Triampur compositum. 50 tablets
Triampur compositum. 50 tablets
Qualitative and quantitative composition
Active substance :
1 tablet contains 25 mg triamterene and 12,5 mg hydrochlorothiazide
Excipients: lactose monohydrate, starch , polyvidone K25 , highly disperse silica, sodium carboxymethylcellulose, magnesium stearate.
Formulation and CONTENTS
Tabletka.Triampur compositum ® is available in packs of 50 and 100 tablets.
Triampur compositum is an antihypertensive agent and diuretic.
? high blood pressure;
? swelling caused by diseases of the heart, liver and kidneys, especially when you need to prevent the loss of potassium;
? In addition to cardiac glycosides treatment of heart failure with permanent predisposition to the formation of edema .
In what cases should not take Triampur compositum ?
Triampur compositum should be taken in case of hypersensitivity to the active substance , any of the excipients or to sulphonamides in severe impairment of renal function in the absence of urine output ( anuria ) priostri inflammation of the kidneys (acute glomerulonephritis ) in severe damage liver function ( hepatic coma and coma ) in abnormal electrolyte imbalance ( elevated serum potassium or calcium , decreased serum potassium or sodium ) , or decreased volume of circulating blood ( hypovolemia )
In what cases only after consultation with your doctor can take Triampur compositum ?
The following describes the cases in which only under certain conditions and with the emphasis may use Triampur compositum . Counsel , please , on these issues with your doctor. This also applies in the event that the data were valid for you in an earlier etap.Neobhodimi are rigorous assessment of the benefit / risk ratio , and strict control of your doctor during treatment with reduced renal function , presence of kidney stones , impaired liver function , gout, diabetes (Diabetes mellitus) and suspicion of folic acid deficiency (eg liver cirrhosis caused by chronic alcohol consumption ) . During the treatment must be repeated to control the respective laboratory parameters .
Special precautions for use
What special measures should be considered ?
With longer treatment Triampur compositum should be tested periodically certain laboratory parameters (residual nitrogen concentration in serum electrolytes , especially potassium , serum creatinine, lipid profile , blood glucose and uric acid). Particularly in elderly patients and in patients with concomitant treatment with cardiac glycosides , adrenal hormones ( glucocorticoids, such as . Betamethasone , prednisone , triamcinolone ) or laxatives medicines should be frequently examined potassium, creatinine and blood zahar.Pri suspected shortage folic acid ( vitamin B eg . during liver cirrhosis in chronic alcoholism ) recommend regular monitoring of blood kartina.Predi study the function of parathyroid glands and at least three days before the oral glucose tolerance test should be discontinued Triampur ® compositum , otherwise it can get unreal rezultati.Konsultirayte your doctor if you know that you have an intolerance to some sugars .
Drug interactions and other forms of interaction
What other drugs affect the action of Triampur ® compositum or are affected by it ?
The antihypertensive effect may be enhanced by other hypotensive , diuretic , vasodilators , sedatives (eg, barbiturates ) , central nervous system depressant drugs ( phenothiazines ) or antidepressants ( tricyclic antidepressants) . When concomitant administration of ACE inhibitors ( drugs that also lower blood pressure) can early treatment lead to a strong drop in blood ????????.??????????????????? and diuretic effect can be reduced by use of painkillers and anti-inflammatory drugs ( NSAIDs / anti-rheumatic drugs eg . salicylates , indomethacin ) . Indomethacin may by concomitant Triampur ® compositum affect renal function ( glomerular limited filtratsyya } . Cholestyramine and colestipol By ( medicines that lower blood lipids) decreases absorption of hydrochlorothiazide , which can lead to a weakening of its operation and increase the level of potassium in seruma.Mnogo rarely with concomitant antihypertensive drug methyldopa were no changes in the blood picture ( hemolysis by antibody against hydrochlorothiazide ) . upon further use of potassium salts, kaliysahranyavashti drugs or certain drugs that lower blood pressure ( ACE inhibitors) may cause an increased level of potassium in the serum. during concomitant adrenal hormones ( glucocorticoids ) and abuse of laxatives medicines can lead to a loss of potassium.
Other possible interactions Triampur compositum ® are:
? slimming effects of medicines for treating diabetes , and gout , and medicinal products containing the noradrenaline and adrenaline ;
? during concomitant treatment with high doses of lithium are growing undesired effects ;
? during concomitant treatment with high doses of salicylates intensify their adverse effects on the central nervous system;
? strengthening effect of kurarepodobni muscle relaxant drugs ;
? strengthening effects and side effects of cardiac glycosides in available potassium and / or magnesium deficiency ;
? reducing the secretion of quinidine during concomitant quinidine ;
? gain bone marrow damage with concomitant administration of cytotoxic drugs ( medicines for the treatment of tumors) ;
? interference potency of combination therapy ( 3 - blockers.
Please note that this information may apply to previously used drugs.
What food and drink should you avoid ?
Antihypertensive action of Triampur ® compositum can be exacerbated by alcohol. Avoid excessive use of alcohol.
What you should consider during pregnancy and lactation ?
Triampur compositum should not be taken during pregnancy and lactation or the need to discontinue breastfeeding.
Effects on ability to drive and use machines
Treatments, this medicine requires regular medical supervision. Through individual appearing different reactions can impair the ability to actively participate in traffic , use machines or work without safe support. This is especially true at the beginning of treatment , when increasing the dose , changing the drug or interaction with alcohol.
What else you should consider ?
