Tavanic table. 500 mg. 7 table
Tavanic table. 500 mg. 7 table
Each tablet Tavanic 500 mg tablet contains 512.5 mg of levofloxacin 0,5 H2O, corresponding to 500 mg of levofloxacin.
Other ingredients: crospovidone, ???????????????????????????, microcrystalline cellulose, natrievstearil fumarate, polyethylene glycol, talc, dyes: titanium dvioksid (E171), yellow iron oxide (E172) and red iron oxide (E172).
Group of substance and mode of action
type of medicine is Tavanic?
Tavanic is a broad antibacterial agent fluorhinolonoviya class active-levofloxacin. Tavanic has bactericidal effect on many bacteria.
Under what conditions is used Tavanic 500 mg?
Tavanic 500 mg tablets are used to treat mild to moderately severe bacterial infections in adults caused by bacteria susceptible to levofloxacin.
Acute sinusitis (inflammation of one or more of the paranasal sinuses)
Inflammation of the lower respiratory tract exacerbation of chronic bronchitis, pneumonia acquired in the community,
Uncomplicated urinary tract infections,
Complicated urinary tract infections (including those in and kidneys)
Chronic bacterial prostatitis.
Infections of skin and soft tissues. Contraindications
When should you not use Tavanic 500 mg tablets?
Tavanic 500 mg tablets should not apply in the following circumstances, or if you belong to any of the following groups as possible the drug could cause more harm than good.
Hypersensitivity to levofloxacin, quinolone antibiotic or another one of the other sastavki.patsienti suffering from epilepsy
Patients with a history of tendon disorders due to treatment with antibiotic fluorhinolonoviya class
Children and adolescents.
What to consider during pregnancy and lactation?
As no clinical studies on humans and thus possible damage to the cartilage of the growing organism of quinolones Tavanic should not be administered to pregnant women and breast-feeding. If ustanovenapo pregnancy during treatment with Tavanic, the physician should be notified.
What should be considered in children and the elderly?
Tavanic should not be given to children and adolescents as not to exclude damage hrushtyala.Pri elderly should take into account that they are more likely to have decreased renal function (see "Dosage, route and duration of treatment ").
Warnings and precautions for use What precautions be taken into account?
In the most severe cases of pneumococcal pneumonia Tavanic may not be optimal therapy. Hospital acquired infections caused by certain pathogens (P. aeruginosa) may require combination therapy. The risk of seizures during treatment with Tavanic may be increased if in the past the brain is damaged by stroke or severe brain injury, for example. Therefore tell your doctor of detailed previous illnesses. Should not be treated with Tavanic if you have epilepsiya.Riskat of convulsions may also be increased by concomitant administration of nonsteroidal fenbufen or similar antiflogistitsi or theophylline (see also "Interactions").
Although photosensitisation (hypersensitivity to light effects like burning) is very rare in the use of levofloxacin, it is recommended that patients should not be exposed unnecessarily to strong sunlight or artificial UV rays (ie, solar lamp, solarium) for To prevent photosensitivity.
The doctor should be notified immediately if severe, persistent and / or bloody diarrhea during or after treatment with Tavanic. This may be symptomatic or severe inflammation of the bowel (colitis) caused by antibiotics. If pseudomembranous colitis is suspected, treatment with Tavanic must stop immediately and immediately begin appropriate therapy. In these cases should not apply products that inhibit peristalsis. Tendinitis rarely observed during treatment with quinolones may lead to rupture in particular Achilles tendon. Elderly patients are more likely to develop tendinitis. The danger of tendon rupture may be increased by concomitant administration of corticosteroids. If tendinitis is suspected, nezabavnoda seek medical advice Tavanic tablets therapy should be discontinued and for the affected tendon to be an appropriate treatment eg. immobilization (see also "Contraindications" and "Side Effects").
Patients deficient in glucose-6-phosphate dehydrogenase (an inherited disease) may be prone to destruction of red blood cells (hemolysis) during treatment with quinolone antibacterial agents, so levofloxacin should be used with caution.
What to consider when driving or operating machinery, or as no seatbelt?
Some side effects such Tavanic vertigo / dizziness, drowsiness, visual disturbances (see also "Side Effects") may impair your ability to concentrate and react. This may constitute a risk in situations where these abilities are of special importance (eg driving a car or operating machinery, working without a net). This is especially true when combined with alcohol.
Interactions with other drugs
What should be taken into account at the same time Tavanic 500 mg tablets taken or is taking other medicines?
