XORIMAX 250 mg. 10 tablets

XORIMAX 250 mg. 10 tablets
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Cefuroxime axetil belongs to a group of antibiotics called cephalosporins. All cephalosporins (B-lactams) inhibit the synthesis of bacterial cell wall, thus causing lysis of the bacterial cell. 

XORIMAX 250 mg. 10 tablets
What is Xorimax?
Cefuroxime axetil belongs to a group of antibiotics called cephalosporins. All cephalosporins (B-lactams) inhibit the synthesis of bacterial cell wall, thus causing lysis of the bacterial cell.
What is it used Xorimax?
For the treatment of infections caused by bacteria susceptible to cefuroxime:
- Infections of the upper respiratory tract infection (infection of the nose, ears and throat, such as otitis media, sinusitis, tonsillitis and pharyngitis);
- Infection of the lower respiratory tract infections (pneumonia, bronchitis, acute and chronic bronchitis, in the phase of exacerbation);
- Urinary tract infections (pyelonephritis, cystitis and urethritis);
- Gonorrhoea, acute uncomplicated gonococcal urethritis and cervicitis;
- Soft tissue infections and skin (furunculosis, pyoderma and impetigo);
- Treatment of the early manifestations of Lyme disease and subsequent prevention of late disease in adults and children over 12 years.
When not to apply Xorimax? 
Xorimax should not be taken if:
• You have or suspect that you are hypersensitive (allergic) to cephalosporins and / or any of the excipients in tablets
• have had a previous hypersensitivity reaction to penicillin or any other type of beta-lactam antibiotics.
What special precautions should I follow when using Xorimax? 
If after taking Xorimax sensitivity reactions occur, the use should be discontinued immediately and initiate appropriate lechenie.Osobeno caution is indicated in patients with a prior allergic reaction to penicillins or other beta-lactam antibiotics.
As with other antibiotics with a broad spectrum of action, long-term use of Xorimax can cause superinfection with resistant strains (e.g.. Candida, enterococci and Clostridium difficile), which may require cessation of treatment.
Severe and persistent diarrhea should cause suspicion provoked by antibiotic pseudomembranous colitis, which can be life-threatening. In these cases, the adoption of Xorimax should be immediately discontinued and assign specific treatment established. Adoption of antiperistaltichni drugs is contraindicated (see. Undesirable effects). In the treatment of Lyme disease for 20 days can quicken the onset of diarrhea.
Patients with severe gastrointestinal disorders with vomiting and diarrhea should be treated with Xorimax®, since it can not ensure adequate absorption. In these cases it is recommended parenteral treatment with cefuroxime. Prolonged treatment with Xorimax can develop superinfection caused by resistant strains to cefuroxime axetil. In these cases it is extremely important that patients be carefully monitored for the development of a superinfection priproyavata them to be taken appropriate measures (see. Undesirable effects) .There reports of reaction of Jarisch-Herxheimer after treatment of Lyme disease Xorimax *. Reaction results directly from the bactericidal activity of cefuroxime axetil on the spirochaete Borrelia burgdorferi. Patients should be informed of this common and usually self-limited reaction is due to the treatment of Lyme disease with antibiotics. Concomitant administration of drugs enhancing the pH of gastric juice (see. Interactions).
There is no clinical experience with the use of Xorimax in infants younger than 3 months. In the treatment of Lyme disease in an early phase clinical trial is only for adults and children over the age of 12 godini.Spetsialno caution is indicated in patients with phenylketonuria as tablets contain aspartame in its composition:
Xorimax 125 mg tablet contains 0,2 mg aspartame per tablet.
Xorimax 250 mg tablet contains 0,3 mg aspartame per tablet.
Xorimax 500 mg tablet contains 0,4 mg aspartame per tablet.
In patients taking Xorimax are recommended to determine blood glucose and plasma performed by the glucose oxidase or hexokinase method. Cefuroxime does not interfere in the determination of creatinine by the alkaline picrate method (see. Interactions) .Po during treatment with cefuroxime sodium, some children have experienced mild to moderate hearing loss.
Adoption of Xorimax with food and drink:
To achieve optimal absorption, tablets Xorimax should be taken immediately after a meal.
Other products that interfere with the effect of Xorimax or may be affected by a?
Tell your doctor about medicines you are taking right now, even those bought from a pharmacy without a prescription. Concomitant use of drugs with Xorimax enhancing the pH of the stomach, ranitidine, cimetidine, omeprazole, lansoprazole, pantoprazole (for the treatment of peptic ulcer or HEARTBURN), reduces the bioavailability of Xorimax *. It is recommended to avoid this combination (see. Special warnings and precautions for use).
Since bacteriostatic drugs may interfere with the bactericidal action of cephalosporins should avoid giving tetracyclines, macrolides and chloramphenicol with cefuroxime axetil. Concurrent administration of probenecid may result in the maintenance of high and sustained concentrations of cefuroxime in the serum and bile (to inhibit the release of the antibiotic in the kidneys).
Xorimax on image can affect some of the methods for determination of blood glucose and urinata.Priemaneto of Xorimax can lead to false positive results in the use of test Coombs. This can affect cross matching blood group compatibility. Cephalosporin antibiotics at high dosage should be given with caution to patients receiving potent diuretics, aminoglycosides and amphotericin as these combinations increase the risk of nephrotoxicity.
What you need to know about the use of the product during pregnancy and lactation?
Please consult your doctor or pharmacist before taking any lekarstvo.Nyama insufficient data on the use of Xorimax during pregnancy in order to assess the possible harmful effects of it. Conducted experimental studies in animals showed no evidence of harmfulness. Cefuroxime crosses the placenta. Xorimax should not be used during pregnancy unless after careful risk assessment by the physician. Cefuroxime is excreted in small amounts in breast milk. Breast-feeding women should stop breast-feeding during treatment with Xorimax. 
