PROPASTAD table. 150 mg. 50 tablets

PROPASTAD table. 150 mg. 50 tablets
€ 16.00
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Symptomatic and requiring treatment for supraventricular arrhythmias (abnormal heart rhythm with elevated heart rate, which is derived from parts of the heart chambers located above)



PROPASTAD table. 150 mg. 50 tablets
 

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Symptomatic and requiring treatment for supraventricular arrhythmias (abnormal heart rhythm with elevated heart rate, which is derived from parts of the heart chambers located above), ie:
  AV conduction tachyarrhythmias (increased heart rate due to pro-water violations between the sinoatrial node, atrial and ventricular)
  Supraventricular tachycardia in WPW syndrome (paroxysmal intermittent rapid heart rate due to increasing conductivity of impulses from the atria to the camera)
  Paroxysmal atrial fibrillation (paroxysmal appearing abnormal heart rhythm due to abnormally increased excitability, angry).
 
Excipients
 
Symptomatic paroxysmal tachyarrhythmias (fast heart rhythms in the ventricles).
 

Contraindications

 
When you must not be taken Propastad  150?
  Patients with overt cardiac failure
  Patients with cardiogenic shock, unless it is due to abnormal heart beat-ing
 Patients with severe symptomatic bradycardia (slow heart rate)
 During the first 3 months after myocardial infarction or in patients with reduced heart (left ventricular ejection volume of less than 35%) than in patients with life-threatening ventricular arrhythmias
  Patients with pre-existing sinoatrial conduction disturbances, atrioventricular conduction disturbances or vatrekamerni
  Patients with sick sinus syndrome node, which can be expressed in sinus bradycardia (heart rate <60 bpm), bradycardia-tachycardia syndrome, sinoatrial block or sinus arrest
 Patients with hypotension
  Patients with marked electrolyte imbalance (ie, diseases related to potassium metabolism) - Patients with severe obstructive pulmonary disease, patients with abnormal muscle weakness or fatigue, caused immunological disorders of skeletal muscle (my-asthenia gravis
  Patients with known hypersensitivity to the active substance, propafenone, or any of the excipients.
 
What needs to be considered during pregnancy and lactation?
 
There is insufficient clinical data on the use of non-propafe during pregnancy and lactation. When using therapeutic doses have adverse effects on newborns in experiments on animals. It should be borne in mind that propafenone crosses the placenta and is secreted in human milk. The application of propafenone during pregnancy and lactation should only be done under medical supervision explicitly.
 

 What should be considered in young children and adults?

 
Safety Propastad  150 for children is ustanovena.Doziraneto in elderly patients and patients with severe heart muscle must be very carefully and gradually according to medical appointments during the stabilization phase.
 
Special warnings
 
What should I keep in mind?
 
During treatment with propafenone hydrochloride frequency and sensitivity of cardiac pacemakers may change. The function of a pacemaker should be checked and if necessary to be preprogramira.Tryabva whereas no prolongation of experience-bridge with any drug from Class I antiarrhythmic drugs.
 
In the treatment of paroxysmal atrial fibrillation during the phase when atrial fibrillation passes in fluter 2:1 or 1:1 impulses to the ventricles, it is possible to develop a very fast heart rate (ie> 180 bpm) .
 

What you should consider when driving or operating machinery?

 
Propafenone reduces the possibility of rapid response needed when driving or operating machinery, even in exact compliance with the dosing regimen. This is particularly pronounced at the beginning of therapy, during dose escalation, and acceptance of alcohol.
 
Interactions with other drugs
 
Which medicines may influence the effects of Propastad  150 or 150 how Propastad  may affect the way other medicines?
 
Concomitant use of drugs with local anesthetic properties (ie during the implantation of a pacemaker, surgical or dental procedures), and drugs inhibiting effects on heart rate and / or contractility (ie, beta blockers, tricyclic antidepre- Santi) may increase the effects of Propastad  150.
 
In addition, increased plasma concentrations and blood levels of propranolol, metoprolol, desipramine, digoxin, and cyclosporine have been observed during treatment with Propastad  150. This may lead to increased effects of these drugs.
 
Described is the first case of double increase plasma concentrations of theophylline with concomitant use of propafenone. If symptoms of overdose of these drugs should be moni-torirat plasma concentrations and if necessary dose namali.Ednovremennoto-use of cimetidine or quinidine can Propastad 150 (due to increased plasma concentrations of propafenone-) to enhance effects of Propastad  150.Ednovremennoto using Propastad  150 and phenobarbital or re-fampitsin can (due to reduced plasma concentrations of propafenone) to reduce the effects of antiarrhythmic Propastad  150.Pri patients taking medicines that reduce blood clotting (oral anticoagulants, such as phenprocoumon) should regularly monitor the coagulation as a concomitant intake Propastad ® 150 can increase the efficiency of these lekarstva.Tryabva keep in mind that these warnings may apply to the medicines taken recently.
 

Dosage and duration of therapy

 
Dosing instructions below only when a physician otherwise prescribed dosing regimen Propastad ®150. Follow the exact instructions of the physician for an effective and safe therapy Propastad  150.
 

How much and how often you should take Propastad  150?

