Capecitabine 500 mg. 120 tablets

Capecitabine 500 mg. 120 tablets
€ 289.00
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Capecitabine Zentiva belongs to a group of medicines called "cytostatic agents", which stop the growth of cancer cells. Capecitabine Zentiva contains 500 mg capecitabine, which itself is not a cytostatic agent.

Capecitabine 500 mg. 120 tablets

What Capecitabine Zentiva and what it is used
Capecitabine Zentiva belongs to a group of medicines called "cytostatic agents", which stop the growth of cancer cells. Capecitabine Zentiva contains 500 mg capecitabine, which itself is not a cytostatic agent. Only after being absorbed by the body, it is converted into an active anti-cancer agent (more in tumor tissue than in normal tissue).
Capecitabine Zentiva prescribed by physicians for the treatment of cancer of the colon, rectum, stomach cancer, or breast cancer. Furthermore, Capecitabine Zentiva is prescribed by doctors to prevent new occurrence of colon cancer after complete removal of the tumor by surgery.
Zentiva capecitabine can be administered alone or in combination with other medicines.

2 What you should know before taking Capecitabine Zentiva
Do not take Capecitabine Zentiva:
if you are allergic (hypersensitive) to capecitabine or to any of the other ingredients of Capecitabine Zentiva. You must tell your doctor if you know that you have an allergy or extreme sensitivity to capecitabine Zentiva;
if you are pregnant or breast-feeding;
if you have blood disorders;
if you have a diseased liver or kidney problems;
if you know that you have a deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD);
if you are taking now or have been treated in the last 4 weeks with brivudine sorivudine or similar classes of substance as part of the treatment of herpes zoster (chickenpox or shingles).
Take special care with Capecitabine Zentiva
Talk to your doctor before taking Capecitabine Zentiva:
have liver or kidney disease;
have or have had other illnesses, such as heart problems or chest pain;
have brain diseases;
have an imbalance of calcium;
have diabetes.
Other medicines and Capecitabine Zentiva
Tell your doctor or pharmacist if you are taking, have recently taken or might take other medicines. This is extremely important as taking more than one medicine at the same time can strengthen or weaken the effect of the drugs.
You should be especially careful if you are taking any of the following:
drugs for gout (allopurinol);
medicines for blood clotting (coumarin, warfarin);
some antiviral medicines (sorivudine and brivudine);
medicines for seizures or tremors (phenytoin).
Capecitabine Zentiva with food and drink
You should take Capecitabine Zentiva no later than 30 minutes after a meal.

Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine. Before starting treatment, you must tell your doctor if you are pregnant, think you are pregnant or intend to become pregnant. You should not take Capecitabine Zentiva if you are pregnant or think you may be pregnant.
You should not breastfeed if you are taking capecitabine Zentiva.

Driving and using machines
Capecitabine Zentiva may feel dizzy, nauseous or tired. It is therefore possible Capecitabine Zentiva affect your ability to drive or operate machinery.

3 How to take Capecitabine Zentiva
Always take this medicine exactly as prescribed by your doctor or pharmacist. If you are not sure, ask your doctor or pharmacist.
Capecitabine tablets Zentiva should be swallowed with water.
Your doctor will prescribe a dose and treatment regimen that is right for you. Zentiva capecitabine dose is based on your body surface. It is calculated from your height and weight. The usual dose for adults is 1250 mg / m2 body surface area taken twice daily (morning and evening). Here are two examples: a person whose body weight is 64 kg and height - 1,64 m, has a body surface 1,7 m2 and should take 4 tablets of 500 mg and 1 tablet of 150 mg twice daily. A person whose body weight is 80 kg and height - 1,80 m, has a body surface 2,00 m2 and should take 5 tablets of 500 mg twice daily.
Capecitabine tablets Zentiva usually taken for 14 days followed by a 7-day rest period (during which not a tablet). This 21-day period is one treatment cycle.
In combination with other agents the usual dose for adults may be less than 1250 mg / m2 body surface, and may need to take the tablets for different periods of time (eg. Every day without rest period).
Your doctor will tell you what dose you need to take, when and how long you should take it.

