Memantine. 10 mg. 28 tablets

ACTAVIS
Memantine. 10 mg. 28 tablets
€ 45.00
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Memantine Accord belongs to a group of medicines known as anti-dementia drugs. Memory loss in Alzheimer's disease is due to a disturbance of message signals in the brain. The brain contains so-called N-methyl-D-aspartate (NMDA)-receptor involved in the transmission of nerve signals, which are important for learning and memory. 

Memantine. 10 mg. 28 tablets

 
 
What Memantine Accord and what it is used
How does Memantine Accord:
Memantine Accord belongs to a group of medicines known as anti-dementia drugs. Memory loss in Alzheimer's disease is due to a disturbance of message signals in the brain. The brain contains so-called N-methyl-D-aspartate (NMDA)-receptor involved in the transmission of nerve signals, which are important for learning and memory.
Memantine Accord belongs to a group of medicines called NMDA-antagonist receptors. Memantine Accord acts on these NMDA-receptors such as improving the transmission of nerve signals and the memory.

For what use Memantine Accord:
Accord Memantine is used for treatment of patients with moderate to severe Alzheimer's disease.

2. What you should know before taking Memantine Accord
Do not take Memantine Accord:
If you are allergic to memantinov hydrochloride or any of the other ingredients of this medicine (listed in Section 6).
Warnings and Precautions
Talk to your doctor or pharmacist before taking Memantine Accord:
If you have a history of epileptic seizures;
If you have recently experienced a myocardial infarction (heart attack) or if you are suffering from congestive heart failure or hypertension (high blood pressure).
In these situations the treatment should be carefully monitored and the clinical benefit of memantine Accord be determined by your doctor.
If you have renal impairment (kidney problems), your doctor should closely monitor your kidney function and if necessary adapt the memantine doses accordingly.
Taken at the same time of medicines amantadine (for the treatment of Parkinson's disease), ketamine (a substance which is generally used as an anesthetic), dextromethorphan (generally used for treatment of cough) and other NMDA-antagonists should be avoided.

Children and adolescents
Accord memantine is not recommended in children and adolescents under 18 years.

Other medicines and Memantine Accord
Tell your doctor or pharmacist if you are taking, have recently taken or might take other medicines.

In particular, Memantine Accord may alter the effects of these drugs and may be necessary for your doctor to adjust their dose:
amantadine, ketamine dextramethorphan;
dantrolene, baclofen;
cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine;
hydrochlorothiazide (or any combination with hydrochlorothiazide);
anticholinergic agents (substances that are generally used to treat movement disorders or intestinal cramps);
anticonvulsants (substances to be used for the prevention or treatment of seizures);
barbiturates (substances that are commonly used to induce sleep);
dopaminergic agonists (substances such as L-dopa, bromocriptine);
neuroleptics (substances that are used to treat psychiatric disorders);
oral anticoagulants.
If you go into hospital, let your doctor that you are taking Memantine Accord.

Memantine Accord with food and drink
Tell your doctor if you have recently changed or intend to change your diet (eg from normal diet to strict vegetarian diet) or if you suffer from renal tubular acidosis (RTA), an excess of acid-forming substances in the blood due to renal dysfunction (poor kidney function)) or severe infections of the urinary system (urinary tract), as may be necessary to adjust the dose of the drug.

Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
Tell your doctor if you are pregnant or plan to become pregnant. Memantine is not recommended for use in pregnant women.
Women taking memantine Accord, should not breastfeed.

Driving and using machines
The doctor will tell you whether your illness allows you to safely drive or operate machinery.
Moreover Memantine Accord can change your reactivity, making driving or operating machinery.

Memantine Accord contains lactose.
This medicinal product contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicine for advice.

3. How to take Memantine Accord
Always take this medicine exactly as your doctor tells you. If you are not sure, ask your doctor or pharmacist.

dosage
The recommended dose Memantine Accord for adults and elderly patients is 20 mg once daily. To reduce the risk of side effects this dose is achieved gradually by the following daily schedule:
Week 1: half a tablet of 10 mg;
Week 2: one tablet of 10 mg;
Week 3: one and a half tablet of 10 mg;
week 4, then: 2 tablets of 10 mg once a day.
The usual starting dose is half a tablet once a day (1 x 5 mg) in the first week. This is increased to one tablet once per day (1 x 10 mg), and in the second week to 1 ½ tablet per day (1 x 15 mg) for the third week. From the fourth week on, the usual dose is 2 tablets once daily (1 x 20 mg).

Dosage in patients with impaired renal function
If you have impaired kidney function, your doctor will decide what dose is appropriate for your condition. The doctor will monitor your kidney function at regular intervals.

application
Accord Memantine should be administered orally once daily. To benefit from your medicine, you should take it regularly every day at the same time of day. The tablets should be swallowed with some water. The tablets can be taken with or without food.

Duration of treatment
Taking Memantine Accord long as it is of benefit to you. Your doctor should assess your treatment on a regular basis.

If you take more dose Memantine Accord
Usually taking too much Memantine Accord should not harm you. You may experience increased symptoms as described in section 4. "Possible side effects".
If you take Memantine Accord at a dose much higher than prescribed, contact your doctor or seek medical advice, as you may need medical attention.

If you forget to take Memantine Accord
If you find that you forgot to take your dose Memantine Accord, wait and take your next dose at the usual time.
Do not take a double dose to make up for a missed dose.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Usually, the observed side effects are mild to moderate.

Common (may affect up to 1 in 10 people):
Headache, drowsiness, constipation, elevated liver function tests, dizziness, balance disorder, asthma, high blood pressure and drug hypersensitivity.
Uncommon (may affect up to 1 in 100 people):
Fatigue, fungal infections, confusion, hallucinations, vomiting, abnormal gait, heart failure and venous blood clotting (thrombosis / thromboembolism).
Very rare (may affect up to 1 in 10,000 people):
Seizures.
Not known (data can not be estimated frequency):
Inflammation of the pancreas, liver inflammation and psychotic reactions.
Alzheimer's disease is associated with depression, suicidal thoughts and suicide attempts. These events have been reported in patients treated with memantine.

If you get any side effects, tell your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Adverse event reporting
If you get any side effects, tell your doctor or pharmacist. This includes all listed in this leaflet. You can also report side effects directly through the national system of communication. As reported side effects, you can do your bit to get more information on the safety of this medicine.

5. How to store Memantine Accord
Keep out of reach of children.
Do not use Memantine Accord after the expiry date stated on the carton and blister after "EXP". The expiry date refers to the last day of that month.
This medicinal product does not require any special storage conditions.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Contents of the pack and other information
What does Memantine Accord
The active substance is memantinov hydrochloride. Each tablet contains 10 mg of memantinov hydrochloride equivalent to 8,31 mg memantine.
The other ingredients are lactose monohydrate, microcrystalline cellulose, silica, colloidal anhydrous, crospovidone, magnesium stearate - in the tablet core; hypromellose, polysorbate 80, macrogol 400, titanium dioxide (E 171) - in the tablet coating.

Memantine Accord looks like and contents of the pack
Memantine Accord coated tablets are white, oblong, coated, scored, debossed with "MT" of one divided by the score and "10" on the other side, separated by a score line. The tablet can be divided into two equal doses.
Memantine Accord coated tablets are available in blister packs (PVC / PE / PVDC-aluminum blister) of 14 tablets, 28 tablets, 30 tablets, 42 tablets, 50 tablets, 56 tablets, 98 tablets, 100 tablets and 112 tablets.
Not all pack sizes may be marketed.
 
 
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