STANDACILLIN 500 mg. 12 capsules

SANDOZ
STANDACILLIN 500 mg. 12 capsules
€ 9.00
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What is Standacillin?
Ampicillin is a broad spectrum bactericidal penicillin from aminopenicillin group. As with other penicillins and cephalosporins, it inhibits cell wall synthesis. Ampicillin has a broad spectrum of activity that covers both gram-positive and gram-negative microorganisms. Clinically significant pathogens affected by ampicillin are Escherichia coli, Proteus mirabiiis, Salmoneilae, Shigellae, Haemophilus influenzae and Bordeteila pertussis. Other pathogens ranging from the spectrum of ampicillin are all those which are sensitive to penicillin G incl. streptococci groups A, B, C, G, H, L and M, Streptococcus pneumonias, group D streptococci (enterococci), penicillinase-non producing staphylococci, and Neisseria, Brucella, Erysipelothrix rhusiopathiae, Corynebacteria, Bacillus anthracis, Actinomycetes, Streptobacilli, Spirillium minus, Pasteurella multocida, Listeria and spirochetes (such as Leptospira, Treponema, Borrelia, etc.), as well as a number of anaerobes including peptokoki, peptostreptokoki, clostridia, etc. fuzobakterii. Established a comprehensive (primary) resistance of Bacteroides fragilis, Klebsella, Enterobacter, Proteus vulgaris, Proteus rettgeri, Proteus morganii, Pseudomanas aeruginosa and Serratia marcescens. Ampicillin is not active against beta-lactamase (penicillinase) producing staphylococci.

What is Standacillin?
Oral Standacillin is active in the following mild to moderate conditions caused by organisms susceptible to ampicillin:
Respiratory tract infections

Infections of the upper respiratory tract and ear, nose and throat infbktsii
e. sinusitis, acute otitis media.
Infections of the lower respiratory tract infections such as acute and chronic
bronchitis, pneumonia, pertussis (incubation period and infancy) Infections of the skin and soft tissue infections Urogenital
Acute and chronic pyelonephritis, pyelitis, cystitis, urethritis, prostatitis and others.
gonorrhea
Infections of the female genital and pelvic eg. febrile abortion, adnexitis, salpingitis, endometritis, parameterisation, pelvis peritonitis, puerperal sepsis, and others.
Infections of the gastrointestinal tract
Bacterial diarrhea, salmonellosis, shigellosis, typhoid, paratyphoid
Infections of the biliary tract (holangiolit, cholecystitis)
leptospirosis
Acute and latent listeriosis
Oral Standacillin is also used for initial parenteral therapy in patients with Standacillin :.
- Endocarditis (eg. With enterococcal origin; in combination with an aminoglycoside)
- Bacterial meningitis
- Septicaemia caused by ampicillin-susceptible pathogens Listeriosis (in combination with chloramphenicol, if necessary) Additional treatment during the recovery period
antibacterial prophylaxis
For prophylaxis of endocarditis in risk patients undergoing gastrointestinal or urological surgery Standacillin may be used alone or in combination with an aminoglycoside.
In patients with hepatic encephalopathy ampicillin was used with success for reducing the ammonium content in the gastrointestinal tract.
 
When you should not take Standacillin?
Known hypersensitivity to penicillins or to any component of the product. In patients with known hypersensitivity to cephalosporins should be considered possible occurrence of cross-allergies.
Ampicillin should not be used in patients with infectious mononucleosis, cytomegalovirus infection or lymphatic leukemia, due to increased frequency of skin rashes. Ampicillin should not be administered to patients with severe gastrointestinal disorders accompanied by diarrhea or persistent vomiting, as the absorption of the drug can be altered.
Severe infections (meningitis, arthritis, septicemia, pericarditis) require parenteral therapy.
In patients with allergic diathesis or bronchial asthma, and those with mycosis need particular attention.

When necessary precautions when adopting Standacillin?
Patients should be informed of the possible occurrence of allergic reactions and be instructed to report them. Sudden allergic reactions such as hives and anaphylaxis require discontinuation of treatment and appointment of relevant usual agents incl. epinephrine, antihistamines and corticosteroids.
Treatment with antibiotics is not suitable for the treatment of cholangitis and cholecystitis, except for mild cases without severe cholestasis. In patients on high doses, should be monitored liver function. In underlying renal disease or in case of skin reactions should be appointed studies of renal function .. To establish antibody-associated reactions of hematopoietic system, especially the occurrence of hemolytic anemia, is appointed blood counts.
Prolonged therapy can lead to the growth of resistant organisms and fungi. Patients receiving the drug by infusion, the application site should be changed every 48 hours. Superinfection is treated in the usual way. Persistent and severe diarrhea should hint antibiotic-associated pseudomembranous colitis (watery diarrhea with blood and mucus; dull, diffuse to cramping abdominal pain, fever and rarely painful colic). Since this condition can be life-threatening, the application of Standacillin should be stopped immediately and replace with a specific treatment (eg. Oral vancomycin 250 mg four times daily). Antiperistaltichni are contraindicated.
 
