LEKOKLAR 14 tablets 250 mg

SANDOZ
LEKOKLAR 14 tablets 250 mg
€ 18.00
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What is Lekoklar and what it is used
Clarithromycin is an antibiotic belonging to the macrolide antibiotics group. They inhibit the growth of certain bacteria.
Lekoklar be used for treatment of:
infections of the throat and sinuses;
infections in the chest area, such as bronchitis and pneumonia;
infections of skin and soft tissues;
stomach ulcers caused by the bacterium Helicobacter pylori.
2. Before you take Lekoklar
Do not take Lekoklar
if you are allergic to clarithromycin, other macrolide antibiotics or any of the other ingredients of this medicine (listed in section 6);
if you have had certain abnormal heart rhythm (ventricular arrhythmias, including torsades de pointes) or changes in heart activity established by electrocardiogram known as "QT prolongation";
if you suffer from severe liver disease and kidney problems simultaneously;
if the level of potassium in your blood is low;
if you take:
ergotamine, dihydroergotamine (medicines used to treat migraine);
cisapride (a medicine for stomach);
pimozide (antipsychotic);
terfenadine or astemizole (allergy medications);
lovastatin, simvastatin (medicines to lower cholesterol).
Warnings and Precautions
Tell your doctor before taking this medicine:
if you have impaired liver or kidney function;
if you are allergic to clindamycin or lincomycin (antibiotics);
if you use any antibacterial ear drops, such as gentamicin and neomycin;
if you suffer from myasthenia gravis, a rare disease which causes muscle weakness;
if you have diabetes;
if you have or have had heart problems or;
if your potassium and magnesium levels in the blood were low before treatment.
Tell your doctor:
if you develop severe diarrhea while taking Lekoklar or even several weeks after you stop taking it (see further information in paragraph 4);
if you get any symptoms of infection (eg. fever, sore throat).
Other medicines and Lekoklar
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Some other medicines may influence the effects of Lekoklar, and vice versa. These include:
Lekoklar may enhance the effect of the following medicines:
astemizole, terfenadine (antiallergic medicine), pimozide (antipsychotic), cisapride (a medicine for stomach), ergotamine, dihydroergotamine (medicines for migraine), lovastatin, simvastatin (medicines to lower cholesterol) (see. "Do not take Lekoklar");
alprazolam, triazolam, midazolam (sedatives);
digoxin, verapamil (a heart medicine);
theophylline (antiasthmatic drug);
warfarin (an anti-clotting drug);
atorvastatin, rosuvastatin (cholesterol lowering agents);
cyclosporine, sirolimus, tacrolimus (medicines that suppress the immune system);
carbamazepine, phenytoin, valproate (medicines to treat epilepsy)
cilostazol (used to improve circulation in the legs);
colchicine (for gout);
insulin and other medicines to treat diabetes (such as glibenclamide, nateglinide, repaglinide, rosiglitazone or pioglitazone);
methylprednisolone (cortisone in the treatment of inflammation);
omeprazole (a medicine for stomach);
sildenafil, tadalafil, vardenafil (medicines to treat erectile dysfunction);
tolterodine (for the treatment of the symptoms of overactive bladder);
vinblastine (a drug for the treatment of cancer);
drugs with risk of the hearing, especially aminoglycosides such as gentamicin or neomycin (antibiotic group);
aprepitant (used to prevent vomiting during chemotherapy);
eletriptan (medicines for migraine);
halofantrine (a medicine for the treatment of malaria);
ziprasidone (antipsychotic).

As the effect of Lekoklar and the effect of these drugs may be enhanced when taken together:
atazanavir, saquinavir (medicines for the treatment of HIV);
itraconazole (medicine for the treatment of fungal infections).
If your doctor has recommended you especially to take Lekoklar and any of the above medicines at the same time, you need a doctor to monitor you more closely.

The following medicines may reduce the effect of Lekoklar:
rifampicin, rifabutin, rifapentine (antibiotics);
efavirenz, nevirapine (medicines for the treatment of HIV);
phenytoin, carbamazepine, phenobarbitone (antiepileptic drugs);
St. John's Wort.
Please note:
Ritonavir (antiviral drug) and fluconazole (medicine to treat fungal infections) may enhance the effect of Lekoklar;
Lekoklar can weaken the effect of zidovudine (antiviral medicine). To avoid this, you must leave an interval of 4 hours between taking these drugs;
Use of Lekoklar simultaneously with digoxin, quinidine or disopyramide or verapamil (a heart medication) or other macrolide antibiotics can cause serious side effects.
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
If you are pregnant or breast-feeding, do not take Lekoklar before checking with your doctor.

Driving and using machines
Overall, clarithromycin no effect on the ability to drive or operate machinery. If you feel dizzy, sleepy or confused while taking this medicine, do not drive or operate machinery.

3. How to take Lekoklar
Always take this medicine exactly as prescribed by your doctor. If you are not sure, ask your doctor.

