Pyrazinamid table. 500 mg. 100 table
Pyrazinamid table. 500 mg. 100 table
PYRAZINAMID WHAT IS AND WHAT IT IS USED
1 tablet contains 500 mg pyrazinamide.
Folding box of 100 tablets in a glass bottle.
Pyrazinamide is a drug used to treat tuberculosis (tuberkulostatik). It destroys tuberculosis intracellular phase division. It is particularly effective in the first few months of treatment. Always used in conjunction with other tuberculostatics (isoniazid, ethambutol, rifampicin) to prevent the development of resistant strains of tuberculosis.
What used Pyrazinamid?
The drug is used to treat all forms of tuberculosis (in combination with other tuberculostatics).
BEFORE YOU TAKE PYRAZINAMID
Tell your doctor if you have a chronic disease, metabolic diseases, if you are allergic or if you take other medicines.
Who should not take Pyrazinamid?
You should not take this medicine if you are hypersensitive to pyrazinamide or any other ingredients of this medicine if you have severe liver dysfunction or acute gout.
Precautions and warnings
Before beginning treatment tell your doctor if you are being treated for diabetes, liver disease, kidney disease, gout or porphyria. During treatment of patients with diabetes your blood sugar levels are maintained hard.
Patients with porphyria pyrazinamide can cause an acute attack of porphyria.
In patients with renal insufficiency pyrazinamide may begin to accumulate in the body.
Before the start of treatment and during the treatment your doctor will occasionally send you for a blood test. The frequency of the tests will be determined by your doctor.
It is important to take regular medication and continue treatment even if you feel better. If there is no response to treatment within two or three weeks, or if the disease worsens, consult your doctor.
Immediately stop taking the medicine and tell your doctor if you experience:
pain in the upper right abdomen, loss of appetite, morning nausea, dark urine, and / or jaundice
swelling, redness and pain at the joint of the big toe or some other joint. Tell your doctor if you are hypersensitive to ethionamide, isoniazid, niacin, or other chemically related drugs, as you may be hypersensitive also to pyrazinamide.
Taking Pyrazinamid with food and drin
Take this medicine with some liquid, as a single dose after breakfast.
It is not recommended to drink alcohol during treatment with pyrazinamide, as pyrazinamide may increase the toxic effects of alcohol.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
Although no evidence of harmful effects on the fetus pyrazinamide, the risk can not be excluded.
Before beginning treatment tell your doctor if you are pregnant or breastfeeding. Tell your doctor if you become pregnant during treatment.
Pregnant women should not take this medicine if definitely need it. Treatment decisions during pregnancy or discontinuation of treatment made by a physician.
Pyrazinamide is excreted in small amounts in breast milk and therefore breastfeeding is not recommended during treatment.
Effects on ability to drive and use machines
Pyrazinamide is not known to affect the patient's general alertness while driving a motor vehicle or operating machinery.
What other drugs could interact with Pyrazinamid?
Tell your doctor or pharmacist if you are taking or have recently taken any other drugs except those prescribed for you.
We need to tell your doctor if you are taking medication for epilepsy (phenytoin), diabetes, viral infections (zidovudine), medicines for gout or elimination of uric acid (allopurinol, colchicine, probenecid, sulfinpyrazone) and immunosuppressants (cyclosporine) .
Concomitant administration of pyrazinamide and phenytoin can lead to intoxication with phenytoin. If during concomitant treatment with pyrazinamide and phenytoin appear uncoordinated movements (ataxia), enhanced reflexes (hyperreflexia), involuntary eye movements (nystagmus) and / or trembling or shaking of the hands (tremor), stop taking the drug and consult your doctor.
Concomitant use of pyrazinamide and other drugs mentioned above can change the action to increase or decrease the effects of these drugs or pyrazinamide.
HOW TO TAKE PYRAZINAMID
Dosage and method of administration
Strictly follow the instructions of your doctor. You must not change dose or discontinue therapy without consulting their physician first.
Pyrazinamide usual dose in adults is 15 to 30 mg / kg body weight per day.
The maximum daily dose should not exceed 2 g.
The usual dose for children is also 15 mg to 30 mg / kg body weight per day, the maximum daily dose should not exceed 2 g.
When administered two or three times a week for the elderly, patients with renal or hepatic impairment and in patients on hemodialysis or peritoneal dialysis dose is determined by the doctor. Your doctor will determine the duration of treatment.
If you feel that the effect of the drug is too strong or too weak, please consult your doctor or pharmacist.
If you take more than you need Pyrazinamid
If you take a larger dose than necessary, consult your doctor or pharmacist.
If a patient has swallowed more tablets and is conscious, induce vomiting and consult a doctor.
If you forget to take Pyrazinamid
Do not take a double dose to make up for the forgotten.
POSSIBLE SIDE EFFECTS
Like all medicines, Pyrazinamid can also have side effects. The most serious side effects are liver function abnormalities (by jaundice, enlarged liver, asymptomatic elevations of hepatic transaminase activity to rare cases of severe active liver atrophy and death), depending on the dose. Therefore, stop taking the medicine and tell your doctor if you are experiencing pain in the upper right abdomen, fever, loss of appetite, weakness, morning nausea, vomiting, dark urine and / or jaundice.
A rarely seen vomiting, aching muscles and joints with an increase in body temperature, hypersensitivity reactions (rash, urticaria, pruritus, photosensitivity), sideroblastic anemia and thrombocytopenia.
Rare side effects of treatment with pyrazinamide are acne, pellagra, porphyria, pain during urination (dysuria) and inflammation of the kidneys (nephritis). If you notice any side effects, even those not mentioned in this leaflet, please tell your doctor or pharmacist.
t should not be used after the expiry date stated on the packaging.
Protect from moisture and light. Do not store above 25 ° C. Keep out of reach of children.
Active substance: pyrazinamide (Pyrazinamide).
Other ingredients: corn starch, pregelatinised starch, sodium starch karboksilmetilovo (type A), talc, magnesium stearate, sodium lauryl sulfate.