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Agen. 10 mg. 30 tablets

Product Code: Agen. 10 mg. 30 tablets
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Agen. 10 mg. 30 tablets

Agen. 10 mg. 30 tablets




Farmakogerapevtichna group: antihypertensives , calcium channel blockers .
Agen belongs to the group of medicines called calcium channel blockers Agen reduces the permeability of calcium channels. It reduces the tonus of the muscle fibers in the walls of blood vessels , and it lowers the blood pressure - blood flow more easily through the blood vessels . Gradual onset of action prevents positional hypotension ( dizziness sudden change of posture ) . Adopting Agen once daily leads to a lowering of blood pressure for a period of 24 hours. Applying an agent once a day in patients with angina ( revealed with a typical chest pain), increases the supply to the heart muscle with blood and therefore oxygen , which leads to reduced angina and nitroglycerin consumption . Patients with heart failure may be used as agents to treat hypertension or angina.

The agen is used for the treatment of hypertension and angina pectoris ( chest pain due to insufficient blood supply to the heart muscle) . Can be used alone or in combination with other medicines that lower blood pressure.


Do not get an agen
• if you are allergic (hypersensitive) to the active ingredient amlodipine or any of the excipients of agents;
• if you suffer from significant aortic stenosis (narrowing of the aortic valve ) , unstable angina (chest pain).
The product should not be administered to patients in shock, including cardiogenic shock ( a violation of the pumping function of the heart ) with hypotension ( low blood pressure) and heart failure ( reduced pumping function of the heart ) following acute myocardial infarction (heart attack) .
The use of amlodipine ( active ingredient ma agent) in children has not yet been demonstrated .
Be especially careful with the Agency :
- Particular attention should be observed patients with low blood pressure and cardiomyopathy ( heart muscle disease ), heart failure and impaired liver function.

- In elderly patients the dose increase should be done carefully.

Taking other medicines

Please tell your doctor if you are taking or have recently taken any other medicines, even those sold without prescription
• Diltiazem ( a drug for the treatment of high blood pressure and heart rhythm problems ): diltiazem , amlodipine slows down in the liver - in the elderly this may result in a stronger effect of amlodipine.
• ketoconazole , itraconazole ( medicines for the treatment of fungal infections) or ritonavir ( medicine for the treatment of HIV / AIDS ) may increase the effect of amlodipine , more than diltiazem .
• Erythromycin ( a drug for the treatment of bacterial infections) slows down the degradation of amlodipine in the liver of young patients , and also leads to a stronger effect of amlodipine.
• Effect of amlodipine may be reduced by drugs that accelerate the degradation of amlodipine , such as rifampicin (used in some infections ) and St John's wort ( product against depression , which can be purchased without a prescription ) .
• Grapefruit juice , cimetidine , aluminum / magnesium (medicines for indigestion ) or sildenafil (a medicine for impotence ) do not change the effect of amlodipine.
• Amlodipine may potentiate the effect of other medicines used to lower blood pressure ma .
• Amlodipine not alter the effect of atorvastatin , digoxin, alcohol , warfarin, or cyclosporine .

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines that are sold without a prescription

Station agents with food and drink
Drug absorption is not affected by food intake
Pregnancy and lactation

Seek the advice of your doctor win pharmacist before using any medications.
During pregnancy and lactation ma , amlodipine should be used only if your doctor considers necessary stamps .

Driving and using machines

Medicinal product may , especially early in treatment , cause increased fatigue and dizziness , headache, or malaise and thus affect your ability to drive or operate machinery. These activities can be carried out after consultation specifically by your doctor.

3 . HOW outsource?

Always take Agen exactly as prescribed by your doctor. Ask your doctor or pharmacist if you are unsure.
After taking the tablet drink less liquid ( water).
The initial dose for adults is 5 mg (I Agen 5 tablet ) daily. The doctor may increase the dose to 10 mg ( 1 tablet or 10 Agency Agency 5 2 tablets ) daily. It is recommended that you take at the same time of day tablets .

The recommended starting dose for children ( 6 to 17 years) is 2,5 mg daily. The maximum recommended dose is 5 mg daily.
The dose of 2,5 mg can be obtained from Amlodipine 5 mg tablets as they are produced so as to be divided into two equal halves .
The safety and efficacy of amlodipine on blood pressure in children less than 6 years of age have not yet been established , therefore , amlodipine, should not be used in children less than 6 years of age.

If you take more than the required amount of the agen :
The main manifestations of overdosage with agents are abnormally increased heart rate and low blood pressure that occurs with dizziness and eventually unconsciousness. If you take more tablets than prescribed or someone else use your medication , tell your doctor immediately or consult the nearest emergency room .

