Metoprolol. 100 mg. 30 tablets

Metoprolol. 100 mg. 30 tablets
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Metoprolol STADA medicine blocking beta receptor used in the treatment of heart diseases. 

Metoprolol. 100 mg. 30 tablets

What is the Metoprolol STADA and what it is used?

Metoprolol STADA medicine blocking beta receptor used in the treatment of heart diseases .

Metoprolol STADA its used in:

- High blood pressure (hypertension )
- Coronary Artery Disease
- Irregular heart beat ( extrasystole ) and increased heart rate (tachycardia)
- Prophylactic treatment of migraine ( migraine prophylaxis ) .

2 . What you should consider " before taking Metoprolol STADA?

Do not take Metoprolol STADA:
- If you are allergic ( hypersensitive) to Metoprolol or to other beta -blockers , or to any of the excipients.

- If you have severe heart failure ; in the event of a shock ;

- If you have interference in impulse conduction from the atria to the chambers of the heart (II and III degree AV block) ; if you suffer from syndrome sick sinus ; if you have sinoatrial block; for bradycardia (heart rate below 50 beats per minute before starting therapy )

- If you suffer from hypotension (systolic blood pressure lower than 90 mm Hg ) ;

- In the case of acidosis ( increased acidity of the blood) ;

- If you are prone to bronco-obstructive diseases ( asthma , COPD) ;

- In the case of progressive disorders of the peripheral arterial circulation ( arterial occlusive conditions) ; If you take MAOIs ( excluding inhibitors MAO-IS ) .

Metoprolol STADA should be administered with caution in :

? patients have impaired impulse conduction from the atria to the chambers of the heart (patients with first degree AV- block) ;

? diabetics with marked instability of the concentrations of glucose in the blood

? patients undergoing strict diet for long periods of time and those exposed to heavy physical exertion (due to risk of severe hypoglycaemic attack )

? patients with hormone -producing tumor of the adrenal medulla ( pheochromocytoma ) . Metoprolol Stada in these cases can only be used after prior treatment with alpha - blockers )

? patients with impaired liver function (see section 3 . How and when to take Metoprolol STADA?)

Patients with psoriasis or a family history of psoriasis , beta- blockers should be used only after careful consideration of the anticipated benefits against the potential risks.

Beta- blockers may increase sensitivity to allergens and the severity of anaphylactic reactions. Therefore, they should be used only if they are indispensable in patients with a predisposition to severe hypersensitivity reactions and those receiving specific anti-allergic drugs ( due to risk of excessive anaphylactic reactions) .

Warning signs of reduced concentration of blood sugar ( hypoglycemia ) can be masked or attenuated. , So requires regular monitoring of blood sugar ( see Chapter 4 . What are the possible side effects ?) . When wearing contact lenses should be taken into account the reduction in the tear fluid .

Suspension or modification of therapy with Metoprolol Stada is permitted only after prior consultation with your doctor.

If treatment village Metoprolol Stada should be interrupted or discontinued after prolonged use in general medicine should be reduced gradually because abrupt discontinuation can lead to cardiac ischemia (reduced blood supply to the heart muscle) with exacerbation of angina pectoris , myocardial infarction or exacerbation of hypertension (high blood pressure ) .

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any medicines , incl. relaxing drugs without a prescription.

When concomitantly Metoprolol Stada and insulin or oral antidiabetic agents , the effect of the latter may be enhanced or extended ' the symptoms of the reduced concentration of blood sugar ( hypoglycemia ) and particularly rapid heart rate (tachycardia) and tremor (shaking finger Hand ) disguise or weaken . So requires regular monitoring of blood sugar.

Concomitant use of Metoprolol Stada and tricyclic antidepressants , barbiturates, phenothiazines , glyceryl trinitrate , diuretics, vasodilators , or other antidepressants can lead to very low blood pressure . Concomitant Metoprolol Stada with calcium antagonists of nifedipinov type can cause rapid drop in blood pressure and, in isolated cases - the development of heart failure.

Cardiodepressant action Metoprolol Stada and that of antiarrhythmic drugs may be superimposed .

Patients taking concomitant Metoprolol Stada and calcium channel blockers of the verapamil or diltiazem or other antiarrhythmic agents (such as disopyramide ) should be carefully monitored, because the risk of hypotension ( very low blood pressure) , bradycardia or other cardiac arrhythmias :


Treatment with calcium channel blockers of the verapamil or diltiazem , and antiarrhythmics (eg disopyramide ) is contraindicated in patients treated with Metoprolol Stada ( except in intensive care mode ) . Co-administration of Metoprolol Stada and cardiac glycosides , reserpine , alpha -methyldopa , clonidine, guanfacine or clonidine can cause severe slow heart " rhythm or conduction delays cardiac impulse .

