DERMAZIN cream 50 g
Dermazin is a medicinal product of the local chemotherapy. Dermazin cream is used for the prevention and treatment of infections in patients with burns and other skin wounds.
Silver sulfadiazine disintegrate in the wound, which leads to a slow and sustained release of silver ions. These ions bind to bacterial DNA and inhibit the growth and reproduction of the bacterial cells without damaging the cells of the skin and subcutaneous tissue of a human. Dermazin cream has a very broad spectrum of antibacterial activity including almost all microorganisms causing infections burn wounds and other skin wounds.
Dermazin cream penetrates into necrotic tissue and mucus. This feature is of particular importance, since systemic antibiotics are ineffective against bacteria in wounds due to interrupted blood flow to tissue necrosis.
What is Dermazin?
Dermazin cream used for the treatment and prophylaxis of infections in patients with burns.
Dermazin cream is also used for the treatment and prophylaxis of infections in pressure sores, leg ulcers, abrasions, minor trauma, cuts, wounds and other contaminated donor in the skin graft for the treatment of the sections without skin.
When you must not use Dermazin?
• if you are hypersensitive to sulfadiazine or any other ingredient of the product
• If you are in the last months of pregnancy; exceptionally Dermazin cream can be used during pregnancy and lactation only if absolutely necessary and the expected benefit to the mother outweighs the potential risk to the fetus (see. Pregnancy and lactation)
• in neonates and premature infants during the first two months after birth, due to possible kernicterus (nuclear jaundice)
When necessary precautions when applying Dermazin?
• if you have hypersensitivity to sulfonamides (due to possible allergic reactions)
• If you have an innate Glucose-6-phosphate dehydrogenase deficiency (due to possible hemolysis after applying the cream on large areas)
• if you have impaired liver or kidney function
• If you have porphyria
Tell your doctor about these conditions or if you suffer from any chronic diseases or metabolic disorders. Avoid getting cream in your eyes.
Important information about some of the ingredients of the cream Dermazin
Dermazin cream contains methyl parahydroxybenzoate and propyl, are known that can cause urticaria or more often delayed reactions such as contact dermatitis. Rarely cause immediate reactions with hives and difficulty in breathing due to bronchospasm.
With continued use of Dermazin cream on large areas of skin should be regularly monitored the number of white blood cells, as they may arise leukopenia, thrombocytopenia and eosinophilia. In the treatment of major burns, sulfadiazine concentrations in the blood can reach therapeutic levels. Therefore serum concentrations of sulfadiazine and renal function should be regularly checked and urine examined for possible crystalluria. Systemic absorption of glycol may affect serum osmolarity.
What to be aware when driving, operating machinery or insecure (eg. Climbing stairs)?
No data Dermazin influence on the ability to drive or operate machinery.
What special precautions should be taken during pregnancy and lactation?
Ask your doctor or pharmacist; before taking any medicine.
No evidence of harmful effects on the fetus Dermazin. However, avoid use during pregnancy, especially in the last
months, unless it is essential and the expected benefit to the mother outweighs the potential risk to the fetus.
Because sulfonamides pass into breast milk and may cause unwanted effects (nuclear jaundice) infant, avoid the use of Dermazin cream during lactation.
What other products influence the effect of Dermazin or may be affected by product?
It is important to tell your doctor about medicines you are taking or have recently taken any prescription or bought without a prescription.
• silver may inactivate local proteolytic enzymes (enzymes that break down proteins) when coadministered
• concomitant use with cimetidine (medicine for the treatment of gastritis and ulcer) is often reported decrease in the number of white blood cells
How it should be applied Dermazin?
Apply Dermazin exactly as directed by your doctor. Do not change the dosing schedule and do not interrupt the treatment before consulting.
Dermazin is intended for external use on the skin.
First clean the burn and remove dead tissue. Cover the area with Dermazin cream thickness 2-4 mm; recommended that the cream be applied to sterile gauze to put on the wound.
Dermazin may also be applied using a sterile spatula or a sterile glove. It is usually given once daily; in severe burns and may again. Before each application, you should clean the wound and remove all remnants of a previous application of the cream, and secretions from the wound, which is abundant after application of cream and Dermazin resemble pus, but do not contain microorganisms (aseptic). Use of water or antiseptic solution for washing of a wound. Can then put on the wound dressing, but is not mandatory.
Dermazin not cause pain in the application. It does not leave stains on clothes and underwear.
What should you do if you apply more than the recommended amount Dermazin?
If you apply more than the recommended dose Dermazin®, ask your doctor or pharmacist.
Prolonged high doses Dermazin extensive areas may cause systemic adverse reactions to sulfonamides. Treatment is symptomatic.
The probability of poisoning of silver due to its increased systemic absorption is minimal.
What should you do if you miss
If you forget to apply Dermazin®, do it as soon as you remember. If it is time for your next dose, wait. Do not take a double dose to make up for a missed dose.
What side effects can cause the application of Dermazin?
Like all medicines, Dermazin® can cause side effects.
Patients with burns may occur local reactions at the injection site of Dermazin®: skin irritation, warmth and skin hypersensitivity reactions with itching, rash and photosensitivity. It is possible to increase and body temperature.
If you notice any of these, tell your doctor or pharmacist.
In 3-5% of patients with burns reported decrease in the number of white blood cells (leukopenia). This reaction occurs 2-3 days after initiation of treatment and usually does not require termination or other special measures. It is recommended that blood counts of the patient.
Prolonged use of high doses Dermazin cream on large areas, can be observed side effects typical of systemic sulfonamides: changes in blood count (eosinophilia, leucopenia, anemia, thrombocytopenia), skin and allergic reactions, nausea, vomiting, diarrhea , hepatic and renal impairment, crystalluria. They are serious but uncommon reactions requiring emergency medical care. If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Keep out of reach of children!
The product should be stored in the original container at a temperature below 25 ° C.
The shelf life of the product is printed on the packaging. Do not use after the expiry date!