CURAM 625 mg. 16 tablets

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CURAM 625 mg. 16 tablets
€ 23.00
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Curam 625 mg film-coated tablets therapeutically active ingredients: 1 tablet contains: 500 mg amoxicillin, corresponding to 574 mg amoxicillin trihydrate and 125 mg clavulanic acid, corresponding to 148,9 mg potassium davulanate.
Other ingredients:
Magnesium stearate, talc, polyvidone, microcrystalline cellulose, croscarmellose sodium, triethyl citrate, ethyl cellulose, hypromellose, sodium lauryl sulfate, cetyl alcohol, titanium dioxide E 171.Curam® 156,25mg / 5ml powder for oral suspension
The therapeutically active ingredients:
1 ml of ready to use suspension (corresponding to 0,09 g) contains 25 mg amoxicillin, corresponding to 28,70 mg amoxicillin trihydrate and 6,25 mg clavulanic acid, corresponding to 7,44 mg potassium davulanate.
Other ingredients:
Citric acid, aspartame, trisodium citrate, talc, gum galactosamine flour, silica powder, lemon juice, powdered peach-apricot flavor, powdered essence portokal.Curam® 312,5mg / 5ml powder for oral suspension
The therapeutically active ingredients:
1 ml of ready to use suspension (corresponding to 0.125 g) contains: 50 mg amoxicillin, corresponding to 57,40 mg amoxicillin trihydrate and 12,50 mg clavulanic acid, corresponding to 14,90 mg potassium davulanate.
Other ingredients:
Citric acid, aspartame, trisodium citrate, talc, gum galactosamine flour, silica powder, lemon juice, powdered flavoring peach-apricot, orange essence powder.
 
Pharmaceutical form:
film-coated tablets
packing:
Curam 625 mg: 12, 15, 16, 21, 30 and 100 film-coated tablets
 
Pharmaceutical / therapeutic group and mode of action
How does Curam?
Curam is an antibiotic of the penicillin with a broad spectrum of activity and is intended for implementation both in children and in vazrastni.V basis of operation of Curam is amoxicillin, which is protected from the inactivating effect of the bacteria with the clavulanic acid. Thanks to the combination of these two active ingredients Curam acts on a number of amoxicillin resistant microorganisms.
 
indications
When used Curam?
Curam used in the treatment of infections caused by microorganisms sensitive to Curam:
- Infections of the upper and lower respiratory tract
• otitis (otitis media)
• acute sinusitis
• exacerbation of chronic bronchitis
• pneumonia
- Urogenital infections
- Infections of skin and soft tissue
 
Contraindications
When not to use Curam?
Contraindications are diseases or conditions where you do not need to take the medicine or to take it after the research and evaluation of your condition. So your doctor can properly assess whether the conditions exist for you contraindications you have to inform all spent neposledak diseases, other diseases or other medicines (even those who themselves are bought from a pharmacy) you are taking, as also your lifestyle and habits Vi.Ako patient had an allergic reaction to some p-lactam antibiotics (eg. penicillin cephalosporins) or some of the ingredients of Curam®, the drug should not be taken as there is a risk of an induced allergic (anaphylactic) shok.Vie should not take Curam if you suffer from severe hepatopathy or if the previous treatment with this medicine you received damage function in the liver drob.Pri patients with infectious mononucleosis and patients with lymphatic leukemia Curam should to be used for the treatment of concomitant bekterialni infections in these patients, since there is a high risk of the occurrence of skin rash.
 
Pregnancy and lactation
Can you take Curam during pregnancy and lactation?
The doctor will assess whether you and how to take the drug during pregnancy and lactation.
 
Special measures for the safe use
Under what circumstances need special attention when adopting Curam?
 