What should be considerate when driving or operating machinery?
Found no influence of Xorimax on ability to drive and use machines.
Dosage, method and duration of administration
Your doctor will prescribe Xorimax how many tablets to take. Xorimax tablets are coated to mask their taste - they should not be chewed. To achieve optimal absorption Xorimax tablets should be taken after meals. The duration of treatment is usually 7 days (5 to 10 days). In case of pharyngotonsillitis caused by Streptococcus pyogenes is recommended that treatment be continued for at least 10 days. Lyme disease at an early stage, the duration of treatment should be 20 days.
The dosage depends on the severity of the infection. In severe infections is recommended in parenteral forms of cefuroxime. Xorimax is effective in the treatment of pneumonia and acute exacerbations of chronic bronchitis, administered after initial parenteral treatment with cefuroxime sodium.
Recommended dosages:
Adults and children over 12 years:
- In the majority of infections - 250 mg BID
- For urinary tract infections - 125 mg twice daily
- In low to moderately developed infections of the lower respiratory tract such as bronchitis - 250 mg BID
- In severe infections of the lower respiratory tract or suspected pneumonia - 500 mg twice daily
- In pyelonephritis - 250 mg BID
- Infections of skin and soft tissues: 250-500 mg bid
- Lyme disease - 500 mg twice daily for 20 days
- In uncomplicated gonoreya- single dose of 1000 mg, if necessary, can be combined with 1000 mg of probenecid.
Transition from parenteral to oral therapy:
- For pneumonia: 1.5 g cefuroxime sodium in two or three doses (iv or im) for 48 -72 hours, followed by oral administration of 500 mg Xorimax (cefuroxime axetil) twice daily for 7 -10 days; 
- In acute exacerbation of chronic bronchitis: 750 mg cefuroxime sodium in two or three doses (iv or im) for 48 -72 hours, followed by oral administration of 500 mg Xorimax® (cefuroxime axetil) twice daily za5 -10 days.
Children aged 5 to 12 years:
- For the majority of infections - 125 mg twice daily.
- Acute otitis media - 250 mg twice daily.
Children under 5 years:
Xorimax tablets are not suitable for use in children under 5 years. For patients in this age group is recommended to use the oral suspension. There is no experience with the use of the drug in infants under 3 months of age.
Dosage in patients with renal impairment, dialysis patients and the elderly:
If the daily dose does not exceed 1 gram no need for special precautions in patients with renal impairment and in elderly patients. Xorimax tablets dosage should be carefully evaluated in patients with renal impairment and creatinine clearance below 20 ml / min. In patients on dialysis, a further dose of cefuroxime at the end of each dialysis.
Tell your doctor if you think that the effect of Xorimax is too strong or too weak for you.
What should I do if Xorimax was adopted in very large quantities (intentional or unintentional overdose)?
Please consult your doctor if you take a higher dose than necessary Xorimax. Overdose of cephalosporins can cause convulsions. Do not take on its own initiative a higher dose than prescribed!
What should you do if you forget to take Xorimax®?
If you miss a dose of this medicine, take it as soon as you find it. Do not take a double dose to replace propusnatata.Ne modify or discontinue the treatment on their own initiative, even if you feel better, to avoid complications or deterioration.
What side effects can cause the application of Xorimax®?
Like all medicines may cause side effects
Classification of adverse events in frequency and organ specificity as: Common (10% or less but more than 1% of patients treated)
Uncommon (1% or less, but more than 0.1% of patients treated)
Rare (0.1% or less, but more than 0.01% of the treated patients)
Very rare (0.01% or less)
Infections and infestations: Rare Pseudomembranous colitis.
As with other antibiotics, prolonged use may lead to secondary superinfections caused by resistant microorganisms such as Candida, Enterococci and Clostridium difficile (see. Special warnings and precautions for use).
Blood and lymphatic system disorders Rare: Decreased hemoglobin concentration, eosinophilia, leukopenia, neutropenia, and thrombocytopenia (reduced number of blood cells).
Very rare: Haemolytic anemia.
Immune system disorders:
Common: Reaction Jarisch-Herxfieimer in the treatment of Lyme disease cefuroxime axetil (see. Special warnings and precautions for use).
Rare Serum sickness.
Very rare: Anaphylaxis.
Nervous system.
Rare: Headache, dizziness.
Very rare: Anxiety, nervousness, confusion.
Gastrointestinal disorders:
Common: Diarrhoea, nausea and vomiting. The incidence of diarrhea is related to the administered dose and can reach 10% with tablets. The incidence is even higher (around 13%) with a continuous 20-day treatment of Lyme disease in an early stage.
Disorders of the liver and gallbladder:
Rare: Transient increases in liver enzymes (AST, ALT and LDH) and serum bilirubin.
Very rare: Jaundice.
Skin and subcutaneous tissue disorders:
Common: Skin rashes, urticaria, pruritus.
Very rare: Erythema multiforme syndrome, Stevens-Johnson and toxic epidermal necrolysis.
Renal and urinary disorders
Common Increased levels of creatinine and urea in the serum, especially in patients with renal impairment. Rare: Acute interstitial nephritis.
General disorders resulting from the application:
Rare Drug fever.
IzsledvaniyaPrilozhenieto of cefuroxime axetil may result in a false positive test result of Coombs. This can affect the cross matching blood (see. Interactions).
What measures should be taken in relation to the side effects?
Please consult your doctor when you experience any side effects, even those not mentioned in this leaflet.
Storage Instructions
Keep out of reach of children.
Keep in the original container at a temperature below 30 ° C.
Shelf life
The expiry date is stated on the carton. Do not use the drug expired.
€ 16.00
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