CARVETREND 25 mg. 28 tablets

CARVETREND 25 mg. 28 tablets
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Carvedilol is recommended as an adjunct to the main treatment of chronic heart failure (NYHA) CLASSES II and III with drugs as deuretitsi, digitalis or ACE inhibitors. In these patients the use of carvedilol results in slowing the progression of the disease.

CARVETREND 25 mg. 28 tablets

 
 
Carvedilol is recommended as an adjunct to the main treatment of chronic heart failure (NYHA) CLASSES II and III with drugs as deuretitsi, digitalis or ACE inhibitors. In these patients the use of carvedilol results in slowing the progression of the disease.

Patients (NYHA) CLASS II chronic heart failure is characterized by a slight limitation of physical activity. They are comfortable at rest, but ordinary physical activity feel fatigue, palpitations and shortness of breath.

Patients (NYHA) CLASS III chronic heart failure is characterized by fatigue during physical exertion lighter than usual. They are comfortable at rest, but even in normal physical activities feel fatigue, palpitations or shortness of breath.

Due to lack of sufficient clinical experience, carvedilol should not be used in patients with severe heart failure.

 

essential hypertension

Carvedilol is indicated for the treatment of essential hypertension.

 

Chronic stable angina pectoris

Carvedilol is shown in the prophylactic treatment of chronic stable angina pectoris.

 

Dosage and method of administration:

Carvedilol should be taken with fluid and in chronic heart failure should be taken with food.

CHF

Treatment with carvedilol should be done only under the supervision drug, taking into account the patient's condition.

Before each dose adjustment, patients should be examined at the date of the change from an experienced professional.

The dosage should not be increased at patsientis worsening heart failure after last checkup or with signs of decompensated or unstable chronic heart failure.

Dosage regimen is strictly individual.

In patients taking deuretitsi and / or digoxin and / or ECE inhibitors adoption of carvedilol may begin only after doses of the products are balanced.

 

adults:

The recommended dose for the initiation therapy is 3,125 mg twice dnevnoza two weeks. If tolerated this dose, it can be gradually increased at intervals of not less than 2 weeks, up to 6.25 mg twice a day, and then 12.5 mg twice a day, and finally 25 mg BID . The patient must take the highest dose that can be tolerated.

The recommended maximum daily dose is 25 mg twice daily in patients weighing less than 85 kg and 50 mg twice daily in patients weighing over 85 kg.

Dose changes in patients with systolic blood pressure less than 100 mm Hg can be observed deterioration of renal and / or cardiac function, therefore before any increase in dose in these patients should be performed studies of renal function and symptoms of worsening heart failure or vasodilation. Transient worsening of symptoms of heart failure or fluid retention can be corrected with a change in the dose of diuretic or ACE inhibitor or changing the temporary reduction in the dose of carvedilol received. Under these conditions the dose of carvedilol should not be increased until symptoms of worsening heart failure or vasodilation is not normal. When you stop taking carvedilol for more than two weeks, it is recommended that therapy be resumed at a dose 3,125 mg twice daily and then be increased linearly to the recommended dosage.

 

In elderly patients

As with adults

 

children

Safety and effectiveness in children under 18 years have not been established.

 

essential hypertension

The daily dose should be taken at a reception.

adults

The recommended starting dose of 12.5 mg once daily for the first two days. Then the recommended daily dose is 25 mg once daily.

Changing the dosage should occur at intervals of at least two weeks.

 

Elderly

The recommended starting dose of 12.5 mg per day, to achieve satisfactory control in some cases. An unsatisfactory response to treatment dose can be changed up to the maximum recommended daily dose of 50 mg administered once daily or divided into two doses.

children

Efficacy and safety in children under 18 years have not been established.

 

Chronic stable angina pectoris

adults

The recommended starting dose of 12.5 mg once daily for the first two days, and then, the recommended dose is 25 mg once daily.

 

In elderly patients

The recommended maximum daily dose is 50 mg in two divided doses.

 

children

Efficacy and safety in children under 18 years have not been established.

 

Interactions

As with other medicinal products with B-blocking activity, carvedilol may potentiate the effect of concomitantly administered product with antihypertensive action or causing such hipotentsiya as part of its side effects.

Isolated cases of conduction with concomitant korvedilol and diltiazem. Therefore, the concomitant use of calcium channel blockers of the verapamil or diltiazem or antiritmichni products of class I, caution, blood pressure monitoring and frequent ECG monitoring. The concomitant use of carvedilol and listed antiritmichni funds administered intravenously. The effect of insulin or oral hypoglycaemic agents may be enhanced because it is recommended to regularly check your blood sugar.

Concomitant use of carvedilol and digoxin may lead to increased plasma levels of digoxin with an average of 16% in patients with hypertension.

If you need to stop the concomitant administration of carvedilol and clonidine, carvedilol first stop, a few days before gradually decreasing the dosage of clonidine.

Caution should be exercised in patients receiving medicinal products that induce the action of oxidases of mixed type that lower serum levels of carvedilol or oxidase inhibitors, such as cimetidine, which increase serum levels of carvedilol.

 

Pregnancy and lactation

There is not enough accumulated clinical experience with carvedilol in pregnant women. It should not be used in pregnant and breastfeeding women, if not evaluated the potential risks and benefits.

 

Effects on ability to drive and use machines

As with other drugs causing changes in blood pressure, patients taking carvedilol should be advised not to drive or operate machinery in a state of dizziness or similar symptoms. These conditions are reinforced at the beginning of treatment, with dose adjustment and intake with alcohol.

 

Undesirable effects

In chronic heart failure

The most common reaction was dizziness. Other common are bradycardia, postural hypotension, overload and fluid retention, visual disturbances, weight gain and more.

Rarely syncope, AV- block or heart failure, in increasing dosage, acute renal failure and renal abnormalities in patients with diffuse vascular and / or reduced renal function.

 

In hypertension and angina

Symptomatic postural hypotension occurred most frequently during initiation of treatment or when increasing the dose, but the reaction is minimized subject to the prescribed dosage. Commonly observed dizziness, headache, fatigue, gastrointestenalni disorders (diarrhea, nausea, vomiting), bradycardia and hypotension. These reactions were generally mild, transient and occur early in the course of treatment.

Other commonly reported side effects are pain in the extremities and decreased tear secretion and in predisposed patients may occur dyspnoea and asthma.

Rarely depression, sleep disorders, wheezing, flu-like symptoms, rare and isolated skin reactions. May occur from PSORIASIS skin lesions or exacerbate existing ones. Rarely, a decrease in peripheral circulation (cold extremities) or peripheral edema.Ryadko monitor AV-block pertoris angina, exacerbation of symptoms of patients suffering from intermittent claudication, or progressive heart failure. Incidentally may appear stuffy nose.
 
 
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