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WHAT THIS MEDICINE IS AND WHAT IT IS USED FOR?
Angetop apply for the symptomatic treatment of mild to moderate acute and chronic pain of different origins - headache, toothache, neuralgia, neuritis, muscle and menstrual pain, renal and biliary colic, post-traumatic and postoperative pain. It is recommended that in the internationally agreed scheme to alleviate the pain of malignancy prior to the administration of narcotic analgesics.
As temperature decreasing agent is applied in complex therapy of acute catarrh of the upper respiratory tract, tracheitis, tracheobronchitis, infectious diseases - flu, measles, chicken pox, when other agents are ineffective or contra-indicated.
2. BEFORE YOU TAKE ANGETOP
Do not take this medicine if:
you are allergic (hypersensitive) to the active substance or to any of the ingredients;
you are allergic to pyrazolone derivatives or other HCPBC;
have a genetic deficiency of glucose-6-phosphate dehydrogenase;
have hematologic diseases - leukopenia, agranulocytosis. hemolytic anemia, aplastic anemia, hepatic porphyria;
you have severe liver or kidney disease;
you are pregnant or breast-feeding;
Do not use in children under 7 years of age.
Take care with Angetop:
In patients with impaired renal function, gastric and duodenal ulcers only be used under medical supervision;
Disease with reduction in the number of leukocytes requires their follow in order to prevent leucopenia;
In allergic asthma conditioned;
Use of the product as possible discoloration of urine red.
Using other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Metamizole can reduce the activity of coumarin anticoagulants resulting in accelerating its degradation (metabolism).
Co-administration of metamizol with drugs accelerating its degradation so-called "enzyme inducers" of hepatic metabolism (barbiturates, glutethimide, phenylbutazone) can reduce the effect of metamizol.
Tricyclic antidepressants, oral contraceptives and enhance the effects of allopurinol Metamizol, due to delays in its metabolism. Metamizol lowered plasma levels of ciclosporin in simultaneous use. Reduced therapeutic effect of metamizol was observed in combination with ASE inhibitors and diuretics (in patients with impaired renal function leads to increased risk of acute renal failure).
Coadministered with lithium, metamizole increase its plasma concentration and can reach toxic concentrations of lithium.
Co-administration of metamizol with other antipyretic, analgesic and anti-inflammatory drugs increase the risk of allergic reactions.
There is a risk of myelosuppression when administered with chloramphenicol and other myelotoxic drugs.
Funds CNS depressants and alcohol enhance the analgesic effect of metamizol. Coadministration of chlorpromazine and other phenothiazine derivatives have an increased risk of decreased body temperature.
Taking Angeton with food and drink - alcohol enhances the analgesic effect of metamizol.
Pregnancy and breast-feeding - if you are pregnant, consult your doctor before taking this medicine.
It is not recommended to administer the product during pregnancy, especially during the first and last trimester and during the second quarter - after careful consideration by the doctor. Angetop should not be used during lactation, as its metabolic products pass into breast milk.
Driving and operating machinery - in usual doses Angetop not affect your ability to drive and use machines. When taken in high doses can adversely affect alertness and impaired reactions and unexpected situations.
3. HOW TO TAKE THIS MEDICINE
Adults and children over 12 without prescription - 500 mg 3-4 times daily.
Maximum single dose - 1 g, maximum daily dose - 3 g.
Duration of treatment: 3 to 5 days.
Children under 12 years - with a prescription.
Children from 7 to 9 years - 1/2 tablet 2 times a day, maximum daily dose of 2 tablets.
Children from 10 to 14 years - 1/2 to 1 tablet 3 times daily, maximum daily dose of three tablets.
Angetop is recommended to be taken after meals, if necessary before meals with plenty of fluids.
The duration of the treatment course without consultation with a physician should not exceed 5 days in adults and 3 days in children.
If you take more than you should
Symptoms - nausea, vomiting, dizziness, tinnitus, decrease in body temperature, decreased urine output, bluish skin and shortness of breath. It is possible to strongly lower blood pressure to a shock, acute renal failure, acute hepatic failure, tonic-clonic seizures and coma. In such cases, immediately contact a doctor!
4. POSSIBLE SIDE EFFECTS
Angetop not lead to adverse effects in most patients. In any occurrence, they are usually mild and transient.
In extremely rare cases - blood disorders (hemolytic anemia, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, purpura).
Sometimes it can be observed gastrointestinal disorders - stomach discomfort, nausea, vomiting, increased liver enzyme levels, retention of bile, yellow skin and mucous membranes.
Prolonged intake in very large doses may develop reversible acute renal failure and so-called "analgesic nephropathy" which includes chronic interstitial nephritis and renal papillary necrosis.
Respiratory system - may occur sore throat, shortness of breath often.
Nervous system and sensory organs - at a high dose may develop epileptiform seizures in rare cases - dizziness.
Cardiovascular system - rarely appear fast heartbeat or bluish skin.
Allergic skin reactions - rash, hives, itching, rarely - the destruction of the surface layer of skin syndrome Stevens-Johnson.
Hypersensitivity, in very rare cases, anaphylactic shock.
If any of the side effects gets serious, or if you notice any, please tell your doctor or pharmacist.
Protect from light and moisture at temperatures below 25 ° C, in a place out of sight and reach of children.
Angetop not use after the expiry date, if you notice the integrity of the blisters or discoloration of the tablets.
6. FURTHER INFORMATION
This leaflet does not contain all the information about your medicine.
Further information can be obtained from your doctor or pharmacist.
What does Angetop
Angetop contains active substance of Metamizol Sodium 500 mg, and the excipients: wheat starch, microcrystalline cellulose, sodium starch glycolate, povidone, magnesium stearate, talc, colloidal silica.
Looks like and contents of the pack
Angetop is a round, flat, white or off-white tablets, scored on which the tablet can be divided into two equal halves. 10 tablets are packed in blister PVC / aluminum foil blister 2, together with a package leaflet are placed in a cardboard box.
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