SKOPRIL. 10 mg. 30 tablets

SKOPRIL. 10 mg. 30 tablets
€ 9.00
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Skopril  (lisinopril) is an angiotensin-converting enzyme (ACE). Belongs to a group of antihypertensive lekarstva.Mozhe be prescribed alone or be used in complex therapy with other drugs. Lisinopril is a medicine that reduces blood pressure and gives good effects in patients with heart failure, primarily through inhibition of the narenin-angiotensin-aldosterone. 

SKOPRIL. 10 mg. 30 tablets

 
 
Pharmacotherapeutic group
Skopril  ( lisinopril) is an angiotensin - converting enzyme ( ACE ) . Belongs to a group of antihypertensive lekarstva.Mozhe be prescribed alone or be used in complex therapy with other drugs. Lisinopril is a medicine that reduces blood pressure and gives good effects in patients with heart failure, primarily through inhibition of the narenin -angiotensin- aldosterone .
 
INDICATIONS
Essential and renal hypertension - alone as initial therapy or with other classes of antihypertensive funds from degrees of heart failure - as adjunctive therapy in patients who do not respond adequately to standard therapy with diuretics and digitalis drugs produkti.Ostar myocardial infarction in patients with stable hemodynamics in the first 24 hours of a heart attack - to prevent disturbances left ??????.??????????????????????????????????? to lisinopril or other converting enzyme inhibitors , as well as to any of the excipients produkt.Anamneza of angioedema (swelling of the face, tongue ) related to previous treatment with an inhibitor of converting enzyme inhibitors.
 
SPECIAL PRECAUTIONS FOR USE
Special care is needed with the use of lisinopril in patients with renal - vascular disease and aortic stenosis and other obstructive disorders , in which there is an obstacle in the ejection of blood from the left ventricle .
 
pregnancy and lactation
If you are pregnant or breast-feeding , let your doctor before starting treatment with lisinopril . Pregnancy is relatively contraindication for the use of lisinopril, since it was found that the inhibitors of angiotensin- converting enzyme may cause harm to the fetus . If you become pregnant during treatment, inform your doctor immediately , since the adoption of lisinopril in this case should be discontinued. There is a possibility that medicinal product is excreted in the milk so that the application of lisinopril during lactation is not recommended.
As a consequence of inhibiting the renin -angiotensin -aldosterone system in certain individuals , particularly those with impaired renal function may be anticipated changes in renal function. Particular care is needed in the first 2-5 weeks of treatment and the dose is reduced or therapy with lisinopril interrupted. Caution should be exercised with co-administration of lisinopril and diuretics for further reducing blood pressure effect. Similar considerations have in patients with ischemic heart disease or cerebrovascular disease , or in patients with acute myocardial infarction, where a significant drop in blood pressure can lead to heart attack or cerebrovascular intsident.Pri patients with a history of hereditary or idiopathic angioedema ( edema) treatment with lisinopril or other inhibitors of angiotensin- converting enzyme inhibitors should be avoided because of the increased risk of angioedem.Ne The safety and effectiveness in pediatric patients . Special care is needed when initiating therapy with lisinopril in patients receiving diuretics, patients with limited intake of salts in patients on dialysis , dehydrated ( dehydrated ) or congestive ( congestive ) heart failure , as can occur with hypotension maximum a decrease in blood pressure of 6 to 8 hours after administration of dozata.Patsienti with severe congestive heart failure are most prone to injury and renal they treatment of converting enzyme inhibitors may lead to oliguria (decreased urine output ) and / or progressive azotemia (increase of nitrogen bodies in the blood) and rarely acute renal nedostatachnost.Pri patients with unilateral or bilateral renal artery stenosis (narrowing ) of the renal artery may be an increase in blood urea and serum creatinine, usually reversible after discontinuation lisinopril . In these patients during the first weeks of therapy renal functions; must be kontrolira.Spetsialno attention is no need for patients with peripheral vascular disease and generalized arteriosclerosis receiving lisinopril, the possible presence of subclinical renal disease .
In patients with acute myocardial infarction, treatment with lisinopril should not be taken in evidence of renal dysfunction , defined by a serum creatinine above 177 mmol / l and / or proteinuria ( presence of protein in urine) than 500 mg/24 hours at patients with low blood pressure below 100 mrnHg should not be initiated lisinopril . Patients who are undergoing surgery under general anesthetic should inform the treating doctor that lizinopril.Po during treatment with ACE inhibitors may develop persistent nonproductive cough. This cough was reversible after discontinuation of therapy, and should be kept in mind in the differential diagnosis plan.Pri patients receiving an ACE inhibitor during purification of the blood of low density lipoproteins in patients with high cholesterol in specific desensitization against poisons insects and hemodialysis patients with high-flux membranes (AN 69) , it is possible the development of life-threatening anaphylactic (allergic ) reactions. In the treatment with inhibitors of angiotensin converting enzyme may occur various allergic reactions including angioedema , swelling of face, lips , tongue , in severe cases, cover and upper respiratory tract. In the event of such edema intake of lisinopril should be discontinued and advise lekar.Pri treating patients with renal impairment due to connective tissue disease (eg, systemic lupus erythematosus, scleroderma ) requires periodic monitoring of blood counts and especially levkotsitite.Ryadko intake of angiotensin - converting enzyme may cause injury chernodrbno . In the event of yellowing of the skin and / or eclairs patient must inform the physician.
 