If concomitant treatment with other medication, ask your doctor or pharmacist if any of it is listed below. This applies to drugs that are not prescribed by your lekar.Nalitse are signs of pronounced lowering of seizure threshold in the brain when co-administered with other quinolone agents that lower the seizure threshold of the brain (eg, theophylline). The same applies to the concomitant use of quinolones and fenbufen or nonsteroidal antiinflammatory drugs (medicines used to treat rheumatic diseases). Effect of Tavanic significantly reduced when administered with sucralfate (medicine, protecting the stomach lining). The same goes for co-administration of magnesium or aluminum containing antacids (medicines to treat heartburn and stomach pain) and iron salts (medicines for the treatment of anemia). Tavanic 500 mg tablets is best to apply before or 2 hours after taking these medications.
Elimination (renal depuration) of levofloxacin was slightly reduced by cimetidine and probenecid. However, these interactions are unlikely to have clinically znachenie.Neobhodimo is advised during concomitant administration of levofloxacin with agents that have influenced the ways of elimination (tubular secretion), as probenecid and cimetidine. This is especially true in patients with impaired renal funktsiya.Poluzhivotat of cyclosporine slightly increased when coadministered with levofloxacin.
Dosage, method and duration of treatment
How often and how much Tavanic 500 mg tablets should not take?
Tavanic 500 mg tablets taken once or twice daily. The dose depends on the type and severity of the infection and the sensitivity of the suspected pathogen. The dosage should not be changed without advice from your doctor. Please follow the instructions otherwise Tavanic not work properly. They give the following recommendations for dosing in patients with normal renal function (creatinine clearance> 50 ml / min):
sinusitis (inflammation of the sinuses): 1 tablet Tavanic 500 mg (equivalent to 500 mg levofloxacin).
Acute exacerbation of chronic bronchitis: 1A Tavanic 500 mg tablet once daily (equivalent to 250 mg levofloxacin) to 1 Tavanic tablets 500 mg (equivalent to 500 mg levofloxacin).
Pneumonia: 1 to 2 times daily 1 tablet Tavanic 500 mg (equivalent to 500-1000 mg levofloxacin).
Infections of the urinary tract:! 4 Tavanic tablet 500 mg (equivalent to 250 mg levofloxacin).
Chronic bacterial prostatitis: 1 Tavanic tablets 500 mg (equivalent to 500 mg levofloxacin ') once daily for 28 days.
Infections of skin and soft tissue: ½ tablet Tavanic 500 mg daily (equivalent to 250 mg levofloxacin);, or 1 to 2 times daily 1 tablet Tavanic 500 mg (equivalent to 500-1000 mg levofloxacin).
What should be considered in patients with impaired renal function?
Since levofloxacin is eliminated primarily by the kidneys, patients with renal impairment, dosage should be reduced.
No further doses after hemodialysis or continuous ambulatory peritoneal dialysis (NAPA).
What should be considered in patients with impaired liver function?
Not require dose reduction because levofloxacin is not metabolised to a significant extent by the liver.
How and when to take Tavanic?
The tablets should be taken with plenty of water (1L to 1 cup). Adapting dose tablets can be broken in a dividing line. The tablets may be taken with food or anytime in between meals. See. also paragraph "Vzaimodiystviya."
How long should apply Tavanic?
The duration of treatment is determined by the disease process and not more than 14 days. In clinical studies, treatment duration was 10-14 days with sinusitis, 7-10 days in exacerbation of chronic bronchitis, pneumonia 7-14 days, 7-10 days for complicated urinary tract infections and Zdni neuslooyuneni for urinary tract infections; 7-10 days for infections of skin and soft tissues. As with other antibacterial agents, treatment with Tavanic 500 mg tablets should continue for at least 48 to 72 hours after the body temperature returns to normal or demonstrated destruction of pathogens.
Overdose and other administration errors
What to do if Tvanik overdose?
Most important symptoms (signs) that can be expected from accidental overdose Tavanic symptoms of the central nervous system such as confusion, dizziness, disturbances of consciousness and seizures. Additional occur gastrointestinal disturbances such as nausea and damage to mucous membrane (lining). Announces to symptomatic treatment. Levofloxacin can not be removed by dialysis. There is no specific antidot.Sluchaen taking one tablet of 500 mg Tavanic more will not hurt. If swallowed several tablets more, please tell your doctor immediately.
What should I do if I miss a dose?
Catch up taken as soon as possible unless time for next dose is near. Continue to take Tavanic prescribed by your doctor.
What should be considered if treatment with Tavanic interrupt or finish earlier?
Tavanic treatment should not be interrupted or completed earlier without advice. Otherwise, the success of treatment is uncertain.
