Xorimax 500mg. 10 tablets

Xorimax 500mg. 10 tablets
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What is the active substance?
Each coated tablet contains Xorimax respectively 125, 250 or 500 mg cefuroxime, in the form of cefuroxime axetiI.

What else contain Xorimax?
Sodium lauryl sulphate, copovidone, croscarmellose sodium, magnesium stearate, colloidal anhydrous silica, mannitol, microcrystalline cellulose, crospovidone, talc, soluble starch, titanium dioxide, aspartame.

Formulation and packaging:
Coated tablets.
Original packages containing 8,10,12 and 24 tablets.

What is Xorimax?
Cefuroxime axetil belongs to a group of antibiotics called cephalosporins. All cephalosporins (B-lactam antibiotics) inhibit the synthesis of bacterial cell wall, thus causing lysis of the bacterial cell.

What is Xorimax?
For the treatment of infections caused by bacteria susceptible to cefuroxime:
- Infections of the upper respiratory tract infection (infection of the nose, ears and throat, as otitis media, sinusitis, tonsillitis and pharyngitis);
- Infections of the lower respiratory tract infections (pneumonia, acute bronchitis and chronic bronchitis in the phase of exacerbation);
- Urinary tract infections (pyelonephritis, cystitis and urethritis);
- Gonorrhoea, acute uncomplicated gonococcal urethritis and cervicitis;
- Infections of skin and soft tissue (furunculosis, pyoderma and impetigo);
- Treatment of early manifestations of Lyme disease and subsequent prevention of late-onset disease in adults and children over 12 years.

When should not apply Xorimax?
Xorimax should not be taken if:
• You have or suspect that you are hypersensitive (allergic) to cephalosporins, and / or any of the excipients in tablets
• have had a previous hypersensitivity reaction to penicillin or other product from the group of beta-lactam antibiotics.

What special precautions should follow when using Xorimax?
If after taking Xorimax sensitivity reactions occur, the use should be discontinued immediately and initiate appropriate lechenie.Osobeno caution is indicated in patients with previous allergic reactions to penicillins or other beta-lactam antibiotics.
As with other antibiotics with a broad spectrum of activity, prolonged use of Xorimax® can cause superinfection with resistant strains (eg. Candida, enterococci and Clostridium difficile), which may require discontinuation.
Patients who develop severe diarrhea should cause suspicion provoked by antibiotics pseudomembranous colitis which can be life-threatening. In these cases, the adoption of Xorimax should be discontinued immediately and to appoint a specific treatment according to the agent. The adoption of peristaltic drugs are contraindicated (see. Undesirable effects). In the treatment of Lyme disease for 20 days can be quickened because of diarrhea.
Patients with severe gastrointestinal disturbances with vomiting and diarrhea should be treated with Xorimax, as it can not guarantee adequate absorption. In these cases it is recommended parenteral therapy with cefuroxime. During prolonged treatment with Xorimax may develop superinfection caused by resistant strains cefuroxime axetil. In these cases it is extremely important that patients be carefully monitored for the development of superinfection and priproyavata them to be taken appropriate measures (see. Undesirable effects) .There are reports of reaction Jarisch-Herxheimer after treating Lyme disease with Xorimax *. The reaction results directly from the bactericidal activity of cefuroxime axetil on the spirochaete Borrelia burgdorferi. Patients should be informed of this common and usually limited reaction is a consequence of the treatment of Lyme disease with antibiotics. Not recommended concomitant use of medicines enhancing the pH of the stomach (see. Interactions).
There is no clinical experience from implementation of Xorimax in infants younger than 3 months. In the treatment of Lyme disease in an early stage there is only clinical experience in adults and children aged over 12 godini.Spetsialno care is needed in patients with phenylketonuria as containing coating aspartame:
Xorimax 125 mg contains 0,2 mg aspartame per tablet.
Xorimax 250 mg contains 0,3 mg aspartame per tablet.
Xorimax 500 mg contains 0,4 mg aspartame per tablet.
In patients taking Xorimax it is recommended to determine blood glucose and plasma done by the glucose oxidase or hexokinase methods. Cefuroxime does not interfere in the determination of creatinine by the alkaline picrate method (see. Interactions) .Po during treatment with cefuroxime sodium, some children have experienced slight to moderate hearing loss.

Adoption of Xorimax with food and drink:
To achieve optimal absorption, Xorimax tablets should be taken

What other products influence the effect of Xorimax or may be affected by it?
Tell your doctor about medicines you are taking right now, even for those bought from the pharmacy without a prescription. Concomitant use of Xorimax with medicines enhancing the pH of the stomach, ranitidine, cimetidine, omeprazole, lansoprazole, pantoprazole (for the treatment of peptic ulcers or heartburn), reduces the bioavailability of Xorimax . It is recommended to avoid this combination (see. Special warnings and precautions for use).
Since bacteriostatic drugs may interfere with the bactericidal action of cephalosporins should avoid giving tetracyclines, macrolides and chloramphenicol with cefuroximaxetil. Co-administration with probenecid may result in promoting high and sustained concentrations of cefuroxime in the serum and bile (inhibit the separation of the antibiotic in the kidneys).
Xorimax information to the disc may affect some of the methods for determining blood glucose and urinata.Priemaneto of Xorimax can lead to false positive results when using test Coombs. This can affect cross matching blood type compatibility. Cephalosporin antibiotics at high dosage should be given with caution to patients receiving potent diuretics, aminoglycosides and amphotericin as these combinations increases the risk of nephrotoxicity.