 
Medicines and other forms of interaction
Concomitant use of lisinopril and hydrochlorothiazide or other thiazide diuretics lead to additive hypotensive ( blood pressure lowering ) effect. Lisinopril dose should be reduced when it is coadministered with diuretik.Upotrebata lisinopril concomitant potassium- sparing diuretics ( spironolactone, triamterene, or amiloride ) , potassium- substituent medicines or potassium sadarzhashtisoli can lead to a significant increase in serum kaliy.Saobshtavano is lithium toxicity in patients receiving simultaneously with lithium lizinopril.Preporachva frequent monitoring of serum lithium in concomitant therapy slizinopril.Nesteroidni inflammatory drugs may decrease the antihypertensive effect of the ACE inhibitors , including a lizinopril.Uvedomete doctor about all the medicines you take, including those obtained without prescription.
 
EFFECTS ON ABILITY TO DRIVE AND USE MACHINES
The drug did not affect psychomotor abilities of the patient.
 
Medicines and other forms of interaction
Concomitant use of lisinopril and hydrochlorothiazide or other thiazide diuretics lead to additive hypotensive ( blood pressure lowering ) effect. Lisinopril dose should be reduced when it is coadministered with diuretik.Upotrebata lisinopril concomitant potassium- sparing diuretics ( spironolactone, triamterene, or amiloride ) , potassium- substituent medicines or potassium sadarzhashtisoli can lead to a significant increase in serum kaliy.Saobshtavano is lithium toxicity in patients receiving simultaneously with lithium lizinopril.Preporachva frequent monitoring of serum lithium in concomitant therapy slizinopril.Nesteroidni inflammatory drugs may decrease the antihypertensive effect of the ACE inhibitors , including a lizinopril.Uvedomete doctor about all the medicines you take, including those obtained without prescription.
DOSAGE AND METHOD OF USE
The dosage and duration of treatment with Skopryl be determined by the attending physician The tablets can be administered before , during or after meals. The dosage is individual and can be changed depending on the condition of the patient.
hypertension
In patients with mild essential hypertension , the recommended starting dose is 10 mg once daily. The dose should be adjusted according to the response in terms of blood pressure . The usual dose is 20 to 40 mg daily in a single dose . The daily dose is increased at weekly intervals up to 80 mg. If blood pressure is normal for 1-3 months , your doctor may add to the therapy at low doses diuretic, a calcium antagonist or beta blocker. NBT 12,5 mg once daily was the most favorable combination . In patients with renal hypertension , in particular those with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney , which react very rapidly to the first dose of the ACE inhibitor , the initial dose of Skopryl must be lower . The recommended dose is 2,5-5 mg. The dose is determined by the doctor and the usual maintenance dose is 20 mg once daily.
heart failure
In patients with congestive ( congestive ) heart failure , the starting dose should be lower for . The recommended starting dose of 2,5-5 mg once daily . The dosage is gradually increased in all patients for about 2-4 weeks until the normal effective dose , which varies from 5 to 20 mg once daily.
Acute myocardial infarction
In patients with stable hemodynamics in the first 24 hours of acute myocardial Skopryl apply as follows:
• Patients with systolic pressure higher than 120 mmHg initial dose is 5 mg of lisinopril in the first 24 hours after onset of symptoms, followed by a further dose of 5 mg in 24 hours , then 10 mg after a further 24 hours and was continued at 10 mg once a day for six weeks.
• For patients with a low systolic blood pressure (100-120 mmHg) is applied at the lower dose of 2,5 mg of lisinopril in the first two days after infarction followed by 5 mg for 6 weeks. If it comes to hypotension (systolic pressure < 100 mmHg) a daily maintenance dose of 5 mg is reduced to 2,5 mg. If hypotension is retained (systolic pressure <90 mmHg for more than one hour) treatment with lisinopril should be abandoned.
In patients with acute myocardial infarction therapy lisinopril continued for 6 weeks.
Dosage in renal impairment
In patients with impaired renal function dosing comply with creatinine clearance. In patients with creatinine clearance 10-30 ml / min initial dose is 5 mg once daily in patients with creatinine clearance <10 ml / min , the recommended initial dose is 2,5 mg. The dose may be escalated to the normalization of blood pressure, a maximum of 40 mg per day . In acute myocardial infarction treatment Skopryl should be dosed with caution in patients with underlying impaired renal function .
Dosing with concomitant treatment with a diuretic
When concomitant treatment with Skopryl diuretic , the diuretic should be discontinued 2-3 days before starting treatment with Skopryl. In patients with hypertension , as the diuretic can not be stopped , the treatment with Skopryl should be initiated at a dose of 5 mg, and then adjusted by the physician according to the blood pressure values . If necessary , at the discretion of the treating physician , diuretic therapy may be resumed .
Dosage in the elderly
In elderly patients are typically administered at lower doses .
 
