GABAGAMMA . 300 mg. 100 tablets
GABAGAMMA . 300 mg. 100 tablets
WHAT Gabagamma 100 mg AND WHAT IT IS USE
Gabagamma 100 mg is a medicine for the treatment of certain forms of epilepsy, and some neuralgic pains.
Gabagamma 100 mg is used:
As adjunctive treatment for certain types of seizures (partial epilepsy with or without secondary generalized seizures) in patients who do not respond to treatment with standard antiepileptic drugs (medicines used to treat epilepsy).
In painful diabetic neuropathy (painful neurological symptoms in patients with diabetes), and
With post-herpetic neuralgia (after infection with herpes zoster virus).
BEFORE YOU TAKE Gabagamma 100 mg
Do not take Gabagamma 100 mg:
In case of hypersensitivity (allergy) to gabapentin or any of the excipients;
In case you experience acute inflammation of the pancreas (pancreatic).
Take special care with Gabagamma 100 mg:
When you complain of bouts of absences. Gabapentin is generally considered to be ineffective in the treatment of absence seizures in some patients and may even intensify these attacks. Therefore, Gabagamma 100 mg should be administered with caution in patients with mixed seizures including absences.
If you have not responded to treatment carried out before. In some of these patients, gabapentin may reduce the risk of seizures. If you do not achieve satisfactory effect, gabapentin should be gradually excluded from treatment.
Abrupt discontinuation may cause withdrawal symptoms (see also item 4. "Possible side effects"), increasing number of attacks and even statusepilepticus (series of epileptic seizures long term).
Upon dose reduction, discontinuation, addition or replacement with another antiepileptic product. These changes should be made gradually over at least one week.
When you have reduced kidney function. In this case, the dosage of 100 mg Gabapentin should be adjusted (see section 3 "In the event that your doctor advises otherwise, the usual doses are:").
In the presence of mental disease, mental history. There is no occurrence of psychotic episodes at the beginning of gabapentin therapy in some patients with a history of psychotic illness and less frequent in patients without pre-existing psychotic disorder. In most cases, these episodes resolved after discontinuation of therapy or reduce the dose of gabapentin.
A small number of people being treated with anti-epileptics such as gabapentin, have had thoughts of harming or killing yourself. If you have these thoughts, immediately contact your doctor.
Where you are a person signs of acute inflammation of the pancreas, as long abdominal complaints, nausea, repeated vomiting. In this case, treatment with gabapentin should be stopped and a clinical examination, and to explore the respective laboratory. There are no adequate data from the use of gabapentin in the presence of chronic inflammation of the pancreas (pancreatitis).
Children and adolescents
Gabagamma 100 mg is not recommended for the treatment of epilepsy in children under 12 years, and for the treatment of painful neuralgia in children and young people up to 18 years because there is not enough experience with the efficacy and safety of treatment in this group of patients.
In patients older than 65 years were not conducted systematic studies on treatment with gabapentin. Experience from clinical trials showed no difference between adverse reactions in patients over 65 years compared with those in younger patsienti.Pri elderly patients with declining renal function is recommended to adjust the dose (see section 3. "In the event that Your doctor has told you otherwise, the usual doses are: ").
Pregnancy and lactation
If you are pregnant you should take Gabapentin 100 mg only after careful risk-benefit by your doctor because there are not enough studies on the administration during pregnancy. Like other antiepileptic drugs, especially when they are applied in combination therapy might expect an increased risk to the fetus. In general, the risk of damage to the embryo / fetus is the lowest in the treatment with a medicine containing only one drug (monotherapy), selecting the lowest possible dose and folic acid before and during pregnancy . There potenitsalni risks when used in combination with other antiepileptic sredstva.Informirayte your doctor if you are pregnant, during treatment with 100 mg Gabagamma appears if you are pregnant or planning a pregnancy. Under no circumstances should stop taking medicine without instructions from a doctor since epileptic seizures can lead to damage to the child / fetus.
Active substance of Gabapentin passes into breast milk. Since taking Gabapentin 100 mg can not exclude serious adverse effects on the nursing infant, your doctor must decide: whether it should be discontinued your treatment with Gabapentin 100 mg (given the importance of treatment with anti Gabagamma 100 mg to the mother) or you should stop breastfeeding.
Driving and operating machinery
Gabapentin may affect the ability to drive and use mashini.Preparatat acts on the central nervous system and can cause drowsiness, dizziness, vertigo and other symptoms and is potentially dangerous for patients to drive or operate machinery. This fact must be taken into account, especially when starting treatment or increasing the dose.
Important information about some of the ingredients of Gabapentin 100 mg
This product contains laktoza.Ako your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently started taking another medicine. This also applies to medicinal products which are not shown on the prescription.