Your doctor should know if you are allergic to penicillins and tsefalosproini, and also to you suffer from allergic diseases (eg. Asthma, hay fever, urticaria). Should be given the possibility of cross-hypersensitivity between penicillins and tsefzlosporini. Please tell your doctor at existing pregnancy, as well as in any manifestation of adverse reactions (in particular, diarrhea, skin rashes, severe fatigue, sore throat or infections in the oral cavity).
In elderly patients (60 years and older) treatment should be carried out carefully and functional state of their liver to be monitored (see "Undesirable effects"). Patients with severe gastrointestinal disturbances with vomiting and diarrhea, should not take Curam as it is possible in this case the drug can not be absorbed dostatachno.Nalichieto high concentrations of amoxicillin in the urine may lead to crystallize on the walls of the urethral catheter, the catheter so it is necessary for patients to be checked on periodichno.Analogichno other antibiotics with a broad spectrum of action in adopting Curam long time possible superinfection development of resistant organisms or gabichki.Pri prolonged therapy should be monitored functions of the kidneys, liver and blood counts.
Tell your doctor in a severe diarrhea as possible the development of inflammation of the abdomen, caused by the antibiotic.
Please do not change or stop your treatment on their own initiative without konsultatiya with your doctor, even if you feel better or healthier to avoid complications or worsening of your condition.
In patients with phenylketonuria (a congenital metabolic disorder, wherein the ketone bodies are excreted in the urine) should be borne in mind that Curam® 156,25 mg / 5 ml and Curam® 312,5 mg / 5 ml powder for oral suspension contains aspartame as a sweetener. One dose contains 4,77 mg phenylalanine / 5 mi. Patients with PKU have to accept Curam tablets which do not contain aspartame.
Keep out of reach of children.
drug Interactions
Curam could be taken with other medicines?
The effects of some drugs can be affected while taking other medicines or eg. coffee, tea, alcohol. Such interferences are called interactions. Therefore, please tell your doctor if you are taking other medicines (even those who themselves are bought from a pharmacy). The doctor will decide Can these drugs be taken ednovremenno.Curam® should not be combined with bacteriostatic chemotherapeutics / antibiotics (e. Tetracyclines, macrolides, sulfonamides or chlorine mfenikol) as a possible antagonist efekt.Ednovremenno receiving probenecid leads to increasing and maintaining long time to high concentrations of amoxicillin seruma.Ednovremennoto acceptance of allopurinol may increase the risk of developing allergic skin reaktsii.Curam® can increase the absorption of digoxin when administered simultaneously. Curam should not be used concomitantly with disulfiram.Vazmozhnostta bleeding may be increased with concomitant Curam and anticoagulants group kumarinite.Ryadko in application can reduce the effect of the application of hormonal contraceptives. Therefore, it is advisable to apply additional contraceptives containing hormones In case of diarrhea efficiency of Curam may be impaired due to impaired absorption. Effects of diagnostic laboratory izsledvaniyaMogat to false positive results in the determination of glucose in the urine through the reduction (non-enzymatic) methods. Also, such results may be obtained when determining urbilinogen.
dosage
At what intervals and how Curam should be taken?
This information is used if your doctor advises otherwise. Do not change or stop your treatment on their own initiative.
Curam 625 mg film-coated tablets
The tablets should not be broken into two to give a half dose. If prescribed a half dose (eg. In renal impairment) should be used Curam® 156,25 mg / 5 ml powder for oral suspension or Curam® 312,5 mg / 5 ml powder for oral suspension.
Adults, adolescents and children An over 12 years weighing more than 40 co: 3x1 tablet dnevno.Curam® 156,25 mg / 5 ml or Curam® 312,5 mg / 5 ml powder for oral suspension
Adults, adolescents and children over 12 years weighing more than 40 co: 4 spoonfuls Curam® 156,25 mg / 5 ml powder for oral suspension or 2 spoonfuls Curam® 312,5 mg / 5 ml powder for oral suspension three times daily. 1 scoop = 5 ml = 250 mg amoxicillin + 62,5 mg clavulanic acid SHT
Application of powder for oral suspension in children with phenylketonuria requires special attention (see "Special measures for the safe use").
Patients with liver damage
Curam should not be taken by patients with severe hepatopathy and patients who have received damage to the function in the liver during previous treatment with amoxicillin / clavulanic acid. In patients with hepatic lesion doctor may order additional izsledvaniya.Patsienti with functional impairment of babretsitePri functional renal impairment, the dose should be reduced depending on the severity of the injury and the weight of patsienta.Vashiya doctor will determine what dose should be used in case renal failure.
Dosage in hemodialysis patients
Adults and adolescents: Hemodialysis patients receiving 500 mg amoxicillin + clavulanic acid, 125 mg every 24 hours and the same dose during and at the end of hemodialysis.
Children: The doctor will assess the application of medicines. The dose for children is 15 mg amoxicillin + 3,75 mg clavulanic acid / kg every 24 hours. They also receive this dose during and at the end of dialysis.
 
