Adalat Eins. 30 mg. 30 tablets
Adalat Eins. 30 mg. 30 tablets
Drug veshtestvoADALAT Eins 30 mg coated tablet contains 30 mg nifedipine
Help veshtestvaCrospovidon , colloidal silicon dioxide, medium-and low-viscosity hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose monohydrate, macrogol 4000 , magnesium stearate, maize starch, microcrystalline cellulose, ferric (III) oxide (E 172 ), titanium (IV) oxide ( E 171).
Packing contains 28 coated tablets.
Mode of action and therapeutic group
Calcium antagonist.Lekarstvo for treatment of hypertension.
Essential hypertension (high blood pressure with no identifiable organic cause ) .
When should you not use ADALAT Eins 30 mg?
ADALAT Eins 30 mg should not be used if you :
- You're in cardiovascular shock;
- Have a strong narrowing of the blood vessels leading from the heart to the main artery (high -grade aortic stenosis) ;
- You have unstable angina pectoris ;
- Suffering from acute myocardial infarction (heart attack ) in the last four weeks ;
- If you are taking rifampicin ( tuberculosis medicine ) at the same time ;
- If you are allergic to nifedipine or other ingredients;
- If you are pregnant or breastfeeding.
When should I consult a doctor before taking ADALAT Eins 30 mg?
Described below are those cases where you need to take 30 mg ADALAT Eins in special circumstances and with special care. Please consult your doctor in such cases. You should also consult your doctor if you are writing apply to you in the past.
Especially careful medical supervision is necessary in patients who :
- A very low blood pressure (systolic blood pressure less than 90 mm Hg)
- Have a strong heart failure ( decompensated heart failure), which do not receive adequate treatment.
Caution is recommended in patients on dialysis who also have high blood pressure (malignant hypertension) and reduced cardiac volume ( hypovolemia ) ; enlargement of blood vessels (vasodilatation ) can cause significant decreases in blood pressure .
What you should know when you are pregnant or breast-feeding?
ADALAT Eins 30 mg should not be used during the entire pregnancy because katoprouchvaniya with drug nifedipine demonstrate evidence of damage to the fetus. Nyamadostatachni evidence in humans. If you find that you are pregnant while taking ADALATEins 30 mg, you should consult with your doctor about alternative lechenie.Nifedipine passes into breast milk . If you need ADALAT Eins 30 mg while breastfeeding , you should drop your baby because there is no data on the possible effects of nifedipine varhukarmacheto .
Special warnings and precautions for use What precautions should be taken ?
Nifedipine can be degraded very slowly in your body if you have liver dysfunction . Your doctor will monitor your condition and reduce the dose if neobhodimo.Patsientite a serious breach of the blood circulation in the brain ( cardiovascular disease) should receive a lower dose.
What precautions should be taken when driving , operating machinery or work without safe foothold ?
Use of this medication requires regular medical follow-up . Reactions to this drug may vary in individuals and the effect of your reaction may impair the ability to drive , operate machinery or work without stable support . This is especially true at the beginning of treatment when the dose is increased , a change in drug and alcohol consumption.
Interactions with other drugs
What other drugs affect the operation of ADALAT Eins 30 mg or themselves influenced by ADALAT Eins 30 mg?
The effect of lowering the blood pressure of nifedipine ( active ingredient of ADALAT Eins 30 mg) may be enhanced by other medications to lower blood pressure , and tricyclic antidepressants ( medicines used to treat depression ) . Concomitant treatment with nitrate (used for the treatment of coronary heart disease) enhances the effect of 30 mg of ADALAT Eins on blood pressure and heart rate.
