Retrovir. 100 mg. 100 capsules

Retrovir. 100 mg. 100 capsules
€ 189.00
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Practically used only in combination with other antiretroviral agents. It is suitable for the treatment of HIV in children and adults.
It is used in HIV-positive mothers and infants because it reduces uteroplacental transmission of the virus.

Retrovir. 100 mg. 100 capsules

 
 
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The preparation is for use in combination !
It is indicated for treatment of infections caused by the Human Immunodeficiency Virus (HIV) - AIDS .
Practically used only in combination with other antiretroviral agents. It is suitable for the treatment of HIV in children and adults.
It is used in HIV- positive mothers and infants because it reduces uteroplacental transmission of the virus.
Dosage and method of administration .
The recommended adult dose in combination with other antiretroviral agents is from 500 to 600 mg. It is divided into two or three oral doses.
In children from 3 months to 12 years, the recommended dose in combination with other antiretroviral agents, is 360 to 480 mg/m2. It is divided into 3 or 4 doses.
The recommended dose for pregnant women after 14 weeks of gestation is 500 mg ( 100 mg respectively, 5 times daily) orally, to start labor. During the expulsion of the birth and can be administered at a dose of 2 mg / kg / body weight ( bw ) in 1 h, followed by a continuous iv infusion of 1 mg / kg / h until the umbilical cord clamp .
The newborn is administered orally at a dose of 2 mg/kg/6 h, starting from 12 hours and continued until the sixth week . If it is impossible for the oral administration of the composition it may be infused intravenously using a syringe pump at a dose of 1,5 mg/kg/6 h. Infusions continued for 30 min.
Contraindications.
Neutropenia (neutrophils < 0,75.1071 ) , hemoglobin <7,5 g / dl.
Increased sensitivity to the drug .
Special precautions for use .
It is used only by physicians specializing in the treatment of AIDS.
To consider the large number of interactions Retrovir and other drugs !
Interactions .
Drugs such as acetylsalicylic acid (aspirin), codeine, morphine, indometacin, ketoprofen, naproxen, oxazepam, lorazepam, clofibrat, cimetidine, dapsone and inosine, can exacerbate the toxicity of zidovudine.
This is done by competitive inhibition of glucuronidation or direct inhibition of hepatic microsomal metabolism .
For systemic treatment with those preparations that are subject to possible adverse interactions.
The risk of ADRs to Retrovir increases with concomitant treatment with potentially nephrotoxic or myelosuppressive drugs such as pentamidine, dapsone, pyrimethamine, co-trimoxazole, amphotericin, Flucytosine, ganciclovir, interferon , vincristine, vinblastine, doxorubicin, chloramphenicol.
Use during pregnancy and lactation .
Pregnancy Risk Category : C
Effects on ability to drive and use machines.
Possible negative response.
Adverse reactions.
Vomiting , anorexia, taste changes , abdominal pain , diarrhea , myalgia , dyspnoea, voiding dysfunction . Headache , tremor , anxiety , and anxiety ( high dosage ) , seizures, encephalopathy.
Skin rash , itching .
Damage to the liver and kidneys, deterioration of general condition.
Bone marrow suppression : a dose-dependent anemia in 25% of patients , granulocytopenia , thrombocytopenia, thrombocytosis . In patients with a deficiency of folic acid and vitamin B12 myelotoxicity Retrovir is more pronounced .
Overdose.
Vomiting , abdominal pain , diarrhea , shortness of breath .
Headache, tremors, convulsions , toxic encephalopathy.
Skin rash , itching .
Damage to the kidneys and liver .
Pharmacokinetic properties:
Metabolism is by glucuroconjugation . Retrovir may affect the metabolism of other drugs.
In co with other antiretroviral drugs have a variety of interactions , which are described in appropriate combinations (Trizivir, Kaletra, etc.)
Pharmacodynamic properties:
• Pharmacotherapeutic group: Antiretroviral drugs. Medicines used against AIDS, HIV. AIDS drugs .
Retrovir is a nucleoside analog which blocks DNA synthesis of the HIV virus . Effect on viral reverse transcriptase is 100 times stronger than on cellular DNA polymerase .


 
 
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