Buprenorphine transdermal patch 35 mcg. . 5

Buprenorphine transdermal patch 35 mcg. . 5
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Buprenorphine. Actavis is analgesic (pain medicine) intended to relieve moderate to severe cancer pain and severe pain that does not comply with treatment with other types of painkillers. Buprenorphine is an opioid (a strong painkiller) .

Buprenorphine transdermal patch 35 mcg. /. 5 

What is Buprenorphine Actavis is and what it is used
Actavis is Buprenorphine analgesic (pain medicine) intended to relieve moderate to severe cancer pain and severe pain that does not comply with treatment with other types of painkillers. Buprenorphine is an opioid (strong painkiller) which reduces pain by acting on the central nervous system (specific nerve cells in the spinal cord and brain). Buprenorphine Actavis is not suitable for the treatment of acute (short-term) pain.

2. What you should know before using Buprenorphine Actavis
Do not use Buprenorphine Actavis
if you are allergic to buprenorphine, soybeans, peanuts, or any of the other ingredients of this medicine (listed in Section 6);
If you are dependent on strong painkillers (opioids);
if you suffer from a disease in which you have or may have severe breathing difficulties;
if you are taking monoamine oxidase (MAO) inhibitors (certain medicines used to treat depression) or have taken this type of medicine in the past two weeks (see "Other medicines and Buprenorphine Actavis");
if you suffer from myasthenia gravis (a certain type of severe muscle weakness);
if you suffer from delirium tremens (confusion and tremors caused by alcohol abuse after the usual excessive drinking or heavy drinking).
Buprenorphine Actavis should not be used for the treatment of symptoms of dependence in addicts.

Warnings and Precautions
Talk to your doctor or pharmacist before using Buprenorphine Actavis
if you drink large amounts of alcohol;
if you suffer from seizures or convulsions;
If your mind is disturbed (feeling light-headed or fainting), for an unknown reason;
if you are in a state of shock (cold sweat can be a sign for him);
if you intracranial pressure increases (e.g. after a head injury or brain disease), and it is not possible to conduct artificial respiration;
if you have difficulty breathing or are taking other drugs that can slow or weaken your breathing (see "other medicines");
If your liver is not working properly;
if you tend to abuse drugs or narcotics.
Please consult your doctor if any of these apply to you, or were applicable to you in the past.

Also, you must know and observe the following precautions:
Some people can become dependent on strong painkillers like Buprenorphine Actavis when using them continuously. They can cause withdrawal effects when you stop using them (see "If you stop using buprenorphine Actavis");
High temperatures and exposure to an external heat may result in the separation of larger amounts of buprenorphine in the blood than normal. Also, exposure to external heat may prevent proper adhesion of the transdermal patch. Therefore, not exposed to external heat (eg sauna, infrared lamps, electric blankets, hot water bottles), and consult your doctor if you have fever;
Use of the drug can lead to positive results when conducting doping test.
Children and adolescents
Buprenorphine Actavis is not recommended for use in persons aged less than 18 years since the product has not been studied in this age group.
Other medicines and Buprenorphine Actavis
Tell your doctor or pharmacist if you are taking, have recently taken or might take other medicines.
Buprenorphine Actavis should not be used concomitantly with monoamine oxidase (MAO) inhibitors (certain medicines used to treat depression and Parkinson's disease), or if you have taken this type of medicine in the last two weeks;
Buprenorphine Actavis can cause some people to feel drowsy, sick or weak, or delay or weaken breathing. These effects may be worse if other drugs with the same effects are taken at the same time. These drugs are other strong painkillers (opioids), some sleeping pills, anesthetics and drugs used to treat certain mental disorders, such as tranquilizers, antidepressants and neuroleptics. Some of these combinations at higher doses can cause serious problems with regulatory respiratory center of the brain, which can be life threatening;
The effects of transdermal patch may increase when Buprenorphine Actavis is used simultaneously with certain medications, such as certain anti-infective / antifungal (eg containing erythromycin or ketoconazole) or medicines to treat HIV infection (eg containing ritonavir);
The effects of transdermal patch can be reduced when Buprenorphine Actavis is used together with other medicines, such as the following products: dexamethasone; drugs for the treatment of epilepsy (e.g., containing carbamazepine or phenytoin) or drugs for treating tuberculosis (e.g., rifampicin).
Buprenorphine Actavis alcohol
You should not drink alcohol while using Buprenorphine Actavis. Alcohol may increase some of the side effects of the transdermal patch and you may feel unwell.

