Curam. 1000 mg. 14 tablets

Curam. 1000 mg. 14 tablets
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In the treatment of bacterial infections caused by gram-positive and gram-negative, resistant to amoxicillin microorganisms whose resistance is due to the beta-lactamases, but which, however, are sensitive to the combination of amoxicillin and clavulanic acid. 

Curam. 1000 mg. 14 tablets

What does Curam 1000 mg?

Curam 1000 mg film-coated tablets
1 tablet contains: Amoxicillin trihydrate 1005 mg, corresponding to 875 mg amoxicillin
Clavulanic acid, potassium salt 149 mg, corresponding to 125 mg clavulanic acid
Excipients: magnesium stearate, talc, povidone, microcrystalline cellulose, croscarmellose sodium,
sodium, triethyl citrate, ethyl cellulose, hypromellose titanium dioxide E171, colloidal
Pharmaceutical form:
Packaging Curam 1000 mg
Single package of 10,12 and 14 tablets.
Treatment group and mode of action
 How does Curam 1000 mg?
Curam 1000 mg active against various bacteria (antibiotics).

When using Curam 1000 mg?
In the treatment of bacterial infections caused by gram-positive and gram-negative, resistant to amoxicillin microorganisms whose resistance is due to the beta-lactamases, but which, however, are sensitive to the combination of amoxicillin and clavulanic acid.
Curam1000 mg film-coated tablets is suitable for the treatment of:
• the upper and lower respiratory tract
•-exacerbation of chronic bronchitis
Antibakteoialen spectrum of amoxicillin / clavulanic acid Gram positive aerobes:
Bacillus anthracis, Corynebacterium species, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Staphylococcus aureus, coagulase negative Staphylococci (including Staphylococcus epidermidis). Streptococcus pneumoniae *. Streptococcus pygenes *. Streptococcus species *, Streptococcus viridans *
Gramlolozhitelni anaerobes:
Clostridium species, Peptococcus species *, Peptostreptococcus species *
* For these bacteria are still no messages that are beta-lactamase producing.
 Gram-negative aerobes:
Bordetella pertussis *, Brucella species *, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Helicobacter pylori *, Klebsiella Species, Legionella species, Moraxelia catarrhal, Neisseria gonorrhoeae, Neisseria meningitidis *, Pasteurella multocida, Proteus mirabilis, Proteus vulgarisa Salmonella, species. Shigella species, Vibrio cholerae. Yersinia enterocolitica
Gram-negative anaerobes:
Bacteroides species (including Bacteroides fragilis), Fusobacterium species
Resistant organisms:
Methicillin-resistant Staphylococci, Citrobacter, Enterobacter, Serratia, Proteus rettgeri, Morganeila morganii, Providencia Pseudomonas aeroginosa, Mycoplasma, Chlamydia, Rikettsia. • For those bacteria still no messages that are beta-lactamase producing.
When should you not use Curam 1000 mg?
There is a risk of an allergic challenge (anaphylactic) shock if the patient has had an allergic reaction to some p-lactam antibiotics (eg penicillins, cephalosporins). Please inform your doctor.
Under what circumstances need special attention?
Please tell your doctor if you have liver damage. (See "Dosage"). Please tell your doctor if you have kidney damage. He will then decide how to take Curam 1000 mg (see "Dosage").
Please tell your doctor if you have severe gastrointestinal disorders with vomiting and diarrhea, as is possible in this case Curam1000 mg not absorb enough.
What precautions are necessary when taken by children and the elderly? In elderly patients (60 years and older), treatment should be carried out carefully and the functional status of their liver to be monitored (see "Undesirable effects").
No need for any special precautions for children with normal renal function and liver.
What precautions are necessary during pregnancy and lactation?
There have been no adverse effects on the fetus or newborn using amoxicillin pregnant women. However, as a precaution Curam 1000 mg should be used during pregnancy only after careful and accurate assessment of the impact and risk of the doctor. Both ingredients pass into the embryo / fetus through the placenta and are excreted in breast milk. In infants it is possible occurrence of diarrhea and infections by fungi mucosa so that in these cases it is necessary to discontinue breastfeeding. Should be given to the possibility for the development of hypersensitivity.
Special precautions for safe use
What precautions should be taken?
With prolonged treatment should be monitored functions of the kidneys, liver and blood count. Patients with liver damage, the parameters of liver function should be monitored irrespective of the duration of treatment. If the values are changed to given interruption. Patients who have a catheter must inform the attending physician, as drugs containing amoxicillin at room temperature in high concentrations in the urine may crystallize on the walls of the catheter.
Patients with severe gastrointestinal disorders with vomiting and / or diarrhea should inform your doctor. In these cases, the drug is contraindicated, since it can not ensure adequate absorption.
Under what circumstances do you need to further consult with your doctor before taking Curam 1000 mg?
The following describes the special circumstances that require consideration before making Curam 1000 mg. If these circumstances are present or have occurred in the past, please contact your doctor.
Please tell your doctor:
- If you suffer from allergies or asthma as the emergence of new allergic reactions in these patients have in common;
 - In the case of disease of the Pfeifer (infectious mononucleosis), or lymphatic leukemia, since in these cases the skin outbreaks are more common;
- In case of severe liver damage or if such damage has been found in the past in connection with taking Curam 1000 mg, as the drug should not be taken in these circumstances.
Do you have restrictions on driving / operating machinery or work requiring a high concentration?
Until now there is no available evidence that Curam 1000 mg affect your ability to concentrate and reactions. In isolated cases, adverse drug reactions (see "Undesirable effects") that affect the activity (eg, anaphylactic shock, convulsions).
Keep out of reach of children!
Drug Interactions
Please inform your doctor in any case if you are taking or have recently taken any other medicines, even those you have bought from a pharmacy without a prescription unless Sigal 1000 mg.
What other substances or medications affect the effect of Curam 1000 mg?
Other antibiotics (e.g. tetracyclines, macrolides, sulfonamides and chloramphenicol) may be
reduce the efficiency of Curam1000 mg.
Probenecid increases the concentration of amoxicillin in the blood and bile.
The simultaneous administration of allopurinol during treatment with Curam ® / Kuramoto 1000 mg may
increase the risk of developing allergic skin reactions.
Diuretics cause an increase in release of amoxicillin, thereby reducing its concentration in the blood.