Antacids (medicines connecting with stomach acid) reduced the bioavailability of gabapentin (current amount of active substance present in the body) to 24%. If you are taking antacid medicine you should take gabapentin no earlier than two hours after the intake.
No interactions were observed between gabapentin and phenobarbital, phenytoin, valproic acid or carbamazepine (other active substances for the treatment of epilepsy). Gabapentin does not affect contraceptive drugs (tablets "anti-baby") containing norethisterone and / or ethinyl estradiol, but it is often used in combination with other antiepileptic drugs, which are known to reduce the activity of hormonal contraceptives (oral contraceptive "pill"). When such combined therapy should be considered failure kontratseptsiyata.Nezhelanite effects of gabapentin-related central nervous system such as dizziness and unsteady gait may be enhanced by alcohol and illicit drugs on produkti.Ukazanie affect renal izsledvaniyaPri combining Gabapentin with other anticonvulsants may be reported false-positive results in the determination of total protein in the urine test strips. It is therefore recommended to use other methods (in particular methods of precipitation with sulfosalicylic acid).
Taking Gabagamma 100 mg with food and drink
Effects of Gabapentin 100 mg is not affected by concomitant intake of alcohol hrana.Konsumatsiyata may increase the side effects of Gabapentin 100 mg on the central nervous system (see "Taking other medicines").
HOW TO TAKE Gabagamma 100 mg
Take 100 mg Gabapentin always only as prescribed by your doctor. Please consult your doctor or pharmacist in case you have any doubts.
Route of administration
Take the capsules without chewing them with enough liquid (eg a glass of water). Admission can be done regardless of hraneniyata.Vremeto between the evening and the next morning dose should not be more than 12 hours to prevent the risk of new attacks.
In the event that your doctor advises otherwise, the usual doses are: In connection with the higher doses available and other relevant concentrations of the drug produkt.Za dosage of 300 milligram dose your doctor will prescribe another drug concentration of - hard capsules containing 300 mg gabapentin.Epilepsiya
The effective dose of gabapentin is 900 - 3600 mg daily.
Adults and adolescents:
Treatment begins with hard capsules containing 300 mg gabapentin.Prez first three days can stepwise to reach 900 mg dosage could also dnevno.Alternativno from day to take three times a day, gabapentin 300 mg (corresponding to 900 mg daily dose). The daily dose may be increased to 1200 mg gabapentin, and if necessary can be held stepping further increase the dosage to 300 mg gabapentin per day to a maximum dose of gabapentin 3600 mg total daily dose dnevno.Vsichki should be divided into three considered denya.Ako using high dose and raising the dose is very fast, increases the risk of onset of vertigo during the establishment of dozata.Ne is necessary to monitor gabapentin plasma concentrations, to optimize therapy.
Painful neuropathy in diabetic neuropathy or after infection with herpes zoster virus: a rule result is achieved with doses of 1800 - 2400 mg per day, but in some cases it may be necessary to increase the dose to a maximum of 3600 mg daily.
Treatment begins with hard capsules containing 300 mg gabapentin.Prez first three days can stepwise to reach 900 mg dosage dnevno.Sled, within a period of one week, the daily dose may be increased up to a dose of 1800 gabapentin mg daily divided in three doses. In demand in the next week, the daily dose may be increased to 2400 mg daily, if necessary, may be held and further stepping upward dosage with 300 mg gabapentin per day to a maximum dose of 3600 dnevno.Zavishavaneto mg gabapentin dosage until a maintenance dose is done slowly to reduce the risk of adverse reaktsii.Lipsvat data on safety and efficacy of gabapentin when used this testimony for more than five months.
Patients on hemodialysis receive the initial dose of 300-400 mg gabapentin. Then appoint 200-300 mg gabapentin (corresponding to 2-3 Gabapentin Capsules 100 mg) every 4-hour hemodialysis. On days without dialysis treatment is conducted with patients gabapentin.Visokoriskovi
Patients in poor general condition, low body weight, or after organ transplantation, raising the dose must be done step by step, using Gabapentin 100 mg (corresponding to 100 mg gabapentin).
Duration of use
The duration of use is determined by the patient's needs. Treatment of epilepsy is usually long.
If you take more than the dose Gabapentin 100 mg:
Tell your doctor immediately for an overdose! It will determine the severity of the overdose and determine necessary merki.Simptomite overdose are dizziness, gait instability, double vision, slurred speech, articulation disorders, drowsiness, disturbances in consciousness (lethargy), apathy and mild diariya.Gabapentin can be removed from plasma by hemodialysis. Past experience shows that this is usually not necessary.
