Pravastatin tab . 20 mg. 30 table
Pravastatin tab . 20 mg. 30 table
Each tablet contains the drug Pravastatin Pravastatin sodium in the amount of 20 mg. The composition of the tablet includes the following inactive ingredients: lactose, microcrystalline cellulose, croscarmellose sodium, magnesium hydroxide, magnesium stearate.
Properties of drug and mode of action
Pravastatin refers to drugs that block the synthesis / formation / cholesterol in the body. Thus, total cholesterol, LDL cholesterol / "bad" cholesterol / triglycerides and apolipoprotein B / protein required for the formation of cholesterol in the blood / fall. This leads to a delay in further damage to the vessels of the atherosclerotic process. As a result, reducing the risk of developing coronary heart disease, strokes and slow the progression of atherosclerosis.
WHAT CASES ARE USED pravastatin?
Treatment with pravastatin takes place in the absence of an adequate response from the enclosed diet and exercise. It is indicated in: Hypercholesterolaemia.
For reduction of elevated total and LDL cholesterol in patients with primary hypercholesterolemia.
Atherosclerotic disease progression and clinical cardiovascular events.
Delay in the progression of atherosclerosis;
Reduce the incidence of clinical cardiovascular events. Prevention of coronary events.
Reduce the need for myocardial revascularization;
Improving survival by reducing cardio - vascular mortality.
Reduce the risk of recurrent myocardial infarction and the need for myocardial revascularisation procedures.
WHAT CASES SHOULD NOT BE USED pravastatin?
Contraindications are diseases or conditions for which use of the drug is associated with a high risk of serious side effects or worsening of the patient's condition.
For these reasons, the adoption of Pravastatin is contraindicated in the following cases:
With known hypersensitivity to the active substance or to any of the excipients;
In the presence of active liver disease or persistent elevated liver tests;
During pregnancy and lactation;
Children under 18 years of age.
SPECIAL WARNINGS AND PRECAUTIONS
It is recommended that treatment with pravastatin in patients with so-called "homozygous familial hypercholesterolemia as its efficacy in such patients is questionable;
Patients who abuse alcohol should inform the doctor about it, because in this case the risk of liver damage increases;
Please inform your doctor if you have abnormal liver function indicator i before treatment;
During treatment with pravastatin patients need to be monitored closely for the onset of muscle pain, muscle weakness, functional state of the liver and kidneys, and also to increase the activity of the enzyme kreatininkinaza. Such monitoring is particularly important in patients with renal transplantation and treatment with cyclosporine.
Consult your doctor immediately if you experience weakness or fatigue in muscles and tendons, at the onset of symptoms "flu-like" or if you notice yellowing of the skin and eyes.
DRUG AND OTHER FORMS OF INTERACTION
During treatment with Pravastatin should be used meals low in cholesterol and avoid fat diet. Food may decrease the absorption of the drug, so that it must be taken before or after meals. It is recommended that it is bedtime.
You should always consult a doctor on concomitant treatment with other medicines, including medicines obtained without a prescription or herbal as pravastatin may have negative interactions with!
Inform your doctor if you are taking any medications, such as cyclosporine, gemfibrozil and other fibrates, nicotinic acid, clarithromycin, erythromycin, itraconazole. Concomitant treatment with these medicines and pravastatin is associated with a risk of damage to the muscular system.
Before initiating therapy with pravastatin need to tell your doctor about all other leskarstva lowering cholesterol you eat, such as cholestyramine, colestipol. Taking pravastatin in these cases should be 1 hour before or 4 hours after cholestyramine or colestipol, respectively.
You should also inform your doctor and your medications for the treatment of thromboembolic diseases, particularly oral anticoagulants.
HOW IT IS USED pravastatin?
DOSAGE AND DIRECTIONS FOR USE
Pravastatin drug is prescribed by a doctor. Only your doctor will determine the correct dosage and duration of treatment. Closely follow the recommended dosage and route of administration of the doctor!
Take the tablet with enough water, the best dose prescribed to be taken at bedtime. Do not take with food.
The recommended starting dose is 10 mg daily, the dose may be increased if necessary to 40 mg gradually by 4 weekly intervals. Therapeutic dose for each individual patient.
Therapeutic efficacy and safety of pravastatin in children have not been studied and therefore should not be given to them.
Patients over age 65:
No evidence of increased sensitivity to medication and change his terapentichnite parameters in patients aged 65 years and therefore does not require special reduction of the dose recommended for them.
Patients with renal insufficiency:
In patients with mild and moderate renal impairment, treatment with pravastatin should be conducted at a lower dose and regular monitoring of renal funktsii.Pri severe renal impairment need treatment with pravastatin should be evaluated carefully by a physician.
During treatment with pravastatin, how-it with any other drug in individual patients may experience adverse reactions to soabshtite physician.
If any of the following side effects need to stop taking it immediately and seek medical advice: Hypersensitivity reactions - difficulty breathing, swelling of the lips, tongue, or face; weakness or muscle pain; symptoms "flu-like" reduce the amount of urine or darken it, seeing blue or yellow skin and eclairs.
There are other side effects that are less serious. If their appearance is necessary, without interrupting treatment to report it to your doctor who will decide on the need to reduce the dosage of the drug.
As such side effects related nausea, vomiting, abdominal pain, constipation, diarrhea, flatulence, cough, headache, dizziness, sleep disturbances.
Please inform your doctor of any other adverse events that may occur during treatment with pravastatin and are not listed in this leaflet! PREDOZIRANEPri adoption of very high dose pravastatin were not observed clinical signs of toxicity or laboratory abnormalities.
However, in case of accidental intake of very high doses of the drug / prezishavashta several times prescribed by a physician / need to immediately consult a doctor for medical help.
20 mg tablets in blister packs of PVC / aluminum foil of 10 tablets each. 3 blisters in a cardboard box.
The medicine should be stored in a dry ventilated place protected from direct sunlight at a temperature no higher than 25 ° C. Keep out of reach of children!
2 / two / year.
Do not use the medicine after the expiry date printed on the package!