PROPITSIL table. 50 mg. 100 tablets

PROPITSIL table. 50 mg. 100 tablets
€ 22.00
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Propitsil 50 mg belongs to a group of medicines known as antithyroid drugs.
Overactive thyroid gland produces too much thyroid hormone, causing a condition known as hyperthyroidism.



PROPITSIL table. 50 mg. 100 tablets
 

WHAT PROPITSIL 50 MG AND WHAT IT IS USED

Propitsil 50 mg belongs to a group of medicines known as antithyroid drugs.
Overactive thyroid gland produces too much thyroid hormone, causing a condition known as hyperthyroidism.
 
This process can lead to symptoms such as rapid or irregular heartbeat, sweating, mood changes, weight changes, weakness, fatigue, heat intolerance, menstrual problems and others. Some patients may develop goiter and bulging of the eyes (disease Grave's). Propitsil used as a medicinal product that corrects the hormonal imbalance. It can also be used in certain other thyroid diseases such as autonomous toxic thyroid adenoma or preparation for surgery (thyroidectomy) or treatment with radioactive iodine.
 

 BEFORE YOU TAKE 50 MG PROPITSIL

 
Do not use Propitsil 50 mg
 
 If you are allergic (hypersensitive) to the active substance or to any of the ingredients of Propitsil 50 mg;
 If you have serious side effects when using products that contain Propylthiouracil, especially the loss of white blood cells (agranulocytosis), and inflammatory liver injury.
 
Take special care with 50 mg Propitsil
 
A special care and careful monitoring by your doctor when your blood count is normal or if you have any liver problems (elevated liver enzymes) or problems with the drainage of bile (cholestasis).
 
Propitsil 50 mg should be taken in a short time and under increasing scrutiny in the thyroid gland, which affects the trachea.
Propitsil can be used in children only when exhausted other therapeutic methods to control thyroid function.
 
Taking other medicines
 
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
 
What other drugs affect Propitsil 50 mg?
 
Application of thyroxine reduces penetration Propitsil 50 mg thyroid, and it requires a powerful suppression of natural hormone synthesis, so it is necessary to use a higher dose of 50 mg Propitsil to achieve relatively satisfactory suppressive thyroid effects .
 
When administered iodine or prior use of iodinated radiopaque agents may reduce the effect of thyroid Propitsil 50 mg. In these circumstances, achieving the therapeutic effect may take longer than usual.
 
Which other medicines may be affected by Propitsil 50 mg?
 
Treatment with 50 mg Propitsil can affect the effective free fraction of propranolol and coumarin derivatives, which may require dose adjustment.
 

Pregnancy and lactation

 
Please tell your doctor before taking any medicine.
 
During pregnancy, the dose of 50 mg Propitsil should be as low as possible in order to avoid abortion, hypothyroidism and goiter in the fetus. During this period must be conducted carefully monitored. Hormone secretion fetus begins between the 10th and 14th week of pregnancy.
 
Breastfeeding is possible during treatment with 50 mg Propitsil. Propitsil dose of 50 mg should be low (150 mg daily). It is especially newborns, since there are few reports of neonatal hypothyroidism.
 
Not recommended combining Propitsil 50 mg and thyroxine during pregnancy and lactation.
 

Driving and operating machinery

 
You should check whether your acts of thyroid disease or possible side effects of Propitsil can affect your ability to drive or operate machinery.
 
Important information about some of the ingredients of the 50 mg Propitsil
 
This medicinal product contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.
 

 HOW TO TAKE 50 MG PROPITSIL

 
Always Propitsil 50 mg tablets exactly as your doctor tells you. If you're not sure, ask your doctor or pharmacist.
 
Propitsil dosage of 50 mg is different for each patient. The dosage should be determined and monitored by your doctor. Please do not stop taking the product or increase the dose of their own, but always consult your doctor.
 
Dosage and method of administration
 
At what dose and how often you should take 50 mg Propitsil?
 
