LEPONEX 100 mg. 50 tablets

NOVARTIS
LEPONEX 100 mg. 50 tablets
€ 35.00
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LEPONEX is an antipsychotic (sometimes called neuroleptics) and belongs to a group of medicines known as dibenzodiazepines.

LEPONEX table. 100 mg. 50 tab
 
What LEPONEX and what it is used?
LEPONEX tablets contain the active ingredient clozapine and are available in two strengths:
 

A tablet of 100 mg:
 
Yellow, round, flat tablet with a bevelled edge. Inscription "Z / A" with a slash on one side and "SANDOZ" in one line on the other.
 
Furthermore, the tablets contain the following inactive ingredients: lactose monohydrate, maize starch, povidone, colloidal silicon dioxide, magnesium stearate and talc.
Both tablets are available in packs containing 50 tablets.


LEPONEX is an antipsychotic ( sometimes called neuroleptics ) and belongs to a group of medicines known as dibenzodiazepines .
Clozaril is used to treat people suffering from schizophrenia . It is used for treatment of humans , who have received at least two other antipsychotic drugs are either not tolerated antipsychotics because of side effects.
Clozaril is also used to treat severe thought disturbances in patients with Parkinson's disease when other treatment had failed .
 
blood tests
 
Before starting treatment with Clozaril you will have a blood test to make sure that you take this medicine.
 
You will have regular blood tests while still taking Clozaril , and if you stop Clozaril for four weeks thereafter. Your doctor will tell you when and where you will have research. They will be performed weekly for the first few months, but may later be reduced to every two weeks. Once you've been on Clozaril for a year , it may be necessary for you to have blood tests every four weeks. It is important not to miss these studies as to your safety , your doctor can not prescribe more tablets. Your co-operation with the blood testing is essential.
 
 
 
2 . Before taking LEPONEX tablets
 
Clozaril will be given to you if you are unconscious .
 
Tell your doctor if any of these statements apply to you:
 
• If you are taking this medicine and you were allergic to it or it hurt you , or any of the other ingredients in the tablet are harmful.
 
• If you are unable to undergo regular blood tests .
 
• If you have ever had low white blood cell count (including after taking Clozaril ), unless it was after cancer treatment.
 
• If you have or have previously suffered from a disease of the bone marrow.
 
• If you suffer from epilepsy ( seizures, convulsions or seizures).
 
• If you have problems with alcohol or substance abuse , eg . Drugs.
 
• If you suffer from any severe heart, liver or kidney problems . If you have ever had a severe disease affecting the heart, it may be necessary to contact a professional .
 
• If you suffer from severe constipation , intestinal blockage , or any other condition that has affected your large intestine.
 
• If you have glaucoma ( an eye disorder) .
 
• If you have diabetes.
 
• If you have difficulty urinating due to an enlarged prostate gland.
 
• If you have an intolerance to certain sugars , eg . lactose.
 
Tell your doctor if you are taking any of the following :
 
- Drugs to treat high blood pressure , e. metoprolol kaltopril
 
• Medicines to treat depression , for example . Fluvoxamine , paroxetine, phenelzine, citalopram
 
• Some antipsychotic drug given by injection , for example . flupenthixol decanoate, fluphenazine decanoate
 
• Benzodiazepines ( tranquillizers ) or sleeping pills , for example . dizaepam , temazepam
 
• Lithium
 
• antihistamines used to treat allergic disorders or hayfever , e. loratadine , chlorpheniramine
 
• antibiotics , e. cotrimoxazole , chloramphenicol , erythromycin , rifampicin or antifungal agents , e. fluconazole
 
• Drugs for the treatment of cancer , e. cyclophosphamide, busulfan
 
• Medicines to treat epilepsy , eg . phenytoin , carbamazepine, sodium valproate
 
• Medicines to treat pain , eg . Morphine , codeine and phenylbutazone
 
• digoxin or warfarin
 
• Cimetidine
 
• Certain drugs used to treat arthritis , for example . penicillamine , naproxen , indomethacin
 
• A drug which is known to cause constipation , including other drugs used for treating depression or schizophrenia , e. chlorpromazine, or drugs to treat symptoms of Parkinson's disease , e. pergolide
 
• adrenaline or noradrenaline
 
• Any antiviral drug , e. ritonavir , indinavir
 
• Omeprazole (a drug for the treatment of excess acid in the stomach)
 
Some medicines may affect your treatment. It is important to ask your doctor before taking any other medicines, even if they are available without a prescription.
You should not drink alcohol while taking Clozaril . Clozaril levels in the blood can be affected by smoking cessation and changes in the number of caffeine - containing drinks are taking. Tell your doctor about any such changes .
 