What you need to know about the application of the product during pregnancy and lactation?
Please ask your doctor or pharmacist before taking any lekarstvo.Nyama sufficient data on the use of Xorimax during pregnancy in order to assess its possible harmfulness. Conducted experimental studies in animals showed no evidence of harmfulness. Cefuroxime crosses the placenta. Xorimax should not be used during pregnancy unless after careful risk assessment by the physician. Cefuroxime is excreted in small amounts in breast milk. Breastfeeding women should stop breast-feeding during treatment with Xorimax.

What must comply when driving or operating machinery?
No studies of the effect of Xorimax on ability to drive and use machines.

Dosage, method and duration of application:
Your doctor will prescribe how many tablets to take Xorimax. Xorimax tablets are coated to mask their taste - they should not be chewed. To achieve optimal absorption, Xorimax tablets should be taken after meals. The duration of therapy is 7 days (5 to 10 days). If pharyngotonsillitis caused by Streptococcus pyogenes is recommended to continue treatment for at least 10 days. Lyme disease at an early stage, treatment duration should be 20 days.
The dosage depends on the severity of the infection. In severe infections it is recommended in parenteral forms of cefuroxime. Xorimax® is effective in the treatment of pneumonia and acute exacerbations of chronic bronchitis, administered after initial parenteral treatment with cefuroxime sodium.
Recommended dosage:
Adults and children over 12 years:
- In the majority of infections - 250 mg twice daily
- For urinary tract infections - 125 mg twice daily
- In low to moderately developed infections of the lower respiratory tract such as bronchitis - 250 mg twice daily
- In severe infections of the lower respiratory tract or suspected pneumonia - 500 mg twice daily
- At pyelonephritis - 250 mg twice daily
- In infections of skin and soft tissue: 250-500 mg twice daily
- Lyme disease - 500 mg twice daily for 20 days
- In uncomplicated gonoreya- single dose of 1000 mg, if necessary, can be combined 1000 mg probenecid.

Moving from parenteral to oral therapy:
- Pneumonia: 1.5 g cefuroxime sodium in two or three doses (i.v. or i.m.) for 48 -72 hours, followed by an oral dose of 500 mg Xorimax® (cefuroxime axetil) twice daily for 7 -10 days;
- In exacerbation of chronic bronchitis: 750 mg cefuroxime sodium in two or three doses (i.v. or i.m.) for 48 -72 hours, followed by an oral dose of 500 mg Xorimax® (cefuroxime axetil) twice daily za5 -10 days.

Children aged 5 to 12 years:
- For much of infections - 125 mg twice daily.
- Acute otitis - 250 mg twice daily.

Children under 5 years:
Xorimax tablets are not suitable for the treatment of children under 5 years. For patients in this age group are advised to use an oral suspension. There is no experience of administration of the drug in infants under 3 months of age.
Dosage in patients with renal impairment, dialysis patients and elderly patients:
If the daily dose does not exceed 1g, no need for special precautions in patients with renal impairment and in elderly patients.
What should I do if Xorimax was adopted in very large quantities (intentional or inadvertent overdose)?
Please consult your doctor if you take a larger dose Xorimax than necessary. Overdose of cephalosporins can cause convulsions. Do not take on its own initiative a higher dose than prescribed!
What should you do if you miss taking Xorimax?
If you miss a dose of medicine, take it as soon as you find it. Do not take a double dose to replace propusnatata.Ne change or stop treatment on their own initiative, even if you feel better to avoid complications or deterioration.

What side effects can cause the application of Xorimax?
Like all medicines may cause side effects
The classification of adverse reactions is known and organ specificity as: Common (10% or less, but more than 1% of the treated patients)
Uncommon (1% or less, but more than 0.1% of treated patients)
Rare (0.1% or less but more than 0.01% of the treated patients)
Very rare (0.01% or less)

Infections and infestations: Rare pseudomembranous colitis.
As with other antibiotics, prolonged use may lead to secondary superinfections caused by resistant microorganisms such as Candida, Enterococci and Clostridium difficile (see. Special warnings and precautions for use).
Blood and lymphatic system disorders Rare Decreased hemoglobin concentration, eosinophilia, leucopenia, neutropenia and thrombocytopenia (decreased number of blood cells).
Very rare: Haemolytic anemia.

Immune system disorders:
Often Reaction of Jarisch-Herxfieimer in treating Lyme disease with cefuroxime axetil (see. Special warnings and precautions for use).
Rare Serum sickness.
Very rare: Anaphylaxis.
Nervous system disorders.
Rare: Headache, dizziness.
Very rare: Anxiety, nervousness, confusion.
Gastrointestinal disorders:
Common: Diarrhoea, nausea and vomiting. The frequency of occurrence of diarrhea is proportional to the dose received and can reach up to 10% with tablets. The incidence is even higher (approximately 13%) during prolonged 20-day treatment of Lyme disease at an early stage.

Liver and gallbladder:
Rare Transient increases in liver enzymes (AST, ALT and LDH) and serum bilirubin.
Very rare: Jaundice.
Skin and subcutaneous tissue disorders:
Common: skin rash, urticaria, pruritus.
Very rare: Erythema multiforme, syndrome of Stevens-Johnson and toxic epidermal necrolysis.
Renal and urinary
Common Increased levels of creatinine and urea in the serum, especially in patients with impaired renal function. Rare: Acute interstitial nephritis.
General disorders resulting from the application:
Rare Drug fever.
IzsledvaniyaPrilozhenieto of cefuroximaxetil can result from a false positive test result of Coombs. This may affect cross-matching of blood transfusion (see. Interactions).

What measures should be taken in relation to side effects?
Please consult your doctor when you experience any side effects, even those not listed in this leaflet.

Storage Instructions
Keep out of reach of children.
Store in the original container at a temperature below 30 ° C.
Expiration date
The expiry date is stated on the carton. Do not use the drug expired.
€ 23.00
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