MONODILAT. 20 mg. 50 tablets

MONODILAT. 20 mg. 50 tablets
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MONODILATE dilates blood vessels (arterial, venous and coronary) and prevents spasm of the coronary vessels. Thus reducing the need for and increasing the supply of oxygen to the heart muscle.
Reduces the peripheral vascular resistance and leads to a lowering of blood pressure.

MONODILAT. 20 mg. 50 tablets

 
 
COMPOSITION
Drug in one tablet MONODILATE 20 mg: Isosorbide mononitrate 20 mg.

Excipients: lactose monohydrate, corn starch , magnesium stearate, talc .
 
PHARMACEUTICAL FORM AND CONTENTS
Tablets.
MONODILATE 20 mg. 10 pieces in blister PVC / aluminum foil. 5 blisters per pack.

 
ACTION
MONODILATE dilates blood vessels ( arterial, venous and coronary ) and prevents spasm of the coronary vessels. Thus reducing the need for and increasing the supply of oxygen to the heart muscle.
Reduces the peripheral vascular resistance and leads to a lowering of blood pressure.
 
INDICATIONS
- Coronary artery disease - prevention and long-term treatment of angina pectoris ;
- In the complex treatment of heart failure ( left-sided and two-sided ) .
 INFORMATION NECESSARY BEFORE USE
 
 
 
CONTRAINDICATIONS
- Hypersensitivity to the active substance or to any of the ingredients contained in the product as well as other drugs of this group;
- Hypertrophic obstructive cardiomyopathy.
 
 
SPECIAL PRECAUTIONS FOR USE
Due to the risk of severe hypotension ( drop in blood pressure), especially when you stand at the start of treatment with MONODILATE, close monitoring blood pressure ! This is particularly important in patients treated with other antihypertensives ( medicines for lowering the blood pressure ) products.
Prolonged treatment with MONODILATE can lead to development of nitrate tolerance ( tolerance to the drug ) , manifested by a decrease in the therapeutic effect , or need a progressive increase of the dose for maintenance of this effect .
Treatment with high doses MONODILATE should not be discontinued abruptly.
Interactions
Concurrent administration with Sildenafil (Viagra) is absolutely contraindicated because of the risk of severe hypotension (one effect) , the risk of deterioration in cardiac Dew and risk of acute cardiovascular event .
Coadministration of MONODILATE with antihypertensive ( blood pressure lowering ) drugs , other vasodilators ( sadorazishryavashti ) and diuretics (water ) leads to mutually enhance the blood pressure lowering effect . Alcohol and MONODILATE mutually reinforce their effects . Sympathomimetic may reduce the therapeutic effect MONODILATE.
 
WARNINGS in special patient groups
Be used with caution in patients with acute myocardial infarction or congestive heart nedostatachost due to the risk of serious decrease in blood pressure and fast heart rate . Treatment with nitrate (particularly MONODILATE) may enhance the pain symptoms by the heart in patients with hypertrophic cardiomyopathy.
 
Pregnancy and lactation
Not recommended treatment MONODILATE during pregnancy unless the potential benefit outweighs the risk.
No data are available for the transmission of MONODILATE in breast milk. Recommended termination of breast-feeding during treatment.
 
EFFECTS ON ABILITY TO DRIVE AND USE MACHINES
Treatment with MONODILATE not affect the ability to drive and use machines.
 
OTHER DATA ON INGREDIENTS
This medicinal product contains lactose and is therefore unsuitable for people with lactase deficiency, galactosemia or glucose / galactose malabsorption .
Due to the presence of wheat starch , the product may be dangerous for people with celiac disease (gluten enteropathy ) .
 
INFORMATION FOR PROPER USE ;
 
DOSAGE AND METHOD OF USE
The dosage and length of treatment is determined by the doctor !
adults:
Typical dose : 20-40 mg, 2 times a day during 7 hr.
children:
In children, the safety and effectiveness has not been proven .
 
 
OVERDOSE
Overdose with MONODILATE can lead to two types of clinical manifestations :
- Collapse due to dilation of blood vessels and drop in blood pressure - flushing, palpitations, hypotension , severe headache , fever and rarely seizures ;
- Methaemoglobinaemia ( changes in the blood) and cyanosis ( bluish ) - tension in head , tiredness, weakness , impaired respiration .
Treatment: Held by a doctor in a hospital . Make a gastric lavage , held intensive symptomatic treatment and monitoring of cardiac and breathing.
 
SIDE EFFECTS
If any of the side effects or other adverse events during treatment should tell your doctor !
Most side effects of treatment with MONODILATE are dose-dependent and due to the vasodilatory effect.
Headache , which occurs early in treatment an indicator of therapeutic effect and does not require dose modification or discontinuation. Successful affected by aspirin or acetaminophen and gradually regresses during the course of treatment.
There are transient episodes of dizziness , usually in relation to changes in blood pressure . Rarely can a severe hypotension, which require discontinuation of treatment.
Very rarely MONODILATE can cause methemoglobinemia ( change in the composition of the blood) , severe flushing or fast heart beat .
STORAGE
Dry and protected from light , at temperatures below 25 ° C. Keep out of reach of children!
 
SHELF LIFE
4 (four ) years from date of manufacture.
The product should not be used after the expiry date stated on the packaging.
 
 
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