What other products influence the effect of Standacillin or may be affected by product?
As penicillins are active against proliferating microorganisms should not be combined with bacteriostatic antibiotics. But if it is in accordance with the susceptibility, may be combined with other bactericidal antibiotics (cephalosporins, aminoglycosides). Upon co-administration of probenecid may lead to higher and prolonged plasma levels by inhibition of renal elimination. As a result, probenecid can reduce the distribution and diffusion of the ampicillin in the body tissues.
Patients who received allopurinol during therapy with ampicillin, were increased risk of developing rashes.
In rare cases, ampicillin, like other antibiotics can reduce the effect of oral contraceptives.
If intramuscular injections are painful, ampicillin can be injected in 0.5% solution of procaine hydrochloride.
Ampicillin may reduce urinary excretion of atenolol.
Ampicillin may have an effect on the determination of amino acids in urine by paper chromatography.
 
What special precautions should be taken during pregnancy and lactation?
So far, no evidence of embryotoxic, teratogenic or mutagenic effects of ampicillin in its application during pregnancy.
 

When and how you can take Standacillin?
It is recommended Standacillin be taken 1-2 hours before a meal because food may affect absorption.
What to be aware when driving, operating machinery or insecure (eg. Climbing stairs)?
No data Standacillin influence on the ability to drive or operate machinery.
 
Dosage, method and duration of administration:
Standacillin dosage depends on the severity of the infection and is determined only by the doctor!
 
How much and how often you can apply Standacillin?
General dosing recommendations
 
Adolescents and adults accept (1d-) 2e - 4e day (1-2 capsules 3-4 times a day); Children should not take (25-) 50-100 mg / kg body weight per day. If necessary, the dose may be increased to 8g per day (200mg / kg body weight).
By improving the meningeal infection Standacillin passage of the blood-brain barrier is made more difficult and the dose administered to patients with meningitis should not be reduced.
The daily dose should be divided into 3-4 doses. If it is not possible oral administration, as an alternative can be used parenteral formulation of Standacillin® (see. Contraindications).
Duration of treatment
 
Infections of the urinary tract are treated at least 4-10 days.
Infections caused by (3- hemolytic streptococci was treated for at least 10 days.
In other infections, 48 hours after clinical treatment or bacterial eradication.
Dosage in patients with reduced elimination and in neonates and premature infants
In patients with severe renal impairment and in neonates and premature infants, the dosage or dosing intervals must be adapted to decreased renal clearance. Patients with severe renal impairment should not receive more than 1g ampicillin every 8 hours. With creatinine clearance below 10 mi / min dose interval should be extended to 12-15 hours.



Storage Instructions:
Keep out of reach of children!
The product should be stored in the original container in the dark at a temperature below 25 ° C.
The shelf life of the product is printed on the packaging.
Do not use after the expiry date!
 
 
What should I do if Standacillin was administered in very large amounts (intentional or inadvertent overdose)?
Symptoms of overdose largely overlap profile of adverse reactions.
There is no specific antidote. In case of overdose, administration should be discontinued and, symptomatic and supportive treatment. In patients with renal impairment, antibiotic ampicillin class can be removed by hemodialysis but not peritoneal dialysis.
What side effects can cause the application of Standacillin?
Generally ampicillin was well tolerated. Gastrointestinal complaints (nausea, diarrhea) usually subside during treatment and as a rule do not require stopping the drug. Intestinal flora recovered for 3-5 days after treatment. The appearance of diarrhea during therapy may be associated pseudomembranous colitis.
Typical ampicillin rashes appear 8-10 days after the first dose. Unlocking response reapplication is 2-3 days. In general rash disappeared for a few days during treatment. In patients with viral infections, kidney disorders or patients receiving doses greater than 6 g daily rashes occur more often. Abnormalities in blood counts as thrombocytopenia, hemolytic anemia, agranulocytosis, leucopenia and eosinophilia were rare. Probably allergic origin, they are reversible upon discontinuation of treatment. Rare cases of exfoliative dermatitis and erythema multiforme have been reported. As with other penicillins, ampicillin intake may be associated with the occurrence of inflammation of the mouth and throat, fever, joint pain, angioneurotic edema or interstitial nephritis. Anaphylactic reactions may occur very rarely. They respond well to antihistamines and corticosteroids.
In patients with typhus, leptospirosis, syphilis, bakteriolizata can unlock Jarisch-Herxheimer reaction.
 
What measures should be taken in relation to side effects?
If you notice any of these side effects, please inform your doctor.
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