Method of administration
How should I take Curam?
Single doses should be taken at regular intervals during the day. Prescribed three daily doses should be taken at 8-hour intervals. Curam should be taken at the beginning of a meal, as this reduces possible gastrointestinal diskomfort.Curam® 625 mg film-coated tablets should be taken whole and not chewed enough technost.Curam® 156,25 mg / 5 ml powder for oral suspension and Curam® 312,5 mg / 5 ml powder for oral suspension is adopted for convenience with a measuring spoon. Before each use, the bottle should be shaken dobre.Preporachva the oral suspension can be prepared by a pharmacist, and failing lekar.Sled unscrewing the bottle cap protective membrane to remove vnimanelno and iztsyalo.Dobavi drinking water just below the mark indicated on the bottle and shake well. Then dobavivoda exactly to the mark indicated on the bottle and shake well once more.
Shake the bottle well before each use.
After preparing the finished oral suspension is almost white tsvyat.Curam® 156,25 mg / 5 ml powder for oral suspension
60 ml suspension was prepared by adding to 1 bottle containing 5,4 g of powder for oral suspension was added 57 ml water.
100 ml suspension is prepared at 1 bottle containing 9,0 g powder for oral suspension is added 95 mi water.
Curam 312,5 mg / 5 ml powder for oral suspensiya60 ml suspension is prepared at 1 bottle containing 7,5 g powder for oral suspension 54 ml of water.
100 ml suspension was prepared by adding to 1 bottle containing 12,5 g of powder for oral suspension was added 90 ml water.
 
