Indometacin. 25mg. 30 table

Indometacin. 25mg. 30 table
€ 29.00
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Indometacin is the group of so-called no drugs, non-steroidal anti-inflammatory agents with an effect greater than that of the salicylates / acetysal, sodium salicylate, salicylamide / and Pyrazolone / phenylbutazone, butapirin /. There analgesic action, the elevated temperature decreases and increases the excretion of uric acid in the body.

Indometacin. 25mg. 30 table
 
ACTION

Indomethacin is the group of so-called no drugs , non-steroidal anti-inflammatory agents with an effect greater than that of the salicylates / acetysal , sodium salicylate, salicylamide / and Pyrazolone / phenylbutazone, butapirin / . There analgesic action , the elevated temperature decreases and increases the excretion of uric acid in the body .

INDICATIONS

Indomethacin is shown in inflammatory diseases of the joints - rheumatoid arthritis , ankylosing spondylitis , other forms of arthritic disease and gout, psoriasis and inflammatory diseases of joint tissue ( periarthritis , tendinitis , bursitis , synovitis ), degenerative diseases of the joints, accompanied by inflammation and pain - coxarthrosis , gonarthrosis , sciatica, plexopathy , sciatica , traumatic disorders - bruises , dislocations , sprains .

INFORMATION REQUIRED BEFORE USE

CONTRAINDICATIONS

• Hypersensitivity to Ivdometatsin or any of the excipients product;

• Acute exacerbations of asthma , urticaria or rhinitis caused by aspirin or other NSAIDs ;

• Active peptic ulcer disease , erosive gastritis , ulcerative colitis ;

• Severe renal and hepatic diseases ;

• Pregnancy ;

• Children under 14 years of age.

SPECIAL PRECAUTIONS FOR USE

Inform your doctor if you are taking Ivdometatsin ! Product be used with caution under strict control of liver function in children over 14 years old and older patients . Requires an individual regimen for each patient at low daily doses that do not lead to adverse drug reactions . Particular attention is given to patients with gastrointestinal diseases. Patients are placed under the control of the occurrence of stomach , abdominal pain and occult blood . Increased risk exists for individuals who abuse alcohol, smoking , debilitated patients , elderly patients , and the concomitant use of Ivdometatsin aspirin and other salicylates . Reactions may occur without prior symptoms . Ivdometatsin be used with caution in patients with kidney disease because of the risk of serious renal impairment. In such patients, lower doses administered for a short period as in the control of certain laboratory values . With attention being used in patients with diabetes mellitus , congestive heart failure , septicemia , depression , epilepsy, psychiatric disorders , Parkinsonism , as it can lead to a deterioration of the underlying disease. Indomethacin can cause fluid retention and thus worsen in patients with cardiovascular disease, hypertension , to inhibit platelet aggregation , to prolong bleeding time and lead to the development of side effects in patients with bleeding disorders and styptic . In patients with liver diseases , periodic monitoring of liver enzymes, which can be further improved . Treatment with the product may be compromised antifertility effect of intrauterine pessary .

The use of indomethacin may impair fertility and is not recommended in women who may become pregnant . For women who have difficulty becoming pregnant or are undergoing investigation of infertility, it is recommended to stop taking the product.

DRUG INTERACTIONS AND OTHER FORMS

Indomethacin interacts with many drugs and its application in combination should be done with caution . Please tell lekueagtsiya doctor if you are taking any medication ! Diflusinal reduced renal excretion of Indomethacin and lead to increased plasma concentrations and associated adverse events. Aspirin and nonsteroidal anti-inflammatory drugs - decreased the plasma concentrations of Ivdometatsin average of 20 % when co-administered more common side effects from the gastrointestinal tract and hypersensitivity . Alcohol increases the risk of side effects on the gastrointestinal tract. Probenecid - increased blood levels of indomethacin . Methotrexate - Ivdometatsin reduces the degree of renal excretion and enhances its toxic effects. Lithium - Indomethacin leads to increased blood levels of lithium and reduced renal excretion of the latter, and the possibility of development of toxic effects. Diuretics - Ivdometatsin reduce the diuretic, natriuretic and antihypertensive effects of diuretics (products enhancing diuresis ) . Beta- adrenergic blockers - Indomethacin reduces the effects of beta-blockers . ACE inhibitors - reduce the antihypertensive effect at the same time. Antiplatelet agents and anticoagulants - increased risk of bleeding due to inhibition of platelet function and irritating effect on the gastrointestinal mucosa. It is necessary to monitor the condition of the patient and monitoring of the bleeding time and prothrombin time . Antacids - decrease absorption of indomethacin , which requires their adoption in two hours.