Unless otherwise prescribed by your doctor, the usual dose is:
 Adults, adolescents and children over 10 years:
 
The starting dose (total daily dose) expressed moderate hyperthyroidism is 100 to 300 mg Propylthiouracil (2 to 6 tablets) of 2-3 separate doses of 50-100 mg (1 -2 tablets). In severe cases after intake of iodine is recommended for higher initial doses of 300 to 600 mg Propylthiouracil (6-12 tablets a day), divided into 4 to 6 doses. The maintenance dose is 50 to 150 mg Propylthiouracil (1 to 3 tablets daily).
 Children between b and 10 years of age:
 
The starting dose is 50 to 150 mg Propylthiouracil (1 to 3 tablets) per day, and approximately 25 to 50 mg RTU (1/2 to 1 tablet) daily as a maintenance dose.
 Elderly:
 
The use of a dose at the lower limit of the normal dose.
 Patients with impaired renal function:
 
Propylthiouracil dosage should be reduced by 25% in patients with mild to moderately impaired renal function and in cases with advanced renal failure by 50%.
 Patients with impaired hepatic function:
 
The dose of Propylthiouracil in patients with reduced hepatic function should be reduced.
Prior to initiating therapy with 50 mg Propitsil to explore the function of the kidneys and liver.
Please consult your doctor if you think that the effect of Propitsil 50 mg is too strong or too weak.
 
How and when should you take 50 mg Propitsil?
 
The tablets should be swallowed whole with plenty of fluids, without chewing.
 
How long should you take 50 mg Propitsil?
 
The duration of treatment will be determined by your doctor according to individual needs.
In the initial treatment of hyperthyroidism, the above doses should be taken at regular intervals during the day. The maintenance dose may be taken once after breakfast.
Maintenance treatment usually lasts 1/2 to 2 years (median 1 year), but the improvement is greater at longer treatment.
 
In cases requiring surgical treatment of hyperthyroidism is recommended that treatment with 50 mg Propitsil begin H to 4 weeks (in some cases earlier) before surgery and stopped one day before surgery.
 
Patients with very great enlargement of the thyroid gland and trachea narrowed to be treated with 50 mg Propitsil for a short period of time, otherwise there is a risk of further growth of the thyroid gland and obstruction of the upper airway. The therapeutic process must be carefully monitored and given combined with thyroxine.
 
If you take more than 50 mg dose Propitsil, you should immediately contact your doctor.
 
There are recorded cases of acute poisoning Propitsil 50 mg.
 
Chronic overdose leads to the appearance of goiter and hypothyroidism. The events include malaise, fatigue, difficulty tolerating the temperature changes constantly feeling cold, lack of sweating, loss of interest in daily life, loss of ability to concentrate, and weight gain. There are also heart pain, impaired circulation, shortness of breath, rheumatic disorders (pain in the legs) and numbness of the fingers.
High doses can lead to onset of goiter or increase existing is enough.
There are some special measures overdose. You may have to carry out gastric lavage and removal of residues ingested tablets endoscope. In cases of chronic overdose formation of goiter, your doctor will stop taking Propitsil 50 TDs. If necessary, you will be given thyroxine. In general, thyroid function will recover spontaneously.
 
If you forget to take 50 mg Propitsil
 
Completely miss the intake and take the next dose at the right time. Do not take a double dose to make up for a missed dose.
 
If you stop taking 50 mg Propitsil
 
Treatment should never be interrupted or discontinued without advance directed by your doctor.
 

 POSSIBLE SIDE EFFECTS

 
Like all medicines, Propitsil 50 mg can cause side effects, although not everybody gets them.
 
For a description of the frequency of adverse reactions following terms are used:
 
Very common: More than 1 in 1 0 patients
 
Common: More than 1 in 1 00 patients
 
Uncommon: More than 1 in 1000 patients
 
Rare: More than 1 in 0000 patients first
 
Very rare: In 1 or less on the first 0,000 patients, including isolated
 
Adverse Reactions
 
Blood and lymphatic system
 
Common: Decreased defined subset of white blood cells (neutropenia) without clinical manifestations.
 
Uncommon: severe side effect is loss of white blood cells (agranulocytosis), partly with severe complications. Agranulocytosis can develop within a few hours of the first symptoms of stomatitis, sore throat (adenofaringit), fever and occurrence of furuncles. When these symptoms occur, especially in the first weeks of treatment, immediately discontinue the Propitsil 50 mg and consult with your doctor to control blood counts. Symptoms can occur weeks or months after initiating treatment. They often resolve spontaneously.
 
