Co RENAPRIL. 20 mg. 12.5 mg. 28 tablets

Co RENAPRIL. 20 mg.  12.5 mg. 28 tablets
€ 15.00
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Co-Renapril a combination preparation for the treatment of hypertension (high blood pressure). It contains two active substances. Enalapril composition is a medicine of the so-called ACE-inhibitors. It dilates blood vessels, thus easier for the heart to pump blood to all parts of the body. 

Co-RENAPRIL. 20 mg. / 12.5 mg. 28 tablets

 
 
What is Co- Renapril and what it is used
Co - Renapril a combination preparation for the treatment of hypertension (high blood pressure ) . It contains two active substances. Enalapril composition is a medicine of the so -called ACE-inhibitors . It dilates blood vessels , thus easier for the heart to pump blood to all parts of the body. The other ingredient hydrochlorothiazide resulted in release of more water and salts in the kidneys. Together the two components helps to lower high blood pressure .
Co - Renapril used to treat hypertension (high blood pressure ) in patients , which is suitable for combination therapy.

2 . What you should know before taking Co- Renapril
Do not use Co- Renapril
If you are allergic (hypersensitive) to enalapril , thiazides, other sulfonamides, or any of the other ingredients of this medicine (listed in Section 6) ;
If previous treatment with drugs like co- Renapril (ACE ) inhibitors have an allergic reaction such as swelling of the face , lips , tongue and / or throat with difficulty in breathing and swallowing . You should not take Co- Renapril if you had these reactions without known cause or if you have been diagnosed with congenital or idiopathic angioedema ;
In severe hepatic impairment ;
In severe renal impairment ;
If you have difficulty with urination decreased urine output ;
If you are pregnant for more than three months . ( It is advisable to avoid the use of Co- Renapril and in early pregnancy - see Pregnancy section ) .
Warnings and Precautions
Talk to your doctor or pharmacist before taking Co- Renapril . Tell him about all your medical problems , as well as any allergies.
Tell the doctor if you have heart or liver disease, gout , if you are on dialysis or are taking diuretics ( medicines that increase the flow of water from the body) , if you have recently had a severe and prolonged vomiting or diarrhea. You should also report if you are on a diet with salt restriction , take potassium supplements, potassium -sparing drugs or potassium-containing salt substitutes , if you have diabetes or kidney problems, as they can lead to a significant increase in the level of potassium in the blood, which can cause serious disturbances in the work of the heart. In these cases it may be necessary to adjust the dose of Co- Renapril or monitoring the levels of potassium in the blood.
Tell your doctor if you have diabetes because thiazide diuretics may result in the need to adjust the dose of antidiabetic drugs.
Tell your doctor if you have ever had an allergic reaction with swelling of face , lips , tongue and / or throat with difficulty in swallowing and breathing.
Tell your doctor if you notice symptoms such as fainting or dizziness, especially when getting up , talking about low blood pressure (orthostatic hypotension) .
Before surgery or anesthesia (even in dental procedures ) , tell the surgeon or dentist that you are taking Co- Renapril . This is necessary because during anesthesia can be obtained a sudden drop in blood pressure.
Upon treatment with ACE inhibitors, including Co- Renapril may appear cough . It is a dry, persistent and resolves after discontinuation.

Use in children
Efficacy and safety in children has not been established .

Use in elderly patients
Clinical tests of effectiveness and tolerability in combined administration of enalapril and hydrochlorothiazide on the elderly and younger patients showed no differences.

pregnancy
We need to tell your doctor if you think you are pregnant or planning a pregnancy . Not recommended the use of co- Renapril in early pregnancy . It should not be taken during pregnancy over 3 months , as it may cause serious harm to your baby if used after the third month (see section Pregnancy and lactation ) .

ethnic differences
As with other ACE inhibitors , enalapril is less effective in lowering blood pressure in black patients than in non-black .

Anti-doping test
Contained in this medicine hydrochlorothiazide may lead to positive results with anti -doping test .

Other medicines and Co- Renapril
Tell your doctor or pharmacist if you are taking , have recently taken or might take other medicines.
Basically Co- Renapril can be taken with other medicines. Some drugs , however, can interfere with one another. To clarify the dose of Co- Renapril doctor is very important to know if you are taking other blood pressure lowering drugs , diuretics , potassium-containing products (including dietary salt substitutes ) , antidiabetic agents , antidepressants, digitalis glycosides, anti-arrhythmics products lithium - containing drugs ( used to treat certain types of depression ) , pain relieving and anti-inflammatory drugs , including gold - containing agents.

