Pregnyl. 5000 IU 2 ml. 1 ampul
Pregnyl. 5000 IU 2 ml. 1 ampul
Medicine that has been prescribed is called PREGNYL.
PREGNYL contains a hormone known as human chorionic gonadotropin ( or briefly hCG) at a dose of 500 , 1500 or 5000IU ( international units ) for ampoule.
PREGNYL has an impact only if it is administered by injection . It is a dry substance in a glass vial , to be dissolved with the solvent contained in the other vial . Furthermore hCG dry substance contains mannitol, disodium hydrogen phosphate , sodium dihydrogen phosphate, and sodium carboxymethylcellulose . The solvent contains sodium chloride (° Mg) and distilled water (1ml).
PREGNYL belongs to a group of medicines called gonadotropins. These are hormones that are essential for fertility and reproduction .
HOW DOES PREGNYL AND WHAT IT IS USED
PREGNYL exhibit activity as luteinizing hormone (LH), which plays a major role in natural reproduction . Along with follicle -stimulating xopMOH (FSH), LH is necessary for proper growth and development of eggs in a woman , for the production of sperm in men , and for the production of hormones in both sexes .. On the back of this leaflet you will find more information for PREGNYL and its use.
BEFORE YOU USE PREGNYL
In women :
DO NOT USE PREGNYL, if:
• You are allergic to gonadotropins or any of the substances contained in PREGNYL.Strogoto monitoring of patients by doctors is very important. Usually this includes regular reviews of the ovaries with ultrasound and blood tests. The results of these studies and reviews will allow the doctor to select the most appropriate daily dose of FSH- preparations. This is important , because if the dose of FSH administered is too high, the ovaries will be over- stimulated , and this very rarely can lead to dangerous complications. Such over- stimulation may begin with pain in the abdomen, which is an important warning, especially if there is also polycystic (presence of multiple cysts ) of the ovary . Regular monitoring of the response of the body during treatment with gonadotropins allows the physician to prevent the occurrence of over- stimulation. If you experience abdominal pain , consult your doctor.
DO NOT USE PREGNYL, if:
• You are allergic to gonadotropins or any of the substances contained in PREGNYL.
• There is established androgen dependent tumor - prostate cancer or breast cancer or suspected of being such .
Additional monitoring by a physician is recommended in the treatment of boys who have not yet entered puberty. This is necessary because PREGNYL may stimulate increased production of the male sex hormone testosterone, which can lead to premature onset of puberty and stopping rastezha.Redovni examinations are necessary , and in some other cases . So be sure to consult your doctor if you have suffered or are suffering from :
• Disease of the heart or blood vessels ; in men - high blood pressure;
• A disease of the kidneys;
• Epilepsy ;
• Migraine headaches.
No evidence of interference with the operation of PREGNYL coadministration of other drugs.
If after treatment with gonadotropins pregnancy occurs, it is likely to be multiple and having twins . Slightly increased risk of ectopic pregnancy in women with damaged fallopian tubes. In women undergoing fertility treatment have a slightly increased risk of a miscarriage.
Pregnyl should not be used during breastfeeding.
Ability to drive and use machines. According to existing data PREGNYL no effect on alertness and concentration.
That the medicine
This medication is administered by intramuscular injection , which is made by a doctor or nurse or subcutaneous injection , which you can make your own or Spomolite your partner about it. Your doctor will give you relevant instruktsii._V what dose ? Dose will be determined by your lekar.Obiknoveno in women administered an injection to induce ovulation and up to three for hormonal support the development and normal functioning of the so-called " yellow body " in the ovaries.
In men , according to the complaints , the injections are made several times per week for several weeks or months.
How are the injections ?
Before use, the dry substance is dissolved in the solvent. Injections are given slowly into a muscle (eg buttocks, upper leg or upper arm ) or subcutaneously ( under the skin fold of the abdominal wall , for example) .
Toxicity is very PREGNYL niska.Pri people found free from symptoms of acute overdose .
POSSIBLE SIDE EFFECTS OF PREGNYL
There is evidence that use of urinary gonadotropins may occur local reactions at the injection site such as pain, redness, swelling , itching and bruising . Sometimes reported the occurrence of allergic reactions manifested by pain and rash at the injection site . In some cases, the rash can be generalized and be accompanied by fever.
