CIFRAN 500 mg. 20 tablets

CIFRAN 500 mg. 20 tablets
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What is the numbers and what it is used
The CIFRAN is an antibiotic of the fluoroquinolone. The active substance is ciprofloxacin. Ciprofloxacin works by killing the bacteria that caused the infection. Only works on certain types of bacteria.

CIFRAN used in adults to treat the following bacterial infections:
respiratory tract infections;
prolonged or repeated ear infections or sinus;
urinary tract infections;
infection of the testicles;
infections of the genital mutilation;
infections of the gastrointestinal tract, and abdominal infections;
infections of skin and soft tissue;
infections of bones and joints;
for the treatment of infections in patients with a very low number of leukocytes in the blood (severe neutropenia);
for the prevention of infections in patients with very low blood leukocytes (severe neutropenia);
Prevention of infection with Neisseria meningitidis;
inhalation of anthrax spores.
If you suffer from severe infection or one caused by more than one type of bacteria you may be given additional antibiotic treatment than numbers.

Children and adolescents
CIFRAN used in children and adolescents under specialist medical supervision for the treatment of the following bacterial infections:
acute respiratory infections in children and adolescents suffering from cystic fibrosis;
complicated urinary tract infections, including infections that have reached the kidneys (pyelonephritis);
inhalation of anthrax spores.
CIFRAN can also be used to treat other specific severe infections in children and adolescents when your doctor considered this necessary.

2. What you need to know before taking CIFRAN
CIFRAN do not take if you:
are allergic (hypersensitive) to numbers or other quinolone drugs or any of the other ingredients of the tablets CIFRAN (see. section 6);
taking tizanidine (see. section 2. Taking other medicines).
Warnings and Precautions
Talk to your doctor, pharmacist or nurse before taking CIFRAN if:
have ever had kidney problems because your treatment needs to be corrected;
suffer from epilepsy or other neurological diseases;
have a history of tendon problems during previous treatment with antibiotics such figure;
have myasthenia gravis (a type of muscle weakness);
have a history of abnormal heartbeat (arrhythmias).
Heart problems
Care should be taken when using this type of medicine, if you were born with a family history or have a family history of QT prolongation (observed ECG, electrocardiogram of the heart), if you have an imbalance of salts in the blood (especially low potassium or magnesium in the blood) if you have a very slow heartbeat (called "bradycardia") if you have a weak heart (heart failure), if you had a heart attack (myocardial infarction), if you are a woman or if you are elderly or are taking other medicines leading to abnormal ECG changes (see. section Taking other medicines).

While the figures
Tell your doctor immediately if you experience any of the following symptoms while taking numbers. Your doctor will decide whether treatment with the figures should be discontinued:
Severe, sudden allergic reaction (anaphylactic reaction / shock). Even with the first dose is a small chance that you may develop a severe allergic reaction with the following symptoms: chest tightness, feeling light-headed, fainting, or faint or get dizzy when standing up. If you have this happens, stop taking the figures and immediately contact your doctor;
Pain and swelling in the joints and tendinitis may occur occasionally, particularly if you are elderly and you are treated with corticosteroids. At the first sign of pain or inflammation, stop taking the numbers and let rest the painful area. Avoid unnecessary stress because it may increase the risk of tendon rupture;
If you suffer from epilepsy or other neurological disorders such as cerebral ischemia or stroke, it is possible to obtain effects associated with the central nervous system. If this happens stop taking numbers and contact your doctor immediately;
The first time the figures it is possible to obtain psychiatric reactions. If you suffer from depression or psychosis, it is possible that your symptoms get worse during treatment with digits. If this happens stop taking numbers and contact your doctor immediately;
You may experience symptoms of neuropathy, such as pain, numbness, tingling and / or weakness. If this happens stop taking numbers and contact your doctor immediately;
You may develop diarrhea while taking antibiotics, including CIFRAN, or even several weeks after you stop taking them. If it becomes severe or persistent or you notice that your stool contains blood or mucus, stop taking the figures, because this condition can be life threatening. Do not take medicines that stop or slow down bowel movements and contact your doctor;
Tell the doctor or laboratory that the figures if you take samples of blood or urine;
CIFRAN may cause liver damage. If you notice symptoms such as loss of appetite, jaundice (yellowing skin extraction), dark urine, itching or tenderness of the stomach, stop taking numbers and contact your doctor immediately;
Ciprofloxacin can reduce the number of white blood cells and your resistance to infection may be decreased. If you have an infection with symptoms such as fever and serious deterioration of your general condition, or fever with local infection symptoms such as sore throat / pharynx / mouth or urinary problems you should immediately see your doctor. A blood test will check possible reduction of white blood cells (agranulocytosis). It is important to inform your doctor of medicine;
Tell your doctor if you or a member of your family has a deficiency of glucose-6-phosphate dehydrogenase (G6PG), since you may have a risk of anemia with ciprofloxacin;
When the figures your skin becomes more sensitive to sunlight and UV rays. Avoid exposure to strong sunlight or artificial sources of UV light such as tanning beds.
Other medicines and CIFRAN
Please tell your doctor or pharmacist if you are taking or may take other medicines, including medicines obtained without a prescription.
You must tell your doctor if you take other medicines that can change your heart rhythm, medications that belong to the group of antiarrhythmics (eg. Quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, certain antimicrobial substances (belonging to the macrolide group), certain antipsychotics.
Not the figures together with tizanidine, because this may lead to side effects such as low blood pressure and sleepiness (see. "Do not take the figure").
It is known that these drugs interact with the figures in your body.
If the figures together with these medicines can influence the therapeutic effects. Also, it can increase the likelihood of experiencing side effects.

