Climate. 21 tablets

Climate. 21 tablets
€ 15.00
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Clement was coated tablet for hormone replacement therapy (HRT). In what packages are available change? One package contains 21 coated tablets. How does it change? (Product Features)

Climate. 21 tablets

What change? (Composition)

Each white tablet contains 2 mg estradiol valerate, and each pink tablet contains 2 mg estradiol valerate and 1 mg cyproterone acetate as medicinal substances.
Clement also contains the following inactive ingredients:
lactose monohydrate, maize starch, povidone 25 000, talc, magnesium stearate, sucrose, povidone
700 000, macrogol 6000, calcium carbonate, montanglikolov wax, glycerol 85%, titanium dioxide, iron oxide yellow colorant, iron oxide red dye.

What is climate? (Pharmaceutical form and pharmaco-therapeutic group)

Clement was coated tablet for hormone replacement therapy (HRT). In what packages are available change? One package contains 21 coated tablets. How does it change? (Product Features)
Clement contains two types of hormones that reduce and disappear during the climax ("change of life") - estradiol and progesterone. Thus it replaces the hormones that your body no longer produces. Although this change of life is natural, it often leads to disturbing symptoms that are associated with progressive loss of hormones produced by the ovaries. In some women the loss of hormones leads to bone loss in later life (postmenopausal osteoporosis).
Contained in Clement estradiol prevents and relieves symptoms disturbing characteristic of climax: hot flushes, sweating, sleep disturbances, nervousness, irritability, dizziness, headache and involuntary loss of urine, burning and dryness in the vagina.
After inclusion of progesterone (tsiproteron acetate) in women with an intact uterus, menstrual cycle occurs in the free tablet-7-day interval. Therefore, change can not be used in women with menstrual disorders or in cases where an off pregnancy and no organic cause menstruation.
Clement probably cause bleeding regularly even if you are in menopause.
In young women Clement helped to establish menstrual cycle in the absence of menstrual bleeding (primary amenorrhea) or monthly cycles have ceased (secondary amenorrhea) in off pregnancy, lactation or organic cause 
Some women are at higher risk of developing osteoporosis, depending on their medical history and lifestyle. Clinical studies have shown HRT to reduce the risk of bone fractures in long-term treatment. If you are suitable, you may be given the climate for the prevention of osteoporosis. Your doctor will advise you on further treatment.
In clinical trials, the risk of developing colon cancer in postmenopausal women (after last bleeding) may decrease.
Why should we accept change? (Statement)
Climate provides hormone replacement therapy for menopausal symptoms, degenerative changes of the skin, bladder and genitals, depressive mood swings in menopause, menopause symptoms after monthly cycles. It is also used to treat symptoms caused by decreased activity of the ovaries (hypogonadism) or after removal or, if the ovaries are not functioning (primary ovarian failure). In addition, it is used to prevent osteoporosis in later stages of life, the so-called postmenopausal osteoporosis.
 Change can be useful in women with menstrual disorders (primary and secondary amenorrhea) or in cases where an off pregnancy, lactation and organic cause, not menstruating.
When you have to accept change? (Contra)
You should not change, in case you have or have had any of the following conditions. If any of these conditions applies to you, tell your doctor will advise you what to do.
  If you are pregnant or breast-feeding;
  Do you have undiagnosed vaginal bleeding;
  If you have breast cancer or suspected case;
  If you have other malignancies affecting of hormones or suspected as such;
  If you have or have had a benign or malignant tumor of the liver;
  If you have severe liver disease;
If you have recently had a heart attack and / or stroke;
  If you have or have ever had a thrombosis (blood clot) in the blood vessels of the legs (deep vein thrombosis) or lungs (pulmonary embolism);
  If you repeatedly elevated triglycerides (a type of blood fat);
  If you are allergic to any ingredient change (see Composition)
If any of these conditions appear for the first time while using Clement, stop taking and consult your doctor.

What you should know before taking change?