Pregnancy, lactation and fertility
If you are pregnant or breast-feeding, you think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist before using this medicine.

Not enough experience on the use of buprenorphine in pregnant women. Therefore you should not use Buprenorphine Actavis if you are pregnant or may become pregnant during treatment.

Buprenorphine, the active ingredient contained in the transdermal patch, inhibits the production of milk and passes into breast milk. Therefore, you should not use Buprenorphine Actavis if you are breastfeeding.

Driving and using machines
Buprenorphine Actavis may make you feel dizzy and affect your reactions to such an extent that you can not respond adequately or quickly enough in the event of unexpected or sudden events. This is especially:
at the beginning of treatment;
when another anesthetic switch to buprenorphine Actavis;
If you use other medicines that act on the brain;
if you drink alcohol.
During treatment with buprenorphine Actavis and at least 24 hours after treatment should not drive or operate machinery.

Buprenorphine Actavis contains soya oil
If you are allergic to peanut or soya, do not use this product.

3. How to use Buprenorphine Actavis
Always take this medicine exactly as your doctor tells you. If you are not sure, check with your doctor or pharmacist.
Buprenorphine Actavis is available in three strengths: Buprenorphine Actavis 35 mcg / h transdermal patch Buprenorphine Actavis 52.5 micrograms / hour transdermal patch and buprenorphine Actavis 70 mcg / h transdermal patch.
Choosing the most appropriate for you Buprenorphine concentration Actavis will be made by your doctor. During treatment, if necessary doctor can alter the concentration of a transdermal patch, use of which to the lower or higher.

The recommended dose is:
Unless your doctor tells you something different, stick a transdermal patch Buprenorphine Actavis (as detailed below) and replace it at least every three days.
To help you remember when to change the transdermal patch should make a note in the calendar of the outer packaging. If your doctor has advised you to take other painkillers, in addition to the transdermal patch, strictly follow the doctor's instructions, otherwise the benefits of buprenorphine Actavis will be full.

There is no need for dosage adjustment in elderly patients.

Patients with kidney disease / dialysis patients
In patients with kidney disease and dialysis patients, there is no need for dose adjustment.

Patients with liver disease
In patients with liver disease, intensity and duration of action of buprenorphine Actavis may be affected. If this applies to you, your doctor will monitor you more closely.

Use in children and adolescents
Buprenorphine Actavis should not be used in people aged under 18 years, because until now there is no experience of use in this age group.

Route of Administration
This patch is for transdermal administration (application to the skin). Buprenorphine Actavis operates through the skin. When a transdermal patch applied to the skin, the active substance buprenorphine passes through the skin into the bloodstream.

Method of administration
Prior to administration, the transdermal patch
Select a skin surface which is smooth, clean and depilated in the upper part of the body, preferably on the chest below the clavicle or on the upper part of the back. If we can not apply the transdermal patch, get help;
If the selected area has hair, cut them with scissors. Do not shave!;
Avoid skin that is red, irritated or has some other defects, such as large scars;
Area of skin that you choose must be dry and clean. If needed, wash it with cold or lukewarm water. Do not use soap or other detergents. After a hot bath or shower, wait until your skin is completely dry and become cool. Do not use lotion, cream or ointment on the selected area. This can prevent proper adhesion of the transdermal patch.
Instructions for opening the sachet, child-
Please do not open the sachet before actually going to use a transdermal patch.
1. Cut to the mark / top of the arrows on each side.
2. Tear heat sealed bag along side marked two places.
3. Open the pouch and place the patch.

The use of a transdermal patch
1. Each transdermal patch is sealed in a sachet.
2. Begin by separating the protective film.
3. Peel off one side of the peelable film coating of the transdermal patch and try not to touch the sticky side.
4. Glue transdermal patch over the area you have chosen and remove the other half of the foil.
5. Squeeze transdermal patch to the skin with the palm of your hand for 30 to 60 seconds. Make sure all the transdermal patch is in contact with the skin, especially on the edges.
6. Wash hands after use of the transdermal patch. Do not use cleaning products.
Wearing the transdermal patch
You can wear a transdermal patch to 3 days. Provided that you have correctly transdermal patch, the risk of it comes off a little. You can bathe in a bath or shower or swim while wearing it. However, do not expose the transdermal patch of very high temperature (eg sauna, infrared lamps, electric blankets, hot water bottles).
Unlikely Your transdermal patch to drop before you need to replace it, do not use the same transdermal patch again. Immediately stick the new one (see "Replacing the transdermal patch" below).