Very rare: decreased platelet count (thrombocytopenia), reducing the number of all blood cells (pancytopenia), defective formation of red blood cells, destruction of blood cells (hemolysis), positive Soombs - test (see below), swollen lymph nodes (lymphadenopathy).
 
Immune System
 
Common: hypersensitivity reactions
Common Allergic skin reactions (itching, hives). Usually these events are not severe and usually disappear with continued treatment (see also Skin and subcutaneous tissue).
 
Uncommon: drug fever, liver damage (see also Hepatobiliary disorders).
 
Very rare: arthralgia (see also disorders of the musculoskeletal system and connective tissue).
 
Nervous System
 
Rare: vertigo, neuromuscular disorders.
 
Vascular Disorders
 
Very rare: inflammation of blood vessels (vasculitis) lupusopodoben syndrome (see below), periarteritis nodosa (see below), edema, especially in the extremities (peripheral edema).
 
Skin and subcutaneous tissue
 
Common: pruritus, urticaria
 
Very rare: baldness
 
Respiratory, thoracic and mediastinal disorders
 
Very rare: inflammation of the lungs (interstitial pneumonia), asthma
 
Gastrointestinal Disorders
 
Common: gastrointestinal disturbances, nausea, vomiting.
 
Uncommon: abnormal taste and smell (dysgeusia, ageusia), which are reversible and disappear within a few weeks after discontinuation of Propitsil.
 
Hepatobiliary disorders
 
Rare: liver problems, especially when using high doses.
Described are inflammatory liver damage with destruction of liver cells (liver reaction with necrosis of liver cells) and cholestasis (transient cholestasis). Usually these symptoms are reversible after cessation of treatment.
 
Very rare: few cases described severe liver failure induced by Propylthiouracil.
 
Musculo - skeletal system and connective tissue
 
Very rare: arthralgia without signs of inflammation.
 
Endocrine disorders
 
Very Rare: goiter formation in newborns.
 
Ear and labyrinth disorders
 
Very rare: in rare cases may cause hearing loss.
 
Research (laboratory results)
 
Very common: transient increases in enzymes indicative of liver function (transaminases).
 
Explanations
 
Lupus erythematosus is a disease of the whole body (systemic disease), in which antibodies are formed against his own body (autoimmune disease), causing inflammatory reactions. The disease is allotropic and characterized by a variety of different ways of affecting the organs and systems.
 
Periarteriitis nodosa is a disease of the whole organism, which is manifested by inflammation of blood vessels (vasculitis) and destruction of the arteries. Symptoms include fever, weight loss and kidney damage, heart and joints.
 
Soombs - the test is testing for the presence of antibodies to red blood cells.
 
Comments
 
Propitsil reduces the energy consumption of the body, which is abnormally high due to hyperthyroidism. This means that treatment with 50 mg Propitsil possible to increase the weight at constant food intake. Basically, from a medical standpoint, it is desirable during treatment with 50 mg Propitsil.
 
An additional increase of the already enlarged thyroid gland in depressed levels of TSN (TSN is a hormone that stimulates the thyroid) was noted as a result of the underlying disease and can be prevented by further treatment with thyroid hormones.
 
Emergence or worsening of eye disease (endocrine orbitopatiya), which can occur in patients with thyroid disease, independent of the course of thyroid disease, such complication is not grounds for a reassessment of the therapeutic approach and should not be treated as spam response to adequate treatment.
 
A small number of patients during treatment with 50 mg Propitsil may occur hypothyroidism. This is not a side effect of treatment, and inflammation of the thyroid tissue.
 
During antithyroid treatment should be permanent monitoring of thyroid function in order to avoid overdose. It is also necessary to control blood count, liver enzymes indicative of cholestasis enzymes.
If you notice any side effects not listed in pelvic leaflet, please tell your doctor or pharmacist.
 

 HOW TO STORE PROPITSIL 50 MG

 
Keep out of reach of children.
Do not use Propitsil 50 mg after the expiry date stated on the pack.
 
Storage:
 
No special storage conditions.
 

 ADDITIONAL INFORMATION

 
What Propitsil 50 mg
 
The active substance is Propylthiouracil
 
Excipients are: lactose, maize starch, magnesium stearate, colloidal silicon dioxide, povidone, pregelatinized starch.
 
How does Propitsil 50 mg and contents of the pack
 
Propitsil 50 mg is available in packs of 100 tablets per carton.
€ 22.00
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