It has been shown , careful monitoring of the patient when nifedipine is administered concurrently with a beta blocker ( a drug used to treat high blood pressure and coronary heart disease) , as this may result in a very strong decrease of the blood pressure ; in some cases , cardiac ??????????????.????????????? of nifedipine using specific enzymes ( cytochrome P450 ZA4 ) . As a result, the simultaneous use of drugs, which are known to affect this enzyme system , may result in interaction between the drug and nifedipine.Diltiazem ( medicine used to treat high blood pressure), reduces the degradation of nifedipine. If you are taking this medicine , your doctor will carefully monitor your disease and reduce the dose of nifedipine, if neobhodimo.V isolated cases nifedipine reduces the concentration of quinidine (a drug used to treat cardiac arrhythmias ) or significantly increases the level of quinidine in blood , which may occur after discontinuation of nifedipine; level of quinidine levels should therefore be monitored in case of simultaneous upotreba.Nifedipine may increase blood concentrations of digoxin (a drug used primarily to treat heart failure) and theophylline (a drug used to treat respiratory diseases) : therefore recommended monitorirane.Ednovremenno using quinupristine / dalfopristin (antibiotics) and nifedipine may enhance the effect of nifedipine. Therefore, the blood pressure of the patient should be monitored and if necessary, the dose of nifedipine to korigira.Tsimetidin ( a drug used for the treatment of gastric and intestinal ulcers) increases the concentration of nifedipine in the blood and , therefore, enhances the effect of nifedipine.Rifampitsin ( drug used to treat tuberculosis ) , accelerates the decomposition of nifedipine. Rifampicin is to be administered at the same time with nifedipine, as will be prepared effective concentrations of nifedipine in kravta.Nifedipine reduces excretion of vincristine ( a drug used to treat cancer ), which means that the side effects of vincristine may be increased . For this reason it is recommended to reduce the dose of vinkristin.Povisheni blood concentrations of cephalosporin were observed after concomitant administration of cephalosporins ( eg antibiotic cefixime ) and nifedipine.Ednovremennata use of phenytoin (a medicine used to treat cardiac arrhythmias and epilepsy ) and nifedipine attenuates the efficacy of nifedipine. If the two drugs are used simultaneously , the patient's response should be monitored and if it is necessary to increase the dose of nifedipine. It may be necessary to adjust the dosage of nifedipine after phenytoin is interrupted.
The risk of the amplification effect of nifedipine can not be ruled out when nifedipine is used at the same time with drugs containing the following active ingredients:
- Erythromycin (antibiotic) ,
- Fluoxetine, nefazodone ( antidepressant )
- Amprenavir , indinavir , nelfinavir , ritonavir or sangvinaeir ( medicinal substances used for treatment of certain viral infections)
- Ketoconazole , itraconazole or fluconazole ( drugs used to treat certain fungal infections) .
Simultaneous use of tacrolimus ( substance used for the prevention of transplant rejection , e.g. after renal transplantation ) and nifedipine may lead to elevated levels of whole blood ; in isolated cases, it may be necessary to reduce the dose of tacrolimus. It is recommended that regular monitoring of tacrolimus levels in kravta.Opitat calcium antagonist nimodipine shows that the possibility of co-administration of carbamazepine or phenobarbital (medicines used to treat epilepsy ) attenuated the effect of nifedipine.
Please note that this information may also apply to drugs currently used .
What food should be avoided ?
Do not take ADALAT Eins 30 mg of grapefruit juice as it inhibits the decomposition of nifedipine in the body and thereby enhances the effect of ADALAT Eins 30 mg.
Dosage and Administration
Unless prescribed otherwise by your doctor , you should use ADALAT Eins 30 mg as it is written below. Please follow the instructions carefully as ADALAT Eins 30 mg will not work correctly.
How should you take ADALAT Eins 30 mg and how often?
Wherever possible, treatment should be tailored to the severity of your illness and your response to treatment.
1 tablet ADALAT Eins 30 mg once daily (equivalent to 30 mg nifedipine). Depending on the clinical recommended dose should be achieved gradually; e. by initial treatment with ADALAT Eins 30 mg.
Dosage in patients with impaired hepatic function:
The starting dose is 1 tablet always ADALAT Eins 30 mg once daily (equivalent to 30 mg nifedipine). This is usually a maintenance dose. The patient should be carefully monitiriran .
If your doctor has found serious damage to the blood circulation in the brain ( mazachno - vascular damage), treatment should be started at a lower dose.
When and how to take ADALAT Eins 30 mg?
ADALAT Eins 30 mg coated tablets should be swallowed whole with plenty of fluid (eg one glass of water) , preferably in the morning - the best time is 14 hours before breakfast. ADALAT Eins 30 mg coated tablet can provide a lasting effect if swallowed whole without breaking or chewed .
How long should you take ADALAT Eins 30 mg?
Your doctor should determine the duration of treatment.
Misuse and overdose
What should you do if you took a lot ADALAT Eins 30 mg ( intentionally or accidentally ) ? If you think you have taken a high dose , you should immediately inform your doctor / emergency physicians , so that he may decide what measures to take . In case of overdose risk of marked lowering of blood pressure , slowing or accelerating heartbeat , clouding of consciousness to coma , elevated blood sugar levels ( hyperglycemia ) , shortage in the blood supply to major organs and shock caused by heart failure, leading of fluid in the lungs (pulmonary edema) .
What should you do if you have taken several tablets ADALAT Eins 30 mg or you forgot to take your dose ?