What side effects can occur during treatment with Tavanic 500 mg tablets? Medicines can have side effects, or so-called side effects. However, they do not occur in any patient. Adverse effects seen in
Frequency of side effects encountered
In Common 1 to 10 of 100 patient
Not often in less than 1 in 100 patients
Rare Less than 1 in 1000 patients
Very rare in less than 1 in 10,000 patients
Isolated cases even more frequently
Skin reactions and generalized allergic reactions
Uncommon: Pruritus and rash.
Rare: Common allergic reactions (anaphylaxis / anaphylactoid) reactions with siptomi as urticaria, bronchospasm and possible severe breathing problems, and in rare cases, swelling of the skin and mucous membranes (such as the face or throat).
Very rare: a sudden drop in blood pressure or shock. Increased sensitivity to sun or ultraviolet light (also see "Warnings"). Isolated Severe reactions of the skin and mucosal blistering, events: as Stevens-Johnson syndrome, toxic epidermalnanekroliza (Lyle syndrome) and erythema multiforme eksudativum (rare skin condition with redness of the skin).
Common allergic reactions can sometimes be preceded by mild skin reactions. Aforementioned reactions can sometimes occur even after the first dose and may occur within minutes or hours after the dose.
Gastrointestinal System / metabolizamMnogo rare: Nausea, diariya.Zaguba of appetite, vomiting, abdominal pain, and dyspepsia. Bloody diarrhea, which in rare cases may be indicative of enterocolitis, including pseudomembranous colitis (also see "Warnings"). Decrease blood sugar (hypoglycemia), which may be of particular importance in patients treated for diabetes. Symptoms of hypoglycemia may be nervousness, sweating, treperene.Za other quinolones is known that they can trigger an attack of porphyria (a rare metabolic disease) in patients with pre porphyria. Therefore, it may be true for Tavanic
Effects on the nervous system
Uncommon: Headache, vertigo / dizziness, drowsiness, trouble sleeping.
Rare: Paraesthesia, ie numbness in hands, shaking, anxiety, agitation, seizures and confusion. Very rare: Visual and auditory disturbances, disturbances of taste and smell, numbness, psychotic reactions, including hallucinations and depressive moods.
Movement disorders, including difficulty in walking.
Effects on the cardiovascular system
Rare: Abnormally rapid heartbeat, low kravnotonalyagane.Mnogo rare circulatory (like shock) collapse.
Effects on muscles, tendons and bones
Isolated cases: tendon pain, including inflammation, joint or muscle bolki.Skasvane tendon (Achilles tendon eg). As with other quinolones, this undesirable phenomenon can occur within 48 hours after initiation of treatment and may be bilateral (also see "Warnings"). Muscle weakness, which can be of particular importance in patients with myasthenia gravis (a rare disease of the nervous system). Muscle damage (rhabdomyolysis).
Effects on the liver and kidneys
Common: Elevated liver enzymes (eg, AST, ALT). Uncommon: Increased bilirubin and serum creatinine (signs nauvredena hepatic or renal dysfunction). Very rare: Hepatic inflammation, disorders of renal function in renal failure, for example. due to allergic reactions (interstitial nephritis).
Effects on blood
Uncommon: Increase in the number of certain blood cells (eosinophilia), low white blood cells (leukopenia).
Rare: Increased number of certain white blood cells (neutropenia), decreased number of blood platelets (thrombocytopenia), leading to easy bruising and bleeding.
Very rare: Severe reduction in the number of white blood cells (agranulocytosis), leading to severe symptoms such as fever or resumption of prolonged fever, sore throat and resume bolestta.Izolirani Reduced number of red blood cells because of their cases: destruction (hemolytic anemia), reduced the number of all types of blood cells (pancytopenia).
Uncommon: Weakness (asthenia).
Very rare: Fever, allergic lung inflammation (allergic pneumonitis) or small blood vessels (vasculitis).
Any antibacterial therapy can lead to changes in microorganisms (bacteria / fungi) that normally exist in humans. Therefore, the number of other bacteria or fungi that are resistant to the antibiotic used may be increased (superinfection), so in some cases require additional treatment.
What to do for adverse likarstvenireaktsii?
Please tell your doctor if you experience any of these here adverse effects or any other unexpected effects during treatment with Tavanic. Contact immediately with any doctor if you have side effects or sudden onset of rapid development, because some side effects (eg, pseudomembranous colitis, certain blood dyscrasia, severe anaphylactic or anaphylactic-like reactions and serious skin reactions) can be life-threatening. In such cases, do not continue to take the medicine without the counsel of a doctor.
How to store this medicine?
How long are usable Tavanic 500 mg tablets?
The shelf life of this product is printed on the packaging. Do not use after this date
How to keep Tavanic 500 mg?
It is best to store Tavanic 500 mg tablets in the original container in a dry place. Please always keep in mind that drugs are kept out of sight of detsa.Sahranyavayte at temperatures below 25 ° C.