The sudden interruption of the use of clonidine in both treatment Metoprolol Stada may lead to excessive increase in pressure 1favnoto . Therefore , when clonidine was administered simultaneously with Metoprolol Stada, should not be interrupted , delayed until the reception of metoprolol was not stopped a few days earlier . Only after that clonidine may be gradually reduced until discontinuation.

Concomitant use of Metoprolol Stada with noradrenaline , adrenaline or other sympathomimetics (eg entering into the composition of medicines cough , nasal drops or eye ) can cause a significant increase in blood pressure.

Patients treated with Metoprolol Stada can react less dose of epinephrine commonly used in the treatment of allergic reactions.
MAOIs must be used simultaneously due to the risk of Metoprolol excessive increase in blood pressure.
Indomethacin and rifampicin may reduce the antihypertensive effect of Metoprolol Stada.
Cimetidine may increase the plasma concentration of Metoprolol Stada
Metoprololat may reduce the excretion of other drugs (eg, lidocaine ) . Concomitant use of Metoprolol Stada and drugs / analgesics may cause very low blood pressure. Negative inotropic effects of these medicines may be superimposed .

Neuromuscular blockade with peripheral muscle relaxants (eg, succinylcholine halide, tubocurarine) can be enhanced by inhibition of beta- receptors of Metoprolol Stada.

If Metoprolol Stada can not be stopped before procedures requiring general anesthesia or prior use of peripheral muscle relaxants, the anesthetist should be informed of its use.

Please note that this information applies when you are taking these medicines recently.

Pregnancy and lactation

Please refer to - your doctor before taking any medicine.


Metoprololat can be used during pregnancy only after careful assessment of the expected benefits against the potential risks of treating physician , as there are currently no adequate information on its use in pregnant women.

Metoprolol crosses the placenta and reduced placental perfusion which can lead to damage of the fruit.

Treatment with metoprolol should be discontinued 48-72 hours before the estimated date of birth, if this is not possible, the newborn should be monitored closely during the first 48-72 hours after birth for signs of ' beta- blockade.


Metoprololat is excreted in breast milk. Infants should be monitored for signs of beta- blockade , although side effects were observed in accordance with the therapeutic dosage.

The amount of metoprolol, taken with milk may be reduced to the lowest possible level by refraining from breastfeeding 3-4 hours after taking this medicine.

Effects on ability to drive and use machines

Patients taking this drug should be under constant medical supervision . Individually different reactions can alter attention to such an extent as to impair the ability to actively participate in road traffic, operating machinery or working on unstable platforms . This is especially true for the beginning of treatment , increasing the dose or abrupt change of treatment , and the concomitant use of alcohol.

Important information about some of the ingredients of Metoprolol STADA

This medicine contains lactose (milk sugar). If you receive information from your doctor that you ' have an intolerance to some sugars , consult with him before taking Metoprolol STADA.

3 . How and when to take Metoprolol STADA?

Always take Metoprolol STADA exactly as prescribed by your doctor. Please consult your doctor or pharmacist if you are unsure. The usual dose is :

The dose should be adjusted individually - in particular in relation to therapeutic response - and should not be changed unless specifically instructed by the doctor.

The usual dose is :

High blood pressure (hypertension )

1/2 tablet of Metoprolol Stada once or twice daily, or 1/2-1 tablets once per day (equivalent to 50-100 mg daily metoprolol tartrate ) . If necessary , the daily dose may be increased to 1 tablet twice daily ( equivalent to 200 mg metoprolol tartrate per day).

Ischemic heart disease :

1/2 tablet of Metoprolol Stada once or twice daily, or 1/2-1 tablets once per day (equivalent to 50-100 mg daily metoprolol tartrate ) . If necessary , the daily dose may be increased to 1 tablet twice daily ( equivalent to 200 mg metoprolol tartrate per day).

Irregular heart beat ( extrasystole ) and increased heart rate (tachycardia ):

1/2 tablet of Metoprolol Stada once or twice daily, or 1/2-1 tablets once per day (equivalent to 50-100 mg daily metoprolol tartrate ) . If necessary , the daily dose may be increased when the blood pressure monitor 1 tablet twice daily ( equivalent to 200 mg metoprolol tartrate per day).

Prophylactic treatment of migraine ( migraine prophylaxis ): 1 tablet of Metoprolol Stada once or twice daily ( eq. of 100-200 mg a day metoprolol tartrate ) .

Patients with impaired hepatic function

In patients with severe hepatic dysfunction , Metoprolol Stada elimination is delayed and therefore the dosage should be reduced.

Method of administration

The tablets should be swallowed whole with plenty of water after a meal. Unless otherwise specified , a single dose Metoprolol should be taken in the morning and the twice - morning and evening

How to share Metoprolol STADA tablets (STADA Vario-Tabs ®)?

For easy and accurate dispensing tablets Metoprolol STADA are available in a new tablet form (STADA Vario-Tab ® technology). The tablets can be separated by breaking them in half with the other hand such a tablet , or by placing them on a hard level surface with the groove upward and thumb pressure , wherein the tablet will be divided into four equal parts.

