cilexetil belongs to a group of medicines called angiotensin II receptor antagonists. It relaxes and widens your blood vessels. This helps to lower your blood pressure.
Hydrochlorothiazide belongs to a group of medicines called diuretics (water tablets). It helps your body to secrete water and salts like sodium in the urine. This leads to a lowering of your blood pressure.
Your doctor may prescribe AKRUKS Plus if your blood pressure is lowered enough with candesartan or hydrochlorothiazide alone.
2. BEFORE YOU TAKE AKRUKS PLUS
Do not take AKRUKS PLUS
if you are allergic (hypersensitive) to candesartan cilexetil or hydrochlorothiazide or any of the other ingredients of AKRUKS PLUS (see section 6);
if you are allergic to sulfa drugs. If you are not sure if this applies to you, please ask your doctor;
if you are pregnant after the third month (it is better to avoid taking AKRUKS Plus in early pregnancy - see pregnancy section);
If you have severe kidney problems;
if you have severe liver disease or biliary obstruction (problems with drainage of the bile from the gall bladder);
if you have a constant low levels of potassium in the blood;
if you have persistently high levels of calcium in the blood;
if you have ever had gout.
If you are not sure if any of these apply to you, please contact your doctor or pharmacist before you start taking AKRUKS PLUS.
Take special care with AKRUKS PLUS
Before you start taking AKRUKS PLUS or while taking it, tell your doctor if:
you have heart problems, liver and kidneys;
Rather you a kidney transplant;
vomit if you have recently had severe vomiting or have diarrhea;
You have a disease of the adrenal gland called Conn's syndrome (also called primary aldosteronism);
ever had a disease called systemic lupus erythematosus (SLE);
have low blood pressure;
You have ever had a stroke;
you have ever had allergy or asthma;
You should tell your doctor if you are pregnant (or might be pregnant). AKRUKS PLUS is not recommended to be taken in early pregnancy, and after the third month of pregnancy should not be taken because during this period can cause serious harm to your baby (see pregnancy section).
If you have any of these conditions, your doctor may want to see you more often and you do further research.
If you have an operation, tell your doctor or dentist that you are taking AKRUKS PLUS. The reason for this is that the combination of AKRUKS PLUS with certain anesthetics can cause a sharp drop in blood pressure.
AKRUKS PLUS may cause increased skin sensitivity to the sun.
Use in children
There is no experience with the use of AKRUKS PLUS in children (under 18 years). Therefore AKRUKS PLUS should not be given to children.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. AKRUKS PLUS may affect the way some other medicines work and some medicines can affect AKRUKS PLUS. If you are taking certain medications may be necessary sometimes Your doctor may make blood tests.
Tell your doctor, especially if you are taking the following medicines:
Other drugs used to lower blood pressure, including beta-blockers, diazoxide and angiotensin-converting enzyme (ACE) inhibitors such as enalapril, captopril, lisinopril or ramipril;
Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen or diclofenac;
Celecoxib or etoricoxib (medicines to relieve pain and inflammation);
Acetylsalicylic acid (if you are taking more than 3 g per day - medicines to relieve pain and inflammation);
potassium supplements or potassium-containing salt substitutes (medicines that increase potassium levels in your blood);
Supplements containing calcium and vitamin D;
Medicines to lower cholesterol such as colestipol or cholestyramine;
Medicines used to treat diabetes (tablets or insulin);
Medicines to control heart rhythm (antiarrhythmic agents) such as digoxin and beta-blockers;
Drugs whose action can be influenced by potassium levels in the blood, such as some antipsychotic drugs;
Heparin (a medicine used to thin the blood);
Water pills (diuretics);
Amphotericin (for the treatment of fungal infections);
Lithium (a medicine used for mental disorders);
Steroids such as prednisolone;
Hormone of the pituitary gland (ACTH);
Medicines to treat cancer;
Amantadine (for the treatment of Parkinson's disease or of serious infections caused by viruses);
Barbiturates (sedatives, which are also used for the treatment of epilepsy);
Carbenoxolone (to treat disease of the esophagus or mouth ulcers);
Anticholinergic agents such as atropine and biperiden;
Cyclosporine, a drug used after organ transplant to prevent rejection;
Other drugs that may enhance the antihypertensive effect such as baclofen (a medicine for relief of spasticity), amifostine (used in cancer treatment) and some antipsychotic drugs.
Taking AKRUKS Plus with food and drink (in particular alcohol)
You can take AKRUKS PLUS with or without food.
When you are prescribed AKRUKS PLUS, ask your doctor before taking alcohol. Alcohol can cause weakness or dizziness.
Pregnancy and lactation
Tell your doctor if you are (or might become) pregnant. Your doctor will normally advise you to stop taking AKRUKS Plus before you become pregnant or as soon as possible after making sure that you are pregnant and will advise you to take another medicine instead AKRUKS PLUS. The use of AKRUKS PLUS is not recommended in early pregnancy and must not be taken if you are pregnant after the third month, as it may seriously harm your baby.
Tell your doctor if you are breastfeeding or planning to breastfeed. AKRUKS PLUS is not recommended for mothers who are breastfeeding, and your doctor may choose another treatment for you if you wish to breastfeed, especially if your baby is newborn, or was born prematurely.
Driving and using machines
During the intake AKRUKS PLUS some people may feel tired or dizzy. If this happens, do not drive or operate any tools or machinery.
Important information about some of the ingredients of AKRUKS PLUS
AKRUKS PLUS contains lactose which is a type of sugar. If your doctor has told you that you have an intolerance to some sugars, talk to him before you start taking this medicine.
