Naproxen 250 mg. 20 tablets

ACTAVIS
Naproxen 250 mg. 20 tablets
€ 17.00
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WHAT Naproxen Actavis AND WHAT IT IS USED?

Actavis Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and anti-inflammatory action. Naproxen Actavis is used to treat rheumatoid arthritis, osteoarthritis (degenerative arthritis), ankylosing spondylitis, acute Musculoskeletal injuries (sprains and strains, direct trauma, pain in the low back region, cervical spondylitis, tenosynovitis and fibrositis) and dysmenorrhea.

2. WHAT YOU NEED TO KNOW BEFORE treatment with naproxen Actavis?

Naproxen Actavis does not apply to:

• Active ulcer or bleeding from the gastrointestinal tract or a history of it;

is Hypersensitivity to naproxen;

• For patients that NSAIDs induce asthma, rhinitis, nasal polyposis and urticaria due to cross-sensitivity.

In this medicinal product, please note the following:

Actavis drugs such as naproxen may be associated with a small increased risk of heart attack (myocardial infarction) or stroke. Any risk is more likely with high doses and prolonged treatment.

The recommended dose should not be exceeded!

If you have heart problems, previous stroke or think that you might be at risk of these conditions (eg. If you have high blood pressure, diabetes or high cholesterol or are a smoker) you should discuss your treatment with your doctor or pharmacist. Adverse effects can be reduced using the minimum effective dose for the shortest period. Patients treated with NSAIDs for a long time should be monitored for adverse reactions.

Elderly patients are particularly susceptible to the adverse effects of NSAIDs. Prolonged treatment in this group of patients is not recommended.

In patients treated with Naproxen Actavis reported bleeding from the gastrointestinal tract. In patients with a history of bleeding the product is applied with caution.

Serious side effects can occur at any time during treatment with VOPOVS. The risk of appearance is not dependent on the duration of treatment. Elderly or debilitated patients suffer bleeding from the gastrointestinal tract more severe. The majority of serious gastrointestinal reactions that occurred in this age group.

High temperature and anti-inflammatory action of Naproxen Actavis inhibits fever and inflammation, and also can complicate diagnosis. In patients suffering from bronchial asthma and allergic diseases or a history of such can be induced bronchospasm. May occur sporadic changes in laboratory tests (eg. Liver tests) .Naproksen Actavis reduces platelet aggregation and prolongs bleeding time. This effect should be taken into account in determining these parameters. Mild peripheral edema in patients taking the product. Although no reports of sodium retention in some patients with compromised cardiac function are at increased risk, taking Naproxen Actavis.

Patients with impaired renal function

Since naproxen is excreted largely (95%) in the kidneys, the product should be used with caution in patients with impaired renal function and the monitoring of serum creatinine and / or creatinine clearance should be done regularly. The product is not recommended in patients with creatinine clearance below 20 ml / min.

In some patients, particularly those in which the altered circulation through the kidneys due to extracellular volume depletion in liver cirrhosis, low sodium, congestive heart failure and renal disease exists requires assessment of renal function prior to and during treatment with naproxen Actavis. Some patients with impaired renal function and patients on diuretic therapy may be placed in this category. Should be given to reducing the daily dose to avoid the accumulation of metabolites of naproxen.

Patients with impaired hepatic function

Chronic alcoholic liver disease and other forms of cirrhosis reduce the total plasma concentration of naproxen, but increased plasma concentration of unbound naproxen.

Haematological reactions

Patients with bleeding disorders or therapy that it affects must be closely monitored when taking products containing naproxen. Patients at high risk of bleeding or those on full anticoagulation therapy (dicoumarol derivatives) are at increased risk of bleeding while taking naproxen-containing products.

Anafgtaktichni (anafipaktoidni) reactions

Hypersensitivity reactions may occur in susceptible individuals. Anaphylactic (anaphylactoid) reactions may occur in patients without a history of hypersensitivity acceptance of NSAIDs. They can occur in individuals with a history of angioedema, bronchospasm (asthma), rhinitis and nasal polyps.

Ocular effects

In rare cases during treatment can be monitored papillitis, retrobulbar nerve neuritis, papilloedema, although a causal link has not been firmly established.
Warnings on fertility
Application of naproxen, as well as any product inhibit cyclooxygenase-prostaglandin synthesis, may impair fertility and is not recommended for women who intend to become pregnant. In women with difficulty in conceiving or who are studying for infertility should be considered discontinuation of Naproxen Actavis.

Combination with other NPV

Not recommended because such a combination kulumativen a risk of serious side effects.

Application of Naproxen Actavis intake of foods and beverages

No evidence of the need for special diets or restrictions on certain types of foods and beverages during treatment with this product.

Pregnancy

Before taking any medicine, consult your doctor or pharmacist
Naproxen Actavis does not apply during the last three months of pregnancy and should be avoided in the first six months. In need of application should be a rigorous risk / benefit assessment. Due to the mechanism of action of the product is possible to suppress uterine contractions to extend the time to wear, to develop cardio-pulmonary and renal failure in the newborn, increase the risk of bleeding in the mother and child.