Duration of treatment

The duration of treatment should be determined by your doctor . Please consult your doctor if you have the impression that the effect of Metoprolol STADA is too strong or too weak .

What should you do in case of an overdose ( intentional or unintentional ) of Metoprolol Stada?

In case of suspected overdose , please tell your doctor who will decide on the necessary measures.

Depending on overdose may cause severe hypotension , bradycardia, to the point of cardiac arrest, heart failure and cardiogenic shock. Other signs of overdose may include difficulty breathing , bronchospasm , vomiting, clouding of consciousness , and in isolated cases - . Generalized seizures .

In case of overdose or very slow heart rate and / or blood pressure lowering treatment with Metoprolol Stada must be stopped.

What should you do if you take more than the prescribed dose or you miss a dose ?

Continue with Metoprolol Stada as prescribed and do not take a double dose after dose.

What should you do if you interrupt or stop treatment prematurely ?

Treatment with Metoprolol Stada may be interrupted or suspended only by prescription. Abrupt stopping can cause myocardial ischemia by exacerbation of angina ( angina ) , myocardial infarction , or an increase in blood pressure .

If you have any questions about using this medicine , consult your doctor or pharmacist.

4 . What are possible side effects?

Like other drugs Metoprolol STADA can cause side effects , although not everyone gets them.


Rare excessive lowering of blood pressure.

Very rare: weight gain, increases in serum transaminases (GOT, GPT).

Cardiovascular system

Rare Palpitations , bradycardia, conduction disorders or exacerbation of heart failure with peripheral edema and / or dyspnea on exertion .

Very rare deterioration of anginal attacks in subjects suffering from angina pectoris induced by coronary artery spasm .

Blood and lymphatic system

Very rare: Thrombocytopenia or levkopekiya .


Uncommon especially during initiation of therapy may be disturbed in the central nervous system such as fatigue , depression , dizziness, confusion, headache , sweating , nightmares or abnormal increased activity of dreaming , sleep disturbances and hallucinations , paraesthesia . Rare Syncope .


Rare conjunctivitis or reduced tear secretion (to be considered in patients wearing contact lenses) . Very rare: visual disturbances .

Ear and labyrinth

Very rare: Hearing impairment and tinnitus .

Respiratory, thoracic and mediastinal
Very rare: allergic rhinitis.

Not frequency : Patients with bronchospastic disease ( especially those with obstructive airway disease ) can obtain apnea, because this drug increases airway resistance .

Gastro intestinal disturbances
Uncommon: Possible occurrence of transient gastrointestinal symptoms , incl. nausea , vomiting , abdominal pain, constipation and diarrhea Rare Dry mouth .

Renal and urinary disorders

Very rare: Since patients with severe renal failure in individual cases deterioration of renal function during treatment with beta blockers , treatment with Metoprolol Stada must be accompanied by special monitoring function.

Skin and subcutaneous tissue

Uncommon: Allergic skin reactions ( erythema , pruritus , exanthema , photosensitivity ) .

Very rare: beta-blockers in isolated cases may provoke or worsen psoriasis or induce psoriasiform skin rash , alopecia .

Musculoskeletal system and connective tissue
Rare Muscle weakness or cramps.

Very rare: Prolonged use of Metoprolol Stada has been associated with arthropathy (- mono or polyarthritis ) .

endocrine disturbances

Not known : Metoprolol STADA can " mask " the symptoms of hyperthyroidism .

Metabolism and nutritional disturbances

Rare: It is " unlock " latent diabetes or worsening of the symptoms one. Patients complying with the absolute diet long period of time , and those subjected to great physical stress can obtain hypoglycaemia if used at the same time Metoprolol Stada. The warning signs of hypoglycemia ( in particular tachycardia and tremor) may be masked .

Not known : Treatment with Metoprolol 'Stada may be associated with disruption of lipid metabolism. While total cholesterol was generally normal , HDL- cholesterol was reduced and plasma triglycerides were elevated .

vascular disturbances

Unknown: There were isolated reports of worsening of symptoms in patients with impaired peripheral circulation ( including patients with Raynaud's syndrome ) . : Common disorders

Uncommon: Feeling cooling of the extremities.

immune system

Not known: beta-blockers may enhance susceptibility to allergens and the severity of anaphylactic reactions. Patients with a history of severe hypersensitivity reactions and those of specific immunotherapy / desensitization can get excessively strong anaphylactic reactions.

Hepatobiliary disorders
Very rare: hepatitis.

reproductive system

Very rare libido disorders and impotence , induration of the penis ( Peyronie's disease ) .

psychiatric disorders

Very rare: Personality changes (eg, emotional lability, short term memory loss ) .

If any of the above side effects get worse or if you encounter any side effects not listed in this leaflet patient , please report it to your doctor or pharmacist.

5 . How should I store Metoprolol STADA?
Keep out of reach of children !

Metoprolol STADA not use after the expiry date printed on the box and blister.

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