Do not take more ADALAT Eins 30 mg coated tablets for the next dose; just continue the treatment as prescribed by lekarya.Kakvo need to do if you want to interrupt treatment or stop using ADALAT Eins 30 mg before the end of the treatment course ? should always consult with your doctor before you decide to interrupt or stop treatment taking ADALAT Eins 30 mg.Ako want to stop using ADALAT Eins 30 mg, especially high dose , this should be done gradually.
What side effects may occur when using ADALAT Eins 30 mg? Reported the following adverse reactions following administration of nifedipine ( active substance of ADALAT Eins 30 mg). The frequency is expressed as follows:
Very common: More 1 in 10 patients treated
Frequently : Less than 1 in 10 patients treated, but more than 1 at 100 -treated patients
Sometimes : Less than 1 in 100 patients treated , but more than 1 at 100 -treated patients
Rarely : Less than 1 in 1000 patients treated, but more than 1 pri10000 treated patients
Rarely : Less than 1 in 10,000 patients treated, vklyuchitelnoizolirani cases
At the beginning of the treatment may very often occur headache and peripheral edema (fluid retention in the legs ) , which is due to the dilation of blood vessels ; These side effects are usually transient .
Especially early in treatment may occur flushing , flushing with heat sensation (erythema ), conditions involving painful swelling and redness of the hands and feet ( erythromelalgia ) .
Fast heart rate ( tachycardia), temporary loss of consciousness due to very low blood pressure ( syncope) and lowering blood pressure below normal ( hypotonic circulatory reaction). Also there are reports of palpitations, dizziness , drowsiness, feeling of weakness and nausea.
Treatment with nifedipine sometimes causes diarrhea , abdominal pain , constipation , dyspepsia, flatulence , nausea , vomiting , and dry mouth .
Additionally may occur weakness, breathing difficulties ( dyspnea) , nervousness , weakness , sleep disturbances or insomnia, decreased sensitivity to touch ( hypoaesthesia ) , tingling in hands and feet ( paresthesia ) , tremor of the fingers, muscle pain or joint pain and muscle spazmi.Ponyakoga observed hypersensitivity skin reactions such as itching (pruritus ), skin rash ( exanthema ) , swelling of the skin and mucous membranes ( angioedema, swelling of the face ) , sweating, and liver function disorders ( intrahepatic cholestasis , elevated transaminases) . in patients with renal insufficiency, the use of nifedipine may sometimes cause deterioration of the transient liver function. Also it can sometimes occur urinary frequency and an increased amount of urine per day . Reported were mild, transient changes in zrenieto.Spetsialno early in treatment may occur angina attacks in patients with angina to enhance seizure frequency , duration and severity of pristapite.V isolated cases have been described myocardial infarction.
Treatment with nifedipine rarely causes a feeling of bloating , belching , and loss of appetite . In rare cases, continued treatment may cause changes in the gums ( gingival hyperplasia ), which are fully reversible after discontinuation. Rarely seen rash ( urticaria), inflammation of the skin after sun exposure and UV radiation ( photodermatitis ) and zhaltenitsa.V rare cases, especially in older men with long-term treatment was observed breast enlargement ( gynecomastia ) ; until now this was reversible after discontinuation of lechenieto.V rare cases in connection with the use of nifedipine are described changes in the number of blood cells as a reduction of red or white blood cells or platelets (anemia , leukopenia, thrombocytopenia), bleeding from the skin and mucous membranes and a decrease in platelets ( thrombocytopenic purpura) and small hemorrhages in the skin and mucous membranes ( purpura) .
In rare cases, you may experience severe generalized allergic reactions such as fever , swelling of the larynx ( glottis edema ) , spasms of the bronchial muscles can cause shortness of potentially fatal degree ; these reactions resolve after stopping treatment. Are rare reports of impaired zrenie.V rare cases , increases in serum blood sugar ( hyperglycemia ) . This is especially important consideration in patients with diabetes diabet.Mnogo Ryadkov very rare cases reported marked reduction of certain blood cells ( agranulocytosis ), and scaly inflammation of the skin ( exfoliative dermatitis) . In isolated cases of in vitro fertilization treatment with calcium channel blockers such as nifedipine is associated with transient changes in sperm and impaired sperm function.If have side effects not listed in this leaflet, please tell your doctor or pharmacist.
What should you do if you experience any of these side effects ?
Most of the above side effects are transient and do not require special treatment. You should tell your doctor and he can decide what measures to take.
Information about the shelf life of the product
The shelf life of this product is printed on the carton and blister . Do not use after expiry date .
How should I store ADALAT Eins 30 mg?
The tablets can be stored in their original packaging . Keep out of reach of children .