Active ingredient: Each ampoule contains 10,000 KIU / ml solution of concentrated aprotinin (100,000 KIU
Excipients: sodium chloride, benzyl alcohol, water for injections.
What is Gordox injection and what is it used?
The active ingredient of the injection solution is aprotinin, which is an enzyme inhibitory protein isolated from tissues of bovine lung. It inhibits human trypsin, plasmin, as well as plasma and tissue kallikrein. Its activity is expressed in kallikrein inhibitory units (KIU. 1 KIU equals 140 ng aprotinin, ie 100.000 KIU equals 14 mg of aprotinin.
Gordox can be used to treat primary hiperfibrinolitichno bleeding.
What you should know before you are given Gordox injection?
It should be used after a rigorous individual assessment where you have had prior therapy aprotininova as repeated administration of aprotinin increases the risk of allergic reactions.
The active ingredient is proteinaceous and has lolipeptidna structure, because this might cause hypersensitivity reactions. In order to determine hypersensitivity at least 10 min. Before the initial dose should be administered intravenously called. test dose of 1 ml (10.000 KIU) aprotinin. Gordoks should not be applied in case of occurrence of any allergic reaction caused by the administration of the test dose, as the therapeutic dose could also cause severe allergic reactions.
In children, the daily dose is 20,000 KIU aprotinin / kg body weight. Parenteral products containing benzyl alcohol should not be used in infants, because this preservative is associated with fatal toxic syndrome in premature infants.
Is it permissible application of Gordoks injection during pregnancy and lactation?
The existing experience with pregnant women and during lactation is limited and insufficient to assess the safety, which is why its use is contraindicated during the first trimester of pregnancy. In the second and third trimester of pregnancy and during lactation may be applied only after rigorous assessment by your doctor.
You affect the application of Gordox injection ability to drive and use machines?
No data is available whether the application of Gordoks injection affects the ability to drive and use machines.
How should you apply Gordox injection?
Gordox injection will be administered by slow intravenous injection or infusion. If necessary Gordoks can be diluted with 0.9% sodium chloride or in at least 500 ml of 5% glucose infusion.
In order to determine hypersensitivity at least 10 min. Before the initial dose should be administered intravenously called. test dose of 1 ml (10.000 KIU) aprotinin.
What are the possible side effects of the application of Gordox injection?
During administration of the drug can be severe hypersensitivity reactions.
They can also occur in allergic repeated administration (with a frequency of less than 0.5%). Following repeated venipuncture in applying Gordoks injections may occur local inflammatory reactions (eg. Thrombophlebitis).
Gordoks should be administered after strict medical assessment where you have been administered therapy with aprotinin as readmission of aprotinin increases the risk of allergic reactions.
The administration of a therapeutic dose may lead to the development of hypersensitivity (anaphylactic) reactions, even in cases where they are not observed allergy to the test dose. Of hypersensitivity reactions administration of aprotinin injection should be discontinued immediately and should take appropriate therapeutic actions.
Can you take other medicines during treatment with Gordox?
Gordox should not be administered together with infusions containing dextran. During treatment with Gordoks You should tell your doctor if you are currently taking or have recently taken any other medicines, even those not on prescription.
How to store Gordox injection?
This medicinal product does not require any special storage conditions.
The drug should not be administered if the contents of the vial is cloudy.
Once opened, the vial should be used immediately.
Do not use after the expiry date stated on the packaging.
Keep out of the reach and sight of children.