ZEVESIN 5 mg. 30 tablets

ZENTIVA
ZEVESIN 5 mg. 30 tablets
€ 28.00
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WHAT ZEVESIN AND WHAT IT IS USED
Zevesin is a drug that is used to treat overactive bladder. Symptoms include the need to go to the toilet, often going to the toilet and wetting if you do not come on time in the toilet.
When Zevesin is adopted, the active ingredient, solifenacin, is released in your body. Solifenacin belongs to a group of medicines called anticholinergic medicines. This means that acts on specific cells, reducing the activity of your bladder and helps control.

2. BEFORE YOU TAKE ZEVESIN
Do not take Zevesin:
If you are allergic or hypersensitivity (eg rash, itching or shortness of breath) to Zevesin, solifenacin or any of the excipients;
if you are undergoing dialysis;
if you have been treated with drugs that reduce the secretion of Zevesin of the body (eg, ketoconazole) and suffer from severe kidney disease or moderate liver disease;
if you are told by your doctor that you have an intolerance to some sugars;
if you have severe liver disease.
Zevesin Do not take if you have or are at risk to suffer from:
inability to separate urine, or empty the bladder (urinary bladder);
severe gastric and intestinal conditions (including toxic megacolon, complications associated with ulcerative colitis);
muscle disease called myasthenia gravis, which can lead to weakening of the muscle activity;
increased intraocular pressure by gradual loss of vision (glaucoma).
Take special care with Zevesin:
If you suffer from obstruction of bladder outflow at risk for urinary retention;
gastrointestinal obstructive disorders;
risk of reduced gastrointestinal motility;
suffer from reflux disease (including the presence of acids) or have a hiatus hernia;
if you have severe kidney disease that does not allow you to take more than 5 mg per day;
if have moderate liver disease, which does not allow you to take more than 5 mg per day;
if you are taking medications that reduce and remove Zevesin body. Your doctor or pharmacist should tell you if there is such a case;
If you have a group of symptoms caused by damage to the nerves innervating certain internal organs (called autonomic neuropathy).
Ask your doctor or pharmacist before taking this medicine if you think any of these apply to you. Before taking Zevesin, your doctor will assess whether there are other reasons why urinate frequently, such as heart or kidney problems or urinary tract infection.

Taking other medicines
If you take other medicines while you are taking Zevesin, they can influence the effects and lead to side effects.
If you are taking any of these medicines, ask your doctor or pharmacist before taking Zevesin:
other medicines in the same group (anticholinergics), since the effects and side effects of both medicines may be increased. It is recommended that an interval of one week after discontinuation of Zevesin before initiation of treatment with such agents;
Medicines called cholinergic receptor agonists (the most common of which is pilocarpine used for the treatment of glaucoma) as they may reduce the effects of Zevesin;
Drugs that increase the motility of the gastrointestinal tract (eg. Metoclopramide, cisapride) as Zevesin can reduce their effects;
Drugs that can cause inflammation of the esophagus, such as aspirin, ibuprofen and other nonsteroidal anti-inflammatory drugs, and some medications prescribed by your doctor to protect your bones - bisphosphonates;
Rimfapitsin drugs such as phenytoin and carbamazepine, which can increase the rate of excretion of solifenacin from your body;
You should take only 5 mg of Zevesin a day, in case you are taking medicines that increase the excretion of your body (eg. Ketoconazole, ritonavir, nelfinavir, itraconazole, verapamil and diltiazem). Also, if you suffer from severe kidney disease or moderate liver disease should not take Zevesin.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Taking Zevesin with food and drink
It can be taken with or without food.

Pregnancy and lactation
Zevesin should not be used in pregnancy, since there is no information for use during pregnancy. Ask your doctor or pharmacist before taking any medicine if you think you may be pregnant.
Zevesin should not be used during breastfeeding.

Driving and using machines
Sometimes Zevesin can cause blurred vision and less frequently drowsiness and fatigue. Do not drive or operate machinery if you observe any of these side effects.

Important information about ingredients of Zevesin
The product contains lactose monohydrate. If you are told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

3. HOW TO TAKE ZEVESIN
Always take Zevesin exactly as your doctor has told you. If you are unsure, check with your doctor or pharmacist.
The daily dose is 5 to 10 mg. Your doctor will inform you on the most appropriate dose for you.
Try to take Zevesin every day at the same time;
Zevesin tablets should be swallowed whole with liquid. Tablets should not be crushed;
ask your doctor or pharmacist if you have the impression that the effect of Zevesin is too strong or too weak.
If you take more than necessary Zevesin
Contact your doctor or nearest hospital immediately and tell you how many tablets you have taken. If children take Zevesin by mistake, seek medical advice immediately.
Symptoms of overdose can be headache, dry mouth, dizziness and blurred vision. Symptoms of serious overdose can be hallucinations, agitation, convulsions and respiratory problems (respiratory insufficiency), fast heart beat (tachycardia), urinary retention, dilation (widening) of the pupil. Of particular concern was observed in patients at risk of abnormal heart rhythms, including prolonged QT interval), heart failure or insufficient blood supply to the heart.

If you forget to take Zevesin
If you forget to take a dose at the usual time, take it as soon as possible unless it is time for the next dose intake. Do not take a double dose to make up for the forgotten. Do not take more than the daily dose.

If stop taking Zevesin
If you stop taking Zevesin symptoms of overactive bladder may occur or worsen. Always consult your doctor if you plan to stop treatment.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
As with all drugs, and Zevesin may cause side effects, although not everyone gets them. Zevesin may cause the following side effects:

Very common:
dry mouth.
Common:
constipation, nausea, indigestion, stomach pain;
blurred vision.
Uncommon:
reflux disease (including heartburn);
urinary tract infections, bladder inflammation (cystitis);
difficulty in separation of water;
abnormal or impaired taste;
dry skin, dry eyes, dry throat or nasal passages;
fatigue; drowsiness;
swelling of lower limbs.
Rare:
retention of urine (urinary retention);
bowel obstruction.
Very rare:
dizziness, headache;
vomiting;
hallucinations, convulsions;
itching, rash, allergic rash.
If any of the side effects gets serious, or you notice any not listed here, please tell your doctor or pharmacist.

5. HOW TO STORE ZEVESIN
Keep out of reach of children!
Do not use after the expiry date which is stated on the box / blisters as EXP. The expiry date refers to the last day of that month.
This medicinal product does not require any special temperature storage conditions. Store in original container to protect it from light.
Medicines should not be disposed of in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help to protect the environment.

6. ADDITIONAL INFORMATION
What Zevesin
The active ingredient is solifenacin succinate.
Each tablet contains 5 mg Zevesin mg solifenacin succinate 5, corresponding to 3.8 mg solifenacin.
Each tablet contains 10 mg Zevesin mg solifenacin succinate 10, corresponding to 7.5 mg solifenacin.

Other ingredients are:
Tablet core: maize starch, pregelatinised; lactose monohydrate; microcrystalline cellulose; hypromellose; magnesium stearate;
Film-coating: hypromellose; macrogol 6000; titanium dioxide (E171); iron oxide yellow (E172) - Zevesin 5 mg; red iron oxide (E172) - Zevesin 10 mg.
Zevesin looks like and contents of the pack
Zevesin 5 mg: white to pale yellow round tablet. Zevesin 10 mg: pink round biconvex film-coated tablet. Box 10, 30 and 100 tablets.
Not all pack sizes may be marketed.
€ 28.00
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