Your doctor may ask you to take a combination of tablets of 150 mg and 500 mg per dose.
Take the tablets in the combination prescribed by your doctor for your morning and evening doses;
Take the tablets within 30 minutes after a meal (breakfast and dinner);
It is important that you take all your medication as prescribed by your doctor.
If you take more than the dose of capecitabine Zentiva, contact your doctor before taking the next dose.

If you forget to take Capecitabine Zentiva
Do not take the missed dose at all and do not double the next dose. Instead, continue your regular dosing schedule and check with your doctor.

If you stop taking capecitabine Zentiva
There are no side effects caused by stopping treatment with capecitabine Zentiva. If you are using coumarin anticoagulants (eg. Phenprocoumon), stopping capecitabine Zentiva may need your doctor to adjust the dose of anticoagulant.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4 Possible side effects
Like all medicines, Capecitabine Zentiva can cause side effects, although not everybody gets them.
Capecitabine Zentiva when administered alone, the most common side effects of capecitabine Zentiva, which may affect more than 1 in 10 people are:
diarrhea, nausea, vomiting, stomatitis (inflammation of the mouth and throat) and abdominal pain;
skin reaction "hand and foot" (burning sensation in the palms of the hands or soles of the feet tingle, become painful, swollen or red), rash, dry or ITCHY SKIN;
loss of appetite (anorexia).
These side effects can become severe; it is therefore important to always immediately contact your doctor when you experience a side effect. Your doctor may advise you to reduce the dose and / or temporarily discontinue treatment with capecitabine Zentiva. This will reduce the likelihood of adverse reactions continue or become severe.

Immediately discontinue capecitabine Zentiva and contact your doctor if any of the following symptoms:
Diarrhea: if you have 4 or more bowel movement per day than usual or diarrhea during the night;
Vomiting: if you vomit more than once in a 24-hour period;
Nausea: if you lose your appetite and eat each day is much less than usual amount of food;
Stomatitis: if you have pain, redness, swelling or sores in the mouth;
Skin reaction "hand and foot": if you have pain, swelling and redness of the hands and / or feet;
Fever or Infection: if you have a temperature of 38 ° C or higher or other signs of infection;
Chest pain: if you have pain localized to the center of the chest, especially if it occurs during exercise.
If caught early, these side effects usually improve within 2 to 3 days after treatment discontinuation. If these side effects continue, immediately contact your doctor. Your doctor may advise you to restart treatment with a lower dose.

There have also been other more common and usually mild side effects which may affect between 1 and 10 people 100: decrease the number of white blood cells or red blood cells, skin rash, slight HAIR LOSS, fatigue, fever weakness, drowsiness, headache, numbness or tingling sensations, changes in taste, dizziness, insomnia, leg swelling, constipation, dehydration, cold sores, inflammation of the nose and throat, chest infection, depression, EYE PROBLEMS, inflammation the veins (thrombophlebitis), shortness of breath, nosebleeds, cough, runny nose, bleeding from the gut, HEARTBURN, excessive flatulence, dry mouth, discoloration of the skin, nail disorder, pain in the joints, chest or back and weight loss.
If you are concerned about these or other unexpected effects, talk to your doctor.

If any of the side effects gets serious, or if you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

5 How to store Capecitabine Zentiva
Keep out of reach of children.
Do not store above 30 ° C.
Capecitabine Zentiva not use after the expiry date stated on the carton after "EXP". The expiry date refers to the last day of that month.
Any unused product or waste material should be disposed of in accordance with local requirements for cytotoxic agents.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6 Package Contents and more information
What does Capecitabine Zentiva
The active ingredient is capecitabine. Each tablet contains 500 mg.

Core: croscarmellose sodium, microcrystalline cellulose, hypromellose, anhydrous colloidal silica, magnesium stearate.
Tablet coating: hypromellose, titanium dioxide (E171), talc, macrogol 400, yellow iron oxide (E172), red iron oxide (E172).

Capecitabine Zentiva looks like and contents of pack
Orange, oblong, film-coated tablets embossed with "500" on one side. Approximately 17,1 mm x 8,1 mm.
Zenitva capecitabine 500 mg tablet contains 120 tablets.
€ 289.00
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