Breastfeeding

Before taking any medicine, consult your doctor or pharmacist
Since NSAIDs are excreted via breast milk, it should not be used during breastfeeding.

Driving and using machines

No data to influence the ability to drive and use machines. Information about excipients.
This medicinal product contains lactose, which makes it unsuitable for patients with lactase deficiency, galactosemia or glucose / galactose syndrome malabsorbtsiya.Lekarstveniyat product contains wheat starch as an excipient, which can be dangerous for people with celiac disease.

Taking other medicines

Please tell your doctor or pharmacist if you are taking Goth recently taken any other medicines, even if they have not been prescribed by your doctor. Coadministration with antacids or cholestyramine can delay the absorption of naproxen. Concomitant administration of food can delay the absorption of the product. Due to the high binding of naproxen with plasma proteins, concurrent therapy with hydantoins, anticoagulants, or sulfonamides, also with a high degree of coupling, there is a risk of overdose to these products. Not recommended acceptance of NSAIDs with warfarin or heparin, except under strict medical supervision. No interactions of naprokesn with anticoagulants or sulphonylureas, but caution, as there are potential interactions with other NSAIDs. Natriurichniyat effect of furosemide can be suppressed by products of this class. It has been reported inhibition of renal excretion of lithium and increase its plasma concentration. Naproxen and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers may increase the risk of renal impairment associated with the use of ACE inhibitori.Probenetsid administered simultaneously, increases plasma levels of naproxen and extended plasma half-life. Caution should be used because of methotrexate may increase its toxicity, since naproxen reduces its renal excretion in animal studies. NSAIDs may enhance heart failure, reduce glomerular filtration rate and thus increase plasma levels of cardiac glycosides in combination with cardiac glycosides. As with all NSAIDs, combination with cyclosporine requires caution because of the risk of renal toxicity. NSAIDs should be administered 8-12 days after administration of mifepristone, as they may reduce its effect.

The combination of naproxen with corticosteroids may result in increased risk of bleeding. Should be avoided combination of two or more NSAIDs. Patients taking quinolones are at increased risk of developing convulsions. Treatment with naproxen must be temporarily stopped 48 hours before examination of adrenal function, since it is possible to interfere with some tests for 17-ketosteroids. Similarly, naproxen may interfere with some tests for urinary 5-hydroxy-indole-acetic acid.

3. HOW TO USE naproxen Actavis?

Always take Naproxen Actavis exactly as your doctor or pharmacist! Adults and adolescents over 16 years - 1 tablet every 8-12 hours. You can start with 2 tablets in a single dose followed by administration of 1 tablet after 8-12 hours. The maximum daily dose is 3 tablets.

In elderly patients the dose of 2 tablets per day should not be exceeded.

In patients with mild to moderate renal impairment the dose should be redutsira.Za tablets should preferably be taken after meals. For the relief of pain Naproxen Actavis is taken not longer than 7 days, and for lowering the temperature of - not more than 3 days.

If you take a large amount of the drug:

When taking a higher dose than prescribed immediately consult a doctor! Symptoms - gastrointestinal discomfort, rash, headache, visual disturbances, low blood pressure, kidney failure. Treatment - gastric emptying, administration of alkalinizing agents, activated carbon. It is necessary to ensure monitoring due to the risk of bleeding.

If you forget to take Naproxen Actavis

If you forget to take another dose, take it as soon as possible.

4. POSSIBLE SIDE EFFECTS

Like any other medicine Naproxen Actavis can cause side effects. Actavis drugs such as naproxen may be associated with a small increased risk of heart attack (myocardial infarction) or stroke.

Like other NSAIDs, naproxen Actavis may cause the following side effects:

Common

"Gastrointestinal - nausea, heartburn, vomiting;

"Nervous system - headache, drowsiness, dizziness.

Rare

is Gastrointestinal tract - diarrhea, constipation, bleeding;

Others - allergic reactions (facial edema and angioedema), chills, rashes and itchy skin, peripheral edema, visual disturbances, tinnitus, hearing disorders; Rare or very rare • Gastrointestinal - duodenal ulcer, colitis, stomatitis;

»Hepatobiliary system - jaundice, hepatitis, abnormal liver function;

• Blood - anemia (aplastic or hemolytic), low number of platelets and white blood cells;

• Respiratory system - difficulty breathing, asthma;

Others - photosensitivity, hair loss, bullous rash, increased heart rate, decreased kidney function. As with other NSAIDs may experience severe allergic reactions (anaphylactic and anaphylactoid reactions) in patients with or without previous administration of drugs in this group. The characteristic symptoms are a sudden drop in blood pressure, accelerate or slow heart rate, weakness, restlessness, unconsciousness, difficulty breathing, itching, rash, angioedema, nausea, vomiting, abdominal cramps, diarrhea. If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

5. Storage

At temperatures below 25 ° C. Keep out of reach of children! Do not use after the expiry date stated on the package! Shelf life - 3 (three) years
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