TUBOTSIN caps. 300 mg. 100 caps

TUBOTSIN caps. 300 mg. 100 caps
€ 35.00
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The active substance in Tubotsin capsules is an antibiotic rifampicin. It is active against bacteria that cause tuberculosis and other common diseases in humans. Its action is due to inhibition of the action of enzymes (enzymes) in bacterial cells, thus disturbing their growth and division.

TUBOTSIN caps. 300 mg. 100 caps


The active substance in Tubotsin capsules is an antibiotic rifampicin. It is active against bacteria that cause tuberculosis and other common diseases in humans. Its action is due to inhibition of the action of enzymes (enzymes) in bacterial cells, thus disturbing their growth and division. Tubotsin is used to treat:
 Tuberculosis of lung, bone, skin, stomach, intestines and other organs;
 Leprosy (a chronic infectious disease caused by bacteria such as those causing tuberculosis);
 Brucellosis (an infectious disease that is transmitted to humans by infected animals in contact with or ingestion of contaminated milk or meat);
 Severe infections caused by staphylococci or other common microorganisms (eg, H. influenzae);
Tubotsin suitable for prophylaxis (prevention) of meningococcal meningitis (inflammation of the lining of the brain caused by a specific bacteria).


Do not take Tubotsin
 If you are allergic (hypersensitive) to rifampicin, Rifamycin or any of the other ingredients of Tubotsin;
 If you have a history of liver disease and / or jaundice;
 If you have porphyria (an inherited liver disease);
 If you have severe kidney disease.
 If Tubotsin while taking medicines to treat HIV infection (eg, ritonavir) or medicines for fungal infections (eg, itraconazole)
Take special care with Tubotsin
Treatment should only be used under the appointment and control specialist. Admission should not be terminated without valid reasons and this should be done in consultation with a doctor.
In some cases of severe allergic reactions after initiation of treatment, such as fever, difficulty breathing, hives, collapse. In these cases or suspected allergies need of the product to be discontinued immediately and seek medical advice. If you have kidney disease, the product must not be administered in high doses. In all patients with renal impairment produkatat should be used with caution.
With special attention to the product should be used in patients with liver disease. In these cases it is necessary before treatment to make certain laboratory tests and periodically during treatment to monitor liver enzymes and bilirubin, and general condition. In case you appear fever, jaundice or other signs of deterioration, physicians will decide whether it is necessary termination of treatment to avoid possible damage to the liver. These measures are particularly pertinent to older patients, patients with lower body weight, individuals abusing alcohol, young children, especially in cases when taking concomitant medications to treat tuberculosis, eg. izoniaid.
Your doctor will decide whether you need periodically to control the number of tiles Crouch (platelets), and other blood parameters.
During treatment with this product it is necessary to regularly visit your doctor who will monitor your condition and will monitor for possible adverse effects that can not be excluded.
If you suffer from porphyria (an inherited disease of the liver) is a possible deterioration in the administration of rifampicin - increased blood pressure, rapid pulse, abdominal pain. So Tubotsin should not be taken for porphyria.
If you are taking tablets to prevent pregnancy you need to have in mind that "your pill" may be ineffective because this product may change their action. Therefore need to be discussed with an expert ability to use other appropriate methods to prevent pregnancy. If you wear contact lenses you should consider that Tubotsin may permanently stain soft contact lenses (see Possible side effects).

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Rifampicin can change the action of many medications, when taken together with them, and a number of drugs in turn may alter its operation. Therefore, it is important to tell your doctor about all the medicines you are taking or plan to take.
This applies in particular to:
 Medicines used to treat heart (antiarrhythmics, beta-blockers, calcium channel blockers, diuretics, cardiac glycosides, statins, etc..)
 Medications to reduce blood clotting;
 Medicines for epilepsy (napr.fenitoin) antipsychotics (napr.haloperidol) drugs to reduce stress (eg, anxiolytics), hypnotic drugs (barbiturates);
 Some antibiotics, antiviral drugs (efavirenz, zidovudine, nevirapine), medicines used to treat fungal, medication for immunosuppression (cyclosporine, tacrolimus);
 Medicines to treat diabetes;
 Administered orally, preparation for birth control;
 Thyroid hormones, estrogens, etc. hormone antagonists;
 Some pain medications - NSAIDs (etoricoxib, rofecoxib), narcotic analgesics (morphine, codeine, methadone);
 Drugs to treat nausea and vomiting (ondansetron, tropisetron);
If you need to undergo surgery and will be applied to halothane
and tell your doctor and anesthetist that this medicine.
Tubotsin should be administered at least one hour before taking medications that reduce
acidity of gastric juice (antacids etc.).
If you need to make certain laboratory tests, tell your doctor that you are taking Tubotsin because the results can be altered as a result of interaction.
Taking Tubotsin with food and drink
Rifampicin daily dose should be taken at least 1 hour before or 2 hours after meals to
can use the drug in the stomach and intestines to be enough.

Pregnancy and lactation

Ask your doctor or pharmacist before taking any medicine.
Pregnancy: Animal studies have shown that rifampicin may harm the fetus and newborn. There is no known effect on pregnant women, so in these cases, this medication should not be used without absolute necessity.
Your doctor will decide to conduct the treatment.
Breastfeeding: Rifampicin is found in breast milk, so it is necessary to consider possible
cessation of breastfeeding during the treatment with this product.
Driving and operating machinery
No evidence of adverse effects of rifampicin on ability to drive and use machines, but must take into account the possibility of inducing drowsiness.
Important information about some of the ingredients of Tubotsin
Tubotsin contains the excipient colorant E122, which can cause allergic reactions.