If you forget to take Gabapentin 100 mg
Please, no missed doses and do not take a double dose if you miss the previous administration! Continue to follow the scheme taking Gabapentin 100 mg, as you lekar.Popitayte directed by your doctor whether missed a single dose gabapentin could be offset by an additional later a dose (eg in case Time since last dose was more than 12 hours).
If you stop taking Gabapentin 100 mg
You should not stop treatment with 100 mg Gabapentin in its sole discretion, without medical ukazanie.Molya to consider that reducing the dose, discontinuation, or substitution with another antiepileptic product should be carried out gradually over at least one week. Abrupt discontinuation may cause withdrawal symptoms increase the risk of increasing the number of attacks and even lead to a prolonged series of epileptic seizures (statusepilepticus).
The most common side effects are possible: central nervous system, reduced alertness and ability to concentrate, drowsiness, fatigue, gait instability, dizziness, headache, nausea, vomiting, weight gain, nervousness, insomnia, nystagmus, disturbance sensitivity as tingling, loss of appetite.
In combination with other antiepileptic drugs in 50% of patients reported adverse events.
Violations of the general condition:
Common: lethargy, fatigue, somnolence, fatigue, dizziness, headache, insomnia, weight gain, loss of appetite, peripheral edema, or swelling of the body (water retention in the tissues), increased apetit.Sravnitelno rare accidental injury, svetovartezh.Redki: withdrawal reactions (pain, excruciating pain in the chest, sweating).
Nervous system disorders:
Common: gait disturbances, nystagmus, tremor, amnesia, sensitivity disturbances such as tingling, twitching, increased, decreased or absent reflexes, reduced alertness and ability to concentrate, mental, speech and impaired memory, difficulty in articulation, impaired pohodkata.Nechesti confusion, decreased sensitivity to touch drazniteli.Redki: movement disorders (choreoathetosis, dyskinesia, dystonia).
Common: vomiting, nausea, diarrhea, dry mouth, indigestion, constipation, abdominal pain, dental abnormalities, gingivitis, nerazpolozhenie.Nechesti: flatulence (excessive gas in the stomach). Very rare: hepatitis.
Common: anxiety, depressed mood, disorientation, confusion and emotional instability trevozhnost.V addition, in clinical trials in children below 12 years have been reported aggressive behavior and increased motorika.Nechesti: mental health problems (depression, psychosis / hallucinations), hostility.
Common: visual disturbances such as loss of vision (lazy eye), double vision, decreased vision.
Ear and labyrinth disorders:
Rare: tinnitus (tinnitus).
Musculoskeletal, connective tissue and bone disorders:
Common: arthralgia, muscle cross bone fractures.
Blood and lymphatic system disorders:
Common: a decrease in the number of white blood teltsa.Nechesti: changes in blood zahar.Redki: decrease in platelet count, changes in blood sugar in patients with diabetes.
Common: dilation of blood vessels hipertoniya.Redki: palpitations.
Respiratory, thoracic and mediastinal disorders:
Common: fever, inflammation of the throat, kashlitsa.Nechesti: shortness of breath.
Rare: upper respiratory tract.
Skin and subcutaneous tissue disorders:
Common: pruritus, skin hemorrhages (purpura) obriv.Redki: urticaria, alopecia, edema of the skin and mucosa (angioedema). Very rare: allergic skin conditioned zabolyavaniya (Stevens-Johnson-Syndrome and Erythema multiforme).
Renal and urinary disorders:
Common: urinary retention, urinary patishta.Redki: acute renal nedostatachnost.Zasyagane the genitals and breast disorders:
Effects on laboratory tests:
There are reports of elevated liver enzymes in a combination of gabapentin with other antiepileptic sredstva.Ima cases of inflammation of the pancreas (pancreatitis haemorrhagic), low blood pressure, slow heart rate, syncope, atrial fibrillation, abnormal electrocardiograms and maculopapular rash in patients treated with gabapentin.Pri few patients were seen as dose-dependent increase in seizure frequency. There are also reports of dose-related, repetitive, unusual attacks.
If any of the side effects gets serious, or if you notice the effects not listed in this leaflet, please tell your doctor or pharmacist.
HOW TO STORE Gabagamma 100 mg
Medicinal product to be stored out of reach of children mesta.Ne Gabapentin use after the expiry date stated on the carton and blister after "EXP" The date of the expiration date is the last day of instructions stored at mesets.Da temperatures below 25 ° C. Blisters in the outer carton.
Medicines should not be disposed of in sewer wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
What Gabagamma 100 mg hard capsules
The active substance is gabapentin.Vsyaka capsule contains 100 mg of gabapentin.
Other ingredients: Capsule contents: lactose monohydrate, maize starch, talc.
Capsule shell: gelatin, titanov dioxide (E 171).