On which other substances or medications affect Curam 1000 mg? Rarely application of amoxicillin may decrease the effect of the application of hormonal contraceptives. Therefore, it is advisable to take extra contraceptive containing hormones.
Curam 1000 mg may increase the absorption of digoxin (a component of different cardiac medicines).
Curam 1000 mg should not be used concomitantly with disulfiram (alcoholism). What other interactions are possible?
Possibility of bleeding may be increased by concomitant administration of Curam 1000 mg group and anticoagulants of the coumarin.
In case of diarrhea, the efficacy of Curam 1000 mg may be impaired.
Can be false positive results in the determination of glucose in urine by
the reduction (non-enzymatic) methods. Also, such results may be obtained in determining the
Please note that this information may also apply to drugs taken recently.
If there are good reasons to expect that the microorganisms mentioned above are the cause of infection, treatment with Curam 1000 mg may be initiated before the results of susceptibility testing.
This information is used in the event that your doctor has prescribed otherwise. Please note that otherwise Curam 1000 mg does not work properly! Tablets must be broken into two to give the half dose. Please consult with your doctor respectively.
How many tablets Curam 1000 mg should be taken la and at what intervals?
Adults, adolescents and children over 12 years weighing more than 40 kg: 2 x 1 tablet daily. Elderly:
Above depicted scheme is sufficient, in the event that there is no damage to the kidney or liver.
Patients with hepatic impairment:
If there are signs of liver damage, as prescribed by your doctor you should periodically review the parameters of liver function and if values change be considered a change in treatment Curam ® / Kurama 1000 mg (see "Contraindications"). Patients with renal function impairment.
Please tell your doctor if you have kidney failure. Then he will decide to you can be prescribed Curam 1000 mg
When kidney function impairment, the dose should be reduced depending on the severity of the injury and the patient's weight.
Only in patients in whom the creatinine clearance below 30 ml / min Curam 1000 mg film-coated tablets should be taken once daily.
Method of administration
How and when to take Curam 1000 mg?
The tablets should be taken whole with sufficient liquid.
Most preferably Curam 1000 mg to be taken at the beginning of a meal, as will be more effective and thus also tolerated better. It is also effective however, if taken before or after meals. Single doses should be taken at regular intervals during the day; if prescribed two doses a day they should be taken at 12-hour intervals.
 How long should I take Curam 1000 mg?
The doctor will determine the duration of treatment.
Do not stop treatment at your request, even if you feel better. As a rule Curam1000 mg is administered for 3 to 4 days after improvement or disappearance of the symptoms of the disease. Curam ® / Kurama 1000 mg should not be taken more than 14 days without the consent of your doctor.
If Curam1000 mg is prescribed for the treatment of specific bacterial infections (0-hemolytic streptococci), it should be taken at least 10 days to have a certain therapeutic effect. Otherwise there is a risk of late complications (eg rheumatic fever, glomerulonephritis).
Overdose and other errors
What should I do in case of the adoption of a very large amount of Curam 1000 mg (intentional or accidental overdose)?
Generally do not require specific measures in case of overdose except discontinuation of the drug.
Symptoms of overdose largely resemble those side effects. For very large dose can be observed nausea, vomiting, abdominal pain and diarrhea.
What should you do if you've taken too little Curam1000 mg or did you forget to take it?
If you have missed taking time Curam ® / Kurama 1000 mg, take it as soon as possible thereafter. The next intake should be according to the scheduled time.
What should you do if you stop or interrupt treatment periodically?
Please do not stop your treatment with Curam ® / Kurama 1000 mg without consulting your doctor.
As a result of disruption may worsen your condition.
Undesirable effects
What side effects may occur when taking Curam 1000 mg? (As when taking any medicine and the adoption of Curam1000 mg can be observed adverse reactions. Some of the following side effects may occur when taking Curam 1000 mg
Hypersensitivity reactions:
Cases of skin reactions, which occur as rash and itching. Typical rash morbilliform type sometimes occurs 5 to 11 days after initiation of treatment. Immediate reaction with hives in most cases is indicative of a typical penicillin allergy and require treatment be discontinued.
Severe allergic reactions due to hypersensitivity to 6-APA group are observed in rare cases, eg. in the form of threatening (anaphylactic) shock, fever, increasing the number of certain blood cells (eosinophilia), painful swelling of the skin and mucosa (edema Quincke), swelling of the larynx with central narrowing of the airways and difficulty breathing (laryngeal edema ), serum sickness, hemolytic anemia, allergic vasculitis or nephritis. If any of these symptoms you should seek immediate medical assistance.
There may be a link between the antigen and dermatophytes penicillin, so that patients with fungal infection can not be excluded effects similar to those observed with repeated administration, even after the first administration of penicillin.
Reactions svrhchuvstvitelnost all grades - including allergy-induced (anaphylactic) shock were observed even after the oral administration of penicillins, but with a much lower frequency than after injection (intravenously or intramuscularly).
Sometimes it can be observed inflammation of the mucous membranes, especially in the mouth. In very rare cases, it may be observed dark spots on the tongue. Possible dry mouth and impairment in the perception of taste.
Severe skin reactions with common life-threatening Syndrome Stevens-Johnson, Lyeli syndrome and exfoliative dermatitis (rash to life-threatening conditions) have been reported in rare cases of application of Curam 1000 mg. Gastrointestinal reactions:
Disorders in the form of heavy stomach, nausea (mainly at higher doses), vomiting, flatulence, loose stools or diarrhea may occur sometimes after making amoxycillin / clavulanic acid. Most often, they are mild and usually disappear simultaneously or shortly after discontinuation of treatment. The tolerability may be improved by adopting the amoxicillin / clavulanic acid during a meal.
If severe persistent diarrhea during treatment or during the first few weeks of treatment should be given to the possibility for the development of pseudomembranous colitis (in most cases caused by Clostridium difficile). This intestinal disease caused by antibiotic treatment can be life-threatening (see "What measures should be taken if there are side effects").
In very rare cases severe colonization with intestinal candidiasis.