Co- Renapril with food, drinks and alcohol
No evidence of a need for a special diet or restrictions on certain types of food and beverages during treatment with this product.

Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you may be pregnant or planning to become pregnant , ask your doctor or pharmacist before taking this medicine.

pregnancy:
We need to tell your doctor if you think you are pregnant or planning a pregnancy . Usually the doctor will advise you to stop taking Co- Renapril before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine in place of Co- Renapril . Co- Renapril not recommended in the early months of pregnancy , and should not be taken after the third month of pregnancy because it may cause serious harm to your baby if used at that stage .

lactation
Tell your doctor if you are breast-feeding or breast-feeding. Co- Renapril not recommended for nursing mothers , and your doctor may choose another treatment for you if you want to breast-feed , especially if your baby is newborn, or was born prematurely .

Driving and using machines
When driving vehicles or operating machinery it must be borne in mind that it can sometimes get dizzy or general weakness .

Co - Renapril contains lactose monohydrate.
If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this product.

3 . How to take co- Renapril
Always take Co- Renapril exactly as your doctor tells you . If you are not sure, ask your doctor or pharmacist.
The dosage and duration of treatment is determined by the attending diagnostician, as are individual , depending on the effect and tolerability of concomitant medications . Administer orally with a sufficient amount of liquid.
The usual dose of Co - Renapril one (20 mg / 6 mg or 20 mg/12.5 mg) tablet taken once daily . The dose may be increased to 2 tablets per day .
Co- treatment with Renapril usually long , the length is determined by your doctor. Do not take more tablets than prescribed .

If you take an overdose of Co- Renapril
When taking a higher dose than prescribed , immediately contact a doctor !
The most common symptoms in overdose are dizziness, vertigo ( due to sharp and very low blood pressure), and / or thirst , confusion , decreased urine output and rapid heartbeat .

If you forget to take Co- Renapril
Do not take a double dose to make up for a missed dose. Do this in the next regular dose.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4 . Possible side effects
Like all medicines, Co- Renapril can cause side effects, although not everybody gets them . If you are not sure what the following side effects , ask your doctor to explain them to you .

Below are listed possible side effects by frequency.
Very common: They can be seen in more than 1 in 10 patients ;
Common: may occur in 1 to 10 in every 100 patients ;
Uncommon: may occur in 1 to 10 out of 1000 patients ;
Rare: may occur in 1 to 10 out of 10 000 patients ;
Very rare: may occur in less than 1 in 10,000 patients ;
Not known: frequency can not be estimated from the available data.
Blood and lymphatic system disorders:
Uncommon conditions with a reduced number of red blood cells ( aplastic anemia, hemolytic anemia) ;
Rare: changes in the cellular composition of blood (neutropenia , thrombocytopenia , agranulocytosis, suppression of bone marrow function , leukopenia , pancytopenia ) , damage to the lymph nodes , autoimmune diseases .
Endocrine disorders
Unknown: syndrome of inappropriate antidiuretic hormone secretion .
Metabolism and nutrition disorders:
Common: reduced levels of potassium in the blood, high cholesterol , elevated triglycerides , elevated uric acid;
Uncommon : low blood sugar , low magnesium content , gout ;
Rare: elevated blood sugar;
Very rare : increase in calcium in the blood.
Nervous system and psychiatric disorders:
Common: headache , depression , syncope, taste perversion ;
Uncommon: confusion , drowsiness, insomnia , nervousness, paresthesia , dizziness, decreased libido ;
Rare sleep disorder , abnormal dreams , paresthesia ( abnormal neuromuscular conduction due to low potassium ) .
Eye disorders :
Very common : blurred vision .
Ear and labyrinth disorders:
Uncommon: tinnitus.
Cardiac and vascular disorders:
Very common: dizziness ;
Common: low blood pressure, a sharp drop in blood pressure on standing , heart rhythm problems , angina ( chest pain breakthrough ) , rapid heartbeat ;
Uncommon: discomfort heartbeat , flushing , myocardial infarction or cerebrovascular accident , possibly secondary to a strong decrease in blood pressure in patients at high risk;
Rare: Raynaud's phenomenon .
Respiratory and thoracic disorders:
Very common: cough;
Common: shortness of breath ;
Uncommon: runny nose , sore throat and hoarseness, bronchospasm / asthma ;
Rare: fever, inflammatory lung processes ( pulmonary infiltrates , respiratory distress / including pneumonitis and pulmonary edema / allergic alveolitis / eosinophilic pneumonia) .
Gastrointestinal disorders:
Very common: nausea ;
Common: diarrhea , pain in the abdomen ;
Uncommon: volvulus , vomiting , constipation, stomach irritation , indigestion , pancreatitis, anorexia, dry mouth, peptic ulcer , increased flatulence ;
Rare: inflammation of the tongue and oral aphthous ulcers ;
Very rare: edema of the intestinal wall ( intestinal angioedema) .
Hepato-biliary disorders:
Rare: hepatic failure, hepatic tissue (possibly fatal ), hepatitis ( hepatocellular or cholestatic ) , jaundice , cholecystitis (inflammation of the gallbladder , especially in patients with a prior gallstone disease) .
Skin and subcutaneous tissue disorders:
Common: rash ( exanthema ) , hypersensitivity / angioneurotic edema: swelling of the soft tissues of the face, extremities, lips, tongue , throat and / or larynx ;
Uncommon : pruritus , urticaria, increased sweating , hair loss ;
Rare: severe skin reactions ( erythema multiforme, exfoliative dermatitis, pemphigus , toxic epidermal necrolysis , purpura , Stevens -Johnson syndrome, cutaneous lupus erythematosus, erythroderma ) .
There have been observing a set of symptoms ( fever, serositis , vasculitis, myalgia / myositis , arthralgia / arthritis, positive ANA, elevated erythrocyte sedimentation rate , eosinophilia and leukocytosis . Might appear rash , photosensitivity or other skin manifestations ) .