 
 
Birth control and pregnancy
 
If you are pregnant , planning to become pregnant or become pregnant during your treatment , it is important that you tell your doctor before taking Clozaril .
Some women taking certain antipsychotic drugs have irregular or no periods stop. If you are a woman and you have been affected in this way , your periods may be resumed if your medication is changed Clozaril . Under these circumstances, you should make sure to take adequate measures to prevent pregnancy .
 
breastfeeding
 
Women should not breast-feed while taking Clozaril because the drug can pass through breast milk to the baby .
 
Driving and using machines
 
You should avoid driving or operating machinery , especially in the early stages of treatment.
 
 
 
3 . How to take LEPONEX tablets
 
Clozaril is only suitable for adults over the age of 16 .
Please follow the instructions given to you by your doctor or pharmacist. He / she will tell you how many tablets to take and how often to take them. You must follow these instructions carefully and it is important not to change your dose or stop taking Clozaril unless your doctor tells you to.
 
Treatment of schizophrenia
 
The usual dose of Clozaril is between 200 mg and 450 mg per day. The dose is usually in divided doses, some being in the morning and the other night. Treatment generally begins with a half tablet of 25 mg (12,5 mg) once or twice daily for the first day . Then your doctor will slowly increase your dose until the ideal dose for you. Your Clozaril treatment will continue for at least six months. Some may require higher doses of up to 900 mg daily.
 
Treatment of severe thought disturbances in patients with Parkinson's disease
The usual dose is between 25 mg and 37,5 mg per day and is usually given in a single dose every night. Treatment is usually started with half a tablet of 25 mg (12,5 mg) evening and then the dose is gradually increased until the ideal dose for you. Some patients may require doses of up to 100 mg per day. During the first weeks of treatment will be measured blood pressure.
 
Always take the tablet with water and swallow them whole .
 
Clozaril is long . If it is stopped , it is possible to reappear previous symptoms. It is therefore important to take tablets every day.
 
 
 
If you forget to take LEPONEX
 
Clozaril should be taken regularly every day. If you forget to take a dose, take another as soon as you remember. If it's time for the next dose , skip the forgotten tablets and take the next dose at the right time. It is important to remember that if you are taking any Clozaril for more than 48 hours, you should contact your doctor as soon as possible .
 
If you take more tablets than you should Clozaril
 
If too much of your medicine, you should contact your doctor immediately or go to the nearest emergency room .
 
 
 
4 . POSSIBLE SIDE EFFECTS
 
Effects on blood
 
Clozaril can cause changes in the number of certain types of cells ( white cells) , which are found in the blood. In some cases, patients may develop a decrease in the number of a type of white blood cells called neutrophils. Neutrophils are responsible for fighting infections and so if you fall , your body may be less able to fight off infection. You may hear it called " neutropenia " or " agranulocytosis " . For this reason, you should perform regular blood tests . If a significant decrease in white blood cells will require additional blood tests and if at any time the number of white blood cells drops below a certain level , should immediately stop taking Clozaril . It is very important not to miss blood tests . After Clozaril stop , the number of white blood cells to recover. If you develop neutropenia or agranulocytosis , you can not get Clozaril again.
While taking Clozaril is important that you immediately inform your doctor if you develop signs of infection such as fever and flu-like symptoms or sore throat . This will allow your doctor to perform an urgent blood test to check whether your symptoms are related to your medicine .
 
Sometimes Clozaril can cause an increase in the number of white blood cells.
 
Additionally, Clozaril may also cause an increase in a type of white blood cells called eosinophils . If it rises above a certain level, Clozaril treatment should be stopped . Clozaril will start again after the number of eosinophils .
In some very rare cases, a decrease in the number of platelets (blood cells essential for blood clotting) . If the platelet count falls below a certain level, Clozaril treatment will be stopped. Can also occur , and an increase in platelet counts .
 