If you forget to get an agen
In case you forgot to take your dose , skip the missed dose and take the next dose on time. Do not take a double dose to make up for a missed dose.

If you stop taking Agen
It is important to discontinue use of the product at its own discretion in case of doubt , consult your doctor or pharmacist.
If you have further questions on the use of this product, ask your doctor or pharmacist.


As with all drugs , agents can cause side effects , although not all of them suffer . List of possible side effects by frequency is:
Very common: affects more than 1 in 10 patients
Common: affects I and 10 patients in 100 .
Uncommon : affects I and 10 patients in 1000
Rare: affects 1 to 10 users in 10,000
Very rare: affects less than I per 10 000 patient

Not known: frequency can not be estimated from these data

Common: drowsiness , dizziness , headache ( especially at the beginning of treatment) ; flushing ( especially at the beginning of treatment) ; stomach pain, nausea , swelling of ankles , swelling of the organ or tissue due to accumulation of excess fluid (edema) ; fatigue.

Uncommon: sleep problems , mood changes , including anxiety, depression, uncontrollable shaking ( tremors ), changes in sense of taste , fainting ( syncope ), loss of skin sensitivity to pain or touch (hypoaesthesia ) , unpleasant tingling in the hands or feet paresthesia ; vision problems , ringing or buzzing in the ears ( tinnitus) ; perception of heartbeat ( palpitations ) ; low blood pressure (hypotension) ; shortness of breath ( dyspnoea) ; inflammation in the nose with fever ( rhinitis) ; vomiting ; indigestion (dyspepsia ), changes in bowel habits (including diarrhea or constipation , dry mouth , hair loss , skin rash resulting from bleeding of small blood vessels in the skin , discoloration of the skin , increased sweating , itching skin rash , rash itching and spots , joint pain , muscle pain , muscle cramps, back pain, increased need to urinate , nocturia , impotence, gynecomastia ( breast enlargement) in men , chest pain and weakness (asthenia ) , pain general discomfort ( malaise ) , increase or decrease in weight.

Rare : Confusion

Very rare: Scream of white blood cells, which increases the risk of infections ( leucopenia) ; scream platelets , which increases the risk of bruising (thrombocytopenia) ; Allergic reactions (including itching, sudden redness (rash) ; amgioedem ; increase blood sugar ( hyperglycemia ), increased muscle tension and reduce their ability to stretch (muscle hypertension) burning sensation or weakness in the arms and legs (peripheral neuropathy ), heart attack : abnormal heart rhythms ( increased heart rate , decreased heart rate , atrial fibrillation) , inflammation of the blood vessels (vasculitis ), cough , inflammation of the pancreas, and severe pain in the upper abdomen (below ribs ) that spreads to the back (pancreatitis ), inflammation of the stomach lining ( gastritis) , swelling of the gums, inflammation of the liver , jaundice, elevated liver enzymes in the blood is a sign of liver dysfunction , sudden swelling of the skin or mucous membranes (eg throat or tongue) with difficulty breathing and / or itching and rash (angioedema ), skin rash with irregular red patches ( erythema multiforme) , hives , inflammatory skin reaction ( hives) ; extreme redness and peeling of the skin ( exfoliative dermatitis) ; serious allergic reactions with fever , red spots, joint pain and / or eye problems (Stevens -Johnson syndrome, edema Kvipke , increased skin sensitivity to sunlight ( photosensitivity ) , mostly associated with reduced bile formation or bile flow ( cholestasis )

If any of the side effects gets serious, or if you notice any side effects not specified in this leaflet , please ask your doctor or pharmacist

5 . HOW TO STORE agen?

Keep out of reach of children.
Do not use agents after the expiry date printed on the package. Expiry date refers to the last day of the indicated month.
Store in the original package to protect from light.
Medicines should not be disposed of via waste water or household waste. Ask your doctor or pharmacist how to dispose of medication that you no longer need . These measures will help protect the environment .

What does an agen?
The active ingredient is amlodipine besylate 6,935 mg or 13,870 mg, which correspond to 5 mg or 10 mg of amlodipine into a tablet .
Excipients : microcrystalline cellulose , sodium starch glycolate, calcium hydrogen phosphate dihydrate , magnesium stearate

What agen and contents of the pack ?

Agen are white or off-white , oval shaped tablets , tablet has a score line and etched "A" and "5" or "A" and " 10 " on one side of the tablet . The tablets can be divided into two equal halves ..
Pack sizes: 10, 30 and 90 tablets Not all types are on the market.



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