Musculo - skeletal and connective tissue disorders:
Common: muscle cramps ;
Uncommon: joint pain .
Renal and urinary disorders:
Uncommon : abnormal renal function , renal failure , protein in the urine;
Rare: reduced amount of urine, inflammation of the renal pelvis and renal tissue ( pyelonephritis and interstitial nephritis) .
Reproductive system and breast disorders:
Uncommon: impotence ;
Rare: gynecomastia ( breast enlargement in men ) .
General disorders and administration site conditions:
Very common: fatigue ;
Common: fatigue, pain in the chest ;
Uncommon : fever , malaise .
Investigations
Common: Increased potassium, elevated serum creatinine ;
Uncommon: blood urea , low sodium;
Rare: decreased hemoglobin , decreased hematocrit, elevated liver enzymes , increased serum bilirubin.
If any of the side effects gets serious , or you notice other effects not listed in this leaflet , please tell your doctor or pharmacist.

5 . How to store co- Renapril
At temperatures below 25 ° C.
Keep out of reach of children.
Do not use this medicine after the expiry date stated on the carton. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required . These measures will help to protect the environment.

6 . Contents of the pack and other information
What does co- Renapril
Co - Renapril 20 mg / 6 mg:
The active substances in one tablet Co- Renapril 20 mg / 6 mg are enalaprilov maleate 20 mg and hydrochlorothiazide 6 mg (enalapril maleate / hydrochlorothiazide).
Other ingredients include: croscarmellose sodium, lactose monohydrate, magnesium stearate , Dye Blue ( lactose monohydrate, E132 ) , pregelatinized corn starch , sodium bicarbonate .

Co - Renapril 20 mg/12, 5 mg:
The active substances in one tablet Co- Renapril 20 mg/12, 5 mg are enalaprilov maleate 20 mg and hydrochlorothiazide 12,5 mg (enalapril maleate / hydrochlorothiazide).
Other ingredients include: croscarmellose sodium, lactose monohydrate, magnesium stearate, yellow colorant ( lactose monohydrate, yellow iron oxide , red iron oxide) , pregelatinized corn starch , sodium bicarbonate .

Looks like Co- Renapril and contents of the pack
Co- Renapril 20 mg / 6 mg - light blue , round , biconvex tablets with a diameter of 9 mm.
Co- Renapril 20 mg/12, 5 mg - light orange , round , biconvex tablets with a diameter of 9 mm.
Package Contents Co- Renapril 20 mg / 6 mg and 20 mg/12, 5 mg tablets:
14 tablets in a blister of Al / Al foil of 1 and 2 in the blister pack.
At 7 tablets in blister Al / Al foil, 2 and 4 cards per pack.
 
 
€ 15.00
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