LEKOKLAR table. 500 mg. 14 tablets

LEKOKLAR table. 500 mg. 14 tablets
€ 30.00
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Clarithromycin is an antibiotic that belongs to the group of macrolide antibiotics. They stop the growth of certain bacteria.

LEKOKLAR table. 500 mg. 14 tablets

What Lekoklar and what it is used

Clarithromycin is an antibiotic that belongs to the group of macrolide antibiotics. They stop the growth of certain bacteria.
Lekoklar is used to treat:
 infections of the throat and sinuses;
 infections in the chest, such as bronchitis and pneumonia;
 infections of skin and soft tissue;
 stomach ulcers caused by the bacterium Helicobacter pylori.

 Before you take Lekoklar

Do not take Lekoklar
 if you are allergic to clarithromycin, other macrolide antibiotics or to any other ingredients of this medicine (listed in Section 6);
 if you have had certain heart rhythm (ventricular arrhythmias, including torsades de pointes) or changes in heart rate, established by electrocardiogram, known as "QT prolongation"
 If you suffer from severe liver failure and kidney problems simultaneously;
 if the level of potassium in your blood is low;
 if you are taking ergotamine, dihydroergotamine (medicines used to treat migraine);
cisapride (a medicine for stomach);
pimozide (antipsychotic);
 terfenadine or astemizole (allergy medicines);
 lovastatin, simvastatin (drugs to lower cholesterol).
Warnings and Precautions
Tell your doctor before taking this medicine:
 if you have impaired liver or kidney function;
 if you are allergic to clindamycin or lincomycin (antibiotics);
 if you use any antibacterial ear drops, such as gentamicin and neomycin;
 If you suffer from myasthenia gravis, a rare disease which causes muscle weakness;
 if you have diabetes;
 if you have or have had heart problems or;
 If your potassium and magnesium levels in the blood were low before treatment.
Tell your doctor:
 If you develop severe diarrhea while taking Lekoklar or even several weeks after you stop taking it (see further details in section 4);
 if you experience any signs of infection (eg fever, sore throat).
Other medicines and Lekoklar
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Some other medicines may influence the effects of Lekoklar, and vice versa. These include:
Lekoklar may increase the effects of the following medicines:
 astemizole, terfenadine (antiallergic drug), pimozide (antipsychotic), cisapride (a medicine for stomach), ergotamine, dihydroergotamine (for migraine drug), lovastatin, simvastatin (drugs to lower cholesterol) (see "Do not take Lekoklar");
 alprazolam, triazolam, midazolam (sedatives);
 digoxin, verapamil (heart medicines);
 theophylline (antiasmatichno medicine);
 warfarin (an anticlotting medication);
 atorvastatin, rosuvastatin (means lower cholesterol);
 cyclosporine, sirolimus, tacrolimus (medicines that suppress the immune system);
 carbamazepine, phenytoin, valproate (medicines used to treat epilepsy)
 cilostazol (used to improve circulation in the legs);
 Colchicine (for gout);
 insulin and other medicines for diabetes (eg glibenclamide, nateglinide, repaglinide, rosiglitazone or pioglitazone);
 methylprednisolone (cortisone to treat inflammation);
 Omeprazole (stomach medicine);
 sildenafil, tadalafil, vardenafil (medicines to treat erectile dysfunction);
 tolterodine (used to treat symptoms of overactive bladder);
 vinblastine (a drug to treat cancer);
 drugs with the risk of hearing impairment, especially aminoglycosides such as gentamicin or neomycin (antibiotic group);
 aprepitant (used to prevent vomiting during chemotherapy);
 eletriptan (for migraine medications);
 halofantrine (a medicine to treat malaria);
 ziprasidone (antipsychotic).
As the effect of Lekoklar and effects of these medicines may be increased when taken together:
 atazanavir, saquinavir (medicines to treat HIV);
 itraconazole (a medicine used to treat fungal infections).
If your doctor specifically recommends you take Lekoklar and any of these drugs at the same time, you may need your doctor to monitor you more closely.
The following medicines may reduce the effect of Lekoklar:
 rifampicin, rifabutin, rifapentine (antibiotics);
 efavirenz, nevirapine (medicines to treat HIV);
 phenytoin, carbamazepine, phenobarbitone (antiepileptic drugs);
 St. John's Wort.
Please note:
 Ritonavir (an antiviral medicine) and fluconazole (medicine to treat fungal infections) may enhance the effect of Lekoklar;
 Lekoklar can weaken the effect of zidovudine (an antiviral drug). To avoid this, you must leave an interval of 4 hours between intake of these drugs;
 Using Lekoklar while digoxin, quinidine or disopyramide or verapamil (heart medications), or other macrolide antibiotics can cause serious side effects.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
If you are pregnant or nursing, do not take Lekoklar before checking with your doctor.
Driving and operating machinery
Overall, clarithromycin had no effect on the ability to drive or operate machinery. If you feel dizzy, drowsy or confused while taking this medicine, do not drive or operate machinery.

