TUBOCIN 300 mg. 100 capsules

ACTAVIS
TUBOCIN 300 mg. 100 capsules
€ 49.00
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WHAT TUBOCIN AND WHAT IT IS USED
The active substance contained in Tubocin capsules is the antibiotic rifampicin. It is active against bacteria that cause tuberculosis and other common diseases in humans. Its action is due to the suppressing the action of enzymes (enzymes) in bacterial cells, thereby disrupting their development and differentiation. Tubotsin be applied for the treatment of:
Tuberculosis of lung, bone, skin, stomach, intestines and other organs;
Leprosy (a chronic infectious disease caused by bacteria such as those causing tuberculosis);
Brucellosis (an infectious disease that is transmitted to humans from infected animals in contact with them or consume contaminated milk or meat);
Severe infections caused by staphylococci or other common organisms (eg. H. influenzae);
Tubotsin is suitable for prophylaxis (prevention) of meningococcal meningitis (inflammation of the lining of the brain caused by specific bacteria).
2. BEFORE YOU TAKE TUBOCIN
Do not take Tubocin
If you are allergic (hypersensitive) to rifampicin, rifamycins or any of the other ingredients of Tubocin;
If you have or have had liver disease and / or jaundice;
If you have porphyria (an inherited liver disease);
If you have severe kidney disease.
If simultaneously Tubotsin taking medicines to treat HIV infection (eg. Ritonavir) or medicines to treat fungal infections (eg. Itraconazole)
Take special care with Tubotsin
Herceptin treatment should only take place after the appointment under control specialist. The intake should not be terminated without valid reasons and this should be done after consulting a doctor.

In some cases of severe allergic reactions after treatment initiation, such as fever, difficulty breathing, rashes collapse. In these cases or suspected symptoms of allergy necessary intake of the product be discontinued immediately and seek medical advice. If you have kidney disease, the product must be administered in high doses. In all patients with renal impairment, produkatat should be used with caution.
With particular reference product must not be used in patients with liver diseases. In these cases it is necessary before starting treatment to make certain laboratory tests and during treatment periodically to monitor liver enzymes and bilirubin, and general condition. In case appeared fever, jaundice or other signs of deterioration, the treating specialist will decide whether it is necessary discontinuation of therapy to avoid possible damage to the liver. These measures concern especially for older patients, patients with low body weight, people abusing alcohol, young children, especially when taken at the same time another medicine to treat tuberculosis, for example. izoniaid.
Your doctor will decide whether it is necessary periodically to control the number of krachnite plates (platelets), and other blood parameters.
During treatment with this product it is necessary to regularly visit your doctor who will monitor your condition and will monitor the possible occurrence of side effects that can not be excluded.
If you suffer from porphyria (an inherited disease of the liver) is possible deterioration when taking rifampicin - a rise in blood pressure, rapid pulse, abdominal pain. So Tubotsin should not be taken for porphyria.
If you take pills to prevent pregnancy you should have in mind that "Your pill" may be ineffective, because this product can change their action. It is therefore necessary to consider a specialist possibility of using other appropriate methods to prevent pregnancy. If you wear contact lenses, you should consider that Tubotsin can permanently stain soft contact lenses (see possible side effects).
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Rifampicin can change the action of many drugs when taken at the same time and a number of drugs in turn can alter its operation. It is therefore very important to tell your doctor about all medicines you are taking or plan to take.
This applies in particular to:
Drugs for treatment of the heart (antiarrhythmics, beta blockers, calcium channel blockers, diuretics, cardiac glycosides, statins, etc.);
Medications to reduce blood clotting;
Medicines to treat epilepsy (napr.fenitoin); antipsychotics (napr.haloperidol); drugs to reduce stress (eg. anxiolytics); sleeping pills (barbiturates);
Some antibiotics, antiviral drugs (efavirenz, zidovudine, nevirapine), drugs to treat fungus; drugs to suppress the immune system (cyclosporine, tacrolimus);
Medicines to treat diabetes;
Orally, preparation for birth control;
Thyroid hormones, oestrogens, etc. hormone antagonists;
Some pain medications - NSAIDs (etoricoxib, rofecoxib); narcotic analgesics (morphine, codeine, methadone);
corticosteroids;
Drugs to treat nausea and vomiting (ondansetron, tropisetron);
Theophylline.
If you have to undergo surgery and will apply halothane should
tell both your doctor and the anesthetist that you are taking this medicine.
Tubotsin should be administered at least one hour before taking medications that reduce
the acidity of gastric juice (ie antacids).
If you need to make certain laboratory tests, tell your doctor that you are taking Tubotsin because the results can be altered as a result of interaction.
Taking Tubotsin with food and drink
The daily dose of rifampicin should be administered at least 1 hour before or 2 hours after a meal to
may absorption of the drug from stomach and intestine to be sufficient.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
Pregnancy: Studies in animals have shown that rifampicin may harm the fetus and newborn. There is no known effect on pregnant women, so in these cases, this drug should not be administered without absolute necessity.
Your doctor will decide to conduct the treatment.
Lactation Rifampicin is found in breast milk, therefore it is necessary to consider any
discontinue breast-feeding during the treatment with the product.
Driving and using machines
No evidence of adverse effects of rifampicin on ability to drive and use machines but must be taken into account ability to induce drowsiness.


