OSPEXIN 1000 mg. 12 tablets

OSPEXIN 1000 mg. 12 tablets
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Ospexin is an oral broad-spectrum antibiotic from the group of semi-synthetic cephalosporins. At normal concentrations has bactericidal activity against sensitive proliferating microorganisms, which results in inhibition of cell wall biosynthesis. Ospeksin is also suitable for patients with sensitive stomachs.

OSPEXIN 1000 mg. 12 tablets
OSPEXIN WHAT IS AND WHAT IT IS USED
Ospexin is an oral broad-spectrum antibiotic from the group of semi-synthetic cephalosporins. At normal concentrations has bactericidal activity against sensitive proliferating microorganisms, which results in inhibition of cell wall biosynthesis. Ospexin is also suitable for patients with sensitive stomachs.
Ospexin be used in mild to moderate infections caused by susceptible microorganisms cephalosporins, eg .:
• Infections of the genitourinary system, incl. prostatitis caused by E. coli, Pr. mirabilis and Klebsiellae;
• Infections of skin and soft tissue caused by Staphylococci and / or Streptococci
• Infections of the bones and joints, incl. osteomyelitis, caused by staphylococci and / or Pr. mirabilis
• Infections of the respiratory tract caused by S. pneumoniae and Group A beta-hemolytic streptococcus
• Otitis media and pharyngitis caused by S. pneumoniae, H. influenzae, staphylococci, streptococci and Neisseria catarrhalis.
• In stomatologiyata- infections caused by staphylococci and / or streptococci.
• Continuation of initial parenteral therapy with cephalosporins.
2 BEFORE YOU TAKE OSPEXIN
Do not take Ospexin
• if you are allergic (hypersensitive) to cephalosporins
• if you are allergic (hypersensitive) to penicillin, the probability of cross-allergy
5-10%
• in severe systemic infections requiring parenteral therapy with cephalosporins should not be treated orally in the acute stage
Take special care with Ospexin
In the case of pre-penicillin allergy necessary caution. In patients who develop severe systemic reactions immediately after taking penicillin, cephalosporins should be appointed only after careful medical evaluation.
If a hypersensitivity reaction, especially anaphylaxis, treatment should be discontinued and the patient should undergo the usual treatment with epinephrine, antihistamines and corticosteroids.
Possible development of resistant organisms or fungi after prolonged therapy. If a secondary infection, you should take the necessary measures.
In the event of severe and persistent diarrhea (blood in veins, mucoid and watery diarrhea with dull or diffuse cramping abdominal pain, fever and sometimes tenesmus) should be considered pseudomembranous colitis, which is associated with the antibiotic and can be life-threatening . In such cases, taking Ospeksin® should be discontinued immediately and to start therapy based on bacteriological studies (eg. Oral vancomycin 250 mg four times daily). Antiperistaltichni drugs are contraindicated.
biochemical reactions
False positive results may show tests for the determination of glucose in urine and test direct Coombs (also in newborns whose mothers were taking cephalexin during childbirth). In these cases, may use methods based on glkzhozooksidaznata reaction. Several cases of mild transient elevations of SGOT and SGPT were found after treatment with cephalexin.
Cephalosporins may affect the determination of ketone bodies in urine.
Taking other medicines
Because cephalosporins, such as cephalexin and act only on proliferating microorganisms, they must be combined with bacteriostatic antibiotics. Concomitant use of probenecid (napr.0,5 g orally four times daily, which is contraindicated in children under 2 years of age) leads to inhibition of renal elimination. Combining cephalosporins with loop diuretics (ethacrynic acid, furosemide) or other potentially nephrotoxic antibiotics (aminoglycosides, polymyxin B, colistin) may increase the nephrotoxic effect.
Concomitant administration of cephalosporins and oral anticoagulants may prolong prothrombin time. Cephalosporins can reduce the effect of oral contraceptives. It is possible that an interaction between cephalexin and metformin, leading to accumulation of metformin.