Tell your doctor if you take:
Vitamin K antagonists (eg. warfarin, acenocoumarol, phenprocoumon or fluindione) (blood thinning);
probenecid (gout);
methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis);
theophylline (for breathing problems);
tizanidine (for muscle spasms in multiple sclerosis);
clozapine (an antipsychotic);
ropinirole (for disease Parkiison);
phenytoin (for epilepsy);
certain premedikamenti used before surgery (e.g., opiates, papaveretum), hyoscyamine, atropine or hydrobromide, benzodiazepines);
painkillers known as nonsteroidal anti-inflammatory drugs (NSAIDs);
glibenclamide (for diabetes);
metoclopramide (stimulating peristalsis);
cyclosporine (for suppression of the immune system).
CIFRAN may increase the levels of these medicines in your blood:
pentoxifylline (for circulatory disorders);
duloxetine (antidepressant);
mexiletine (to treat arrhythmia);
lidocaine (an anesthetic);
sildenafil (for erectile dysfunction).
Some drugs reduce the effect of numbers. Tell your doctor if you take or want to take:
omeprazole (used to treat indigestion and stomach ulcers);
mineral supplements;
phosphate-binding polymer (eg., sevelamer);
medications or supplements containing calcium, magnesium, aluminum or iron.
If these products are important for you, the figures about 2 hours before or no sooner than four hours after them.

CIFRAN of food, beverages and alcohol
If the figures during regular meals, do not eat or drink any dairy products (like milk or yogurt) or drinks with added calcium when taking the tablets because they can affect the absorption of the active ingredient.

Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine. Ask your doctor or pharmacist before taking any medicine.
It is preferable to avoid the use of CIFRAN in pregnancy.
Are the figures during lactation because ciprofloxacin is excreted in breast milk and may harm your baby.

Driving and using machines
CIFRAN may reduce your attention. Some neurological side effects may occur. So check your response to the CIFRAN before driving a vehicle or operating machinery. If in doubt, consult your doctor.

3. How to CIFRAN
Always CIFRAN exactly as you have been told your doctor or pharmacist. If you are not sure, ask your doctor or pharmacist.
Your doctor will tell you how many CIFRAN you need to take and how often and for how long. This depends on the type of infection and the weight of it.
Tell your doctor if you have kidney problems, because they may require dose adjustment.
Treatment usually lasts 5 to 21 days but may be longer in severe infections.
Swallow the tablets with plenty of fluid. Do not chew them because their taste is not pleasant.
Try to take your tablets at the same time each day.
You can take the tablets with regular intake of food or another.
Calcium, which is a normal part of the diet will not seriously affect absorption. CIFRAN do not take the tablets with dairy products such as milk or yoghurt or with fortified fruit juices (eg. Calcium fortified orange juice).
Remember to drink plenty of fluids when taking numbers.

If you take more than the amount of CIFRAN
If you take more than your prescribed dose, seek medical attention immediately. If possible, take your tablets or their packaging with you to show the doctor.

If you forget to take CIFRAN
Take the normal dose as soon as possible and then continue on the prescribed schedule. However, if it is almost time to become next dose, skip the missed dose and continue with the scheme. Do not take a double dose to make up for a missed dose. Finish the full course of treatment.