How long should I take Curam?
The doctor will determine the duration of lechenieto.Normalno Curam apply for 3 to 4 days after improvement or resolution of symptoms zabolyavaneto.Ako Curam is prescribed to treat infections caused by beta-hemolytic streptococcus, it should be taken at a minimum of 10 days for sure have a therapeutic effect and to avoid late uslozhneniya.Curam® should not take more than 14 days without the consent of your doctor. Overdose and other errors
What should be done if it is adopted very large amount of Curam® (intentional or accidental overdose)?
In case of overdose may occur gastrointestinal symptoms such as nausea, vomiting and diarrhea, as well as disorders of fluid and electrolyte balance.
Information for doctor:
There is no specific antidote for overdose. Symptomatic measures are aimed in particular at maintaining water and electrolyte balance. Administration of activated charcoal and gastric lavage is only recommended in cases of adoption of a very large dose (more than 250 mg / kg). For patients with severe renal disease Curam can be separated by hemodialysis.
Effects on ability to drive and use machines
Not available any evidence that certain side effects affect active participation in traffic or operating machinery.
Adverse reactions observed in rare cases (ab. Anaphylactic shock, convulsions) can povliayat partial participation in traffic or work with mashini.Nezhelani reaktsiiKakvi drug side effects (which are not monitored at all petsienti) can be occur in adopting Curam? As with the adoption of certain other drugs and acceptance of Curam can be observed adverse reactions. They do not occur in all patients and not with the same frequency and severity. Apo principle Curam tolerated dobre.Reakiii Hypersensitivity: Common (> 1% - <10%) are possible. skin reactions, which occur as rash and itching. Typical rash of measles-type sometimes occurs 5 to 11 days after the start of treatment. In patients with infectious mononucleosis and patients with lymphatic leukemia often appear skin rash. Immediate reaction with urticaria in most cases it is indicative of a typical penicillin allergy and require treatment to be discontinued and should not be administered the treatment with beta-lactam antibiotics in badeshte.Ponyakoga may occur inflammation of the mucous membranes of the mouth. Possible dry mouth and impairment in perception of vkusa.Ryadko (> 0.01% - <0.1%) Bullous or exfoliative skin reactions (ab. Exudative erythema multiforme syndrome Stevens-Johnson, toxic epidermal necrosis) are reported in rare sluchai.Tezhki allergic reactions as a result of sensitization to antibiotics of 6-aminopenicillin observed in rare cases, eg. in the form of drug fever, increase in the number of certain blood cells (eosinophilia), painful swelling of the skin and mucosa (edema Quincke), swelling of the larynx with the central narrowing of the airways and difficulty breathing (laryngeal edema), serum sickness, anemia due to destruction of the integrity of red blood cells (hemolytic anemia), allergic vasculitis or nefrit.Mozhe exist antigenic relationship between dermatophytes and penicillin so that in patients with mycosis can not exclude effects similar to those observed with repeated administration even after the first application of penitsilin.Mnogo rarely (<0.01%) in very rare cases can be observed dark spots on ezika.Reaktsii of svrhchuvstvitelnost at all levels - including induced allergic (anaphylactic) shock - are observed even after oral administration of penicillins. Severe reactions svrhchuvstvitelnost observed with much lower frequency than after intravenous or intramuscular injection require taking appropriate emergency merki.Stomashno-intestinal effects: Common (> 1% - <10%) disorders in the form of heaviness in the stomach, nausea (usually at higher doses), vomiting, flatulence, loose stools or diarrhea may occur sometimes after taking amoxicillin / clavulanic acid. Most often, they are mild and usually disappear simultaneously or shortly after discontinuation of treatment. Tolerance can be improved by taking amoxicillin / clavulanic acid during hranene.Ryadko (> 0.01% - <0.1%) In very rare cases of intestinal colonization kandidoza.Pri if severe persistent diarrhea during treatment or during the first few weeks after treatment should be given to the possibility for the development of pseudomembranous colitis (mostly caused by Clostridium difficile). This enteric disease caused by antibiotic treatment can be life-threatening and requires immediate application of emergency merki.Edno study in women with premature rupture of the amnion showed that prophylactic treatment with amoxicillin / clavulanic acid may be associated with increased risk of necrotizing enterocolitis novorodenite.Cheren in cancer: common (> 1% - <10%) sometimes occurs moderate rise in liver enzymes. Rare (> 0.01% - <0.1%) In rare cases, as with treatment with other penicillins and cephalosporins, due to the suppression of bile passage are observed transient hepatitis and cholestatic jaundice. Dysfunction usually comes on during or immediately after treatment with amoxicillin / clavulanic acid, but in some cases may not occur until several weeks after discontinuation of treatment and is more common in men or elderly (60 and older) . These hepatic impairment may be severe. For children there are very rare reports of the occurrence of this dysfunction. The risk of experiencing adverse reactions from the liver is increased by treatment lasting more than 14 days. Basically symptoms subside. However, in extremely rare cases have been reported fatalities, but it always is in direct relation to serious underlying diseases or concomitant use of other lekarstva.Kravna kaotina: Rare (> 0.01% - <0.1%) in rare cases may to an increase in the number of platelets (thrombocytosis). Very rare (<0.01%) In isolated cases can be observed changes in blood cell counts expressed as such. reduce the number of white blood cells (leukopenia, granulocytopenia), reducing the number of platelets (thrombocytopenia), anemia or inhibiting the formation of blood cells in the bone marrow (myelosuppression), and prolongation of bleeding and clotting.
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