Taking Ospexin with food and drink
Food does not affect the effect of Ospexin. Avoid alcoholic beverages during treatment with Ospexin.
Pregnancy and lactation
So far no evidence of teratogenic effects of cephalexin during pregnancy. It should be borne in mind that Cephalexin passes into breast milk.
Driving and using machines
No data Ospexin to affect your ability to drive or operate machinery.
3 HOW TO TAKE OSPEXIN
Ospexin dosage depends on the severity of the infection and is only determined by your doctor.
adults
The daily dose for infection by susceptible organisms (Gr +) is 1-4, the daily dose for infection with less susceptible organisms (Gr -) 4-6 g or more, divided into 2, 3 or 4 individual doses. The daily dose should be lower than 1, the typical 3 x 1 tablet 1000 mg.
children
The daily dose is 25-50 (up to 100) mg / kg, divided into 2, 3 or 4 individual doses.
Infants and children up to 6 years of age should not take more than 100 mg / kg daily.
In older children and adults the daily dose may exceed 4 g, only if absolutely necessary.
Children aged 6-10 years 3 x 1 tablet 500 mg
Children aged 10-14 years 3-4 x 1 tablet 500 mg
In mild, uncomplicated urinary tract infections, skin and soft tissues and streptococcal pharyngitis, the total daily dosage may be divided into two doses every 12 hours.
Clinical studies show that the treatment of otitis media is a suitable daily dose of 75-100
mg / kg, divided into 4 doses.
Treatment should continue for 2-5 days after symptoms have resolved.
Upon infection with beta-hemolytic streptococci recommended treatment for at least 10 days in order to prevent a relapse.
Dosage in impaired elimination
creatinine
clearance (ml / min)
Single
dose
dosage
interval (h)
40-80500 mg 4-6
20-30500 8-12 mg
10 250 mg 12
5250 mg 12-24
Patients on dialysis therapy cephalexin should receive 250 mg 1-2 times a day and an additional 500 mg after each dialysis treatment, which is equivalent to a total dose of 1 g on the day of dialysis.
Ospexin be taken orally with or without food with a glass of water.
If you take more than you should Ospexin
If you swallow large doses of Ospexin, consult your doctor. Symptoms of overdose Ospexin largely overlap profile of side effects, including. nausea, vomiting, epigastric discomfort, diarrhea, and hematuria.
4 POSSIBLE SIDE EFFECTS
Side effects are relatively rare. There is no reported serious side effects. Infrequently occur gastrointestinal disorders such as diarrhea (which in most cases resolves spontaneously even more during therapy), also headache, weakness, dizziness, confusion, eosinophilia and neutropenia, stomatitis, vaginal candidiasis, anal pruritus.
If diarrhea occurs during therapy, should be considered likely to experience
pseudomembranous colitis. Single occurrence of cases of impaired renal function
reversible.
As with some penicillins and cephalosporins, in rare cases may cause cholestatic
jaundice.
Allergic skin reactions manifested as pruritus, urticaria or hives are very rare (erythema
multiforme syndrome Stevens-Johnosn). In general allergic reactions to cephalosporins
are less prominent than those of penicillins. They occur more frequently in patients with known allergy to penicillin.
Anaphylactic reactions occur very rarely.
Observed rare cases of interstitial nephritis. Allergy symptoms usually resolve after discontinuation.
If you notice any of these side effects, please inform your doctor. He / she
will decide, depending on their weight, what measures to take.
Tell your doctor if you notice any side effects not listed in
leaflet.
5 HOW TO STORE OSPEXIN
Keep out of reach of children. The product should be stored in the original container at a temperature below 30 ° C.
Ospexin not use after the expiry date stated on the pack.
6 FURTHER INFORMATION
Contents Ospexin
• The active substance is cephalexin.
Each tablet contains 500 mg or 1000 mg cephalexin
• The other ingredients are:
Macrogel 6000, magnesium stearate, carboxymethyl starch sodium, povidone, lactose, sodium saccharin, peppermint oil, titanium dioxide (E 171), talc, hypromellose.
Ospexin looks like and contents of the pack
Individual packs of 12, 20 tablets.
MANUFACTURER: Austria
 
 
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