Adults, including the elderly and adolescents (children over 12 years)
The usual dose is 250 mg twice daily.
In severe infections or gastric ulcers caused by Helicobacter pylori, the usual dose is 500 mg twice daily.

Children under 12 years
Use in children under 12 years of age (weighing less than 30 kg) is not recommended. For these patients have other dosage forms e. suspensions. In children weighing more than 30 kg using the same dose as adults.

kidney problems
If you have severe kidney problems, you may need your doctor to reduce the dose by half, i. E. Once daily and restrict treatment to no more than 14 days.

How to take this medicine
For oral use.
Drink a glass of water with the drug.
The drug can be taken with or without food.

Duration of treatment
Your doctor will tell you how long you should take Lekoklar, usually between 6 and 14 days. Do not stop treatment on his own.

If you take more dose Lekoklar
If you take more dose of this medicine, contact your doctor or nearest hospital for emergency care. Take the container and any remaining tablets with you. Symptoms of overdose include nausea or vomiting, diarrhea, indigestion or stomach pain and the possibility of allergic reactions.

If you forget to take Lekoklar
If you forget to take this medicine, continue treatment following the usual dose recommended by your doctor. Do not take a double dose to make up the missed dose.

If you stop taking Lekoklar
It is important to take your medicine as directed by your doctor. Do not suddenly stop taking Lekoklar without first discussing it with your doctor. Otherwise, the symptoms may reappear.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Serious side effects:
If any of these occur, stop taking this medication and tell your doctor immediately or go to the emergency room of the nearest hospital:
Uncommon serious side effects (affects 1 to 10 users in 1000):
Allergic reactions such as sudden difficulty in breathing, speaking and swallowing, swelling of the lips, face and neck, extreme dizziness or collapse, skin rash with blisters and itching;
yellowing of the skin or eyes, unusual tiredness or fever, dark colored urine (signs of inflammation of the liver).
Very rare serious side effects (affects less than 1 in 10,000 users):
diarrhea that is serious, lasts a long time or has blood in the stool, with stomach pain or fever. This may be a sign of severe inflammation of the bowel. Your doctor may stop your treatment. Do not take medicines that slow bowel movements;
pain in the abdomen and back, due to inflammation of the pancreas;
increased or decreased urine output, drowsiness, confusion and nausea caused by kidney inflammation;
heavy or itchy skin rash, especially if accompanied by blistering of the skin and inflammation of the eyes, mouth and genitals;
fast or irregular heart beat.
Serious side effects with unknown frequency:
fever, sore throat, more frequent infections caused by a serious shortage of white blood cells.
These are all serious side effects. You may need urgent medical attention.
Other possible side effects:
Tell your doctor if any of these side effects bother you:
Common (affects 1 to 10 users in 100):
oral thrush, sore mouth and tongue, reversible staining of teeth and tongue;
headache;
changes in sense of smell and taste (eg, metal or bitter taste);
abdominal pain, nausea or vomiting, diarrhea, indigestion;
abnormal results from studies of the kidneys and liver;
sleep problems;
rash;
increased sweating.
Uncommon (affects 1 to 10 users in 1000):
low level of white blood cells, increase in the number of certain white blood cells;
increase in liver enzymes in the blood;
joint and muscle pain;
fungal infections (candidiasis);
vaginal infections;
loss or reduction of appetite;
anxiety;
dizziness, tremor, dizziness;
impaired hearing, ringing in the ears (tinnitus);
sense of palpitations;
extension of certain interval on the electrocardiogram (ECG) called prolongation of QT-interval;
inflammation of the lining of the stomach, constipation, flatulence, dry mouth, belching, bloating or flatulence;
itching, hives;
malaise, weakness, fatigue;
chest pain;
chills.
Very rare (affects less than 1 in 10,000 patients):
unusual bruising or bleeding caused by low platelet count;
irregular or rapid heartbeat;
nightmares, confusion, disorientation, hallucinations, psychosis, a sense of loss of identity;
convulsions, numbness and tingling of the skin;
impaired hearing;
severe hepatic impairment;
renal insufficiency;
low blood sugar, especially after use of the antidiabetic agents and insulin at the same time.
Not known:
certain bacterial infections of the skin and underlying tissues;
bleeding;
impaired sense of smell, loss of sense of smell and taste;
deafness;
acne;
rash, fever, changes in blood (which can be a sign of hypersensitivity syndrome called DRESS syndrome);
depression;
pain or weakness;
unusual color of urine.
Clarithromycin may worsen the symptoms of myasthenia gravis (a condition in which the muscles become weaker and more easily fatigued) in patients who are already suffering from this condition.
If you get any side effects, tell your doctor or pharmacist. This includes any possible effects not listed in this leaflet.

5. How to store Lekoklar
Keep out of the reach and sight of children.
Lekoklar not use after the expiry date stated on the package after 'EXP'. The expiry date refers to the last day of that month.
This medicinal product does not require any special temperature storage conditions. Store in the original carton to protect from light.
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