Fungolon 50 mg. 8 capsules
Fungolon medicine from a group called antifungals (antifungal agents). The active substance is fluconazole.
Fungolon be used for prevention and treatment of infections caused by various fungi. The most common causes are yeasts like Candida.
Your doctor may prescribe this medicine for the treatment of the following infections caused by fungi:
Cryptococcal meningitis - inflammation of the meninges caused by fungi;
Coccidioidomycosis - a disease of the respiratory system (bronchi and lungs);
Infections caused by Candida, which are located in the bloodstream, internal organs (heart, lung) or urinary tract;
Mucosal infections affecting the lining of the mouth, throat and sore mouth when wearing dentures;
Genital thrush - infection of male and female genitals;
Skin infections - eg. foot infections (athlete foot), groin, nail ringworm.
Fungolon may be prescribed in the following cases:
To prevent recurrence of cryptococcal meningitis;
To prevent recurrence of fungal infections in the mucous membranes;
In order to limit the recurrence of vaginal candidiasis;
To limit infections caused by Candida in weak and poorly functioning immune system.
Children and adolescents (0 to 7 years)
This medication you may be prescribed by your doctor for treatment of the following infections caused by fungi:
Mucosal infections affecting the lining of the mouth and throat;
Infections caused by Candida, which are located in the bloodstream, internal organs (heart, lung) or urinary tract;
Cryptococcal meningitis - inflammation of the meninges caused by fungi.
Fungolon can be prescribed for:
Limitation of infections caused by Candida in weak and poorly functioning immune system;
Prevent recurrence of cryptococcal meningitis.
2. What you need to know before taking Fungolon
Do not use Fungolon:
If you are allergic to fluconazole, to other azoles or any of the other ingredients of this medicine (listed in section 6). Symptoms may include: itching, redness of the skin and difficulty breathing;
If you are taking astemizole, terfenadine (allergy antihistamines);
If you are taking cisapride (for stomach ailments);
If you are taking pimozide (used to treat mental illness);
If you are taking quinidine (to restore heart rhythm);
If you are taking erythromycin (antibiotic to treat infections).
Warnings and Precautions
Talk to your doctor or pharmacist if:
have liver or kidney problems;
suffer from heart disease, including heart rhythm disorder;
have abnormalities of potassium, calcium or magnesium in the blood;
get severe skin reactions - itching, redness of the skin, accompanied by difficulty breathing.
Other medicines and Fungolon
Tell your doctor or pharmacist if you are taking, you have recently taken or might take any other medicines, including medicines obtained without a prescription.
Tell your doctor if you are taking astemizole, terfenadine (allergy antihistamines) or cisapride (for stomach disorders), pimozide (used to treat psychiatric illnesses), quinidine (to restore heart rhythm), erythromycin (antibiotic to treat infections) since these drugs should not be taken simultaneously with Fungolon (see section Do not use Fungolon).
Some medicines may interact with Fungolon. Tell your doctor if you are taking any of the following medications:
rifampicin or rifambutin (antibiotics used to treat tuberculosis or other infections);
alfentanil, fentanyl (pain medication);
amitriptyline, nortriptyline (antidepressants);
amphotericin B, voriconazole (to treat fungal infections);
drugs that prevent blood clotting (warfarin or similar drugs);
benzodiazepines (midazolam, triazolam or similar medicines) to help you sleep or adopted anxiety;
carbamazepine, phenytoin (to treat seizures);
nifedipine, isradipine, amlodipine, felodipine and losartan (used to treat high blood pressure);
ciclosporin, everolimus, sirolimus or tacrolimus (used to prevent transplant rejection);
cyclophosphamide, vinca alkaloids (vincristine, vinblastine, and the like) used for the treatment of cancer;
halofantrine (used to treat malaria);
statins (atorvastatin, simvastatin, fluvastatin and the like drugs) to lower cholesterol;
methadone (used to treat pain);
nonsteroidal antiinflammatory drugs (NSAIDs) such as celecoxib, flurbiprofen, naproxen, ibuprofen, lornoxicam, meloxicam, diclofenac;
oral contraceptives (birth control);
zidovudine, also known as AZT; saquinavir (used to treat HIV-infected patients);
chlorpropamide, glibenclamide, glipizide, chlorpropamide or tolbutamide (used for diabetes);
theophylline (for asthma);
vitamin A (a food additive).
Fungolon food, beverages and alcohol
You can take this medicine with or without food.
Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine. You should not take Fungolon while pregnant or breast-feeding, unless your doctor has told you.
Driving and using machines
When driving or operating machinery should be borne in mind that sometimes can occur dizziness or seizures.
Fungolon contains lactose monohydrate
If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.
3. How to take Fungolon
Always take Fungolon just as you have been told your doctor. If you're not sure, ask your doctor or pharmacist.
The capsules should be swallowed whole with sufficient fluid at the same time each day.
Typical doses for various types of infection are described below:
For the treatment of cryptococcal meningitis 400 mg on the first day, and then at 200 to 400 mg once daily for 6 weeks or longer if necessary. Sometimes the dose may be increased to 800 mg.
To prevent recurrence of cryptococcal meningitis 200 mg once daily until your doctor tells you to stop treatment.