Sometimes there is a moderate increase in liver enzymes. In rare cases, as with the use of other penicillins and cephalosporins, the consequence of inhibition of bile passage observed transient hepatitis and cholestatic jaundice. These disturbances of liver function may be severe (see "What measures should be taken if there are side effects"). They are characterized by unusually intense itching, yellowing of the skin or eyes and dark urine and uncharacteristically soft stools. Violations usually hymns during or immediately after treatment but in some cases may not occur until several weeks after discontinuation of therapy and are more often in men or the elderly (60 and older). Generally the symptoms subside.
Blood count:

In rare cases may be temporary changes in blood counts expressed as such. decrease the number of white blood cells (leucopenia), reducing or increasing the number of platelets (thrombocytopenia or thrombocytosis). In isolated cases temporary changes in blood parameters such as reduction in the number of granulocytes (granulocytopenia) deficiency of all blood elements (pancytopenia), anemia or extension of bleeding and clotting.
CNS disorders.
In isolated cases have been reported hyperactivity, anxiety, drowsiness, mental confusion, aggression and convulsions. So on other side effects:
It is possible to develop superinfection, to be treated in an appropriate manner.
 What measures should be taken if there are not side effects?
The following side effects are very rare (for more comprehensive information on these events, see above) and may in certain cases be acutely life-threatening. You must without delay to seek medical advice if any adverse reactions occur suddenly or unexpectedly severe. Pseudomembranous colitis;
In these cases the physician should appoint discontinuation Sigal ® / Kurama 1000 mg if necessary depending on the condition immediately take appropriate treatment (eg oral vancomycin 250 mg four times daily in adults). Depressant medication peristalsis can not be taken.
Severe acute hypersensitivity reactions (eg, anaphylaxis):
Curam1000 mg treatment should be immediately discontinued and should be taken accordingly usual emergency measures (eg antihistamines, corticosteroids, sympathomimetics and, if necessary artificial respiration).
Occurrence of (epileptoformeni) seizures:
The corresponding routine emergency measures (eg maintenance free airway, anticonvulsant drugs such as diazepam or barbiturates).
Adverse reactions affecting the liver:


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