SPECIAL WARNINGS FOR USE IN SPECIFIC PATIENT GROUPS

Inform your doctor if you are pregnant or breast-feeding ! Not used during pregnancy. The product causes disturbances in the normal development of the fetus. Excreted into maternal milk. Not for use in lactating women. It is the cessation of breastfeeding during the treatment with this product.

EFFECTS ON THE ABILITY TO DRIVE AND USE MACHINES

Indomethacin may lead to violation of motor reactions and is not recommended when driving or operating machinery !

INFORMATION FOR PROPER USE

DOSAGE

Prescription ! The course of treatment is determined by the doctor!

Adults - Rheumatoid arthritis , ankylosing spomdilit , osteoarthritis in middle and mild course
The recommended initial daily dose - 25-50 mg If tolerated daily dose was increased to 25-50 mg daily to achieve good therapeutic effect. Maximum daily dose - 150-200 mg In the treatment with indomethacin was necessary individual dosage for accurate reading of the tolerability and efficacy of the product . The daily dose is divided into two or three doses . In patients where there is a continuous nocturnal pain and / or morning stiffness is the last intake before going to bed in time to a higher dose , e. 100 mg at a daily dose of 150 mg .. After the acute phase of the disease , the daily dosage is gradually reduced to the minimum possible treatment an effective dose . The duration of treatment is not more than 14 days. Acute bursitis, tendinitis and periarthritis Daily Dose - 75-100 mg three or four times . Treatment was discontinued in certain clinical signs to control inflammation. Not recommended for the treatment duration can be greater than 7-14 days. Acute gouty arthritis, to arrest the acute pain is recommended that a single dose of 50 mg. In subsequent doses is normally sufficient for the application of lower doses until pain management . Definitive effect on acute pain is achieved within 2 to 4 hours after taking the product. Soreness and redness lasting usually 24-36 pm and otochnostta disappears between 3 and 5 days after cessation of treatment. It is recommended to be taken with food to improve ponosimosttamu .

Children - Not recommended the use of indomethacin in children under 14 years of age. In children over the age limit is applied daily doses of about 2 mg / kg bw in three or four divided doses . The maximum daily dose is 4 mg / kg bw The occurrence of adverse events , product administration is discontinued . In the course of treatment is often necessary to monitor liver function.

ACTION OF OVERDOSE

Ingestion of a greater dosage of the product may occur nausea , vomiting, colic pain , diarrhea, headache .

May experience skin rash , peripheral edema , and respiratory depression , bruising , and low blood pressure. It is necessary to induce vomiting or gastric lavage . Treatment is symptomatic .

SIDE EFFECTS

* Gastrointestinal tract - nausea with or without vomiting, diarrhea , abdominal pain, constipation, bleeding ulcers , liver disorders ;

* Hypersensitivity - itching , rash, urticaria , exfoliative dermatitis , acute anaphylactic reaction , asthma attack ;

* Central nervous system - headache, dizziness, drowsiness , depression , fatigue , memory disturbances, parkinsonism ;

* Psychiatric disorders - worsening epilepsy , depression ;

* Sensory organs - noise and tinnitus , deposits on the corneal and retinal damage ( treatment should be discontinued immediately ); ° the urinary system - kidney problems , fluid retention ;

* Blood - anemia , leukopenia , thrombocytopenia, hypo-or aplasia of the bone marrow ;

* Metabolic disorders - hyperglycemia glycosuria hyperkalemia.

STORAGE

In a dry and dark place at a temperature below 25 ° C

SHELF GODNOST4 (four ) years from date of manufacture. Do not use after the expiry date stated on the package !
COMPOSITION

Drug substance per tablet: Indometacin 25 mg

Excipients: lactose, corn starch, gelatin, microcrystalline cellulose, talc, magnesium stearate, anhydrous silica. Composition of tablet coat: titanium dioxide, macrogol 6000, macrogol 400, diethyl phthalate, Eudragit, colorants.

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