MEMIGMIN. 10 mg. 14 tablets

MEMIGMIN. 10 mg. 14 tablets
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Memigmin is the group of medicines known as anti-dementia drugs. Memory loss in Alzheimer's disease is due to a disturbance of message signals in the brain. The brain contains so-called receptors of the N-methyl-D-aspartate (NMDA), involved in the transmission of nerve signals, which are important for learning and memory. 

MEMIGMIN. 10 mg. 14 tablets

What Memigmin and what it is used
How does Memigmin
Memigmin is the group of medicines known as anti-dementia drugs. Memory loss in Alzheimer's disease is due to a disturbance of message signals in the brain. The brain contains so-called receptors of the N-methyl-D-aspartate (NMDA), involved in the transmission of nerve signals, which are important for learning and memory. Memigmin belongs to a group of medicines called NMDA receptors. Memigmin acts on these NMDA receptors, improving the transmission of nerve signals and the memory.

What is it used Memigmin
Memigmin used for treatment of patients with moderate to severe Alzheimer's disease.

2. What you should know before taking Memigmin
Do not take Memigmin
if you are allergic to memantinov hydrochloride or any of the other ingredients of this medicine (listed in Section 6).
Warnings and Precautions
If you have epileptic seizures;
if you have recently had a myocardial infarction (heart attack) or if you are suffering from congestive heart failure or hypertension (high blood pressure).
In these cases, treatment should be carefully monitored and the clinical benefit of Memigmin be regularly reassessed by your doctor.
If you have renal impairment (kidney problems), your doctor should closely monitor your kidney function and, if necessary, adjust the memantine doses accordingly.
The use of medicinal products amantadine (for the treatment of Parkinson's disease), ketamine (a substance which is generally used as an anesthetic), dextromethorphan (generally used for treatment of cough) and other NMDA antagonists, should be avoided.
Tell your doctor if you have recently changed or intend to change your diet (eg from normal diet to strict vegetarian diet) or if you suffer from renal tubular acidosis (RTA, an excess of acid-forming substances in the blood due to renal dysfunction (malfunction kidney)) or severe infections of the urinary system (urinary tract), as may be necessary to adjust the dose of the drug.

Children and adolescents
Memigmin not recommended in children and adolescents under 18 years.
Other medicines and Memigmin
Tell your doctor or pharmacist if you are taking, have recently taken or might take other medicines.

In particular, Memigmin can change the action of these drugs and may be necessary for your doctor to adjust their dose:
amantadine, ketamine dextramethorphan;
dantrolene, baclofen;
cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine;
hydrochlorothiazide (or any combination with hydrochlorothiazide);
anticholinergic agents (substances that are generally used to treat movement disorders or intestinal cramps);
anticonvulsants (substances that are used to prevent or relieve seizures);
barbiturates (substances that are commonly used to induce sleep);
dopaminergic agonists (substances such as L-dopa, bromocriptine);
neuroleptics (substances that are used to treat psychiatric disorders);
oral anticoagulants.
If you go into hospital, let your doctor that you are taking Memigmin.

Pregnancy and lactation
If you are pregnant or breast-feeding, you may be pregnant or planning to become pregnant, talk to your doctor before taking this medicine.
Memantine is not recommended for use in pregnant women.
Women taking Memigmin should not breastfeed.

Driving and using machines
The doctor will tell you whether your illness allows you to safely drive or operate machinery. Moreover Memigmin can change your reaction, which creates danger when driving or operating machinery.

Memigmin contains lactose
This medicine contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact him / her before taking this medicine.

3. How to take Memigmin
Always take this medicine exactly as your doctor tells you. If you are not sure, ask your doctor or pharmacist.

Memigmin recommended dose for adults and elderly patients is 20 mg once daily.

To reduce the risk of side effects this dose is achieved gradually by the following daily schedule:
week 1 half a tablet of 10 mg (1 x 5 mg) once daily
week 2 one tablet of 10 mg (1 x 10 mg) once daily
week 3 and one half of a tablet and 10 mg (1 x 15 mg) once daily
week 4, and then
2 tablets of 10 mg (1 x 20 mg) once daily

Dosage in patients with impaired renal function
If you have impaired kidney function, your doctor will decide what dose is appropriate for your condition. The doctor will monitor your kidney function at regular intervals.

Method of administration
Memigmin should be administered orally once daily. To benefit from your medicine, you should take it regularly every day at the same time of day. The tablets should be swallowed with some water. The tablets can be taken with or without food.

Duration of treatment
Taking Memigmin long as it is of benefit to you. Your doctor should assess your treatment on a regular basis.

If you take more dose Memigmin
Usually taking too much of Memigmin should not harm you. You may experience increased symptoms as described in section 4. "Possible side effects".
If you accept Memigmin at a dose much higher than prescribed, contact your doctor or seek medical advice, as you may need medical attention.

If you forget to take Memigmin
If you find that you forgot to take your dose Memigmin, wait and take the next dose at the usual time.
Do not take a double dose to make up for a missed dose.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, Memigmin can cause side effects, although not everybody gets them.

Usually, the observed side effects are mild to moderate.
Common (may affect less than 1 in 10 people):
headache, drowsiness, constipation, elevated liver function tests, dizziness, balance disorder, asthma, high blood pressure and drug hypersensitivity.
Uncommon (may affect less than 1 in 100 people):
fatigue, fungal infections, confusion, hallucinations, vomiting, abnormal gait, heart failure and blood clots in the veins (thrombosis / embolism).
Very rare (may affect less than 1 in 10,000 people):
Not known (data can not be estimated frequency):
inflammation of the pancreas, liver inflammation (hepatitis) and psychotic reactions.
Alzheimer's disease is associated with depression, suicidal thoughts and suicide attempts. These events have been reported in patients treated with Memigmin.

If any of the side effects gets serious, or you notice other effects not listed in this leaflet, tell your doctor or pharmacist.

5. How to store Memigmin
Keep out of reach of children.
Do not use this medicine after the expiry date stated on the carton and blister after "EXP". Expiry date refers to the last day of that month.
This medicinal product does not require any special storage conditions. Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Additional Information
What does Memigmin
The active ingredient is memantinov hydrochloride. Each tablet contains 10 mg memantinov hydrochloride, corresponding to 8,31 mg of memantine.
Other ingredients are: microcrystalline cellulose, lactose monohydrate, povidone 30, talc, silica, colloidal anhydrous, magnesium stearate - in the tablet core; and hypromellose, titanium dioxide (B171) and macrogol 400 - in the tablet coating.

Memigmin looks like and contents of pack
Memigmin film-coated tablets are white to off-white, oblong, biconvex, scored on both sides. The tablet can be divided into equal doses.
The film-coated tablets Memigmin are available in blister packages of PVC-PE-PVDC/Al, containing 7, 14, 28, 30, 42, 49, 50, 56, 70, 84, 98, 100 or 112 tablets.
Not all pack sizes may be marketed.
€ 35.00
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