 How to take Lekoklar

Always take this medicine exactly as your doctor tells you. If you're not sure, ask your doctor.
Adults, including the elderly and adolescents (children over 12 years)
The usual dose is 250 mg twice daily.
In severe infections or stomach ulcers caused by Helicobacter pylori usual dose is 500 mg twice daily.
Children under 12 years
Use in children under 12 years of age (weighing less than 30 kg) are not recommended. For these patients have other formulations such. suspensions. Children weighing more than 30 kg using the same dose as adults.
Kidney problems
If you have severe kidney problems, you may need your doctor to reduce the dose in half, ie once a day, and limit treatment to no more than 14 days.
How to take this medicine
For oral use.
Drink a glass of water with medicine.
The drug can be taken with or without food.
Duration of treatment
Your doctor will tell you how long you should take Lekoklar, usually between 6 and 14 days. Do not stop treatment on his own.
If you take more than the dose Lekoklar
If you take an overdose of this medicine, contact your doctor or nearest hospital for emergency medical care. Take the container and any remaining tablets with you. Symptoms of overdose include nausea or vomiting, diarrhea, indigestion or stomach pain and the possibility of allergic reactions.
If you forget to take Lekoklar
If you forget to take this medicine, continue treatment following the usual dose recommended by your doctor. Do not take a double dose to make up for a missed dose.
If you stop taking Lekoklar
It is important to take your medicine as directed by your doctor. Do not suddenly stop taking Lekoklar without first discussing it with your doctor. Otherwise, the symptoms may reappear.
If you have any further questions on the use of this product, ask your doctor or pharmacist.

 Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Serious side effects:
If any of these occur, stop taking this medication and tell your doctor immediately or go to the casualty department at your nearest hospital:
Uncommon serious side effects (affects 1 to 10 users in 1,000):
 allergic reactions such as sudden difficulty in breathing, speaking or swallowing, swelling of the lips, face and throat, severe dizziness or collapse, skin rash with blisters and itching;
 yellowing of the skin or eyes, unusual tiredness or fever, dark colored urine (signs of inflammation of the liver).
Very rare serious side effects (affects less than 1 in 10,000 users):
 diarrhea that is severe, lasts a long time or has blood in stool with stomach pain or fever. This may be a sign of severe intestinal inflammation. Your doctor may discontinue treatment. Do not take medicines that slow down bowel movements;
 pain in the abdomen and back, due to inflammation of the pancreas;
 increased or decreased urine output, drowsiness, confusion, and nausea caused by renal inflammation;
 heavy or itchy rash, especially if accompanied by blistering of the skin and inflammation of the eyes, mouth, and genitals;
 fast or irregular heartbeat.
Serious side effects not known:
 fever, sore throat, frequent infections caused by a serious shortage of white blood cells.
These are all serious side effects. You may need urgent medical attention.
Other possible side effects:
Tell your doctor if any of these side effects bother you:
Common (affects 1 to 10 users in 100):
 oral thrush, sore mouth and tongue, reversible staining of teeth and tongue;
 changes in sensations of smell and taste (eg, metallic or bitter taste);
 abdominal pain, nausea or vomiting, diarrhea, indigestion;
 abnormal tests of liver and kidneys;
 sleep problems;
 increased sweating.
Uncommon (affects 1 to 10 users in 1,000):
 low white blood cells, increasing the number of certain white blood cells;
 elevation of liver enzymes in the blood;
 joint and muscle pain;
 fungal infection (candidiasis);
 vaginal infections;
 loss or decrease in appetite;
 dizziness, tremor, feeling of dizziness;
 hearing problems, ringing in the ears (tinnitus);
 feeling your heartbeat;
 extension of a certain interval of the electrocardiogram (ECG) called prolongation of the QT-interval;
 inflammation of the lining of the stomach, constipation, flatulence, dry mouth, belching, bloating or flatulence;
 itching, hives;
 malaise, weakness, fatigue;
 chest pain;
Very rare (affects less than 1 in 10,000):
 unusual bruising or bleeding caused by a low platelet count;
 irregular or rapid heartbeat;
 nightmares, confusion, disorientation, hallucinations, psychosis, feelings of loss of identity;
 convulsions, numbness and tingling of the skin;
 hard of hearing;
 severe hepatic impairment;
 renal failure;
 low blood sugar, especially after the use of antidiabetic drugs and insulin at the same time.
Not known:
 certain bacterial infections of the skin and underlying tissues;
 impaired sense of smell, loss of sense of smell and taste;
 rash, fever, changes in blood (which may be a sign of hypersensitivity syndrome called DRESS syndrome);
 pain or weakness;
 unusual color of urine.
Clarithromycin may worsen the symptoms of myasthenia gravis (a condition in which the muscles become weak and tire easily) in patients who already suffer from this condition.
If you experience any side effects, tell your doctor or pharmacist. This includes all listed in this leaflet.

 How to store Lekoklar

Keep out of reach of children.
Lekoklar Do not use after the expiry date stated on the carton after "EXP". The expiry date refers to the last day of that month.
This medicinal product does not require any special temperature storage conditions. Store in the original carton to protect from light.
Medicines should not be disposed of via wastewater or household waste.
Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

 Contents of the package is additional information

What Lekoklar
The active substance is clarithromycin (clarithromycin).
Lekoklar 250 mg: 1 tablet contains 250 mg of clarithromycin.
Lekoklar 500 mg: 1 tablet contains 500 mg of clarithromycin.
The other ingredients are:
Core: croscarmellose sodium (E 468), microcrystalline cellulose (E 460), povidone, magnesium stearate (E 572), colloidal anhydrous silica (E 551), talc (E553b).
Coating: hypromellose (E 464), propylene glycol (E 1520), titanium dioxide (E171), hidroksilropiltseluloza (E 463), sorbitan monooleate (E 494), quinoline yellow (E 104), vanillin.
€ 30.00
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