Always Tubotsin exactly as your doctor tells you. If you're not sure, ask your doctor or pharmacist.
The capsules should be swallowed whole, at least 1 hour before or 2 hours after meals. The daily dose is given once, usually in the morning.
Tubotsin should be administered with other effective antimycobacterial agents to achieve
expected therapeutic effect. Treatment should be of sufficient duration to prevent his new appearance, and usually lasts between 12 months and b.
Adults - recommended daily dose of 8 mg / kg (Or 600 mg in weight over 50 kg)
Children aged 6-12 years - recommended daily dose of 10 mg / kg with a maximum daily dose should not exceed 600 mg (2 capsules).
The product should be administered in combination with at least one active agent for the treatment of this disease.
Adults - the recommended dose is 600 mg once a month
Children aged 6-12 years - recommended daily dose of 10 mg / kg once a month.
The duration of treatment is usually 45 days.
Adults - the recommended daily dose is 900 mg taken as a single dose.
 Prevention of meningitis meningokov
Adults - 600 mg twice daily for 2 consecutive days.
Children aged 6-12 years - 10 mg / kg twice daily for 2 consecutive days.
 Treat certain severe infections
Adults and children aged 6-12 years - 20-30 mg / kg daily in two divided doses before meals
 Impaired liver function
In patients with impaired liver function should not be administered in high doses.
Treatment should be initiated only after the appointment of the specialist and after some research on the liver.
In elderly patients renal function is reduced, so your doctor will determine the correct dose that will be treated.
If you take more than the dose Tubotsin
If you have taken more than the prescribed dose, contact your doctor or go to
nearest hospital.
When taking more than prescribed dose is possible onset of nausea, vomiting, abdominal pain, itching, drowsiness, low blood pressure, rapid heartbeat, reddish-brown coloration of saliva, sweat, tears, urine.
In case of overdose, seek medical advice immediately, to hold charcoal. Apply appropriate symptomatic agents. 
If you forget to take Tubotsin
If you forget to take a dose, take it as soon as possible after you
remember. Do not take a double dose to make up for the forgotten. Take your next dose at
If you stop taking Tubotsin
Do not stop taking your capsules if you feel better, unless your doctor tells you
If you have any other questions about the use of this product, ask your doctor
or pharmacist.


Like all medicines, Tubotsin can cause side effects, although not everybody gets them. The following is the frequency with which adverse reactions were reported:
 Common - occurs in more than one of every 100 patients and less than one in ten taking the product.
 Uncommon - found in at least one in 1000 and in less than one in every 100 receiving product
Rare - occurring in one in 10,000 and less than one in 1000, the product received
Very rare - occurs in less than 1 in ten thousand who received the product.
Congenital, familial and genetic disorders
Rare - aggravation of porphyria (an inherited disease of the liver)
Blood and lymphatic system
 Rare - a transient decrease in white blood cells to complete their absence, decreased platelet count (platelets) and related small red skin rash and anemia.
Nervous System
 Common - drowsiness, headache, confusion, dizziness
 Uncommon - disequilibrium
Eye disorder
 Common - red eyes
 Rare - visual disturbances, conjunctivitis
Respiratory, thoracic and mediastinal disorders
 Rare - very rare - breathing difficulties
Gastrointestinal Disorders
 Common - anorexia, nausea, abdominal pain
 Uncommon - vomiting, diarrhea
 Rare - gastritis
Renal and urinary disorders
 Rare - elevated levels of certain salts in the urine have been reported for acute renal failure and other kidney damage.
Skin and subcutaneous tissue disorders
 Common - with or without itching, rash, hives (urticaria), flushing;
 Rare - severe skin damage (eg naStevens Syndrome - Johnoson), widespread allergic reactions like skin etc. exfoliative dermatitis syndrome Lyell) and pemphigoid reactions.
Disorders of the musculoskeletal system and connective tissue
 Rare - muscle weakness 
Endocrine disorders
 Uncommon - causing crises in patients with Addison's disease
Infections and infestations
 Very rare - diarrhea, inflammatory bowel disease (pseudomembranous colitis etc.)
Vascular Disorders
 Rare - sharply blood pressure (collapse to shock)
General disorders and administration site conditions
 Rare - swelling
 Not known - flu-like symptoms, including fever, chills, headache, dizziness, joint pain
Hepatobiliary disorders
 Very common - an increase in liver enzymes
 Uncommon - hepatitis and jaundice, severe disturbances in liver function to liver failure
Psychiatric Disorders
 Uncommon - memory impairment, confusion
Rifampicin can cause reddish discoloration of urine, saliva, sweat, sputum, and
tears. Soft contact lenses may be permanently stained.
If any of the side effects gets serious, or if you get any side effects not listed in this leaflet, please contact your doctor or pharmacist.


At temperatures below 25 ° C.
This medicine does not require any special storage conditions.
Keep out of reach of children.
Tubotsin Do not use after the expiry date stated on the carton. The term of
refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.


What Tubotsin
The active substance rifampicin 300 mg
The other ingredients are: croscarmellose sodium, magnesium stearate.
The capsule shell contains Azorubine coloring (E122), titanium dioxide (E171), iron
oxide red (E172), black iron oxide (E172) and gelatin
€ 35.00
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