NEOFORMIN. 500 mg. 60 tablets
NEOFORMIN. 500 mg. 60 tablets
Qualitative and quantitative composition :
Metformin 500 mg 850
Sodium starch glycolate, Maize starch, povidone, Colloidal anhydrous silica, Magnesium stearate
Hipromellose, Tilanium dioxide E171, Propylene glycol, Macrogol 6000 , Purified talc
Oral glucose- lowering drugs .
Treatment of type II diabetes mellitus in adults , particularly overweight when only a diet and exercise does not lead to the desired glycemic control.
- Hypersensitivity to Metformin hydrochloride or any of the excipients .
- Diabetic ketoacidosis , diabetic pre- coma.
- Renal failure or renal dysfunction.
- Acute conditions with the potential for impairment of renal function such as:
- Severe Infection
- Intravascular administration of iodinated contrast media
- Acute or chronic disease which can lead to :
- Cardiac or respiratory disease
- Recent myocardial infarction,
- Hepatic failure, acute alcohol intoxication, alcoholism
It is not recommended in combination :
There is an increased risk of lactic acidosis in acute alcohol intoxication , especially in :
- Fasting or impaired absorption of food
- Liver failure
Avoid alcohol or alcohol-containing products.
Iodinated contrast agents:
Intravascular administration of iodinated contrast compounds can lead to renal failure , followed by accumulation of Metformin and the risk of lactic atsedoza .
Taking Metformin should be discontinued prior to the study , during it, and for a period of 48 hours after, the treatment is resumed only after a further assessment of renal function and if the results show normal kidney function .
Combinations requiring precautions :
Glucocorticoids , beta -2 agonists, and diuretics have hyperglycaemic activity . Report that patients and more frequent blood glucose control , especially early in treatment . If necessary, adjust the dose of antidiabetic medication while taking other medicines and their suspension.
ACE - inhibitors may decrease the blood glucose . If necessary, adjust the dose of antidiabetic medication while taking other medicines and their suspension.
Use in pregnant and breastfeeding :
When the patient contemplating pregnancy , or during such , Metformin they should be used for the treatment of diabetes , but requires the application of insulin to maintain blood glucose levels as close to normal in order to reduce the risk of malformation of the fetus , associated with abnormal levels of blood glucose .
Metformin passes into breast milk and reaches levels comparable to those in plasma. It is necessary to discontinue nursing or to switch to another treatment.
Effects on ability to drive and use machines :
Self-administration of Neeoformin not lead to hypoglycaemia, which does not affect the ability to drive and use machines.
However, when combining Metformin with other antidiabetic agents, patients should be warned of the possibility of hypoglycemia.
Information on proper use :
Dosage and frequency of administration
Monotherapy and in combination with other oral antidiabetic agents
- The usual starting dose is one tablet 2 or 3 times daily with meals or after.
After 10 to 15 days the dose should be changes on the results of the measurement of blood glucose . The gradual increase in the dose may improve tolerance by the gastrointestinal tract .
The maximum recommended dose of Metformin is 3 g daily.
- When switching from another oral antidiabetic agent : stopping the other agent and initiate treatment with Metformin with the above dose.
Combination with insulin
Metformin and insulin may be administered in the form of combination therapy to achieve better glycemic control . Metformin is applied in the usual starting dose of 1 tablet 2-3 times a day , while the dose of insulin is adjusted based on the results of the measurement of blood glucose .
Elderly : due to the possibility of a decrease in renal function in elderly patients , the dose of Metformin should be determined on the basis of renal function . There should be regular assessment of renal function.
Children: Due to lack of data , Neoformin should not be used in children .
Symptoms of an overdose, and emergency measures
Hypoglycemia has not been observed at doses up to 85 g Metformin , as in such cases there is lactic acidosis . Acute overdose or other risk factors can lead to the onset of lactic acidosis. Lactic acidosis is a medical emergency medicine and required hospital treatment. Hemodialysis is the most effective method to remove lactate and metformin from the body.
Undesirable effects :
- Gastrointestinal symptoms such as nausea , vomiting, diarrhea , abdominal pain and loss of appetite are very common. They resolve spontaneously . For the prevention of these symptoms are the preferred Metformin happens 2 or 3 times a day, during or after it. The gradual increase in the dose may also improve gastrointestinal tolerability.
- There is often a metallic taste
- In some patients with increased susceptibility was observed mild erythema, the frequency of these effects is very low
- Decrease of vitamin B12 absorption with decrease of serum levels was observed in patients treated continuously with Metformin, but generally not clinically relevant.
- Lactic acidosis is very rare.