3. HOW TO TAKE AKRUKS PLUS
Always take AKRUKS PLUS exactly as you have been told your doctor. If you're not sure, ask your doctor or pharmacist. It is important to take AKRUKS PLUS every day.
The usual dose AKRUKS PLUS is one tablet once daily.
Swallow the tablet with some water.
Try to take the tablet at the same time each day. This will help you remember to take it.
If you take a larger dose than necessary AKRUKS PLUS
If you take more doz aAKRUKS Plus than prescribed by your doctor, contact a doctor or pharmacist for advice.
If you forget to take AKRUKS PLUS
Do not take a double dose to make up for a missed tablet. Just take your next dose as usual.
If you stop taking AKRUKS PLUS
If you stop taking AKRUKS Plus, your blood pressure may increase again. Therefore you should not stop taking AKRUKS PLUS without first talking to your doctor.
4. POSSIBLE SIDE EFFECTS
Like all medicines, AKRUKS PLUS can cause side effects, although not everybody gets them. It is important to be informed about these possible side effects. Some of these side reactions AKRUKS PLUS due to candesartan cilexetil, while others are caused by hydrochlorothiazide.
Stop taking AKRUKS Plus and seek medical help immediately if you experience any of the following allergic reactions:
difficulty breathing with or without swelling of the face, lips, tongue and / or throat;
swelling of the face, lips, tongue and / or throat that may cause difficulty in swallowing;
severe itching of the skin (with protruding bumps).
AKRUKS PLUS can reduce the number of white blood cells. Your resistance to infection may be decreased and you may notice fatigue, infection or fever. If this happens, contact your doctor. Your doctor may periodically study the values of your blood to check whether AKRUKS PLUS affect your blood (agranulocytosis).
Other possible side effects include:
Common (affect 1 to 10 users in 100):
Changes in blood test results:
decreased levels of sodium in the blood. If this reduction is large, you may notice weakness, lack of energy, or muscle spasms;
increased or decreased levels of potassium in the blood, especially if you already have kidney problems or heart failure. If this reduction is large, you may notice tiredness, weakness, irregular heartbeat, numbness "bodlichki and needles";
elevated levels of cholesterol, glucose or uric acid in the blood;
Emergence of sugar in the urine;
A feeling of lightheadedness / dizziness or weakness;
Respiratory tract infections;
Uncommon (affect less than 1 user in 100):
Low blood pressure. As a result, you may experience fainting or dizziness;
Loss of appetite, diarrhea, constipation, gastric irritation;
Skin rash, lumpy rash (urticaria), rash as a result of increased sensitivity to sunlight.
Rare (less influenced by 1 member 1 000):
Jaundice (yellowing of the skin or whites of the eyes). If Tovi happens to you, contact your doctor;
Effect on babrechbata function, especially if you already have kidney problems or heart failure;
Difficulty sleeping, depressed mood, anxiety;
Tingling or "pins and needles" in hands or feet;
Unusually fast heartbeat;
Breathing difficulties (including lung inflammation and fluid in the lungs);
High temperature (fever);
Inflammation of the pancreas. This can cause moderate or severe pain in the stomach area;
Damage to the blood vessels, which leads to red or purple spots on the skin;
A decrease in red and white blood cells or platelets. You may notice fatigue, infections, fever or easy bruising;
Severe rash that develops quickly with blistering or peeling of the skin and possibly blistering in the mouth;
Worsening of existing lupus erythematosus like reactions or appearance of unusual skin reactions.
Very rare (affect less than 1 user in 10 000):
Swelling of the face, lips, tongue and / or throat;
Back pain, joints and muscles;
Changes in liver function, including inflammation of the liver (hepatitis). You may notice tiredness, yellowing of skin and whites of the eyes and "flu-like" symptoms;
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.
5. HOW TO STORE AKRUKS PLUS
Keep out of reach of children.
This medicinal product does not require any special storage conditions.
Do not use AKRUKS PLUS after the expiry date stated on the carton after "EXP". The expiry date refers to the last day of that month.
Medicines should not be disposed of in wastewater or household waste. Ask your pharmacist how to dispose of medications that are no longer needed you. These measures will help to protect the environment.
6. FURTHER INFORMATION
What AKRUKS PLUS
The active substances are candesartan cilexetil and hydrochlorothiazide.
Each tablet AKRUKS PLUS contains 8 mg of candesartan cilexetil and hydrochlorothiazide 12,5 mg. Each tablet AKRUKS hydrochlorothiazide contains 16 mg candesartan cilexetil and hydrochlorothiazide 12,5 mg.
The other ingredients are sodium docusate, sodium lauryl sulfate, carmellose calcium, pregelatinized maize starch, hydroxypropyl cellulose lactose monohydrate, magnesium stearate (E572).
AKRUKS looks like and contents of the pack
AKRUKS PLUS 8 mg / 12,5 mg are available in the following packages:
Blister packs of 7 [10, 14, 15, 20, 28, 30, 50, ednodoza package 50x1 tablet 56, 60, 84, 90 98, 100] and white, oval, biconvex tablets with an indication CH and 08 on one side and scored on both sides.
AKRUKS PLUS 16 mg / 12,5 mg are available in the following packages:
Blister packs of 7, [10, 14, 15, 20, 28, 30, 50, ednodoza package 50x1 tablet 56, 60, 84, 90, 98, 100] and white, oval, biconvex tablets with an indication CH and 16 on one side and scored on both sides.
Not all pack sizes may be marketed.
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