OVERDOSE
The most prominent symptom of overdosage with lisinopril is prolonged hypotension. May occur hyperkalemia (increased potassium level in the blood) , hyponatremia (decreased sodium in the blood ) and renal dysfunction, acute renal failure even . In case of overdose, contact lekar.Terapiyata is symptomatic and supportive . Treatment consists of gastric lavage , medical charcoal and correction of dehydration , electrolyte imbalance and hypotension by standard procedures. There is no specific antidote .
 
Omit dose
In the event that a dose is missed , the next dose should be taken as soon as possible . If the timing of the next dose is near , then you should skip the missed dose and continue with the application of the product as specified mode. Do not take two doses at once.
 
SIDE EFFECTS
Lisinopril is welcomed . Lisinopril treatment rarely causes side effects that require discontinuation of therapy in patients with high blood pressure and a little more often act as a reason for discontinuation of therapy in patients with acute myocardial infarction or congestive heart failure.
The most common side effects are hypotension ( low blood pressure ), worsening of renal function , angioedema, skin rash , hives , itching, cough and other symptoms of upper respiratory tract such as rhinitis ( runny nose ) , sinusitis and sore throat , and the part of the gastrointestinal tract are monitored dry mouth, nausea , vomiting , abdominal pain, dyspepsia ( heartburn) , anorexia, diarrhea , and constipation . Patients taking lisinopril may occur : angina , vasculitis, chest pain , orthostatic effects , palpitations, peripheral edema , tachycardia (increased heart rate ), and arrhythmias including ventricular and atrial tachycardia , atrial fibrillation , premature ventricular contractions and bradycardia. Cerebrovascular accidents , pulmonary embolism and infarction, transient ischemic attacks, nocturnal dyspnea (breathlessness ) appear very rarely . Possible deterioration of renal function, including increased plasma levels of urea and creatinine , which is reversible upon discontinuation of lisinopril . Cases with proteinuria (presence of protein in the urine ), which in some patients progressed to nephrotic syndrome. May appear hyperkalemia (increased potassium in the blood ) particularly in patients with severe renal failure and / or diabetes mellitus. Rarely occur changes in liver function tests , resulting in elevated levels of liver enzymes and alkaline phosphatase, cholestatic ( congestive ) jaundice , hepatitis, pankreatit.Promeni blood count including thrombocytopenia ( decrease in trombotsitnte ), neutropenia (decrease in white blood cells) and hemolytic anemia may rarely occur . Other side effects: headache, dizziness , fatigue , insomnia, altered sense of taste , paresthesia ( numbness and tingling of the extremities ) , muscle and joint pain , arthritis , bronchospasm, mental confusion , mood changes , asthenia, impotence and alopecia ( hair loss hair ) . If any of these side effects or other effects not listed in this leaflet , you should tell your doctor.
 
 
SPECIAL STORAGE
Do not store above 25 ° C.
KEEP OUT OF PLACES reach of children !
SHELF LIFE
Three (3 ) years .Da not use after the expiry date stated on the packaging.
Active substance:
Each tablet contains 10 mg lisinopril ( as dihydrate): Excipients , dibasic calcium phosphate, magnesium stearate, corn starch , mannitol, polyvidone , pregelatinized starch , coloring agent ( iron oxide yellow 10 , CI77 492 , E172 ) .
 
Skopril  20mg active substance
Each tablet contains 20 mg lisinopril ( as dihydrate). Excipients: dibasic calcium phosphate, magnesium stearate, maize starch , mannitol, nolividon , pre-gelatinized starch , coloring (iron oxide yellow 30 , CI77 492 , E 172 , iron oxide red 30 CI77 491 , E 172).
 
 
 
 
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