Your doctor will perform a pelvic examination, breast screening and blood pressure, and other appropriate tests. If you have a history of liver disease, your doctor will monitor liver function.
Before starting treatment is necessary to exclude adenoma of the anterior pituitary.
If you are still able to get pregnant, change will not prevent it. If you take contraceptive measures, other than oral (or other hormonal) contraception, continue with them until your doctor thinks that you need contraceptive protection. If you are taking oral (or hormonal) contraceptive should switch to an alternative non-hormonal method of contraception before therapy change.
On the other hand, if your doctor has told you that you do not need more contraceptive protection is not necessary to take measures while taking change.
What precautions should be taken? (Special warnings and precautions for use)

Before initiating therapy with Clement

Your doctor will explain the benefits and risks of taking the medicine.
Two large clinical trials of conjugated equine estrogens (CEE) and medroxyprogesterone (MPA), HRT hormones showed that the risk of angina (myocardial infarction) can be slightly increased during the first year of use. This risk was observed in extensive clinical trial with CEE alone. In two large clinical trials of these hormones, the risk of stroke was increased 30 -40%.
Although there are no data on climate, it should not be used to prevent heart disease and stroke.
If you meet any of the conditions listed below and use HRT may need to be under close observation. Your doctor will explain everything.
So before you start taking this medicine inform you if:
  you or someone close to the family have or have had an increased risk of thrombosis in the leg veins or lungs;
  you are overweight;
  you have varicose veins;
  If you are treated with Clement, tell your doctor prior to any planned surgery or hospitalization. This is necessary in connection with a temporary increased risk of deep venous thrombosis in operations, serious injuries and disability.
  uterine fibroids have;
  have or have had endometriosis (presence of uterine tissue of atypical areas of the body);
  you have gallbladder or liver disease;
  have a history of jaundice during a previous pregnancy or previous use of sex hormones;
  have diabetes;
  have increased levels of triglycerides (a type of blood fat);
  have high blood pressure;
  have or have had chloasma (yellowish-brown pigmentation patches on the skin). In such cases, avoid excessive exposure to sunlight or ultraviolet rays.
  suffer from epilepsy;
  have breast tenderness or nodules (benign breast disease);
  suffer from asthma;
  suffer from migraine;
  have an inherited disease called porphyria;
  suffer from congenital deafness, otosclerosis;
 you have systemic lupus erythematosus (SLE, a chronic inflammatory disease);
  have or have had minor chorea (a disease accompanied by abnormal movements). HRT and cancer
  Endometrial cancer
The risk of cancer of the lining of the uterus (endometrial cancer) increases when estrogen is used alone for an extended period of time. Progesterone used in climate counteract this risk.
Please tell your doctor if you often suffer from disorders have long cycles or bleeding during treatment change.
  Breast Cancer
According to some studies, breast cancer is found slightly more often in women on HRT for several years. This risk increases with duration of therapy. It can be lower or perhaps neutral in preparations containing estrogen alone. When a patient stops taking HRT, the increased risk disappears for a few years.
A similar increase in diagnosed breast cancer as observed. delay of natural menopause, alcohol intake, or obesity.
HRT increases the density of mammographic images. In some cases, this may complicate the mammographic detection of breast cancer. Therefore, your doctor may choose other screening techniques to detect breast cancer.
  Tumors of the liver
During or after the use of hormones, such as those in climate, rarely appear benign and even more rarely - malignant liver tumors. In isolated cases appear life-threatening bleeding in the abdominal cavity. Although such events are extremely unlikely, tell your doctor if you have unusual pain in the upper abdomen that do not go for a short time.
Reasons for immediate discontinuation of Clement
You should immediately stop treatment and consult with your doctor at any of the below cases:
 First attack of migraine (typically a throbbing headache and nausea preceded by visual disturbances);
  Worsening of pre-existing migraine or any unusually strong or frequent headaches;
  Sudden disturbances of vision or hearing;
  Inflammation of the veins (phlebitis).
In case you have thrombosis or suspected such incident while taking Clement, stop taking and contact your doctor. The warning signs are:
  coughing up blood;
  unusual pain and swelling of the extremities;
  sudden shortness of breath;
Accepts change should be discontinued immediately if you become pregnant or have jaundice.
What should I expect when participating in traffic or operate machinery?
No effects.

