HYDREA 500 mg. 100 capsules

Bristol-Myers Squibb
HYDREA 500 mg. 100 capsules
€ 38.00
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WHAT HYDREA AND WHAT IT IS USED
What is Hydrea?
Hydrea is "cytotoxic" drug. Cytotoxic drugs kill cells that divide, including tumor cells.

What is this medicine?
Hydrea is applied for the treatment of refractory chronic myelocytic leukemia, and melanoma. Co-administration of Hydrea radiotherapy is indicated for the treatment of primary squamous cell (epidermoid) carcinoma of the head and neck (excluding oral) and carcinoma of the cervix.

2. BEFORE YOU TAKE HYDREA
Before starting treatment, your doctor will make sure that the adoption of Hydrea is safe for you.
You should not take Hydrea in case of known hypersensitivity (allergy) to any of the ingredients in impaired (suppressed) bone marrow function, as in the case of severe anemia.
Hydrea and most cytotoxic drugs may affect the cells in your bone marrow. These cells divide very quickly to make new blood cells. Your doctor will carry out constant monitoring of your blood by the hospital laboratory will be listed each type of blood cells (platelets, white and red blood cells). Your doctor may decide to change the originally determined dose or stop treatment if the number of your blood cells is too low. This number is recovering very quickly, since bone marrow constantly produces new cells.

Are Possible interactions between Hydrea and other drugs?
Tell your doctor about all other medicines you are taking, and he will consider it appropriate their combination with Hydrea.

What you need to know in case of pregnancy and lactation?
Tell your doctor if you are pregnant or intend to become pregnant. Take this medicine may have harmful effects on the developing fetus, therefore its use during pregnancy should be avoided, and to take precautions against becoming pregnant during treatment.
Hydrea is excreted in breast milk and may cause adverse effects on the infant. Therefore your doctor will decide whether to stop breast-feeding during treatment or not to take the drug during lactation.

Does this medicine influence on the ability to drive and use machines?
Hydrea can lead to drowsiness, headache, dizziness and disorientation, so may impair the ability to drive and use machines.

3. HOW TO TAKE HYDREA
Dosage and duration of treatment is determined only by your doctor.
The nurse will measure your weight, based on which your doctor will determine the exact dosage of the drug, depending on the type of your illness.
During treatment with Hydrea take more liquids.
If you prefer or are unable to swallow capsules, the content and can be emptied in a glass of water and drink immediately. Some inert material used as a binder in the capsule may not dissolve and float on the surface.
Omission of any of the doses tell your doctor immediately.

Usual dosage regimen:
Solid tumors:
Interrupted treatment:
80 mg / kg administered orally as a single dose every third day.
Continuous treatment:
20 to 30 mg / kg as a single daily dose administered orally.
Concomitantly with radiation therapy:
(Carcinoma (cancer) of the head, neck and cervix):
80 mg / kg as a single daily dose administered every third day.
Application of Hydrea should start at least seven days before the beginning of the exposure, continue during exposure and then for an indefinite period, the patient is monitored closely for the emergence of unusual or severe toxicity.

Resistant chronic myelocytic leukemia:
Continuous treatment:
20 to 30 mg / kg administered orally as a single daily dose.

4. POSSIBLE SIDE EFFECTS
Effects on the blood:
Decrease the number of blood cells (platelets, red and white blood cells).

Gastrointestinal:
Inflammation of the lining of the mouth, decreased appetite, nausea, vomiting, diarrhea and constipation.

skin:
Rash, redness of the face and body, the occurrence of skin irritation and ulceration, gangrene, increased pigmentation (color) of the skin, atrophy of skin and nails, desquamation (peeling), the violet patches and alopecia (hair loss). Rarely, skin cancer.

neurological:
drowsiness; Rare cases of headaches, dizziness, disorientation, hallucinations and convulsions.

renal:
Increased serum uric acid nitrogen fixtures and creatinine levels; micturition disorders rarely occur.

other:
Fever, chills, malaise, fatigue, elevated liver enzymes; individual cases of acute pulmonary reactions (difficulty in the structure of the lung and respiratory disorders), acute pancreatitis.

For these and all monitored during treatment side effects, contact your doctor immediately.

What you need to know in case of an overdose?
In case of overdose, get medical help immediately.
The most common symptoms reported with overdose include soreness, violet erythema, edema on palms and soles followed by desquamation (peeling) of the hands and feet, hyperpigmentation (coloring) of the skin and severe acute inflammation of the oral mucosa.
                                          
5. HOW TO STORE HYDREA
Store capsules at room temperature, away from heat, in the original packaging, out of reach of children.
Do not use after the expiry date stated on the packaging.

6. FURTHER INFORMATION
What your medicine?
Each capsule contains as active ingredient acting 500 mg of hydroxyurea.
As excipients Hydrea contain:
The capsule contains: anhydrous citric acid, anhydrous dibasic sodium phosphate, magnesium stearate, lactose 1N2O.

Capsule:
Opaque green cap, yellow iron oxide (E172), FD & C Blue 2 (indigotine E132), titanium dioxide (E171), sodium lauryl sulfate, purified water, gelatin.
Opaque pink body: FD & C Red 3 (erythrosine E172), titanium dioxide (E171), sodium lauryl sulfate, purified water, gelatin.
€ 38.00
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