Wearing contact lenses should be aware that during treatment with Triampur compositum can . lead to reduction in tear fluid ( see section "Possible side effects ') . Dosage , route and duration of prilozhenieSlednite instructions are valid in the event that your doctor has prescribed another for taking Triampur ® compositum . Please adhere to the recommendations for application, otherwise Triampur ® compositum dozhe not act properly.
How much and how often you should take Triampur compositum ?
The dose is determined individually by a doctor.
In general , the following dosage for adults and adolescents over 50 kg body weight: Swelling : In the beginning of treatment taken in the morning and afternoon 2 (-4 ) tablets to the start of drainage . The further dosing is carried out depending on the degree of dewatering . In principle, the maintenance dose is 1 tablet daily in the morning or every second day 2 tablets (respectively split morning and afternoon ) . Maintenance dose if necessary, may be increased to 4 tablets daily ( 2 tablets in the morning and 2 tablets in the afternoon ) .
An initial dose taken in the morning and 2 tablets in the afternoon . In additional intake of other antihypertensive agents , respectively during prolonged therapy almost always enough 2 tablets daily ( 1 tablet in the morning and 1 tablet in the afternoon ) .
In addition to the treatment of glycosides with heart failure :
The dosage is determined by the clinical condition . It is generally administered 2 tablets per day , respectively, to a maximum of 4 tablets a day ( up to 1 respectively, 2 tablets morning and noon ) .
When renal function (serum creatinine 1,5-1,8 mg / dl, respectively . Clearance creatinine 50-30 ml / min) should not exceed a dose of one tablet per day.
How and when to take Triampur compositum ?
The tablets are taken unchewed with some liquid after meals.
Please take care during treatment with Triampur compositum sufficient fluid intake !
How long should I take Triampur compositum ?
The duration of treatment can be determined by the attending physician .
Overdose and other errors in use
What you should consider if you take too little Triampur compositum or you miss some intake ?
In case you have forgotten a single dose as soon as you notice this , take the medicine unless it is late afternoon , because in that case you will have nocturnal urination . Then continue to take your regular dosing schedule .
What you should consider if you interrupt or cancel the pre- treatment ?
Do not stop taking drug without consulting your doctor because it could lead to renewed and increased onset of symptoms to treatment ????????????.??????????????? Triampur compositum ® should not be stopped suddenly . A planned completion of treatment should be done slowly , with gradual dose reduction .
What should be done if you take Triampur compositum very large quantities ?
Overdose Triampur compositum can cause prolonged diuresis , weakness , fatigue , confusion , tingling in hands and feet , low blood pressure , heart rhythm disturbances and possibly garchove.Uvedomete doctor immediately about it !
What side effects may occur when taking Triampur compositum ® ?
When taken before a meal may appear nausea , vomiting and possibly diarrhea. Sometimes occurring adverse reaktsiiPonyakoga observed symptoms associated with central nervous system ( involuntary movements, sleepiness), dry mouth , thirst , complaints in the epigastric , spastic abdominal pain, constipation ( in isolated cases to paralytic ileus ) muscle spasms, muscular hypotonia , leg cramps , fatigue, headache , nervousness , palpitations , irregular heartbeat , and regulatory disturbances of circulation by dizziness , drowsiness or binge kolaps.Predi everything at the beginning of treatment appears transient increase in nitrogen units ( urea , creatinine) in kravta.Pri continuous administration could lead to changes in serum electrolytes , particularly in a reduced concentration of sodium, magnesium and chlorine , reduced or elevated potassium concentrations , as well as disorders of the water is increased obmyana.Vazmozhno uric acid , so that in predisposed patients may rarely provoke attacks podagra.V depending on the total dose administered is possible increase in blood lipids in predisposed patsienti.Chrez increase in blood sugar can present non-declared until diabetes , respectively worsen existing diabetes diabet.Lekarstveniyat product can promote the emergence of excessive acidification of the blood ( metabolic acidosis) . at high dosage and / or massive urine output , resulting in a large loss of fluid and reduce the amount of volume of fluid in the blood vessels can lead to thrombosis and embolism , and in rare cases, cramps , disorientation , circulatory collapse and acute renal failure.
Rarely occurring side effects:
Rarely , mild visual disturbances , worsening of myopia or decrease in tear fluid (observe when wearing contact lenses) . Possibility is not excluded in rare cases to provoke inflammation of the pancreas , and in the presence of gallstones - inflammation gallbladder . Rarely, yellow skin , mucous membranes and eyeballs ( jaundice ) and very rarely - the formation of kidney kamani.V rare cases may show allergic skin changes such as redness , itching, hives, cutaneous lupus erythematosus, sun allergy ( photoallergic skin rash ) and drug fever .
Adverse reactions occurring in isolated cases :
In rare cases, changes were observed in the blood picture , eg . reduction in red or white blood cells or platelets ( aplastic anemia , leukopenia , thrombocytopenia , agranulocytosis, anemia metaloblastna pre-existing lack of folic acid) changes blood ( hemolysis ) by the formation of antibodies in ednovremenenpriem hydrochlorothiazide methyldopa reactions hypersensitivity ( anaphylactic ) reactions , severe inflammation of the blood vessels and nonbacterial interstitial nefriti.V single cases described onset of acute pulmonary edema with shock symptoms. The reason is considered an allergic reaction to the drug hidrohlortiazid.Ako identify side effects not listed in this leaflet, please inform your doctor or pharmacist ..
What countermeasures should be taken with side effects ?
Tell your doctor about adverse drug reactions , which will prescribe the new dosage and most will be able to properly assess the seriousness of the event , and to take the necessary measures or will prescribe another medicine.
The expiry date of this package is imprinted on the bottle and carton.
Do not use this container after that date !
Keep out of reach of children!