For the treatment of coccidioidomycosis 200 to 400 mg once a day for 11 to 24 months or longer, if necessary. Sometimes the dose may be increased to 800 mg.
To treat infections of internal organs caused by Candida 800 mg on the first day, then 400 mg once daily until your doctor tells you to stop treatment.
Mucosal infections affecting the lining of the mouth, throat and sore mouth when wearing dentures. 200 to 400 mg on the first day, then 100 to 200 mg daily until your doctor tells you to stop treatment.
For the treatment of fungal infections in mucosal dosage depends on the localization of the infection 50 to 400 mg once daily for 7 to 30 days until your doctor tells you to stop treatment.
For the prevention of infections of the mucous membranes of the mouth and throat 100 to 200 mg once daily or 200 mg three times a week, while there is risk of infection.
For the treatment of candidiasis, genital 150 mg once.
For limiting the recurrence of candidiasis 150 mg every third day (day 1, 4 and 7) followed by 150 mg once a week for 6 months, whereas there is a risk of infection.
Infections of skin and nails, caused by fungi Depending on the site of infection 50 mg once daily, 150 mg once a week, 300 to 400 mg once a week for 1 to 4 weeks (for infections of the foot (foot of the athlete) caused fungal treatment can last up to 6 weeks, nail infections - while infected fingernail grow again.
To prevent infections caused by Candida in weakened and poorly functioning immune system 200 to 400 mg once daily until there is a risk of infection.
Adolescents (12 to 17 years):
Follow the dose prescribed by your doctor (children or adults).
Children up to 11 years
The maximum dose for children is 400 mg.
The dose is determined by the child's weight in kilograms.
Infections of the mouth and throat infections caused by Candida - dose and duration of treatment depend on the severity and localization of the infection 6 mg / kg on the first day, followed by 3 mg / kg daily.
Cryptococcal meningitis or infections of the internal organs caused by Candida 6 to 12 mg / kg daily.
To prevent infections caused by Candida, when the child's immune system is weak and not functioning well 3 to 12 mg / kg daily.
Use in children aged 0 to 4 weeks
Use in children aged 3 to 4 weeks:
The dosage is the same as described above, but applicable to every 2 days. The maximum dose is 12 mg / kg every 48 hours.
Use in children less than 2 weeks:
The dosage is the same as described above, but is administered every 3 days. The maximum dose is 12 mg / kg every 72 hours.
Doctors can sometimes decorate doses other than those mentioned.
Apply a dose as adults, except in kidney disorders.
Patients with impaired renal function
Your doctor will adjust the dose according to renal function.
If you take more than the amount Fungolon
When taking too much capsules at once will feel bad. Immediately consult a doctor or go to the nearest hospital. Symptoms of overdose are: see, hear or think things that are not there (hallucinations and paranoid behavior). It is appropriate to symptomatic treatment (supportive measures and, if necessary gastric lavage).
If you forget to take Fungolon
Do not take a double dose to make up the missed dose. Take this medicine at the same time each day. If you forget to take your medicine, take it as soon as you remember. If it is almost time for your next dose, do not take the dose that you missed.
If you stop taking Fungolon
Even if you feel better and the symptoms have disappeared, the infection may still be present and may recur if you stop treatment too soon. Take this medicine for as long as prescribed.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Some people develop allergic reactions, although serious allergic reactions are rare. Tell your doctor immediately if you experience any of the following symptoms:
Sudden shortness of breath, difficulty breathing or tightness in the chest;
Swelling of the eyelids, face or lips;
Itching, redness of the skin or itchy red spots;
Severe skin reactions such as rash with bubbles (which can affect the mouth and tongue).
Fungolon can affect the liver. Signs of liver damage include:
Loss of appetite;
Yellowing of the skin or eyes (jaundice).
If any of these reactions immediately stop taking Fungolon and tell your doctor.
Other side effects:
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.
Common side effects which affect 1 to 10 users 100 are described below:
stomach discomfort, diarrhea, feeling sick, vomiting;
elevated blood tests which reflect liver function;
Uncommon side effects which affect 1 to 10 to 1 000 users are described below:
Reducing the number of red blood cells which can lead to pallor, weakness, or shortness of breath;
Convulsions, dizziness, feeling of tingling, pricking or numbness, changes in taste;
Constipation, indigestion, flatulence, dry mouth;
Liver disorders and jaundice (yellowing of skin and eyes);
Rashes, blisters, itching and increased sweating;
Fatigue, malaise, fever.
Rare side effects which affect 1 to 10 10 000 users are described below:
Low white blood cells that protect the body from infection and cells that help to stop bleeding;
Red or purple discoloration of the skin, which is caused by low platelet count, other changes in blood cells;
Changes in blood chemistry (high levels of cholesterol and fats);
Low levels of potassium in the blood;
Abnormal electrocardiogram (ECG), change in heart rate or rhythm;
Allergic reactions (sometimes severe), including widespread rash with blisters and peeling skin, swelling of the lips or face;
If you get any side effects, contact your doctor or pharmacist. This includes any possible effects not listed in this leaflet.
5. How to store Fungolon
Do not store above 25 ° C.
Keep out of reach of children!