 
 
Effects on the heart
 
Rarely reported side effects of the heart , Clozaril . Therefore , before you start taking Clozaril , your doctor will ask you about any previous heart problems that you may have had and will perform a physical examination prior to recording of the heart (electrocardiogram or ECG) . Clozaril can cause ECG changes , changes in heartbeat and pulse . In rare cases it can cause damage to the heart muscle ( cardiomyopathy ) , inflammation of the membrane surrounding the heart muscle ( pericarditis ) , fluid around the heart ( pericardial effusion) and very rarely - heart failure . Moreover, rarely that Clozaril can cause inflammation of the heart muscle ( myocarditis ) . In case of myocarditis , it usually happens within the first two months of treatment. The symptoms of myocarditis may include: increased heart rate at rest, fast or difficult breathing , chest pain, palpitations or abnormal heart rhythm , flu symptoms , unexplained fatigue and an increased number of eosinophils in the blood. If you are taking Clozaril in the past and been diagnosed with myocarditis is very important to tell your doctor because you should not take Clozaril again .
 
 
 
Other side effects
 
Some people Clozaril can cause the following
 
• Sleepiness
 
• Dizziness
 
• Fatigue
 
• Increased salivation
 
• Weakness or slightly dizzy if you stand up suddenly from leganalo position
 
• Weight gain
 
• Blurred vision "
 
• Headache
 
• Shivering , numbness , agitation , restlessness, and abnormal movements
 
• Epileptic seizures (fits , convulsions ) and seizures
 
• Dry mouth
 
• Increased sweating
 
• Increased body temperature - particularly during the initial weeks of treatment
 
• High blood pressure
 
• Feelings of nausea , vomiting , loss of appetite
 
• Involuntary loss of urine or difficulty urinating
 
• Mild disturbances in liver function tests
 
• Neuroleptic malignant syndrome (NMS ) - a severe reaction to antipsychotic treatment
 
• Some patients may develop constipation while taking Clozaril , which may become severe . This should be reported to your doctor as you may need treatment.
 
In rare cases, Clozaril can cause ;
 
• Increased levels of blood sugar and diabetes . Very rarely, some patients may be affected .
 
• Confusion and disorientation
 
• Abnormal muscle movements of the face and body
 
• Increased levels of a type of fat (triglycerides ) in the blood
 
• blood clots in the blood vessels , for example . leg
 
• difficulty in swallowing
 
• Difficulty breathing
 
• accidental inhalation of food ( aspiration)
 
• Severe constipation associated with occlusion of the colon, which may cause abdominal pain and abdominal cramping
 
• Inflammation of the liver and other effects on the liver, causing yellowing of the skin , itching and dark urine
 
• inflammation of the pancreas , leading to abdominal pain
 
• Swelling of the salivary glands and increased salivation .
 
• Inflammation of the kidneys
 
• Rash
 
• Elevated blood levels of an enzyme called creatine
 
• prolonged painful erection of the penis
 
• High levels of blood cholesterol
 
• Anemia ( low hemoglobin )
 
Tell your doctor immediately if you notice any of the above symptoms or if you have any other unexpected symptoms that are not mentioned in this leaflet.
Unless your doctor tells you otherwise, you should not suddenly stop taking your tablets Clozaril because the reactions have been reported on stopping treatment after abrupt discontinuation . These reactions include sweating , headache, nausea , vomiting , diarrhea, and recurrence of your original symptoms.
 
Very rare cases of sudden unexplained death in patients taking Clozaril . Such cases arise in patients with psychiatric disorders , whether treated or not.
 
 
 
5 . Storing LEPONEX tablets
 
Keep your medicine in a safe place , inaccessible to children. Your medicine may harm them .
 
Do not use this medicine after the expiry date stated on the carton / blister .
If your doctor decides to stop your treatment , return any leftover medicine to your pharmacist.
 
Only keep it if your doctor tells you to.
 
 
 
6 . Additional information
 
REMEMBER : This medicine is only for you. Only a doctor can prescribe it for you . Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
 
If you have further questions about your medicine or you are unsure about any of the advice in this leaflet, ask your doctor or pharmacist.
 
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