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What is Typherix and what it is used
Typherix is typhoid vaccine, an infectious disease which is caused by Salmonella typhi.
The vaccine can be administered to adults and children aged 2 years and over.

Typherix contain a small proportion of the causative agent of typhoid. It is not infectious and can not cause disease.
When the vaccine, it stimulates the body's immune system to prepare for the defense of typhoid in the future;
Typherix defend itself from disease caused by Salmonella typhi and can not protect you against gastroenteritis and diseases caused by other salmonella bacteria after consuming contaminated food.
Typhoid fever is an infectious disease that is caused and spread by eating contaminated with Salmonella typhi food or water. Because the bacteria are present in the intestines, infection can occur in any part, but more often it occurs in locations or countries where there is low public or personal hygiene.
The main symptoms of the disease include headache, stomach pain, constipation or diarrhea and fever that may last one or two weeks. Typically, patients are improved after four weeks, but the disease may recur.

2. Before you take Typherix
Typherix should not be applied:
if you are allergic (hypersensitive) to Typherix or any of the other ingredients (listed in Section 6);
if you have a high temperature (fever).
Typherix should not apply if any of the above applies to you. If you are unsure, ask your doctor or pharmacist before you are given Typherix.
Seizure may occur (more common in adolescents) after or even before the injection with a needle. Therefore tell the doctor or nurse if you fainted / your child fainted with a previous injection.

Take special care with Typherix
Consult your doctor before administering the vaccine:
if you have a bleeding disorder or suffer from profuse bleeding. Since vaccination may occur bleeding at the injection site must be pressed for at least two minutes after the injection;
if you have a weakened immune system or taking drugs (eg. corticosteroids), which may affect the immune system.
If you are not sure if any of the above applies to you, ask your doctor or pharmacist.

Using other medicines and vaccines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Typherix can be applied at the same time as some other vaccines. Your doctor will take care, vaccination may be applied separately and in different limbs.

Pregnancy and lactation
Women who are pregnant may sometimes be vaccinated.
Tell your doctor if you think you are pregnant or may become pregnant.
Tell your doctor if you are breastfeeding.

Driving and using machines
Typherix can affect your ability to drive or operate machinery. Do not drive or use machinery if you feel unwell.

3. How to use Typherix
Typherix be administered as an intramuscular injection in the upper arm of at least two weeks prior to exposure to the risk of typhoid fever.
For adults and children over 2 years of age is recommended to administer a dose (0,5 ml) of vaccine.
If you are still at risk of typhoid fever, your doctor may recommend a second dose Typherix three years after administration of the first dose.

If you have any questions about the amount of vaccine you are given, ask your doctor.

4. Possible side effects
Like all vaccines, Typherix can cause side effects, although not everybody gets them. The following adverse reactions may occur after administration of the vaccine:

Allergic reactions (can occur in up to 1 in 10,000 doses of vaccine)
If you have an allergic reaction, immediately contact your doctor. Symptoms may include:
swelling of the face;
lowering blood pressure;
breathing difficulties;
bluish skin;
loss of consciousness.
Symptoms usually occur very quickly after administration of the vaccine. If symptoms occur after leaving the doctor's office, seek medical advice immediately.

Other side effects include:
Common (may occur in up to 1 in 10 doses of vaccine):
pain, redness and swelling at the injection site;
high temperature (fever);
joint pain;
general feeling of being unwell;
Very rare (may occur in up to 1 in 10,000 doses of vaccine):
severe rash (urticaria).

If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

5. How to store Typherix
Keep at temperatures between + 2 ° C to + 8 ° C (in a refrigerator). Do not freeze.
Store in the original package in order to protect from light.
Keep out of the reach and sight of children.
Typherix not use after the expiry date stated on the label and carton. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Further information
What Typherix
The active substance is 25 micrograms Vi polysaccharide antigen of Salmonella typhi.
The other ingredients are sodium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, phenol and water for injections.

Typherix looks like and contents of the pack
Typherix is a clear colorless solution.
Typherix is available in 0,5 ml pre-filled syringes in packs of 1 or 10.
Not all pack sizes may be marketed.
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