MILURIT. 300 mg. 30 tablets
MILURIT. 300 mg. 30 tablets
What's in your medicine
Each tablet contains 300 mg of Milurit 300 mg of drug substance allopurinol.Sadarzha more of microcrystalline cellulose , sodium starch glycolate , gelatin , colloidal anhydrous silietsiev dioxide, magnesium stearate.
Milurit belongs to a group of drugs that are useful for the treatment of metabolic disorders known as gout . Cause of gout is a high content of uric acid in the blood. When it is high, the uric acid crystals formed , which are frequently in the joints . Therefore, the movements are very painful . Milurit works by reducing or at least controlling the amount of uric acid formed in the body. The drug does not eliminate the cause of gout , but helps prevent painful gout attacks.
2 . When should you take Milurit ?
Should not be picking Milurit if you are pregnant , trying to become pregnant or breastfeeding , or if you have previously shown hypersensitivity ( allergic) reaction to drug allopurinol, or if you have swelling of the face or lips after taking allopurinol. If you suffer from severe liver or kidney disease, or if someone in your family suffers from idiopathic hemochromatosis , also should not take this medicine.
Treatment with allopurinol should not be started during an acute attack of gout , but if the onset occurs after initiation of treatment with Milurit , it can proceed with the implementation so far dose. Treatment of seizures on the other hand , will be determined by your doctor.
To avoid acute attacks of gout that allopurinol can cause , doctors recommend the adoption of an NSAID or colchicine with allopurinol, at least a month at the beginning of treatment with allopurinol.
3 . Precautions before you start taking the tablets
It is important to tell your doctor about the medicines you are taking , even those bought without a prescription. Before you start taking Milurit , consider :
- You are taking warfarin, a medicine used to reduce blood clotting ?
- You are taking drugs such as 6-mercaptopurine and azathioprine for the treatment of tumor diseases ?
- Do you suffer from diabetes , and whether you are taking chlorpropamide ?
- You are taking another medicine to treat gout such as probenecid ?
- You are taking aspirin or other salicylates ?
If the answer to either question is positive or if you are not sure of the answer, tell your doctor lekar.Informirayte if you suffer from kidney or liver disease . He may decide to investigate renal or hepatic function before and after starting treatment with allopurinol.
4 . Precautions during treatment
During the first weeks of treatment may occur swelling of the face, extremities , lips, oral mucosa , tongue , pharynx and / or larynx . If this happens, do not take any medication and consult your lekar.Ako occur any allergic reaction such as rash or itching or get a fever , or muscle pain , tell the attending lekar.Lechenieto with allopurinol is not absolute indicated if the level of uric acid in the blood is high, but no complaints . This drug can be administered to children , for the treatment of secondary hyperuricemia associated with malignancies of the hematopoietic system or of tumor diseases as well as in enzymatic disorders ( where elevated levels of uric acid are the result of treating or liver enzyme abnormalities ) . During treatment are recommended to take plenty of fluids. The volume of urine is to be not less than 2 liters per day . Liver function tests should be performed regularly at the beginning of treatment ( first 6-8 weeks). Women of childbearing age should be aware that this drug can cause fetal harm . They should inform their physician and seek advice . Let your doctor know if you are on dialysis during treatment with Milurit . He may recommend a dose of 300-400 mg after each hemodialysis.
5 . What other medicines can affect treatment Milurit ?
Medicinal product can be administered with caution in conjunction with :
- 6 - mercaptopurine , azathioprine,
- Antitumor drugs ( increased risk of damage to the hematopoietic system)
- Chlorpropamide (due to increased risk of permanently low blood sugar in cases of impaired renal function)
- Sulfinpyrazone ( reduces the effectiveness of allopurinol)
- Theophylline ( high content of allopurinol inhibits the excommunication of theophylline)
6 . Driving or operating machines during treatment with Milurit
Allopurinol treatment should not interfere with the daily activities. As may occur fatigue, general weakness, and / or visual disturbances , be cautious when carrying out activities with an increased risk of accidents.
7 . dosage
The dose of allopurinol is chosen individually for each patient . You'll start with a low dose which will gradually increase as recommended by the doctor to achieve the maximum benefit from lechenieto.Obiknoveno appointed the following dosages :
In adults, the initial dose is 100-300 mg once daily. If necessary, your doctor will increase the daily dose of 100 mg, as the next level of uric acid in the blood every 1-3 weeks to achieve better therapeutic rezultat.Poddarzhashtata daily dose is 200-600 mg, the maximum daily dose is 800 mg.Ako daily dose is more than 300 mg, it should be divided into 2-4 with equal doza.Edin two days before the start of antitumor therapy should begin treatment with allopurinol at a dose of 600-800 mg daily which may continue for 2-3 days . Maintenance doses depend on the level of uric acid in the blood.
For children with an increased level of uric acid in the blood due to malignancies of the hematopoietic system or of tumor diseases as well as in enzymatic disorders are commonly treated with 10-20 mg / kg body weight.
Patients with advanced age gives a lower dose Milurit in case of renal or hepatic insufficiency , due to the higher risk of toxicity .
Drug should be taken after meals with plenty of fluid.
If you accidentally take too many tablets or if you suspect that someone else has taken the medicine , contact your doctor. Take any remaining tablets and this leaflet to show the doctor .
8 . Possible side effects
They occur in rare cases , mainly in patients with impaired renal function or hepatic zabolyavaniya.Sarbezh , skin damage and minor bleeding are the most common side effects that may occur at any time during treatment. In such cases, treatment should be stopped immediately . If skin changes improvement after cessation of treatment, it can be started again , but with lower doses ( 5 mg / kg ) and followed by a gradual increase in the dose. If skin changes reappear allopurinol is stopped immediately and no longer applies .
In very rare cases can occur severe skin damage , accompanied by fever, joint pain , enlarged lymph nodes and changes in the number of red blood cells. In these cases, allopurinol is stopped and no longer applies . These reactions occur mainly in patients with kidney and liver disease and can be treated with kortikosteroidi.V isolated cases may occur nausea and vomiting , but it preodobyava the drug is taken after meals.
Can sometimes appear abnormal hepatic function (can be jaundice , yellowing of skin and whites of the eyes) . Your doctor may do blood tests. There may be changes in the number of blood cells and some blood components similar to those in inflammation or kidney and / or liver drob.Ako experience any of the above events occur , or if any other side effects not mentioned in this leaflet , you should inform your doctor !
The expiry date of the medicine is printed on the carton.
You should not use it after that date.
Keep at temperatures below 30 C, in the original packaging.
KEEP all medicines out of reach of children !