In women :
If your ovaries were stimulated with too much FSH- detergent and then be applied PREGNYL, this can lead to unwanted ovarian hyper- stimulation. It can present with abdominal pain, accompanied by nausea and diarrhea. These conditions are very rare , and the risk of their occurrence can be reduced by careful monitoring of egg development during ongoing treatment . If you develop severe abdominal pain, be sure to tell this to your doctor , even if it 's just a few days after the last inzhektsiya.Pri men may show a fluid , which is manifested by swelling of the ankles. Sometimes you may experience breast enlargement . If any of these symptoms be sure to tell your doctor.
HOW TO CARE FOR YOUR MEDICINE
PREGNYL Keep in the original container , in the dark at 2-8 C, out of reach of children. If the solution obtained after mixing contains particles or is cloudy , the preparation should not be used. The expiry date is marked on the packaging with " exp . " Do not use the drug after this date
MORE ABOUT PREGNYL
PREGNYL contain human chorionic gonadotropin extracted from the urine of pregnant women, and having an activity of luteinizing hormone (LH), which is produced by the pituitary gland of males and females. Together with other pituitary hormone follicle stimulating hormone (FSH) - LH controls the activity of the reproductive organs ( ovaries in women and testes in men). Women FSH and IH cause monthly oocyte maturation in one of the ovaries. LH is required for ovulation , ie release of the egg. If the body does not produce enough of these hormones that can lead to infertility . The reasons for it can also be non- FSH and LH. Hormonal preparations containing FSH ( and as the case may be - LH) may be used to support the treatment of infertility in the ovulation induction or controlled ovarian ( ovarian ) hyperstimulation ( in vitro fertilization ( fertilization )-IVF, gamete intrafallopian transfer - GIFT and intracytoplasmic sperm injection - ICSI). Daily injections of the formulation will lead to maturation of the oocyte . Her latest release is supported by applying PREGNYL. Since nature can not be reproduced with absolute precision , the treatment with these hormones can be separated several eggs . This increases the possibility of multiple pregnancy ( twins) . In the context of assisted reproduction programs PREGNYL administered after the onset of ovulatsiyata.Pri men , PREGNYL be used alone or in combination with FSH in cases of insufficient development of the gonads , delayed puberty or when there are abnormalities in the formation of sperm. Since the whole process of development of sperm takes about 74 days , treatment should be continued for at least 3 months before being found positive promeni.V some cases PREGNYL can be applied in boys in which one or both testicles have not descended into madnata bag.
SOME GENERAL RULES FOR USE OF DRUGS
1. This medicine has been prescribed for the treatment of your present condition. It should not be used for treatment of other diseases.
2 . Do not give your medicine to other people and do not take medications prescribed for another.
3 . Every doctor who examines you saying what medication you are taking now. Always wear yourself a card on which is written what medicines you are taking right now. This can be very important in case of an accident.
4 . Be sure to give the people who live or care for you to read this leaflet. The information which is presented below in the package will be printed in a way that separates it from all other information about the patient.
1.1 Posology and method of administration
Dosage in women :
• Induction and training ovulaiiyata follicle puncture
An injection of 5000-10000 IU PREGNYL to complete treatment with FSH- preparation .
• Maintenance of luteal phase
Two or three consecutive injections of 1000-3000 IU was administered for a period of 9 days after ovulation and embryo transfer ( for example on day 3 , 6 and 9Next ovulation induction) .
Dosage in the male
• Hipogonadotuopen hypogonadism
1000 -2000IU PREGNYL, 2-3 times a week. If the main problem is infertility can be applied and FSH- containing preparation (75 IU daily or 2-3 times a week. Treatment should continue for at least three months before any improvement in spermatogenesis . Then treatment can be continued with administration of hCG. during treatment should be discontinued testosterone replacement therapy , if administered one.
• Delayed puberty
1500 IU 2-3 times per week for at least 6 months.
- under 2 years of age : 250IU twice a week for six weeks ;
-2-6 Years : 500-1000 IU twice weekly for 6 weeks
- over 6 years: 1500 IU twice weekly for 6 weeks .
Method of administration
The dry substance was dissolved by adding solvent. Thus obtained solution was injected slowly PREGNYL , intramuscularly or subcutaneously.
After opening the ampoule can not be resealed in a way ensures that the sterility of the contents should be used immediately.