BICNU. 100 mg

Bristol-Myers Squibb
BICNU. 100 mg
€ 68.00
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Your medicine is called BiCNU and its active ingredient is acting carmustine (carmustine).

As an excipient used as a solvent, BiCNU comprises anhydrous alcohol.

BiCNU is "cytotoxic" drug. Cytotoxic drugs kill cells that divide, including tumor cells.

BiCNU applied as a sole drug or in combination with other approved anticancer agents for the treatment of the following diseases:

1. Brain tumors - glioblastoma, brainstem glioma, meduloblostom, astrocytoma, ependymoma, and metastatic brain tumors.

2. Multiple myeloma - in combination with prednisone.

3. Hodgkin's disease - as secondary therapy in combination with other approved drugs for patients with relapsed during primary therapy or who did not respond to primary therapy.

4. Non-Hodzhknnovi lymphomas - as secondary therapy in combination with other approved drugs for patients with relapsed during primary therapy or who did not respond to primary therapy.

5. Other solid tumors - BiCNU is used in combination with other drugs only after failure of other conventional methods.


Before starting treatment, your doctor will make sure that the adoption of BiCNU is safe for you.

Do not use BiCNU

- If you are allergic (hypersensitive) to carmustine or any of the other ingredients of BiCNU.

BiCNU and most cytotoxic drugs may affect the cells in your bone marrow. These cells divide very quickly to make new blood cells. Your doctor will carry out constant monitoring of your blood by the hospital laboratory will be listed each type of blood cells (platelets, white and red blood cells). Your doctor may decide to change the originally determined dose or stop treatment if the number of your blood cells is too low. This number is recovering very quickly, since bone marrow constantly produces new cells.

Using other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Pregnancy and lactation

Tell your doctor if you are pregnant or intend to become pregnant and he will decide if you should apply the drug during this period.

BiCNU may cause serious adverse reactions in nursing infants, therefore you should not breast-feed while being treated with this medicine.
Ask your doctor or pharmacist before taking any medicine.

Driving and using machines

Taking this drug can lead to headaches and fatigue, which can impair your ability to drive and use machines.


The dosage and duration of treatment is determined only by your doctor. The nurse will measure your height and weight, and will calculate your body surface, based on which your doctor will determine the exact dosage of the drug, depending on the type of your illness.

Hospital pharmacists, nurse or doctor will have dissolved BiCNU vial with 3 ml of sterile solvent (anhydrous alcohol) and then to the alcohol solution will add 27 ml of sterile water for injection. In preparing the described way will give a clear, colorless to pale yellow solution, which then may be diluted with physiological saline or 5% dextrose solution. This reconstituted solution will be injected into your veins. This is called "intravenous infusion". This infusion should be performed for 1 to 2 hours. When infusion of the solution for a short time may feel severe pain and burning at the injection site and redness of the skin and conjunctiva (eye inflammation), which should tell your doctor immediately.

Your doctor or nurse will observe in the infusion of the drug does not leak out of your vein. If during the introduction of the drug or after you have pain or swelling, tell about it. If you do not take the necessary measures in time, the expiry of the drug outside the vein can cause inflammation of the surrounding tissue.

Usual dosage regimen:

If you have not previously treated and are treated with BiCNU, the usual dose is 200 mg / m2 intravenously every 6 weeks. She may be given as a single dose or divided into daily injections of 100 mg / m 2 consecutive days.

Your doctor will monitor regularly the number of your blood cells (platelets, white and red blood cells) and a second course of treatment will be given to you earlier than six weeks.

If you use more than the amount BiCNU

As this medicine will be placed only by medical personnel, it is no risk of overdose or missed dose. If you are treated ambulatory is very important to visit the clinic whenever you is determined by your doctor.


Administration of this drug may cause structural changes in the lung (pulmonary infiltrates and / or fibrosis). The occurrence of this effect is significantly increased in children and young patients, in smokers, patients with previous respiratory diseases, as well as those who are subject to intense exposure to the chest area. Therefore, before starting treatment with BiCNU, your doctor will examine the functions of your lung.

Effects on the blood:
Reduce the number of blood cells (platelets, red and white blood cells).

After administration of the drug often occurs nausea and vomiting, which usually last 4 to 6 hours, depending on the dosage administered. Your doctor may suggest something against these side effects.

Reversible hepatic injury, manifested by increased levels of some liver tests after high doses BiCNU.

Reported for renal disorders characterized by a reduced rate of kidney, progressive azotemia (retention of nitrogen) and renal failure in patients receiving high doses after chronic treatment with BiCNU and drugs of this class. In rare cases, there are reports of renal impairment in patients receiving lower doses.

Decrease in blood pressure, rapid heartbeat.

Neuroretinitis (type of damage to the retina), chest pain, headache, allergic reactions.

Burning at the injection site is often, but true thrombosis (blockage) occurs rarely.

For these and all monitored during treatment side effects, contact your doctor immediately.

Like all medicines, BiCNU can cause side effects, although not everybody gets them.

If any of the side effects gets serious, or if you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.


Keep out of reach of children.

Hospital pharmacy must keep vials BiCNU refrigerated (2-8 ° C).

After reconstitution in the prescribed manner BiCNU is stable for 24 hours when stored at 2-8 ° C temperature.

BiCNU not use after the expiry date stated on the carton. The expiry date refers to the last day of that month.

Recommendations for use

To comply with the special requirements for the handling and storage of cytostatics.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.


What BiCNU

The active substance is carmustine. The other ingredient is anhydrous ethanol.

BiCNU looks like and contents of the pack

BiCNU is available in a package including a glass vial containing 100 mg carmustine and a vial or ampoule containing / a 3 ml sterile solution.
€ 68.00
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