If you stop taking CIFRAN
It is important to complete the course of treatment even if a few days already feel better. If you stop taking the medicine too soon your infection is possible to not be completely cured and the symptoms can reappear or worsen. It is possible to develop resistance to the antibiotic.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, numbers can cause side effects, although not everybody gets them.
If any of the side effects gets serious, or if you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

Common side effects (between 1 and 10 in every 100 patients can get these):
nausea, diarrhea;
joint pain in children;
Uncommon side effects (between 1 and 10 in every 1000 patients can get these):
fungal superinfection;
high levels of eosinophils, a type of white blood cells;
loss of appetite (anorexia);
hyperactivity or agitation;
pulmonary embolism (blockage in the main artery of the lung);
epistaxis (nosebleeds);
hemoptysis (coughing blood);
headache, dizziness, sleep problems or disorders of taste sensations;
vomiting, stomach pain, digestive problems or intestinal gas;
increased levels of certain substances in the blood (transaminases and / or bilirubin);
rash, itching or hives;
joint pain in adults, swelling of the joints;
impaired renal function;
pain in the muscles and bones, malaise (asthenia) or fever;
increases in alkaline phosphatase in the blood (a substance in the blood).
Rare side effects (between 1 and 10 in every 10,000 patients can get these):
inflammation of the colon (colitis) associated with the use of antibiotics (in very rare cases can be fatal) (see. Section 2: Take special care with CIFRAN);
changes in blood count (leukopenia, leukocytosis, neutropenia, anemia), increased or decreased number of platelets (responsible for blood clotting);
allergic reactions, swelling (edema) or rapid swelling of the skin and mucosa (angioedema);
high blood sugar (hyperglycemia);
confusion, disorientation, anxiety reactions, abnormal dreams, depression or hallucinations, culminating potentially at risk for self-harm or suicide;
sensation of tingling, unusual sensitivity to sensory stimuli, decreased skin sensitivity, tremors, convulsions (see. Section 2: Take special care with CIFRAN), or dizziness;
problems with vision;
tinnitus, hearing loss, hearing impairment;
increased heart rate (tachycardia);
dilation of blood vessels (vasodilation), low blood pressure, or seizures;
breathlessness, including asthma symptoms;
liver disorders, jaundice (cholestatic jaundice) or hepatitis;
sensitivity to light (see. Section 2: Take special care with CIFRAN);
muscle pain, joint inflammation, increased muscle tone or cramps;
renal failure, blood or crystals in the urine (see. Section 2: Take special care with CIFRAN), inflammation of the urinary tract;
fluid retention or excessive potlivost;
deviations in the values ​​of one of the clotting factors (prothrombin) or elevated levels of an enzyme amylase.
Very rare side effects (less than 1 in 10,000 patients can get these):
certain type of reduction in the number of blood cells (hemolytic anemia); dangerous drop in white blood cells (agranulocytosis); decrease the number of red and white blood cells and platelets (pancytopenia), which can be fatal, bone marrow depression, which can also be fatal (see. Section 2: Take special care with CIFRAN);
severe allergic reactions (anaphylactic reaction or anaphylactic shock, which can be fatal - serum sickness) (see. Section 2: Take special care with CIFRAN);
Mental Disorder (psychotic reactions) (see. Section 2: Take special care with CIFRAN);
nightmares, stress, hot flashes;
migraine, disturbed coordination, unsteady walk (gait disturbance), disorder of sense of smell (olfactory nerve disorders), increased pressure in the brain (intracranial pressure);
changes in the perception of colors;
inflammation of the wall of blood vessels (vasculitis);
death of liver cells (liver necrosis) very rarely leading to life-threatening liver failure;
small pinpoint hemorrhages under the skin (petechiae) various skin eruptions (eg potentially fatal Stevens-Johnson and toxic epidermal necrolysis);
muscle weakness, inflammation of the tendons, tendon rupture - especially of the large tendon in the back of the ankle (Achilles tendon) (see. Section 2: Take special care with CIFRAN); worsening of symptoms of myasthenia gravis (see. Section 2: Take special care with numbers).
Not known (from the available data can not be estimated):
problems related to the nervous system such as pain, burning, tingling, numbness and / or weakness in the limbs;
prolonged bleeding time with concomitant vitamin K antagonists (see. section 2. Taking other medicines);
heart problems, severe heart rhythm disorders, irregular heartbeat (Torsades de Pointes), an abnormally fast heartbeat, life-threatening irregular heartbeat, change in heart rhythm (called QT prolongation observed on the ECG, electrocardiogram of the heart).

5. How to store CIFRAN
Keep your medicine at a temperature below 25 ° C, away from moisture.
Keep out of the reach and sight of children.
Do not use CIFRAN after the expiry date stated on the pack. The expiry date refers to the last day of that month.
Do not use CIFRAN if you notice any signs of damaged Tablet - cracking, discoloration, etc., Check with your pharmacist before taking this medicine.
Do not dispose of medications in wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
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