Important information about some of the ingredients of Tubotsin
Tubotsin comprises as an excipient a colorant E122, which can cause allergic reactions.
3. HOW TO TAKE TUBOCIN
Always take Tubotsin exactly as you have been told by your doctor. If you're not sure, ask your doctor or pharmacist.
The capsules should be swallowed whole, at least 1 hour before or 2 hours after meals. The daily dose is administered once, usually in the morning.
TB
Tubotsin should be administered with other anti-tubercular effective means to achieve
the expected therapeutic effect. Treatment should be of sufficient duration to prevent his new appearance and generally lasts between b and 12 months.
Adults - the recommended daily dose of 8 mg / kg bodyweight (Or 600 mg in weight over 50 kg)
Children aged 6-12 years - the recommended daily dose of 10 mg / kg bodyweight, the maximum daily dose should not exceed 600 mg (2 capsules).
leprae
The product should be administered in combination with at least another active agent for the treatment of this disease.
Adults - recommended dose is 600 mg once a month
Children aged 6-12 years - the recommended daily dose of 10 mg / kg bodyweight once a month.
brucellosis
The treatment time is usually 45 days.
Adults - the recommended daily dose is 900 mg taken as a single dose.
Prevention of meningitis meningokov
Adults - 600 mg twice daily for 2 consecutive days.
Children aged 6-12 years - 10 mg / kg twice daily for 2 consecutive days.
Treatment of some serious infections
Adults and children aged 6-12 years - 20-30 mg / kg daily in two doses before meals
Impaired liver function
In patients with impaired liver function the product must not be administered in high doses.
Therapy should be initiated only after the appointment of a specialist doctor and after some research on liver.
Elderly
In elderly kidney function is reduced, so your doctor will determine the exact dose that will be treated.
If you take more than the amount Tubocin
If you have taken more than the prescribed dose, contact your doctor or go to
the nearest hospital.
In intake higher than the assigned dose may occur nausea, vomiting, abdominal pain, itching, drowsiness, fall in blood pressure, rapid pulse, brown-reddish coloration of saliva, sweat, tears, urine.
In case of overdose should seek medical advice immediately to take medical charcoal. Apply appropriate symptomatic means.
If you forget to take Tubocin
If you forget to take a dose, take it as soon as possible after you
remembered. Do not take a double dose to make up for the forgotten. Take your next dose
the usual time.
If you stop taking Tubotsin
Do not stop taking your capsules if you feel better until your doctor tells you
thereof.
If you have any other questions on the use of this product, ask your doctor
or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Tubocin can cause side effects, although not everybody gets them. The following frequency is that which has been reported adverse reactions:
Common - occurs in more than one patient each at 100 and less than one in ten, receiving the product.
No common - occurring in at least one in 1000 and in less than one in 100, taking the product
Rare - occurring in one in 10,000 and less than one in 1000, taking the product
Very rare - occurs in less than 1 patient in ten thousand who received the product.
Congenital, familial and genetic disorders
Rare - deterioration in porphyria (an inherited disease of the liver)
Blood and lymphatic system
Rare - temporary reduction in the number of white blood cells to complete their absence, decrease the number of platelets (thrombocytes) and related small red rash and anemia.
Nervous system disorders
Common - drowsiness, headache, confusion, dizziness
Uncommon - disequilibrium
Eye disorder
Common - redness
Rare - visual disorders, conjunctivitis
Respiratory, thoracic and mediastinal disorders
Rare - very rare - breathing difficulties
Gastrointestinal disorders
Common - loss of appetite, nausea, abdominal pain
Uncommon - vomiting, diarrhea
Rare - gastritis
Renal and urinary
Rare - elevated levels of certain salts in the urine; There have been reports of acute renal failure and other kidney damage.
Skin and subcutaneous tissue disorders
Common - itching with or without rash, hives (urticaria), flushing;
Rare - severe skin damage (eg. Syndrome naStevens - Johnoson), common allergic skin reactions like etc. exfoliative dermatitis syndrome Lyell) and pemphigoid reactions.
Disorders of the musculoskeletal system and connective tissue
Rare - muscle weakness
Endocrine disorders
Uncommon - inducing crises in patients with Addison's disease
Infections and infestations
Very rare - diarrhea, inflammatory bowel disease (so pseudomembranous colitis)
vascular disorders
Rare - sharp and strong decrease in blood pressure (shock collapse)
General disorders and administration site conditions
Common -otpadnalost;
Rare - swelling
Not known - flu-like symptoms, including fever, chills, headache, dizziness, joint pain
Hepatobiliary disorders
Very common - increase in liver enzymes
Uncommon - hepatitis and jaundice, severe disturbances in liver function to liver failure
Psychiatric disorders
Uncommon - memory impairment, confusion
other
Rifampicin may lead to a reddish colored urine, saliva, sweat, sputum and
tears. Soft contact lenses may be permanently stained.
If any of the side effects gets serious, or get any side effects not listed in this leaflet, please contact your doctor or pharmacist.
5. HOW TO STORE TUBOCIN
At temperatures below 25 ° C
This medicine does not require any special storage conditions.
Keep out of reach of children.
Do not use Tubotsin after the expiry date stated on the carton. The term of
date refers to the last day of that month.
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