PENTILIN amp. 100 mg. 5 ml

PENTILIN amp. 100 mg. 5 ml
€ 19.00
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PENTILIN injection 100 mg / 5 ml
Pentoxifyline / pentoxifylline
Active substance: pentoxifyline
Other ingredients: disodium edetate. sodium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, water for injections.



PENTILIN amp. 100 mg. 5 ml
 
PENTILIN injection 100 mg / 5 ml
Pentoxifyline / pentoxifylline
Active substance : pentoxifyline
Other ingredients : disodium edetate . sodium chloride , sodium dihydrogen phosphate dihydrate , disodium phosphate dihydrate , water for injections.
 
1. What is Rentilin and what it is used?
Ingredients:
5 ml of solution for injection ( 1 ampoule ) contained 100 mg pentoxifyline.
packing:
Carton of 5 ampoules of 5 ml solution for injection ( 100 mg / 5ml).
 
What is Rentilin ?
Rentoxufyline acts on blood viscosity by reducing the adhesion of the cell and its kompyunenti spontaneous increase deforiiruemostta erythrocytes . Thereby improving blood flow in the small blood vessels , especially the microcirculation and supply tissues with oxygen.
What is it used Rentilin ?
It is used for the advanced disorders of the peripheral arterial circulation ( macro-and microcirculation ) caused by atherosclerosis , diabetes and vascular spasm (claudicatio intermittens, diabetic macro and microangiopathy syndrome, Reynaud).
 
2 . Before using Rentilin
Tell your doctor if you have any chronic diseases , metabolic disorders , if you are allergic or if you take other medicines.
Who should not take Rentilin ?
You should not take Rentilin :
if you are hypersensitive to rentoxufyline to the excipients of the medicinal product;
if you are hypersensitive to the xanthine derivatives such as theophylline. caffeine , choline theophyllinate , aminophylline or theobromine ;
If you have suffered an acute myocardial infarction;
If you suffer from heavy bleeding or retinal hemorrhage ;
if you have a disease associated with an increased risk of bleeding .
Special precautions and warnings
Before starting treatment with Rentilin tell your doctor if you are being treated for arteriosclerosis , high blood pressure , heart failure, diabetes , liver or kidney disorder, if you are on dialysis , or if you have very low or unstable blood pressure.
In advanced atherosclerosis rentoxifyline must not be injected into the affected artery .
Rentilin should be prescribed with caution in patients with heart failure because blood nalngane may suddenly fall ( hypotension) .
Caution should be used in patients with diabetes because high intravenous doses rentoxifuline can enhance the action of insulin or oral hypoglycemic agents .
Caution is required in patients with severe hepatic or renal impairment.
Dosage should be reduced in patients with low or unstable blood pressure, may occur because hypotension and angina.
Patients with other diseases or disorders accompanied by bleeding ( conditions after surgery , peptic ulcer ) , should be monitored in the prothrombin time (INR), the hematocrit and hemoglobin.
Safety in patients under 18 years of age has not been established , so they should not take this medicinal product.

