PIROXICAM. 10 mg. 20 capsules

PIROXICAM. 10 mg. 20 capsules
€ 15.00
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Short-term symptomatic treatment of acute and chronic pain in inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis; juvenile rheumatoid arthritis; ankylosing spondylitis; attack of gout and gouty arthritis; osteoarthritis. 

PIROXICAM. 10 mg. 20 capsules

 
 
Each capsule contains piroxicam 10 mg.
 
* Indications
Short term symptomatic treatment of :
o Acute and chronic pain in inflammatory and degenerative diseases of the musculoskeletal system : rheumatoid arthritis; juvenile rheumatoid arthritis; ankylosing spondylitis ; attack of gout and gouty arthritis; osteoarthritis .
o periarticular diseases: tendinitis , bursitis, tendobursiti , tendovaginitis , injuries in athletes .
o disc disease , plexitis, radikulonevriti .
o postoperative pain in dental orthopedic and other minor surgical procedures.
o Dysmenorrhea .
 
* Dosage
Orally.
Adults and children over 14 years:
1 capsule (20 mg) daily or as two doses of 10 mg.
In acute conditions, the initial daily dose is 40 mg in the first 2 days, then 20 mg daily for a period of 1-2 weeks.
In flare usual daily dose is 40 mg over 5-7 days.
Dysmenorrhoea administered 40 mg on day 20 mg in the coming days to abate the pain.
 
* Contraindications
o Hypersensitivity to piroxicam or any of the excipients of the product; hypersensitivity to salicylates or other NSAIDs .
o Active peptic ulcer or stomach ulcer , ulcerative colitis, and / or enterocolitis .
o Severe hepatic and renal failure.
o Pregnancy and lactation .
o Children under 14 years of age.
 
* Special warnings o Piroxicam is administered after careful consideration in patients with a history of gastric ulcer and duodenal ulcer and bleeding from the gastrointestinal tract.
o It is used with caution in patients with known hypersensitivity.
o Piroxicam used with caution in patients with renal impairment .
o Increased risk of side effects from the gastrointestinal tract in patients there is alcohol abusers , smokers, patients over 65 years of age who are concurrently taking oral corticosteroids and anticoagulants.
o Piroxicam can cause fluid retention , which requires careful its use in patients with cardiovascular disease, hypertension , renal diseases .
o It is necessary to appoint caution in patients with a history of coagulation disorders .
o Treatment with piroxicam may cause changes in liver function during long-term treatment , which requires monitoring of liver enzymes.
o When piroxicam risk of hyperkalemia , especially in patients over 65, patients with renal failure, patients treated with ß- blockers , ACE inhibitors and potassium-sparing diuretics. Such patients require monitoring of serum potassium .
o Piroxicam reversibly decreased fertility in women of childbearing age, you should keep in mind when trying to get pregnant .
 
* Drug Interactions
 
o piroxicam alcohol , other NSAIDs and corticosteroids increase the risk of gastrointestinal side effects .
o Piroxicam extended and potentiates the action of lithium salts . ;
o Concomitant use of piroxicam and immunosuppressants leads to an increase in their toxicity .
o Piroxicam decreases therapeutic effectiveness of diuretics when administered concomitantly
o Piroxicam may reduce the antihypertensive effect of ACE inhibitors and ß- blockers for concomitant use.
o When combined administration of anticoagulants, antiplatelet agents and NSAIDs increases the risk of ulcers and bleeding. It is the control of the bleeding time and prothrombin time during co-administration .
o Co-administration of quinolones and piroxicam, may increase the risk of seizures in patients with or without a history of epilepsy or seizures.
 
Pregnancy and lactation
Piroxicam not be used during pregnancy.
 
* Adverse Drug Reactions
Gastrointestinal - anorexia, nausea , vomiting, epigastric pain, abdominal discomfort , constipation, bleeding and ulcers , diarrhea .
CNS - dizziness, vertigo , headache ; rarely somnolence , fatigue , impaired concentration , fatigue ;
Sensory organs - diplopia , blurred vision , hearing impairment , tinnitus , taste disturbance .
Cardiovascular system - rarely palpitations, angina , arrhythmias ;
Skin and appendages - usually itching with or without rash ; rarely - hives;
Urinary system - rarely edema ; very rare - acute kidney failure, nephrotic syndrome, proteinuria, hematuria , interstitial nephritis, papillary necrosis.
Haematological disorders - leukopenia , thrombocytopenia , agranulocytosis, hemolytic anemia , aplastic anemia.
Hepatic impairment - increased serum aminotransferases , transient increase in bilirubin rarely toxic hepatitis with or without jaundice ; rarely - fulminant hepatitis.
Body as a whole - rarely - bronchospasm, asthma attack , anaphylactic reactions in allergic patients.
 
 
* Formulation and packaging
 Piroxicam Capsules 10mg.
10 capsules in blister, 2 blisters in a cardboard box.
 
 
€ 15.00
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