Replacing a transdermal patch
Take old transdermal patch;
Fold in half with the sticky side inwards;
Dispose of it carefully;
Insert the transdermal patch in a different place on the skin (as described above). Wait at least a week before using the same skin surface.
Duration of treatment
Your doctor will tell you how long you can use Buprenorphine Actavis. You should not stop using Buprenorphine Actavis in its decision because the pain may return and become unwell (see "If you stop using buprenorphine Actavis" below).
If you have the impression that the effect of buprenorphine transdermal patch Actavis is too weak or too strong, please tell your doctor or pharmacist.

If you use more than the dose Buprenorphine Actavis
If this happens could be signs of an overdose of the substance buprenorphine. Overdose may increase the side effects of buprenorphine as drowsiness, nausea and vomiting. Your pupils can become pinpoint and your breathing become slow and inadequate. You also get cardiovascular collapse.
As soon as you find that you use more transdermal patches than you should, remove excess transdermal patch and talk to a doctor or pharmacist.

If you forget to use Buprenorphine Actavis
If you forgot to stick the patch, install a new transdermal patch as soon as you remember. If you are very late changing the transdermal patch, the pain can be restored. In this case, please contact your doctor.
Never put two pieces of transdermal patches to make up application!

If you stop using buprenorphine Actavis
If you are interrupted or completed using Buprenorphine Actavis too early, the pain can be restored.
If you wish to stop treatment because of the occurrence of unpleasant side effects please consult your doctor. He / she will tell you what to do and whether it can be treated with other drugs.
Some people may experience withdrawal symptoms if used continuously strong painkillers when they cease to use them. The risk of effects after you stop using Buprenorphine Actavis is very low. However, if you feel agitated, anxious, nervous or instability if you are hyperactive, have trouble sleeping or digestive problems, tell your doctor.

If you have any questions about using this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If the hands, feet, ankles, face, lips, mouth or throat swell and you have difficulty in swallowing or breathing, hives, fainting, yellowing of the skin and eyes (jaundice), remove the transdermal patch immediately and call your doctor or seek care in the emergency room of the nearest hospital. These may be symptoms of a very rare serious allergic reaction.

Observed following side effects:
Very common (may affect more than 1 in 10 people):
Nausea (feeling sick), redness, itching.

Common (may affect up to 1 in 10 people):
Dizziness, headache, shortness of breath, vomiting, constipation, skin changes (rash and fever, usually after repeated use), sweating, edema (swelling of the feet, for example), fatigue.

Uncommon (may affect up to 1 in 100 people):
Confusion, sleep disturbances, anxiety, various degrees of sedation (calming), ranging from fatigue to confusion and reduced consciousness, circulatory disorders (such as low blood pressure, or in rare cases, circulatory collapse), dry mouth, rash, difficulty urination, urinary retention (less than normal urine), fatigue.

Rare (may affect up to 1 in 1000 people):
Loss of appetite, delusions such as hallucinations, anxiety and nightmares, reduced sex drive, difficulty with concentration, speech disorder, confusion and reduced consciousness, impaired balance, abnormal skin sensations (numbness, tingling or burning), visual disturbances, blurred vision, swelling of the eyelids, flushing, difficulty breathing (respiratory depression), heartburn, hives, difficulty achieving erection, withdrawal symptoms (see below), reactions at the injection site.

Very rare (may affect up to 1 in 10,000 people):
Severe allergic reactions, dependence, mood changes, muscle twitching, taste disturbances, pinpoint pupils, ear pain, unusual shortness of breath, hiccups, nausea, pustules (pustules), small blisters, pain in the chest.

If you notice any of the side effects listed above, tell your doctor as soon as possible.

In some cases it is observed in the time delayed allergic reactions, along with marked signs of inflammation. In such cases, you should stop using Buprenorphine Actavis after talking to your doctor.
Some people may experience withdrawal symptoms when used continuously strong painkillers and stop using them. The risk of effects after you stop using Buprenorphine Actavis is very low. However, if you feel agitated, anxious, nervous or instability if you are hyperactive, have trouble sleeping or digestive problems, tell your doctor.

If you get any side effects, tell your doctor or pharmacist. This includes all listed in this leaflet.

5. How to store Buprenorphine Actavis

The expiry date refers to the last day of that month.

Do not dispose of medications in wastewater or household waste. These measures will help to protect the environment.
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