 
Stabilization of patients with ventricular arrhythmias with this medicine should only be done under medical supervision specifically by the physician and cardiologist can only occur if there is equipment for emergency cardiac care and continuous ECG recording. During treatment, patients should regularly visit the doctor (which includes one monthly standard ECG and continuous ECG recording, and if necessary 3 months can be done after exercise ECG). In case of deterioration of the individual parameters, ie widening of the QRS complex or QT interval by more than 25 percent, or extending the PQ interval of more than 50%, or QT interval over 500 ms, or increase the incidence or severity of abnormal heart rhythm, treatment regimen should be reviziran.Individualnata maintenance dose is determined after repeated ECG recording and blood pressure measurements (stabilized phase). During the phase of stabilization and maintenance treatment - a daily dose of 450-600 mg (1 tablet Propastad  150 mg 3 times daily to 2 Propastad  150 tablets 2 times a day) is usually sufficient for a patient weighing 70 kg.
 
In some cases it may be necessary to increase the daily dose to 900 mg (2 tablets Propastad  150 3 times a day). In patients with low body weight, the dose should be reduced. The dose should be increased before passing interval of 3-4 days.Pri elderly patients and patients with significantly reduced LV-function (LVEF <35%) or organic myocardial disease stabilization should begin with attention (gradually) . The same goes for maintaining terapiya.Pri need to increase the dose it should be in the range of 5-8 dni.Pri patients with impaired renal and / or hepatic function, therapeutic doses can cause accumulation. ECG monitoring and measurement of plasma concentrations, these patients can also be stabilized by Propastad  150.
 
Note:
 
It should be borne in mind that no prolongation of survival for any drug from Class I antiarrhythmic drugs.
 
How and when should you take Propastad  150?
 
Tablets should not be chewed or sucked, but should be swallowed whole after meals with a glass of water.
How long should be taken Propastad  150?
 
The duration of treatment is determined by the doctor.
 

Overdose

 
What should I do overdose (accidental or deliberate) of Propastad  150?
 
If overdose is suspected of Propastad  150, you should immediately contact your doctor. He / she will decide what action to take depending on the symptoms. Poisoning and / or severe symptoms require immediate therapy.
 
Symptoms of overdose:
 
Symptoms of heart:
 
The toxic effects of propafenone on the heart are expressed as generating impulses and conduction abnormalities, including prolongation of the PQ interval, widening of the QRS complex, inhibiting the automatism of the sinus node, AV block, ventricular tachycardia, ventricular fibrillation and fluter. In addition, the reduction in contractility (negative inotropic effect) may result in hypotension and cardiogenic shock.
  

Other symptoms:

 Headache, dizziness, blurred vision, paresthesia, tremor (shakiness), nausea, constipation and dry mouth are common symptoms of intoksi-katsiya.Tezhkata intoxication (poisoning) may cause tonic kponichni seizures, paresthesia, drowsiness, coma and stop breathing
 
Therapeutic measures:
 
Therapeutic measures depend on the nature and severity of symptoms. Treatment is symptomatic and vital functions should be monitored and corrected in the ICU.
 
What should you do if you take more than the prescribed dose Propastad  150 or you forget a dose?
 
Next time, do not take a double dose and resume dosing regimen as prescribed by the doctor.
 

Side effects

 
What side effects may occur when taking Propastad  150?
 
Isolated cases of gastrointestinal disorders seen in primary high doses (ie, loss of appetite, nausea, vomiting, bloating, constipation), dry mouth, bitter taste, feeling stiff mouth and paresthesia, blurred vision, dizziness and increased temperatura.Pri adult patients with reduced myocardial function may occur circulatory disorders tend to lower blood pressure on standing or prolonged standing (orthostatic hypotension).
 
Patients may feel proarrhythmic (enhanced arrhythmia's) effects, such as changes in and / or degradation of abnormal heart rhythms that can lead to significantly influence cardiac function and potential for stopping sartseto.Tezi proarrhythmic effects can be expressed in slow heartbeat (bradycardia), abnormal conduction (sinoatrial, atrioventricular or intraventricular block), or increased heart rate (new ventricular tachycardia). There are rare reports of ventricular fibrillation or fluter (or atrial fibrillation). Heart failure can worsen.
 
 Rarely reported fatigue, headaches, mental disorders such as anxiety and confusion, anxiety, nightmares and sleep disturbances, and rarely convulsions have been reported following overdose. Rarely reported extrapyramidal symptoms (involuntary violation of muscle movements), allergic skin reactions (eg erythema, pruritus, rash, urticaria), and dyspnea in patients prone to spasm of the bronchi (bronchospasm). Reported rarely cholestasis (retention bile) as an expression of hi-perergichna/alergichna reaction and / or depressed liver function.
 
High doses of propafenone in isolated cases, were associated with reduced potency and reduced sperm count. These changes are reversible upon discontinuation. Propafenone therapy is life-saving and should not be suspended because of this adverse effect, except as expressly prescription.
 
There are isolated cases of elevation of antinuclear (directed against cell nuclei) antigen, lupus erythematosus-like syndrome, leucopenia, and granulocytopenia or thrombocytopenia (decreased number of granulocytes / platelets in the blood), which are reversible upon discontinuation of propafenone. There are rare reports of agranulocytosis (suppression of blood formation). Should tell your doctor or pharmacist if you experience side effects, especially those listed in the leaflet.
 

Expiration date

 
The shelf life of this product is printed on the packaging and blister.
 
Do not use after the expiration date!
 
Store at temperatures up to +25 ° C.
 
Keep all medicines out of the reach of children!
Each film-coated tablets contain as active responsive drug 150 mg propafenone hydrochloride.
 
Microcrystalline cellulose, macrogol 6000, magnesium stearate, maize starch, modified corn starch, hydroxypropyl metiltselu-sis, sodium lauryl sulfate, colloidal anhydrous silica, more Vido, talc, titanium dioxide (E171).
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