Pregnancy and lactation
Consult your doctor or pharmacist before taking any medicine.
Rentilin effect on the fetus has not been studied , so he appointed during pregnancy only if the doctor considers it vital . Rentilin and its metabolites in breast milk. The doctor will decide whether it can be used during breast-feeding or if breast-feeding should be discontinued.
Effects on ability to drive and use machines
No influence on the ability to drive or operate machinery.
What other drugs could interact with Rentilin ?
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines , even those without a prescription.
Coadministration of rentoxifyline and medicines to lower high blood pressure ( antihypertensives ) reinforce their action , so their dose should be adjusted . Patients taking rentoxifyline while preventing blood clotting drugs or those that prevent platelet aggregation ( anticoagulants or antiplatelet drugs ) may increase the risk of bleeding. Therefore require more frequent monitoring of prothrombin time (INR).
High intravenous doses rentoxifyline can enhance the action of insulin or oral hypoglycemic agents , so their dose should be adjusted. Serum concentrations of rentoxifyline significantly increased when co-administered with cimetidine . You need to pay attention to the signs of overdose rentoxifyline patients . Other H2- receptor antagonists ( famotidine , ranitidine and nizatidine ) have less influence on the metabolism of rentoxifyline . Coadministration of rentoxifyline and theophylline may result in increased serum levels of theophylline . Therefore, serum levels of theophylline should be monitored and the dosage of theophylline can be reduced if necessary .
Concomitant administration of ketorolac rentoxifyline and can lead to prolongation of prothrombin time and increase the risk of bleeding. The risk of bleeding may be increased and the concomitant administration of meloxicam and repentoxifyline . Concomitant use of these drugs is not recommended.
Ciprofloxacin rentoxifyline decreased metabolism in the liver. Concomitant administration of ciprofloxacin and rentoxifiline may result in increased serum concentrations of rentoxifyline . If concomitant treatment with ciprofloxacin rentoxifyline and can not be avoided, rentoxifyline dose should be reduced by half .
 
3 . How to use Rentilin ?
Dosage and method of administration
The exact dosage and duration of treatment should be determined by the physician .
To establish the sensitivity of the patient to rentoxifyline in its beginning to apply 50 mg pentoxifyline ( half of one ampoule ) diluted with 10 ml of saline (0.9% NaCl solution ) .
Intra-arterial injection of rentoxifyline is recommended only in exceptional cases and only in patients with severely threatened limbs where other treatments have failed .
Therapy injections : 1 ampoule (100 mg ) daily injected slowly (about 5 minutes) to a patient in supine or intravenous or intraarterial .
Dosage in infusion therapy :
intra-arterial infusion
Starting dose 100 mg in 100 ml fiz.r Dr.
Maintenance dose , 100 mg to 400 mg in 100 ml . fiz.r Dr.
Total daily dose , 1200 mg .
Infusion - from 10 to 30 minutes .

Intravenous infusion :
Starting dose 100 mg in 250 ml fiz.r Dr.
Maintenance dose to 30 mg to 50 mg / hour
Total daily dose , 800 - 1200 mg .
Infusion of 90 to - 180 minutes

Itravenozna continuous infusion
Maintenance dose 0.6 mg / kg / hr
Total daily dose , 1200 mg .
Infusion - 24 hours

The clinical condition has improved, parenteral treatment is replaced with oral therapy Rentilin tablets.
Dosage in renal insufficiency
When a creatinine clearance less than 10 ml / min (0,16 ml / s), the doses were reduced to 50 - 70% of normal .
If you have the impression that the effect of the medicine is too strong or too weak, you should consult with your doctor or pharmacist.
If you take more than you should Rntilin
Overdose can occur following symptoms: flushing,
drowsiness , decrease in blood pressure , fainting , nausea, vomiting , fever , malaise , cramps .
If you think you have received a higher dose of the drug than it should have to consult your doctor immediately.
 
4 . Possible side effects
Like all medicines , Rentilin can also have side effects .
May appear flushing, headache , dizziness, insomnia , tremor , chest pain, and increased heartbeat .
Are also possible hypersensitivity reactions ( pruritus, flushing, urticaria , angioedema, shock) .
Very rarely can occur hypotension , agitation, nausea , vomiting, diarrhea , cholestasis , increases in liver enzymes , hypoglycemia , thrombocytopenia, leukopenia, prolonged prothrombin time ( or raise INR) or retinal haemorrhage .
Most side effects are dose-dependent. If the dose of Rentilin reduce, they diminish or even disappear. In rare cases discontinued .
If you notice any side effects, even those not listed in this leaflet, please tell your doctor or pharmacist.


5 . Storage Rentilin

Storage Conditions
Do not store above 25 ° C.
Keep out of reach of children.
Shelf life :
The product must not be used after the expiry date stated on the packaging.

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