What to do if you are taking other medicines? (Interactions)

You should not use oral contraceptives. In the event that contraception is required, consult your doctor.
Some medicines may interfere with the effect of hormone replacement therapy (HRT). These include medicines used to treat epilepsy (hydantoins, primidone, barbiturates, carbamazepine) and tuberculosis (rifampicin), and antibiotics (penicillins and tetracyclines). Always tell the doctor prescribing HRT for any other medicine you are using, as well as any other doctor or dentist prescribes another medicine that you are taking climate.
In case you are diabetic, your doctor may change the dose of antidiabetic drugs. If you suspect any medicine you are taking, check with your doctor.
Alcohol abuse during hormone replacement therapy has an effect on treatment. Your doctor will advise you.
HRT may affect some laboratory tests. Always inform your doctor and the laboratory personnel that you use hormone replacement therapy.
How to take the change? (Dosage and administration)
In case you still have your period should begin Clement on the 5th day of the cycle. In all other cases, your doctor may advise you to start immediately.
In the first 11 days is considered one white tablet, followed by a pink tablet in the remaining 10 days. Each pack covers 21 days of treatment, after which follows a pause of 7 days without tablets.
It is very important time of day you take your tablet, but once selected, follow it every day. The tablet should be swallowed whole with some liquid.
During a free tablet-7-day interval bleeding occurs, usually several days after the last dose.
Clement next pack is started after a pause of 7 days. This means that you start a new pack on the same day of the week and the previous package.
Please observe the instructions above, otherwise you will have an overall treatment effect for use change.

What to do if you miss a tablet?

If you were less than 24 hours, take it as soon as you remember and the next tablet at the usual time. But if you are late more than 24 hours, leave the tablet in the pack. Continue to take the remaining tablets at the correct time each day.
If you stop taking the tablets for a few days may appear irregular bleeding.
What happens if you take more tablets than prescribed? (Overdose)
No information about the harmful effects of an overdose. Overdose may cause nausea, vomiting, irregular bleeding. No specific treatment is required, but consult a doctor.
Clement cause you any side effects?
Like all medicines, climate can also have side effects.
Serious side effects
Serious adverse reactions, and symptoms are described in What precautions should I take? (Special warnings and precautions for use), especially in Sub: Before use change, HRT and cancer and Reasons for immediate withdrawal of the change.
Please read these subdivisions enimatelno and consult your doctor immediately if necessary.
The following symptoms may be, but they are not caused by HRT, and in some cases the symptoms of menopause have been reported in patients of different oral HRT:
  Common side effects (between 1 and 9 cases per 100 can have these effects)
Metabolism and nutrition disorders Weight gain or weight loss.
Nervous system disorders Headache.
Gastrointestinal disorders Abdominal pain, nausea.
Skin and subcutaneous redness, itching.
Disorders of the breast and reproductive system
Uterine / vaginal bleeding, including spotting (bleeding irregularly, usually disappear with continued therapy).
  Uncommon side effects (between 1 and 9 cases in 1000 may have these effects)
Immune system disorders Hypersensitivity.
Psychiatric Disorders
Depressive mood
Nervous system disorders Dizziness
Eye disorders Eye disorders
Cardiac Disorders Palpitations
Gastrointestinal disorders Dyspepsia
Nyarusheniya Skin and subcutaneous tissue disorders Erythema nodosum, urticaria
Reproductive system and breast Chest pain, chest tightness.
General disorders and administration site conditions Eden.
Rare side effects (between 1 and 9 cases of 10,000 can have these effects)
Psychiatric Disorders
Anxiety, Decreased or increased libido
Nervous System Migraine
Eye disorders intolerance of contact lenses
Gastrointestinal disorders swelling, vomiting.
Nyarusheniya Skin and subcutaneous tissue disorders hirsutism, acne.
Musculo-skeletal and connective tissue disorders Muscle cramps.
Reproductive system and breast disorders
Dysmenorrhea, vaginal discharge, Pre-menstrual like syndrome, breast augmentation.
General disorders and administration site conditions Fatigue.
If you notice Nakhon unwanted effects not mentioned in this leaflet and you are not sure about the effect of the product, please informairayte your doctor or pharmacist.
How should I store change?
Please refer to the expiry date stated on the pack. Do not use after this date. Keep out of reach of children.
€ 15.00
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